Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease

Redox Proteomics Analysis of Brains from Subjects with Amnestic Mild Cognitive Impairment Compared to Brains from Subjects with Preclinical Alzheimer's Disease: Insights into Memory Loss in MCI

(2018) Christopher D. Aluise et al.   JOURNAL OF ALZHEIMERS DISEASE

The Emerging Role of Glutathione in Alzheimer's Disease

(2018) Sumiti Saharan et al.   JOURNAL OF ALZHEIMERS DISEASE

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

(2017) Mark A. Reger et al.   JOURNAL OF ALZHEIMERS DISEASE

Biphasic Effects of Forskolin on Tau Phosphorylation and Spatial Memory in Rats

(2017) Qing Tian et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin resistance predicts brain amyloid deposition in late middle-aged adults

(2015) Auriel A. Willette et al.   Alzheimers & Dementia

Alzheimer-associated A  oligomers impact the central nervous system to induce peripheral metabolic deregulation

(2015) J. R. Clarke et al.   EMBO Molecular Medicine

Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo

(2015) Shannon L. Macauley et al.   JOURNAL OF CLINICAL INVESTIGATION

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

(2015) Antonella Tramutola et al.   JOURNAL OF NEUROCHEMISTRY

Insulin resistance in Alzheimer disease: Is heme oxygenase-1 an Achille's heel?

(2015) Eugenio Barone et al.   NEUROBIOLOGY OF DISEASE

Glucose indices are associated with cognitive and structural brain measures in young adults

(2015) G. Weinstein et al.   NEUROLOGY

Homocysteine and cytosolic GSH depletion induce apoptosis and oxidative toxicity through cytosolic calcium overload in the hippocampus of aged mice: Involvement of TRPM2 and TRPV1 channels

(2015) İ.S. Övey et al.   NEUROSCIENCE

Diabetes and Alzheimer Disease, Two Overlapping Pathologies with the Same Background: Oxidative Stress

(2015) Sergio Rosales-Corral et al.   Oxidative Medicine and Cellular Longevity

Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer's disease and diabetes

(2015) Mychael V. Lourenco et al.   PROGRESS IN NEUROBIOLOGY

Neuroinflammation and Aβ Accumulation Linked To Systemic Inflammation Are Decreased By Genetic PKR Down-Regulation

(2015) Anne-Sophie Carret-Rebillat et al.   Scientific Reports

Tau aggregation and its interplay with amyloid-β

(2014) Rebecca M. Nisbet et al.   ACTA NEUROPATHOLOGICA

Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain

(2014) D. Allan Butterfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions

(2014) Jimena Baleriola et al.   CELL

Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man

(2014) Alexander Jais et al.   CELL

Targeting Mitochondrial Biogenesis to Treat Insulin Resistance

(2014) Monica Zamora et al.   CURRENT PHARMACEUTICAL DESIGN

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

(2014) F. G. De Felice et al.   DIABETES

Insulin Reverses the High-Fat Diet-Induced Increase in Brain A  and Improves Memory in an Animal Model of Alzheimer Disease

(2014) M. Vandal et al.   DIABETES

Nutrient regulation of insulin secretion and action

(2014) Philip Newsholme et al.   JOURNAL OF ENDOCRINOLOGY

Early detection of Alzheimer's disease using PiB and FDG PET

(2014) Ann D. Cohen et al.   NEUROBIOLOGY OF DISEASE

Association of diabetes with amnestic and nonamnestic mild cognitive impairment

(2013) Rosebud O. Roberts et al.   Alzheimers & Dementia

Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling: Figure 1

(2013) Fei Yin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistancein vivoand cause pancreatic β-cell dysfunction and deathin vitro

(2013) Mauricio Krause et al.   CLINICAL SCIENCE

Mitochondrial Abnormalities in a Streptozotocin-Induced Rat Model of Sporadic Alzheimer's Disease

(2013) Sonia C. Correia et al.   Current Alzheimer Research

Brain Atrophy in Type 2 Diabetes: Regional distribution and influence on cognition

(2013) C. Moran et al.   DIABETES CARE

Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet

(2013) Islam N. Mohamed et al.   DIABETOLOGIA

Reduction in DHA transport to the brain of mice expressing humanAPOE4compared toAPOE2

(2013) Milène Vandal et al.   JOURNAL OF NEUROCHEMISTRY

Oral supplementations with free and dipeptide forms of l-glutamine in endotoxemic mice: effects on muscle glutamine-glutathione axis and heat shock proteins

(2013) Vinicius F. Cruzat et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Diabetes mellitus and progression of vascular brain lesions and brain atrophy in patients with symptomatic atherosclerotic disease. The SMART-MR study

(2013) Minke Kooistra et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits

(2013) Tao Ma et al.   NATURE NEUROSCIENCE

The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: It's time for reconciliation

(2013) Eugenio Barone et al.   NEUROBIOLOGY OF DISEASE

Blockade of Tau Hyperphosphorylation and Aβ1–42 Generation by the Aminotetrahydrofuran Derivative ANAVEX2-73, a Mixed Muscarinic and σ1 Receptor Agonist, in a Nontransgenic Mouse Model of Alzheimer’s Disease

(2013) Valentine Lahmy et al.   NEUROPSYCHOPHARMACOLOGY

Oral free and dipeptide forms of glutamine supplementation attenuate oxidative stress and inflammation induced by endotoxemia

(2013) Vinicius Fernandes Cruzat et al.   NUTRITION

Cerebrospinal Fluid PKR Level Predicts Cognitive Decline in Alzheimer’s Disease

(2013) Julien Dumurgier et al.   PLoS One

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

(2013) Zhichun Chen et al.   PROGRESS IN NEUROBIOLOGY

Glucose Intolerance, Insulin Resistance, and Pathological Features of Alzheimer Disease in the Baltimore Longitudinal Study of Aging

(2013) Madhav Thambisetty et al.   JAMA Neurology

Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions

(2013) Geert Jan Biessels et al.   Lancet Diabetes & Endocrinology

Recent Advances in Obesity-Induced Inflammation and Insulin Resistance

(2013) Sanshiro Tateya et al.   Frontiers in Endocrinology

Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditions

(2012) Sung Min Son et al.   Autophagy

Hypothalamic glycogen synthase kinase 3β has a central role in the regulation of food intake and glucose metabolism

(2012) Jonas Benzler et al.   BIOCHEMICAL JOURNAL

Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease

(2012) Cora O'Neill et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Increased Cerebrospinal Fluid Levels of Double-Stranded RNA-Dependant Protein Kinase in Alzheimer's Disease

(2012) François Mouton-Liger et al.   BIOLOGICAL PSYCHIATRY

Inflammation-induced dysfunction of the low-density lipoprotein receptor-related protein-1 at the blood–brain barrier: Protection by the antioxidant N-acetylcysteine

(2012) Michelle A. Erickson et al.   BRAIN BEHAVIOR AND IMMUNITY

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

The Heme Oxygenase/Biliverdin Reductase Pathway in Drug Research and Development

(2012) C. Mancuso et al.   CURRENT DRUG METABOLISM

Amyloid-  Induces Hepatic Insulin Resistance In Vivo via JAK2

(2012) Y. Zhang et al.   DIABETES

Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells

(2012) Ya-Yun Hsu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Insulin Promotes Neuronal Survival via the Alternatively Spliced Protein Kinase CδII Isoform

(2012) André Apostolatos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus

(2012) Muhammad Sajid Hamid Akash et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Reactive oxygen and nitrogen species generation, antioxidant defenses, and β-cell function: a critical role for amino acids

(2012) P Newsholme et al.   JOURNAL OF ENDOCRINOLOGY

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

Induction of thioredoxin-interacting protein is mediated by oxidative stress, calcium, and glucose after brain injury in mice

(2012) Gab Seok Kim et al.   NEUROBIOLOGY OF DISEASE

JNK3 Perpetuates Metabolic Stress Induced by Aβ Peptides

(2012) Sung Ok Yoon et al.   NEURON

Inhibition of lipid peroxidation and protein oxidation by endogenous and exogenous antioxidants in rat brain microsomes in vitro

(2012) Cesare Mancuso et al.   NEUROSCIENCE LETTERS

Dissociation between Brain Amyloid Deposition and Metabolism in Early Mild Cognitive Impairment

(2012) Liyong Wu et al.   PLoS One

TXNIP, the major player in insulin resistance, is early over-expressed in the brain of the 5XFAD Alzheimer's mice model and is induced by Aβ in vitro: Emerging role of TXNIP and inflammation in Alzheimer's Disease progression

(2011) Tiphany Gouget et al.   Alzheimers & Dementia

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Stimulus-inducedS-Nitrosylation of Syntaxin 4 Impacts Insulin Granule Exocytosis

(2011) Dean A. Wiseman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peripheral markers in neurodegenerative patients and their first-degree relatives

(2011) Diana Olga Cristalli et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy

(2011) Lenore J Launer et al.   LANCET NEUROLOGY

Permissive Role of Insulin in the Expression of Long-Term Potentiation in the Hippocampus of Immature Rats

(2011) Wenchao Zhao et al.   NEUROSIGNALS

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic β-cells

(2010) W. Gehrmann et al.   DIABETES OBESITY & METABOLISM

Oxidative stress and the etiology of insulin resistance and type 2 diabetes

(2010) Erik J. Henriksen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Usurping the mitochondrial supremacy: Extramitochondrial sources of reactive oxygen intermediates and their role in beta cell metabolism and insulin secretion

(2010) Joshua P. Gray et al.   TOXICOLOGY MECHANISMS AND METHODS

The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus

(2009) Jeroen J.M. Hoozemans et al.   AMERICAN JOURNAL OF PATHOLOGY

Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes

(2009) M. J. MacDonald et al.   DIABETOLOGIA

Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell

(2009) P. Newsholme et al.   DIABETOLOGIA

RAGE regulates BACE1 and Aβ generation via NFAT1 activation in Alzheimer’s disease animal model

(2009) H. J. Cho et al.   FASEB JOURNAL

Oxidant stress-induced loss of IRS-1 and IRS-2 proteins in rat skeletal muscle: Role of p38 MAPK

(2009) Tara L. Archuleta et al.   FREE RADICAL BIOLOGY AND MEDICINE

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective amino acid deficiency in patients with impaired glucose tolerance and type 2 diabetes

(2009) Bjoern A. Menge et al.   REGULATORY PEPTIDES

Phosphorylation of IRS proteins, insulin action, and insulin resistance

(2008) Sigalit Boura-Halfon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

PDK1 Deficiency in POMC-Expressing Cells Reveals FOXO1-Dependent and -Independent Pathways in Control of Energy Homeostasis and Stress Response

(2008) Bengt F. Belgardt et al.   Cell Metabolism

Mitochondrial Reactive Oxygen Species Are Obligatory Signals for Glucose-Induced Insulin Secretion

(2008) C. Leloup et al.   DIABETES

Thioredoxin-Interacting Protein: A Critical Link Between Glucose Toxicity and  -Cell Apoptosis

(2008) J. Chen et al.   DIABETES

Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia

(2008) E. C. W. Straaten et al.   JOURNAL OF NEUROLOGY

Clearance mechanisms of Alzheimer's amyloid-β peptide: implications for therapeutic design and diagnostic tests

(2008) K A Bates et al.   MOLECULAR PSYCHIATRY

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

(2008) Judith Miklossy et al.   NEUROBIOLOGY OF AGING

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING

Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo

(2008) Shu-Ling Chiu et al.   NEURON

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

(2008) Tracy O'Connor et al.   NEURON

Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory

(2008) John I Malone et al.   PEDIATRIC DIABETES

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL

Double stranded RNA activated EIF2 α kinase (EIF2AK2; PKR) is associated with Alzheimer's disease

(2007) María J. Bullido et al.   NEUROBIOLOGY OF AGING