Ursolic Acid Attenuates Diabetic Mesangial Cell Injury through the Up-Regulation of Autophagy via miRNA-21/PTEN/Akt/mTOR Suppression

Losartan Affects Glomerular AKT and mTOR Phosphorylation in an Experimental Model of Type 1 Diabetic Nephropathy

(2013) Vasiliki Mavroeidi et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Ursolic acid-induced apoptosis in K562 cells involving upregulation of PTEN gene expression and inactivation of the PI3K/Akt pathway

(2012) Bin Wu et al.   ARCHIVES OF PHARMACAL RESEARCH

Autophagy Promotes Intracellular Degradation of Type I Collagen Induced by Transforming Growth Factor (TGF)-β1

(2012) Sung Il Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of microRNAs in kidney homeostasis and disease

(2012) Karthikeyan Chandrasekaran et al.   KIDNEY INTERNATIONAL

Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

(2012) Steven D. Kunkel et al.   PLoS One

TGFβ-Stimulated MicroRNA-21 Utilizes PTEN to Orchestrate AKT/mTORC1 Signaling for Mesangial Cell Hypertrophy and Matrix Expansion

(2012) Nirmalya Dey et al.   PLoS One

Autophagy inhibition enhances ursolic acid-induced apoptosis in PC3 cells

(2011) Seoung Woo Shin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fa/fa) Rats: A Model of Type 2 Diabetes

(2011) Munehiro Kitada et al.   Experimental Diabetes Research

MicroRNA-21 Orchestrates High Glucose-induced Signals to TOR Complex 1, Resulting in Renal Cell Pathology in Diabetes

(2011) Nirmalya Dey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uncoupling and Antioxidant Effects of Ursolic Acid in Isolated Rat Heart Mitochondria

(2011) Julius Liobikas et al.   JOURNAL OF NATURAL PRODUCTS

The complex world of kidney microRNAs

(2011) Balakuntalam S. Kasinath et al.   KIDNEY INTERNATIONAL

Beta2-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation

(2010) Pablo Aránguiz-Urroz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ursolic acid ameliorates thymic atrophy and hyperglycemia in streptozotocin–nicotinamide-induced diabetic mice

(2010) Jin Lee et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

(2010) Shinji Kume et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

Ursolic acid ameliorates hepatic fibrosis in the rat by specific induction of apoptosis in hepatic stellate cells

(2010) Xu Wang et al.   JOURNAL OF HEPATOLOGY

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Conserved MicroRNA miR-8/miR-200 and Its Target USH/FOG2 Control Growth by Regulating PI3K

(2009) Seogang Hyun et al.   CELL

The Role of the Mammalian Target Of Rapamycin (mTOR) in Renal Disease

(2009) W. Lieberthal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autophagic Elimination of Misfolded Procollagen Aggregates in the Endoplasmic Reticulum as a Means of Cell Protection

(2009) Yoshihito Ishida et al.   MOLECULAR BIOLOGY OF THE CELL

Ursolic acid: An anti- and pro-inflammatory triterpenoid

(2008) Yasutaka Ikeda et al.   MOLECULAR NUTRITION & FOOD RESEARCH