Article
Pharmacology & Pharmacy
Soomaayeh Heysieattalab, Jafar Doostmohammadi, Mahgol Darvishmolla, Negin Saeedi, Narges Hosseinmardi, Masoumeh Gholami, Mahyar Janahmadi, Samira Choopani
Summary: Long-term administration of ASA and SS may have detrimental effects on spatial learning and memory, as well as hippocampal synaptic plasticity, leading to impairments in memory acquisition and retrieval.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marta Zamarbide, Eva Martinez-Pinilla, Francisco Gil-Bea, Masashi Yanagisawa, Rafael Franco, Alberto Perez-Mediavilla
Summary: The study demonstrates the presence of the FFA3 receptor in the human brain and its involvement in cognitive processes. Inactivating the FFA3 gene can prevent AD-like cognitive decline and pathological hallmarks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Ana C. Sanchez-Hidalgo, Francisco Arias-Arag, M. Teresa Romero-Barrag, Celia Martin-Cuevas, Jose M. Delgado-Garcia, Amalia Martinez-Mir, Francisco G. Scholl
Summary: The study indicates that dysfunction in PS/gamma-secretase complex may lead to neuronal deficits in familial Alzheimer's disease. Transgenic mice models in the research show an association between the accumulation of NrxnCTF and impairments in associative memory and short-term synaptic plasticity.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Zijuan Zhang, Ziyang Yu, Ye Yuan, Jing Yang, Shijie Wang, He Ma, Li Hao, Jinlian Ma, Zhonghua Li, Zhenqiang Zhang, Christian Hölscher
Summary: Synaptic impairment and loss are important in Alzheimer's disease (AD), and can cause cognitive dysfunction and memory loss. In this study, a novel CCK analogue was found to improve synaptic plasticity, spatial learning, and memory in an AD mouse model. This effect was achieved through the activation of the PI3K/Akt and PKA/CREB-BDNF/TrkB signaling pathways, leading to protection of synapses and cognition.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Yulia Dembitskaya, Charlotte Piette, Sylvie Perez, Hugues Berry, Pierre J. Magistretti, Laurent Venance
Summary: The study shows that glucose and lactate play different roles in memory engram and neural computation. Lactate is important for high-stimulation load activity patterns and high attentional load in cognitive tasks, while glucose is sufficient for less demanding neural computation and learning tasks.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Ping Liao, Qing-Yun Wu, Sen Li, Kai-Bin Hu, Hui-Lin Liu, Hai-Yan Wang, Zai-Yun Long, Xiu-Min Lu, Yong-Tang Wang
Summary: Abscisic acid (ABA) is a hormone found in plants and animals that regulates blood glucose and inflammation. It has therapeutic effects on obesity, diabetes, atherosclerosis, and inflammatory diseases. Studies have shown that ABA can cross the blood-brain barrier and improve learning, memory, and cognitive ability in the central nervous system. Additionally, it plays a crucial role in improving Alzheimer's disease, depression, and anxiety.
Article
Immunology
Ivan Ballasch, Esther Garcia-Garcia, Cristina Vila, Anna Perez-Gonzalez, Anna Sancho-Balsells, Jessica Fernandez, David Soto, Mar Puigdellivol, Xavier Gasull, Jordi Alberch, Manuel J. Rodriguez, Josep M. Canals, Albert Giralt
Summary: In the last two decades, microglia have been recognized as important contributors to neurological disorders, not only through their immunological functions, but also through their ability to modulate synaptic and neural activity. The Ikzf1 gene, which plays crucial roles in regulating the function of circulating monocytes and lymphocytes, was found to be specifically expressed in adult microglia in the brain. Studies using Ikzf1 deficient mice revealed spatial learning deficits, impaired hippocampal function, and altered microglial morphology, suggesting that Ikzf1 is involved in microglial state and function. Furthermore, altered levels of Ikzf1 were observed in neurological disorder models and Alzheimer's disease patients, indicating its potential role in disease pathology.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Neurosciences
Timothy Tadros, Maxim Bazhenov
Summary: Relational memory is critical for mammalian reasoning. Sleep plays a crucial role in offline processing and improving the ability to make indirect associations.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Zhiwei Xue, Lei Ye, Jianwei Ge, Zhen Lan, Xinxin Zou, Chenglu Mao, Xinyu Bao, Linjie Yu, Yun Xu, Xiaolei Zhu
Summary: In this study, the researchers found that the inhibition of ABHD6 could improve synaptic function and memory impairment in APP/PS1 mice with Alzheimer's disease, without affecting the levels of amyloid-beta and neuroinflammation in the brain. Injection of the ABHD6-specific inhibitor wwl70 enhanced synaptic plasticity and memory function, lowered amyloid-beta levels and neuroinflammation, and promoted the phagocytosis of amyloid-beta by microglia.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Xiying Guo, Min Lei, Jiangyan Zhao, Min Wu, Zhanhong Ren, Xiaosong Yang, Changhan Ouyang, Xiufen Liu, Chao Liu, Qingjie Chen
Summary: The GLP-1/GIP dual agonist tirzepatide has a protective effect against spatial learning and memory impairment in diabetic rats, possibly through regulating insulin resistance and inflammatory responses.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Leigang Song, Huan Chen, Dan Qiao, Bohan Zhang, Fangzhen Guo, Yizhou Zhang, Chang Wang, Sha Li, Huixian Cui
Summary: Androgens regulate learning and memory in mice through ZIP9, which is mediated by the ERK1/2-eIF4E pathway. This study provides new experimental evidence for the improvement of learning and memory in Alzheimer's disease through androgen supplementation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Environmental Sciences
Yifeng Rang, Huan Liu, Chunhong Liu
Summary: This review summarizes the mechanisms underlying Nonylphenol (NP)-induced learning and memory impairment and proposes possible therapeutic methods. Through behavior tests and other studies, oxidative stress, neurotransmitter disorder, synaptic plasticity impairment, and neuron injury are identified as key factors contributing to learning and memory deficits. In addition, chronic inflammation and increased gut permeability are also suggested to be associated with NP-induced learning and memory impairment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Cell Biology
Jessica Cornell, Shelbi Salinas, Hou-Yuan Huang, Miou Zhou
Summary: Microglia are resident macrophages of the central nervous system with diverse morphologies and functions. Resting microglia play a crucial role in regulating synaptic pruning and neuronal activity under normal conditions, while activated microglia secrete proteins that can lead to synaptic plasticity and cognitive deficits associated with various diseases and disorders. This review discusses the role of microglia in synaptic plasticity and learning and memory, as well as the potential of manipulating microglia as a therapeutic approach to alleviate cognitive deficits.
NEURAL REGENERATION RESEARCH
(2022)
Article
Immunology
Shunqin Fan, Xijun Wang, Ning Gao, Songli Wei
Summary: In a rat model, electroacupuncture pretreatment was found to improve learning and memory deficits induced by recurrent propofol exposure. It also enhanced hippocampal synaptic plasticity, activated the pCREB/BDNF pathway, and inhibited neuronal apoptosis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Immunology
Andrea Mancini, Veronica Ghiglieri, Lucilla Parnetti, Paolo Calabresi, Massimiliano Di Filippo
Summary: The basal ganglia network, traditionally known for its role in motor learning and movement execution, is now recognized as a key regulator of cognitive and emotional processes. The striatum acts as an input station in the circuit, influencing the functional output of the whole system through synaptic plasticity. The immune system's regulation of synaptic activity in the striatum may play a role in inflammatory and degenerative CNS diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Ehsan Sharifipour, Soroush Sharifimoghadam, Navid Hassanzadeh, Negin Ghasemian Mojarad, Abdoreza Ghoreishi, Seyyed Amir Hejazi, Kambiz Rohampour
ACTA NEUROLOGICA BELGICA
(2020)
Article
Neurosciences
Motahareh Rouhi Ardeshiri, Narges Hosseinmardi, Esmaeil Akbari
Article
Neurosciences
Parvin Niknam, Mohammad Reza Raoufy, Yaghoub Fathollahi, Mohammad Javan
MOLECULAR AND CELLULAR NEUROSCIENCE
(2019)
Article
Neurosciences
Masoumeh Gholami, Narges Hosseinmardi, Javad Mirnajafi-Zadeh, Mohamad Javan, Saeed Semnanian, Nasser Naghdi, Yaghoub Fathollahi
EXPERIMENTAL BRAIN RESEARCH
(2020)
Article
Behavioral Sciences
Hamideh Zahiri, Mohammad Rostampour, Behrooz Khakpour, Kambiz Rohampour
Summary: The NMDA receptors play a crucial role in learning and memory formation, and the antagonist MK-801 impairs passive avoidance memory. Ghrelin, on the other hand, may ameliorate the memory impairment induced by MK-801 through a compensative effect potentially mediated by NMDA receptors.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Mahmoud Rezaei, Nooshin Ahmadirad, Zahra Ghasemi, Amir Shojaei, Mohammad Reza Raoufy, Victoria Barkley, Yaghoub Fathollahi, Javad Mirnajafi-Zadeh
Summary: The study investigated the inhibitory effects of low frequency stimulation (LFS) on high-K+ induced epileptiform activity (EA) in rat hippocampal slices. The results suggested that LFS partially mediates its anticonvulsant effect through α adrenergic receptors, reducing neuronal hyperexcitability following high-K+ EA.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Samira Rashtiani, Iran Goudarzi, Adele Jafari, Kambiz Rohampour
Summary: Adiponectin (APN) plays a crucial role in regulating insulin sensitivity and glucose homeostasis, while also positively affecting memory. Inhibition of AMPK may block the memory-enhancing effect of APN and impact the expression of IRS1. Overall, APN may improve memory through the AMPK pathway and boost insulin signaling by increasing IRS-1 expression in the hippocampus.
NEUROSCIENCE LETTERS
(2021)
Article
Multidisciplinary Sciences
Ghazaleh Ghamkharinejad, Seyed Hossein Marashi, Forough Foolad, Mohammad Javan, Yaghoub Fathollahi
Summary: The study investigated the effects of the GABA facilitator valproic acid on morphine-induced behavioral tolerance and memory disruption, finding that valproic acid could ameliorate memory dysfunction caused by associative morphine tolerance. The expression of hippocampal GABAr alpha receptors was affected in morphine tolerant rats, with heavier impact observed in associative morphine tolerance rats. This research adds to our understanding of the behavioral and molecular aspects of morphine tolerance and memory effects.
Article
Linguistics
Saha Yekta, Alia Saberi, Kamran Ezzati, Kambiz Rohampour, Somayeh Ahmadi Gooraji, Samaneh Ghorbani Shirkouhi, Sasan Andalib
Summary: This study investigated the effect of bi-hemispheric tDCS on verbal function in patients with stroke-induced Broca's aphasia. The results showed that tDCS treatment significantly improved patients' verbal performance scores, and this effect persisted at the 3-month follow-up.
JOURNAL OF NEUROLINGUISTICS
(2022)
Article
Behavioral Sciences
Batoul Mirbolouk, Kambiz Rohampour, Mohammad Rostampour, Adele Jafari, Behrooz Khakpour-Taleghani
Summary: This study evaluated the role of Orx1R in depressive behaviors using the CMS model, showing that chronic Orx1R antagonism alleviates depressive behaviors induced by CMS and improves PSD-95 expression in PFC.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Mahmoud Rezaei, Samireh Ghafouri, Azam Asgari, Victoria Barkley, Yaghoub Fathollahi, Sareh Rostami, Amir Shojaei, Javad Mirnajafi-Zadeh
Summary: This study investigated the role of dopamine D-2-like receptors in the antiepileptogenic action of deep brain electrical stimulation (DBS). The results suggest that DBS exerts its preventive effect on epileptogenesis, at least partly, through dopamine D-2-like receptors.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Sohrab Anvari, Forough Foolad, Mohammad Javan, Javad Mirnajafi-Zadeh, Yaghoub Fathollahi
Summary: This study aimed to investigate the effects of morphine on synaptic transmission in different regions of the hippocampus. Measurements of field excitatory postsynaptic potentials were taken in transverse slices from different parts of the hippocampus in rats exposed to repeated morphine. The study found that repeated morphine exposure caused changes in synaptic transmission and plasticity in the dentate gyrus and CA1 regions along the hippocampal long axis.
Article
Neurosciences
Mohammad Akhoondian, Samira Rashtiani, Behrooz Khakpour-Taleghani, Mohammad Rostampour, Adele Jafari, Kambiz Rohampour
Summary: Depression symptoms can be alleviated by deep brain stimulation (LHb-DBS), which reduces low-frequency coherence between NAc and PrL cortex, as well as the enhanced brain oscillations in NAc.
BRAIN RESEARCH BULLETIN
(2023)
Article
Nutrition & Dietetics
Seyed Amir Hejazi, Kambiz Rohampour, Ehsan Sharifipour, Soruosh Sharifimoghadam, Sepideh Paybast, Abdoreza Ghoreishi, Navid Hassanzadeh, Mostafa Vahedian
CLINICAL NUTRITION ESPEN
(2020)
Article
Neurosciences
Hanieh Tamadon, Zahra Ghasemi, Fatemeh Ghasemi, Narges Hosseinmardi, Hossein Vatanpour, Mahyar Janahmadi
BASIC AND CLINICAL NEUROSCIENCE
(2019)
Article
Behavioral Sciences
Amine Bahi
Summary: Gestational environmental enrichment (EE) has protective effects on social stress-induced anxiety-like behaviors and excessive ethanol consumption through increasing BDNF levels.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Sarabesh Natarajan, Grant Abass, Lucas Kim, Corinne Wells, Amir H. Rezvani, Edward D. Levin
Summary: Multiple neural systems, including dopamine D1 receptors and glutamate NMDA receptors, are involved in nicotine reinforcement. Acute blockade of D1 receptors decreases nicotine self-administration, while acute blockade of NMDA receptors increases it. Chronic blockade of NMDA receptors decreases nicotine self-administration. Memantine attenuates the decrease in nicotine self-administration caused by chronic D1 antagonist SCH-23390.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
David R. Maguire
Summary: The study found that Lorcaserin alone reduces ventilation and enhances the ventilatory-depressant effects of opioids. This suggests that combining a 5-HT2C receptor agonist with opioids may increase the risk of ventilatory depression without reducing abuse.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Fen Liu, Qing Tian, Hui-Ling Tang, Xiang Cheng, Wei Zou, Ping Zhang
Summary: This study demonstrates the attenuating effect of H2S on PD-associated depression by improving hippocampal synaptic plasticity.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Mehrsa Rahimi-Danesh, Mohammad-Ali Samizadeh, Amir-Ehsan Sajadi, Tara Rezvankhah, Salar Vaseghi
Summary: This study investigated the effects of lithium on freezing behavior and pain perception in a fear-conditioning model in rats. The results showed that lithium had no effect on freezing behavior and pain subthreshold in all rats. Extinction training decreased freezing behavior, with more efficacy in females. Gender differences were also observed in the effects of extinction training.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)