Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases

Exercise and the Prevention of Depression: Results of the HUNT Cohort Study

(2018) Samuel B. Harvey et al.   AMERICAN JOURNAL OF PSYCHIATRY

Cell-Type-Specific Epigenetic Editing at the Fosb Gene Controls Susceptibility to Social Defeat Stress

(2017) Peter J Hamilton et al.   NEUROPSYCHOPHARMACOLOGY

Peripheral administration of lactate produces antidepressant-like effects

(2016) A Carrard et al.   MOLECULAR PSYCHIATRY

Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility

(2016) Rosemary C. Bagot et al.   NEURON

Chronic stress-induced memory deficits are reversed by regular exercise via AMPK-mediated BDNF induction

(2016) D.-M. Kim et al.   NEUROSCIENCE

Epigenetic Basis of Mental Illness

(2016) Eric J. Nestler et al.   NEUROSCIENTIST

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

(2016) Sama F Sleiman et al.   eLife

Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity

(2015) M. Erburu et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Antidepressant action of HDAC inhibition in the prefrontal cortex

(2015) H.E. Covington et al.   NEUROSCIENCE

Image-Guided Synthesis Reveals Potent Blood-Brain Barrier Permeable Histone Deacetylase Inhibitors

(2014) Young Jun Seo et al.   ACS Chemical Neuroscience

Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories

(2014) Johannes Gräff et al.   CELL

Histone Deacetylase 3 Is Necessary for Proper Brain Development

(2014) Jordan Norwood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic Signaling in Psychiatric Disorders

(2014) Catherine J. Peña et al.   JOURNAL OF MOLECULAR BIOLOGY

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

(2014) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional profiles underlying vulnerability and resilience in rats exposed to an acute unavoidable stress

(2012) Cristina Benatti et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Run for your life

(2012) Timothy Noakes et al.   NATURE

HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity

(2012) Mitsumasa Kurita et al.   NATURE NEUROSCIENCE

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Brain Lactate Metabolism: The Discoveries and the Controversies

(2011) Gerald A Dienel   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A standardized protocol for repeated social defeat stress in mice

(2011) Sam A Golden et al.   Nature Protocols

A Role for Repressive Histone Methylation in Cocaine-Induced Vulnerability to Stress

(2011) Herbert E. Covington et al.   NEURON

Hippocampal-dependent antidepressant-like activity of histone deacetylase inhibition

(2011) Herbert E. Covington et al.   NEUROSCIENCE LETTERS

Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing

(2011) Lori A. Newman et al.   PLoS One

Assessment of Social Interaction Behaviors

(2011) Oksana Kaidanovich-Beilin et al.   Jove-Journal of Visualized Experiments

Setdb1 Histone Methyltransferase Regulates Mood-Related Behaviors and Expression of the NMDA Receptor Subunit NR2B

(2010) Y. Jiang et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective Role of Lactate after Cerebral Ischemia

(2009) Carole Berthet et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Histone Deacetylases 1 and 2 Form a Developmental Switch That Controls Excitatory Synapse Maturation and Function

(2009) M. W. Akhtar et al.   JOURNAL OF NEUROSCIENCE

Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice

(2008) Catharine H. Duman et al.   BRAIN RESEARCH