A review on ferulic acid and analogs based scaffolds for the management of Alzheimer’s disease

Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer’s disease

(2020) Zhipei Sang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Curcumin in Health and Diseases: Alzheimer’s Disease and Curcumin Analogues, Derivatives, and Hybrids

(2020) Eirini Chainoglou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Design, synthesis and biological evaluation of novel naturally-inspired multifunctional molecules for the management of Alzheimer’s disease

(2020) Yash Pal Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology

(2019) Scott Ayton et al.   MOLECULAR PSYCHIATRY

Protective Effect of Caffeic Acid against Alzheimer’s Disease Pathogenesis via Modulating Cerebral Insulin Signaling, β-Amyloid Accumulation, and Synaptic Plasticity in Hyperinsulinemic Rats

(2019) Wenchang Chang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Management of oxidative stress and other pathologies in Alzheimer’s disease

(2019) Miriama Simunkova et al.   ARCHIVES OF TOXICOLOGY

Multi-target design strategies for the improved treatment of Alzheimer's disease

(2019) Pengfei Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and evaluation of novel ferulic acid derivatives as multi-target-directed ligands for the treatment of Alzheimer’s disease

(2019) Jin-Shuai Lan et al.   BIOORGANIC CHEMISTRY

Merging memantine and ferulic acid to probe connections between NMDA receptors, oxidative stress and amyloid-β peptide in Alzheimer's disease

(2019) Michela Rosini et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

7-O-Esters of taxifolin with pronounced and overadditive effects in neuroprotection, anti-neuroinflammation, and amelioration of short-term memory impairment in vivo

(2019) Sandra Gunesch et al.   Redox Biology

Design, synthesis, and biological evaluation of ferulic acid based 1,3,4-oxadiazole hybrids as multifunctional therapeutics for the treatment of Alzheimer’s disease

(2019) Avanish Tripathi et al.   BIOORGANIC CHEMISTRY

Development of a PEGylated-Based Platform for Efficient Delivery of Dietary Antioxidants Across the Blood–Brain Barrier

(2018) Carlos Fernandes et al.   BIOCONJUGATE CHEMISTRY

A review on the hybrids of hydroxycinnamic acid as multi-target-directed ligands against Alzheimer’s disease

(2018) Xiao Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Protective effect of kaempferol on the transgenic Drosophila model of Alzheimer’s disease

(2018) Yasir Hasan Siddique et al.   CNS & Neurological Disorders-Drug Targets

Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead

(2018) Devendra Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Microencapsulation of caffeic acid phenethyl ester and caffeic acid phenethyl amide by inclusion in hydroxypropyl-β-cyclodextrin

(2018) E. Manuela P.J. Garrido et al.   FOOD CHEMISTRY

Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease

(2018) Kun Zhang et al.   Neural Regeneration Research

Kaempferol attenuates cognitive deficit via regulating oxidative stress and neuroinflammation in an ovariectomized rat model of sporadic dementia

(2018) Parvin Babaei et al.   Neural Regeneration Research

Design, Synthesis, and Evaluation of Novel Ferulic Acid Derivatives as Multi-Target-Directed Ligands for the Treatment of Alzheimer’s Disease

(2018) Zhipei Sang et al.   ACS Chemical Neuroscience

Synthesis, antioxidant and Aβ anti-aggregation properties of new ferulic, caffeic and lipoic acid derivatives obtained by the Ugi four-component reaction

(2018) Mohamed Benchekroun et al.   BIOORGANIC CHEMISTRY

Hybrid caffeic acid derivatives as monoamine oxidases inhibitors: synthesis, radical scavenging activity, molecular docking studies and in silico ADMET analysis

(2018) Priyanka Dhiman et al.   Chemistry Central Journal

A review on iron chelators as potential therapeutic agents for the treatment of Alzheimer’s and Parkinson’s diseases

(2018) Yash Pal Singh et al.   MOLECULAR DIVERSITY

Comprehensive review of mechanisms of pathogenesis involved in Alzheimer’s disease and potential therapeutic strategies

(2018) Piyoosh Sharma et al.   PROGRESS IN NEUROBIOLOGY

NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

(2018) Michaela Kerstin Müller et al.   Acta Neuropathologica Communications

The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases

(2018) Saima Kausar et al.   Cells

Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease

(2017) Kris Simone T. Dias et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease

(2017) Ziwei Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and evaluation of novel ferulic acid- O -alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease

(2017) Zhipei Sang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel ferulic amide derivatives with tertiary amine side chain as acetylcholinesterase and butyrylcholinesterase inhibitors: The influence of carbon spacer length, alkylamine and aromatic group

(2017) Haoran Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hydroxy-substituted trans -cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease

(2017) Angela De Simone et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease

(2017) Jin Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and evaluation of novel cinnamic acid derivatives bearing N-benzyl pyridinium moiety as multifunctional cholinesterase inhibitors for Alzheimer’s disease

(2017) Jin-Shuai Lan et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease

(2017) Yao Chen et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a “Bio-Oxidizable” Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation

(2017) Ludovic Peauger et al.   JOURNAL OF MEDICINAL CHEMISTRY

The pharmacology of tacrine at N -methyl- d -aspartate receptors

(2017) Martin Horak et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

(2017) Rodrigo E. González-Reyes et al.   Frontiers in Molecular Neuroscience

Ferulic acid–carbazole hybrid compounds: Combination of cholinesterase inhibition, antioxidant and neuroprotection as multifunctional anti-Alzheimer agents

(2016) Lei Fang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer’s disease

(2016) Wanli Pan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Butein provides neuroprotective and anti-neuroinflammatory effects through Nrf2/ARE-dependent haem oxygenase 1 expression by activating the PI3K/Akt pathway

(2016) Dong-Sung Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

New cinnamic – N -benzylpiperidine and cinnamic – N , N -dibenzyl( N -methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties

(2016) Martín Estrada et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Protective effects of a dimeric derivative of ferulic acid in animal models of Alzheimer's disease

(2016) Jun-Sub Jung et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Antioxidant Additive Approach for Alzheimer’s Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators

(2016) Mohamed Benchekroun et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode

(2016) Edgar Sawatzky et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Novel Selective Butyrylcholinesterase Inhibitors Incorporating Antioxidant Functionalities as Potential Bimodal Therapeutics for Alzheimer’s Disease

(2016) Mike Jones et al.   MOLECULES

Synthesis and evaluation of donepezil–ferulic acid hybrids as multi-target-directed ligands against Alzheimer's disease

(2016) Wei Xu et al.   MedChemComm

Mechanisms of Aβ Clearance and Degradation by Glial Cells

(2016) Miriam Ries et al.   Frontiers in Aging Neuroscience

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

(2016) Urmi Sengupta et al.   EBioMedicine

Monoamine Oxidase Inhibitory Activity of Ferulic Acid Amides: Curcumin-Based Design and Synthesis

(2015) Vishnu N. Badavath et al.   ARCHIV DER PHARMAZIE

Compromised MAPK signaling in human diseases: an update

(2015) Eun Kyung Kim et al.   ARCHIVES OF TOXICOLOGY

Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD

(2015) Maria Digiacomo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Water-soluble ferulic acid derivatives improve amyloid-β-induced neuronal cell death and dysmnesia through inhibition of amyloid-β aggregation

(2015) Masaki Kikugawa et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Ferulic Acid and Alzheimer’s Disease: Promises and Pitfalls

(2015) Seyed Nabavi et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Design, synthesis and bioevaluation of tacrine hybrids with cinnamate and cinnamylidene acetate derivatives as potential anti-Alzheimer drugs

(2015) Catarina Quintanova et al.   MedChemComm

Ferulic Acid: A Hope for Alzheimer’s Disease Therapy from Plants

(2015) Antonella Sgarbossa et al.   Nutrients

Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease

(2015) Hiroto Takahashi et al.   Scientific Reports

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

Status of Acetylcholinesterase and Butyrylcholinesterase in Alzheimer's Disease and Type 2 Diabetes Mellitus

(2014) Gohar Mushtaq et al.   CNS & Neurological Disorders-Drug Targets

Recent Development of Multifunctional Agents as Potential Drug Candidates for the Treatment of Alzheimer’s Disease

(2014) Natalia Guzior et al.   CURRENT MEDICINAL CHEMISTRY

Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014

(2014) L. S. Schneider et al.   JOURNAL OF INTERNAL MEDICINE

Protein Folding and Aggregation into Amyloid: The Interference by Natural Phenolic Compounds

(2013) Massimo Stefani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterization of Intermediate Steps in Amyloid Beta (Aβ) Production under Near-native Conditions

(2013) Fredrik Olsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Viewpoint: Crosstalks between neurofibrillary tangles and amyloid plaque formation

(2012) Kailie Luan et al.   AGEING RESEARCH REVIEWS

Design, synthesis and pharmacological evaluation of novel tacrine–caffeic acid hybrids as multi-targeted compounds against Alzheimer’s disease

(2012) Xiaojuan Chao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Tacrine–Ferulic Acid–Nitric Oxide (NO) Donor Trihybrids as Potent, Multifunctional Acetyl- and Butyrylcholinesterase Inhibitors

(2012) Yao Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease

(2012) Robert Howard et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Benzenediol-berberine hybrids: Multifunctional agents for Alzheimer’s disease

(2011) Huailei Jiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Rivastigmine Transdermal Patch

(2011) Sohita Dhillon   DRUGS

Monoamine oxidase inhibition by selected anilide derivatives

(2011) Lesetja Legoabe et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inflammation and Alzheimer’s disease

(2010) Young-Jung Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

The history of the cholinergic hypothesis

(2010) Antonio Contestabile   BEHAVIOURAL BRAIN RESEARCH

REVIEW: Curcumin and Alzheimer's Disease

(2010) Tsuyoshi Hamaguchi et al.   CNS Neuroscience & Therapeutics

Tacrine Derivatives and Alzheimers Disease

(2010) V. Tumiatti et al.   CURRENT MEDICINAL CHEMISTRY

Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors

(2010) Jaroslav Šebestík et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Rosenroot (Rhodiola rosea): Traditional use, chemical composition, pharmacology and clinical efficacy

(2010) A. Panossian et al.   PHYTOMEDICINE

Oxidative stress in Alzheimer disease

(2010) Alejandro Gella et al.   Cell Adhesion & Migration

RNA oxidation in Alzheimer disease and related neurodegenerative disorders

(2009) Akihiko Nunomura et al.   ACTA NEUROPATHOLOGICA

Phenolic Compounds Prevent Alzheimer’s Pathology through Different Effects on the Amyloid-β Aggregation Pathway

(2009) Tsuyoshi Hamaguchi et al.   AMERICAN JOURNAL OF PATHOLOGY

Multipotent natural agents to combat Alzheimer's disease. Functional spectrum and structural features

(2008) Hong-fang JI et al.   ACTA PHARMACOLOGICA SINICA

Ferulic acid and its therapeutic potential as a hormetin for age-related diseases

(2008) Eugenio Barone et al.   BIOGERONTOLOGY

Design and synthesis of tacrine–ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates

(2008) Lei Fang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

How long can patients with mild or moderate Alzheimer’s dementia maintain both the cognition and the therapy of cholinesterase inhibitors: a national population-based study

(2008) Y. Sun et al.   EUROPEAN JOURNAL OF NEUROLOGY