Astrocytes in depression and Alzheimer’s disease

Structure and assembly of calcium homeostasis modulator proteins

(2020) Johanna L. Syrjanen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity

(2020) Michelle Corkrum et al.   NEURON

Pathological ATPergic Signaling in Major Depression and Bipolar Disorder

(2020) Peter Illes et al.   Frontiers in Molecular Neuroscience

Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice

(2020) Haibo Zhou et al.   CELL

Neuroinflammation and depression: A review

(2020) Romain Troubat et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuroinflammation and depressive disorder: The role of the hypothalamus

(2020) Alena Cernackova et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Stress gates an astrocytic energy reservoir to impair synaptic plasticity

(2020) Ciaran Murphy-Royal et al.   Nature Communications

Impaired ATP Release from Brain Astrocytes May be a Cause of Major Depression

(2020) Peter Illes et al.   Neuroscience Bulletin

Astroglia and Tau: New Perspectives

(2020) Gabor G. Kovacs   Frontiers in Aging Neuroscience

A1 astrocytes contribute to murine depression-like behavior and cognitive dysfunction, which can be alleviated by IL-10 or fluorocitrate treatment

(2020) He-Yang Zhang et al.   Journal of Neuroinflammation

Reversing a model of Parkinson’s disease with in situ converted nigral neurons

(2020) Hao Qian et al.   NATURE

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

(2020) Stephen C. Cunnane et al.   NATURE REVIEWS DRUG DISCOVERY

Glucose transporters in brain in health and disease

(2020) Hermann Koepsell   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Astrocyte-Derived Lactate Modulates the Passive Coping Response to Behavioral Challenge in Male Mice

(2020) Ya-Nan Yin et al.   Neuroscience Bulletin

Revisiting the Amyloid Cascade Hypothesis: From Anti-Aβ Therapeutics to Auspicious New Ways for Alzheimer’s Disease

(2020) Md. Sahab Uddin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?

(2020) Shane A. Liddelow et al.   TRENDS IN IMMUNOLOGY

Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala

(2020) Zhi-Heng Zheng et al.   BRAIN BEHAVIOR AND IMMUNITY

Universal Glia to Neurone Lactate Transfer in the Nervous System: Physiological Functions and Pathological Consequences

(2020) Carolyn L. Powell et al.   Biosensors-Basel

Ibrutinib alleviates LPS-induced neuroinflammation and synaptic defects in a mouse model of depression

(2020) Weifen Li et al.   BRAIN BEHAVIOR AND IMMUNITY

A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

(2019) Francesco Panza et al.   Nature Reviews Neurology

Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases

(2019) Nabil Karnib et al.   NEUROPSYCHOPHARMACOLOGY

Astrocyte Biomarkers in Alzheimer’s Disease

(2019) Stephen F. Carter et al.   TRENDS IN MOLECULAR MEDICINE

Sodium rutin ameliorates Alzheimer’s disease–like pathology by enhancing microglial amyloid-β clearance

(2019) Rui-Yuan Pan et al.   Science Advances

Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer’s disease

(2019) Darshpreet Kaur et al.   INFLAMMOPHARMACOLOGY

The Strategic Location of Glycogen and Lactate: From Body Energy Reserve to Brain Plasticity

(2019) Corrado Calì et al.   Frontiers in Cellular Neuroscience

The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications

(2019) Amaia M Arranz et al.   LANCET NEUROLOGY

The Response to Stimulation in Neurons and Astrocytes

(2019) Inés Juaristi et al.   NEUROCHEMICAL RESEARCH

Unifying Hypothesis of Dopamine Neuron Loss in Neurodegenerative Diseases: Focusing on Alzheimer's Disease

(2019) Paraskevi Krashia et al.   Frontiers in Molecular Neuroscience

Astrocyte–Neuron Interactions in the Striatum: Insights on Identity, Form, and Function

(2019) Baljit S. Khakh   TRENDS IN NEUROSCIENCES

Dopamine and Dopamine Receptors in Alzheimer's Disease: A Systematic Review and Network Meta-Analysis

(2019) Xiongfeng Pan et al.   Frontiers in Aging Neuroscience

Astrocyte, a Promising Target for Mood Disorder Interventions

(2019) Xinyi Zhou et al.   Frontiers in Molecular Neuroscience

Questions and (some) answers on reactive astrocytes

(2019) Carole Escartin et al.   GLIA

The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression

(2019) Xiaodong Shu et al.   Cell Death & Disease

Mechanisms and treatment of late-life depression

(2019) George S. Alexopoulos   Translational Psychiatry

Mechanisms of secretion and spreading of pathological tau protein

(2019) Cecilia A. Brunello et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Malva sylvestris extract alleviates the astrogliosis and inflammatory stress in LPS-induced depression mice

(2019) Ye Wu et al.   JOURNAL OF NEUROIMMUNOLOGY

The structures and gating mechanism of human calcium homeostasis modulator 2

(2019) Wooyoung Choi et al.   NATURE

Amyloid-β-independent regulators of tau pathology in Alzheimer disease

(2019) Rik van der Kant et al.   NATURE REVIEWS NEUROSCIENCE

Is Alzheimer’s disease an inflammasomopathy?

(2019) Claudia F. Pereira et al.   AGEING RESEARCH REVIEWS

Therapeutic use of extracellular mitochondria in CNS injury and disease

(2019) Yoshihiko Nakamura et al.   EXPERIMENTAL NEUROLOGY

Ablation of reactive astrocytes exacerbates disease pathology in a model of Alzheimer's disease

(2019) Loukia Katsouri et al.   GLIA

ATP Controls the Aggregation of Aβ16–22 Peptides

(2019) Saikat Pal et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The cost of Alzheimer's disease in China and re-estimation of costs worldwide

(2018) Jianping Jia et al.   Alzheimers & Dementia

3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes

(2018) Marco Campisi et al.   BIOMATERIALS

The Science and Translation of Lactate Shuttle Theory

(2018) George A. Brooks   Cell Metabolism

Tau in Alzheimer's Disease: Mechanisms and Therapeutic Strategies

(2018) Yu Gao et al.   Current Alzheimer Research

Microglia and Astrocytes in Alzheimer's Disease: Implications for Therapy

(2018) Marc Fakhoury   Current Neuropharmacology

Glia in brain energy metabolism: A perspective

(2018) L. Felipe Barros et al.   GLIA

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin regulates astrocyte gliotransmission and modulates behavior

(2018) Weikang Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

CrossTalk opposing view: lack of evidence supporting an astrocyte-to-neuron lactate shuttle coupling neuronal activity to glucose utilisation in the brain

(2018) Lasse K. Bak et al.   JOURNAL OF PHYSIOLOGY-LONDON

Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice

(2018) Adam K. Walker et al.   MOLECULAR PSYCHIATRY

Lactate in the brain: from metabolic end-product to signalling molecule

(2018) Pierre J. Magistretti et al.   NATURE REVIEWS NEUROSCIENCE

Hippocampal 5-HT Input Regulates Memory Formation and Schaffer Collateral Excitation

(2018) Catia M. Teixeira et al.   NEURON

Microglia-Astrocyte Crosstalk: An Intimate Molecular Conversation

(2018) Mithilesh Kumar Jha et al.   NEUROSCIENTIST

The role of dopaminergic midbrain in Alzheimer’s disease: Translating basic science into clinical practice

(2018) Marcello D’Amelio et al.   PHARMACOLOGICAL RESEARCH

Alterations in Serum BDNF and GDNF Levels after 12 Weeks of Antidepressant Treatment in Female Outpatients with Major Depressive Disorder

(2018) Young-Min Park et al.   Psychiatry Investigation

A P2X7 receptor antagonist reverses behavioural alterations, microglial activation and neuroendocrine dysregulation in an unpredictable chronic mild stress (UCMS) model of depression in mice

(2018) Rai Khalid Farooq et al.   PSYCHONEUROENDOCRINOLOGY

Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes

(2018) Manao Kinoshita et al.   EBioMedicine

Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy

(2018) Mariet Allen et al.   ACTA NEUROPATHOLOGICA

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation

(2018) Lige Leng et al.   NEURON

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease

(2018) Bahareh Eftekharzadeh et al.   NEURON

Inhibition of activated astrocyte ameliorates lipopolysaccharide- induced depressive-like behaviors

(2018) Yun Wang et al.   JOURNAL OF AFFECTIVE DISORDERS

Influence of microglia and astrocyte activation in the neuroinflammatory pathogenesis of Alzheimer’s disease: Rational insights for the therapeutic approaches

(2018) Mir Hilal Ahmad et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Fluoxetine Delays the Cognitive Function Decline and Synaptic Changes in a Transgenic Mouse Model of Early Alzheimer's Disease

(2018) Chun-ni Zhou et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A central role for P2X7 receptors in human microglia

(2018) Laura Janks et al.   Journal of Neuroinflammation

Lactate Deficit in an Alzheimer Disease Mouse Model: The Relationship With Neuronal Damage

(2018) Mao Zhang et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Depression

(2018) Gin S Malhi et al.   LANCET

CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination

(2018) Yuan Zhang et al.   MOLECULAR PSYCHIATRY

Brain Glucose Metabolism: Integration of Energetics with Function

(2018) Gerald A. Dienel   PHYSIOLOGICAL REVIEWS

Astrocyte glycogen and lactate: New insights into learning and memory mechanisms

(2017) Cristina M. Alberini et al.   GLIA

An astroglial basis of major depressive disorder? An overview

(2017) Qian Wang et al.   GLIA

Dopamine cross-reacts with adrenoreceptors in cortical astrocytes to induce BDNF expression, CREB signaling and morphological transformation

(2017) Indrek Koppel et al.   GLIA

Dopamine System Dysregulation in Major Depressive Disorders

(2017) Pauline Belujon et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors

(2017) Na Yue et al.   Journal of Neuroinflammation

Lack of appropriate stoichiometry: Strong evidence against an energetically important astrocyte-neuron lactate shuttle in brain

(2017) Gerald A. Dienel   JOURNAL OF NEUROSCIENCE RESEARCH

Release of ATP by pre-Bötzinger complex astrocytes contributes to the hypoxic ventilatory response via a Ca2+ -dependent P2Y1 receptor mechanism

(2017) Vishaal Rajani et al.   JOURNAL OF PHYSIOLOGY-LONDON

Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors

(2017) M Jun et al.   MOLECULAR PSYCHIATRY

Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis

(2017) Jeff A. Stogsdill et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Neural basis of major depressive disorder: Beyond monoamine hypothesis

(2017) Shuken Boku et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Prevalence of depression and depressive symptoms among outpatients: a systematic review and meta-analysis

(2017) Jinghui Wang et al.   BMJ Open

The role of astrocytes in amyloid production and Alzheimer's disease

(2017) Georgia R. Frost et al.   Open Biology

Cortical laminar tau deposits and activated astrocytes in Alzheimer’s disease visualised by 3H-THK5117 and 3H-deprenyl autoradiography

(2017) Laetitia Lemoine et al.   Scientific Reports

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor

(2016) Masaaki Iwata et al.   BIOLOGICAL PSYCHIATRY

Technology-enhanced multi-domain at home continuum of care program with respect to usual care for people with cognitive impairment: the Ability-TelerehABILITation study protocol for a randomized controlled trial

(2016) O. Realdon et al.   BMC Psychiatry

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

(2016) Philipp Mächler et al.   Cell Metabolism

Mitochondrial Dysfunction in Depression

(2016) Yashika Bansal et al.   Current Neuropharmacology

Tau Biology and Tau-Directed Therapies for Alzheimer’s Disease

(2016) Lidia Bakota et al.   DRUGS

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Les bases de pharmacologie fondamentale du système sérotoninergique : application à la réponse antidépressive

(2016) D.J. David et al.   ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE

Depression as a risk factor for Alzheimer’s disease: Genes, steroids, cytokines and neurogenesis – What do we need to know?

(2016) Joe Herbert et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Neuroinflammation pathways: a general review

(2016) Tara Shabab et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Assessing the Risk Factors for Difficult-to-Treat Depression and Treatment-Resistant Depression

(2016) Bradley Gaynes   JOURNAL OF CLINICAL PSYCHIATRY

Role of astrocyte-synapse interactions in CNS disorders

(2016) Elena Blanco-Suárez et al.   JOURNAL OF PHYSIOLOGY-LONDON

Redundant Gs-coupled serotonin receptors regulate amyloid-β metabolism in vivo

(2016) Jonathan R. Fisher et al.   Molecular Neurodegeneration

Peripheral administration of lactate produces antidepressant-like effects

(2016) A Carrard et al.   MOLECULAR PSYCHIATRY

Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression

(2016) Anthony A. Grace   NATURE REVIEWS NEUROSCIENCE

Density of GFAP-immunoreactive astrocytes is decreased in left hippocampi in major depressive disorder

(2016) J.A. Cobb et al.   NEUROSCIENCE

The role of serotonergic, adrenergic and dopaminergic receptors in antidepressant-like effect

(2016) Karolina Pytka et al.   Pharmacological Reports

Astrocytes: Key Regulators of Neuroinflammation

(2016) Emanuela Colombo et al.   TRENDS IN IMMUNOLOGY

What Do We Really Know About 5-HT1A Receptor Signaling in Neuronal Cells?

(2016) Paulina S. Rojas et al.   Frontiers in Cellular Neuroscience

Depression as a Glial-Based Synaptic Dysfunction

(2016) Daniel Rial et al.   Frontiers in Cellular Neuroscience

Editorial (Thematic Selection: A Systematic Review of Depression)

(2015) Ranji Cui   Current Neuropharmacology

Astrocyte development: A Guide for the Perplexed

(2015) Anna Victoria Molofsky et al.   GLIA

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Diversity of astrocyte functions and phenotypes in neural circuits

(2015) Baljit S Khakh et al.   NATURE NEUROSCIENCE

Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

(2015) Sagar H. Barage et al.   NEUROPEPTIDES

Brain glucose metabolism in an animal model of depression

(2015) J. Detka et al.   NEUROSCIENCE

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

(2015) Dora Brites et al.   Frontiers in Cellular Neuroscience

ATP as a multi-target danger signal in the brain

(2015) Ricardo J. Rodrigues et al.   Frontiers in Neuroscience

Depression and the risk of coronary heart disease: a meta-analysis of prospective cohort studies

(2014) Yong Gan et al.   BMC Psychiatry

Tracking neuroinflammation in Alzheimer’s disease: the role of positron emission tomography imaging

(2014) Eduardo Zimmer et al.   Journal of Neuroinflammation

Age-Dependent, Non-Cell-Autonomous Deposition of Amyloid from Synthesis of  -Amyloid by Cells Other Than Excitatory Neurons

(2014) K. Veeraraghavalu et al.   JOURNAL OF NEUROSCIENCE

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

(2014) Lior Mayo et al.   NATURE MEDICINE

Dopaminergic Modulation of Cortical Plasticity in Alzheimer’s Disease Patients

(2014) Giacomo Koch et al.   NEUROPSYCHOPHARMACOLOGY

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

(2014) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Forebrain Engraftment by Human Glial Progenitor Cells Enhances Synaptic Plasticity and Learning in Adult Mice

(2013) Xiaoning Han et al.   Cell Stem Cell

Serotonin – Kynurenine Hypothesis of Depression: Historical Overview and Recent Developments

(2013) Gregory Oxenkrug   CURRENT DRUG TARGETS

Differential Relationships of Reactive Astrocytes and Microglia to Fibrillar Amyloid Deposits in Alzheimer Disease

(2013) Alberto Serrano-Pozo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes

(2013) Akiyuki Taruno et al.   NATURE

Astrocyte-derived ATP modulates depressive-like behaviors

(2013) Xiong Cao et al.   NATURE MEDICINE

Updated Energy Budgets for Neural Computation in the Neocortex and Cerebellum

(2012) Clare Howarth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocyte-Originated ATP Protects A 1-42-Induced Impairment of Synaptic Plasticity

(2012) E. S. Jung et al.   JOURNAL OF NEUROSCIENCE

Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease

(2012) J. L. Furman et al.   JOURNAL OF NEUROSCIENCE

Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin

(2012) Wei Shao et al.   NATURE

Alterations of Gene Expression and Glutamate Clearance in Astrocytes Derived from an MeCP2-Null Mouse Model of Rett Syndrome

(2012) Yasunori Okabe et al.   PLoS One

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Astroglial networks: a step further in neuroglial and gliovascular interactions

(2010) Christian Giaume et al.   NATURE REVIEWS NEUROSCIENCE

Three Repeat Isoforms of Tau Inhibit Assembly of Four Repeat Tau Filaments

(2010) Stephanie J. Adams et al.   PLoS One

Role of Ventral Tegmental Area Glial Cell Line–Derived Neurotrophic Factor in Incubation of Cocaine Craving

(2009) Lin Lu et al.   BIOLOGICAL PSYCHIATRY

Reactive Astrocytes Form Scar-Like Perivascular Barriers to Leukocytes during Adaptive Immune Inflammation of the CNS

(2009) R. R. Voskuhl et al.   JOURNAL OF NEUROSCIENCE

Tripartite synapses: Roles for astrocytic purines in the control of synaptic physiology and behavior

(2009) Michael M. Halassa et al.   NEUROPHARMACOLOGY

Extracellular ATP in the Immune System: More Than Just a "Danger Signal"

(2009) A. Trautmann   Science Signaling

A Polymorphism in CALHM1 Influences Ca2+ Homeostasis, Aβ Levels, and Alzheimer's Disease Risk

(2008) Ute Dreses-Werringloer et al.   CELL

Focal transplantation–based astrocyte replacement is neuroprotective in a model of motor neuron disease

(2008) Angelo C Lepore et al.   NATURE NEUROSCIENCE