Oleanolic Acid Exerts a Neuroprotective Effect Against Microglial Cell Activation by Modulating Cytokine Release and Antioxidant Defense Systems

Long-Term Impact of Neonatal Intake of Oleanolic Acid on the Expression of AMP-Activated Protein Kinase, Adiponectin and Inflammatory Cytokines in Rats Fed with a High Fructose Diet

(2019) Mashudu Matumba et al.   Nutrients

Novel Approaches for the Treatment of Alzheimer’s and Parkinson’s Disease

(2019) Michiel Van Bulck et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prevention of type 2 diabetes in prediabetic patients by using functional olive oil enriched in oleanolic acid: The prediabole study, a randomised controlled trial

(2019) José M. Santos‐Lozano et al.   DIABETES OBESITY & METABOLISM

Aqueous extracts of se-enriched Auricularia auricular attenuates D-galactose-induced cognitive deficits, oxidative stress and neuroinflammation via suppressing RAGE/MAPK/NF-κB pathway

(2019) Jingjing Wang et al.   NEUROSCIENCE LETTERS

Oleanolic Acid Mitigates 6-Hydroxydopamine Neurotoxicity by Attenuating Intracellular ROS in PC12 Cells and Striatal Microglial Activation in Rat Brains

(2019) Zama N. P. Msibi et al.   Frontiers in Physiology

Tetrazolium salts and formazan products in Cell Biology: Viability assessment, fluorescence imaging, and labeling perspectives

(2018) Juan C. Stockert et al.   ACTA HISTOCHEMICA

Protein-C Reactive as Biomarker Predictor of Schizophrenia Phases of Illness? A Systematic Review

(2018) Laura Orsolini et al.   Current Neuropharmacology

Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus

(2018) Xavier Palomer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A decade of nutraceutical patents: where are we now in 2018?

(2018) Patricia Daliu et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Berberine ameliorates lipopolysaccharide-induced learning and memory deficit in the rat: insights into underlying molecular mechanisms

(2018) Sepideh Sadraie et al.   METABOLIC BRAIN DISEASE

Hyperoside inhibits lipopolysaccharide-induced inflammatory responses in microglial cells via p38 and NFκB pathways

(2017) Hui-Hui Fan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

AMPK as a Therapeutic Target for Treating Metabolic Diseases

(2017) Emily A. Day et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Effects of a Saturated Fat and High Cholesterol Diet on Memory and Hippocampal Morphology in the Middle-Aged Rat

(2017) Ann-Charlotte Granholm et al.   JOURNAL OF ALZHEIMERS DISEASE

Physical activity and exercise attenuate neuroinflammation in neurological diseases

(2016) Lindsay Joy Spielman et al.   BRAIN RESEARCH BULLETIN

Effect of agomelatine treatment on C-reactive protein levels in patients with major depressive disorder: an exploratory study in “real-world,” everyday clinical practice

(2016) Domenico De Berardis et al.   CNS SPECTRUMS

Free radical scavenging and α-glucosidase inhibition, two potential mechanisms involved in the anti-diabetic activity of oleanolic acid

(2016) J. M. Castellano et al.   GRASAS Y ACEITES

Inhibition of Nitric Oxide Production in BV2 Microglial Cells by Triterpenes from Tetrapanax papyriferus

(2016) Namki Cho et al.   MOLECULES

Nitric Oxide: Exploring the Contextual Link with Alzheimer’s Disease

(2016) Nicholas Asiimwe et al.   Oxidative Medicine and Cellular Longevity

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

GC-FID determination and pharmacokinetic studies of oleanolic acid in human serum

(2015) Mirela Rada et al.   BIOMEDICAL CHROMATOGRAPHY

Cellular and metabolic alterations in the hippocampus caused by insulin signalling dysfunction and its association with cognitive impairment during aging and Alzheimer's disease: studies in animal models

(2015) Erika Calvo-Ochoa et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Dieckol Attenuates Microglia-mediated Neuronal Cell Death via ERK, Akt and NADPH Oxidase-mediated Pathways

(2015) Yanji Cui et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Paroxetine ameliorates lipopolysaccharide-induced microglia activation via differential regulation of MAPK signaling

(2014) Rong-Pei Liu et al.   Journal of Neuroinflammation

BDNF Mediates Neuroprotection against Oxygen-Glucose Deprivation by the Cardiac Glycoside Oleandrin

(2014) Michael J. Van Kanegan et al.   JOURNAL OF NEUROSCIENCE

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inflammation in Alzheimer’s disease: insights from immunotherapy

(2013) Jonathan M. Schott et al.   BRAIN

Biochemical Basis of the Antidiabetic Activity of Oleanolic Acid and Related Pentacyclic Triterpenes

(2013) J. M. Castellano et al.   DIABETES

Nutraceutical agents with anti-inflammatory properties prevent dietary saturated-fat induced disturbances in blood–brain barrier function in wild-type mice

(2013) Ryusuke Takechi et al.   Journal of Neuroinflammation

Analysis of GSH and GSSG after derivatization with N-ethylmaleimide

(2013) Daniela Giustarini et al.   Nature Protocols

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

State of the art of Ready-to-Use Therapeutic Food: A tool for nutraceuticals addition to foodstuff

(2012) Antonello Santini et al.   FOOD CHEMISTRY

Houttuyniae Herba protects rat primary cortical cells from Aβ25–35-induced neurotoxicity via regulation of calcium influx and mitochondria-mediated apoptosis

(2012) H Park et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Oleanolic Acid Reduces Hyperglycemia beyond Treatment Period with Akt/FoxO1-Induced Suppression of Hepatic Gluconeogenesis in Type-2 Diabetic Mice

(2012) Xiao-Yi Zeng et al.   PLoS One

PI3K and ERK/Nrf2 pathways are involved in oleanolic acid-induced heme oxygenase-1 expression in rat vascular smooth muscle cells

(2011) Jian Feng et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Activation of cannabinoid receptors by the pentacyclic triterpene α,β-amyrin inhibits inflammatory and neuropathic persistent pain in mice

(2011) Kathryn A.B. Simão da Silva et al.   PAIN

Post-prandial lipid metabolism, lipid-modulating agents and cerebrovascular integrity: Implications for dementia risk

(2010) Menuka M.S. Pallebage-Gamarallage et al.   ATHEROSCLEROSIS SUPPLEMENTS

Pentacyclic Triterpenoids from Olive Fruit and Leaf

(2010) Ángeles Guinda et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Increased Mitochondrial Fatty Acid Oxidation Is Sufficient to Protect Skeletal Muscle Cells from Palmitate-induced Apoptosis

(2010) Carole Henique et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A molecular pharmacology study into the anti-inflammatory actions of Euphorbia hirta L. on the LPS-induced RAW 264.7 cells through selective iNOS protein inhibition

(2010) Mei-Fen Shih et al.   Journal of Natural Medicines

Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-α-induced E-selectin expression by cultured umbilical vein endothelial cells

(2010) K. Takada et al.   PHYTOMEDICINE

Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.)

(2010) Lasse Saaby et al.   PHYTOTHERAPY RESEARCH

Relationship between urinary sodium excretion and pioglitazone-induced edema

(2010) Akinobu Nakamura et al.   Journal of Diabetes Investigation

Aralia cordata Protects Against Amyloid β Protein (25–35)–Induced Neurotoxicity in Cultured Neurons and Has Antidementia Activities in Mice

(2009) Soon Ock Cho et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant Extracts

(2009) Sebastian Jäger et al.   MOLECULES

Association between enzymatic and non-enzymatic antioxidant defense mechanism with apolipoprotein E genotypes in Alzheimer disease

(2008) Hadi Kharrazi et al.   CLINICAL BIOCHEMISTRY

Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats

(2008) Alexis M. Stranahan et al.   HIPPOCAMPUS

Oleate Reverses Palmitate-induced Insulin Resistance and Inflammation in Skeletal Muscle Cells

(2008) Teresa Coll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antioxidative and Anti-Inflammatory Protection of Oleanolic Acid and Ursolic Acid in PC12 Cells

(2008) Shih-Jei Tsai et al.   JOURNAL OF FOOD SCIENCE