Depression as a Glial-Based Synaptic Dysfunction

Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress

(2016) Giampaolo Milior et al.   BRAIN BEHAVIOR AND IMMUNITY

Evidence for alterations of the glial syncytial function in major depressive disorder

(2016) Adriana Medina et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Translational potential of astrocytes in brain disorders

(2016) Alexei Verkhratsky et al.   PROGRESS IN NEUROBIOLOGY

Inflammation: Depression Fans the Flames and Feasts on the Heat

(2015) Janice K. Kiecolt-Glaser et al.   AMERICAN JOURNAL OF PSYCHIATRY

Deletion of Adenosine A2A Receptors From Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia

(2015) Marco Matos et al.   BIOLOGICAL PSYCHIATRY

Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?

(2015) Elke Decrock et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting astrocytes in major depression

(2015) Liang Peng et al.   Expert Review of Neurotherapeutics

Different danger signals differently impact on microglial proliferation through alterations of ATP release and extracellular metabolism

(2015) Jimmy George et al.   GLIA

Glial fibrillary acidic protein is differentially expressed across cortical and subcortical regions in healthy brains and downregulated in the thalamus and caudate nucleus of depressed suicides

(2015) S G Torres-Platas et al.   MOLECULAR PSYCHIATRY

Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory

(2015) P Li et al.   MOLECULAR PSYCHIATRY

Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission

(2015) Ciaran Murphy-Royal et al.   NATURE NEUROSCIENCE

Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a

(2015) Tsvetan Serchov et al.   NEURON

Fluoxetine and S-citalopram inhibit M1 activation and promote M2 activation of microglia in vitro

(2015) F. Su et al.   NEUROSCIENCE

Caffeine acts through neuronal adenosine A2Areceptors to prevent mood and memory dysfunction triggered by chronic stress

(2015) Manuella P. Kaster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of glutamate transporter 1 via BDNF-TrkB signaling plays a role in the anti-apoptotic and antidepressant effects of ketamine in chronic unpredictable stress model of depression

(2015) Wen-Xue Liu et al.   PSYCHOPHARMACOLOGY

Do stars govern our actions? Astrocyte involvement in rodent behavior

(2015) João Filipe Oliveira et al.   TRENDS IN NEUROSCIENCES

Depression as a Microglial Disease

(2015) Raz Yirmiya et al.   TRENDS IN NEUROSCIENCES

Understanding the role of P2X7 in affective disorders—are glial cells the major players?

(2015) Leanne Stokes et al.   Frontiers in Cellular Neuroscience

Prenatal stress is a vulnerability factor for altered morphology and biological activity of microglia cells

(2015) Joanna Ślusarczyk et al.   Frontiers in Cellular Neuroscience

Role for astroglial α1-adrenoreceptors in gliotransmission and control of synaptic plasticity in the neocortex

(2015) Yuriy Pankratov et al.   Frontiers in Cellular Neuroscience

Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift

(2015) Leif Hertz et al.   Frontiers in Behavioral Neuroscience

Targeting astrocytes in major depression

(2015) Liang Peng et al.   Expert Review of Neurotherapeutics

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

ATP as a multi-target danger signal in the brain

(2015) Ricardo J. Rodrigues et al.   Frontiers in Neuroscience

Astroglial Control of the Antidepressant-Like Effects of Prefrontal Cortex Deep Brain Stimulation

(2015) A. Etiévant et al.   EBioMedicine

Astrocyte glutamine synthetase: pivotal in health and disease

(2015) Christopher F. Rose et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Astrocyte Regulation of Synaptic Behavior

(2014) Nicola J. Allen   Annual Review of Cell and Developmental Biology

Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides

(2014) Susana G. Torres-Platas et al.   BRAIN BEHAVIOR AND IMMUNITY

Aquaporin-4 Knockout Exacerbates Corticosterone-Induced Depression by Inhibiting Astrocyte Function and Hippocampal Neurogenesis

(2014) Hui Kong et al.   CNS Neuroscience & Therapeutics

Microglia of Prefrontal White Matter in Suicide

(2014) Tatiana P. Schnieder et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Reduced connexin 43 immunolabeling in the orbitofrontal cortex in alcohol dependence and depression

(2014) José Javier Miguel-Hidalgo et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Astrocyte pathology in the prefrontal cortex impairs the cognitive function of rats

(2014) A Lima et al.   MOLECULAR PSYCHIATRY

Astrocytic abnormalities and global DNA methylation patterns in depression and suicide

(2014) C Nagy et al.   MOLECULAR PSYCHIATRY

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Gliotransmitters Travel in Time and Space

(2014) Alfonso Araque et al.   NEURON

Novel astrocyte targets

(2014) Vincenzo Crunelli et al.   NEUROSCIENTIST

Activation of microglia bolsters synapse formation

(2014) Gonçalo Cristovão et al.   Frontiers in Cellular Neuroscience

Optogenetic astrocyte activation modulates response selectivity of visual cortex neurons in vivo

(2014) Gertrudis Perea et al.   Nature Communications

Peripubertal stress-induced behavioral changes are associated with altered expression of genes involved in excitation and inhibition in the amygdala

(2014) S Tzanoulinou et al.   Translational Psychiatry

Are “Resting” Microglia More “M2”?

(2014) Jonathan D. Cherry et al.   Frontiers in Immunology

Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety

(2014) Joana E. Coelho et al.   Frontiers in Psychiatry

Glutamate-Based Antidepressants: Preclinical Psychopharmacology

(2013) Andrzej Pilc et al.   BIOLOGICAL PSYCHIATRY

From Pathophysiology to Novel Antidepressant Drugs: Glial Contributions to the Pathology and Treatment of Mood Disorders

(2013) Gerard Sanacora et al.   BIOLOGICAL PSYCHIATRY

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue

(2013) Grazyna Rajkowska et al.   CURRENT DRUG TARGETS

The A1 adenosine receptor as a new player in microglia physiology

(2013) L. Luongo et al.   GLIA

Fractalkine (CX3CL1) enhances hippocampal N-methyl-d-aspartate receptor (NMDAR) function via d-serine and adenosine receptor type A2 (A2AR) activity

(2013) Maria Scianni et al.   Journal of Neuroinflammation

Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia

(2013) Catarina Gomes et al.   Journal of Neuroinflammation

Antagonistic Interaction between Adenosine A2A Receptors and Na+/K+-ATPase- 2 Controlling Glutamate Uptake in Astrocytes

(2013) M. Matos et al.   JOURNAL OF NEUROSCIENCE

Ecto-5'-Nucleotidase (CD73)-Mediated Formation of Adenosine Is Critical for the Striatal Adenosine A2A Receptor Functions

(2013) E. Augusto et al.   JOURNAL OF NEUROSCIENCE

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis

(2013) T Kreisel et al.   MOLECULAR PSYCHIATRY

A ghrelin–growth hormone axis drives stress-induced vulnerability to enhanced fear

(2013) R M Meyer et al.   MOLECULAR PSYCHIATRY

Astrocyte-derived ATP modulates depressive-like behaviors

(2013) Xiong Cao et al.   NATURE MEDICINE

Glucocorticoid receptor β regulates injury-mediated astrocyte activation and contributes to glioma pathogenesis via modulation of β-catenin/TCF transcriptional activity

(2013) Ying Yin et al.   NEUROBIOLOGY OF DISEASE

Microglia: New Roles for the Synaptic Stripper

(2013) Helmut Kettenmann et al.   NEURON

NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice

(2013) Adam K Walker et al.   NEUROPSYCHOPHARMACOLOGY

Microglia Actively Regulate the Number of Functional Synapses

(2013) Kyungmin Ji et al.   PLoS One

Coffee, caffeine, and risk of completed suicide: Results from three prospective cohorts of American adults

(2013) Michel Lucas et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Burden of Depressive Disorders by Country, Sex, Age, and Year: Findings from the Global Burden of Disease Study 2010

(2013) Alize J. Ferrari et al.   PLOS MEDICINE

Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling

(2013) D J Hines et al.   Translational Psychiatry

No association of genetic variants inBDNFwith major depression: A meta- and gene-based analysis

(2012) Joseph P. Gyekis et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Coverage of Blood Vessels by Astrocytic Endfeet Is Reduced in Major Depressive Disorder

(2012) Grazyna Rajkowska et al.   BIOLOGICAL PSYCHIATRY

Connexin-based intercellular communication and astrocyte heterogeneity

(2012) Martin Theis et al.   BRAIN RESEARCH

Chronic Stress Induced Remodeling of the Prefrontal Cortex: Structural Re-Organization of Microglia and the Inhibitory Effect of Minocycline

(2012) M. Hinwood et al.   CEREBRAL CORTEX

Neuroinflammation, Oxidative Stress and the Pathogenesis of Alzheimers Disease

(2012) Paula Agostinho et al.   CURRENT PHARMACEUTICAL DESIGN

The “quad-partite” synapse: Microglia-synapse interactions in the developing and mature CNS

(2012) Dorothy P. Schafer et al.   GLIA

Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects

(2012) Vanja Duric et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Gene expression of GABA and glutamate pathway markers in the prefrontal cortex of non-suicidal elderly depressed patients

(2012) J. Zhao et al.   JOURNAL OF AFFECTIVE DISORDERS

Deficiency of the Microglial Receptor CX3CR1 Impairs Postnatal Functional Development of Thalamocortical Synapses in the Barrel Cortex

(2012) M. Hoshiko et al.   JOURNAL OF NEUROSCIENCE

Adenosine A2A receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation

(2012) V L Batalha et al.   MOLECULAR PSYCHIATRY

Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin

(2012) Wei Shao et al.   NATURE

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

(2012) Hyo Jung Kang et al.   NATURE MEDICINE

Serotonin in the Modulation of Neural Plasticity and Networks: Implications for Neurodevelopmental Disorders

(2012) Klaus-Peter Lesch et al.   NEURON

Dopaminergic Modulation of Synaptic Transmission in Cortex and Striatum

(2012) Nicolas X. Tritsch et al.   NEURON

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Blockade of Astrocytic Glutamate Uptake in the Prefrontal Cortex Induces Anhedonia

(2012) Catherine S John et al.   NEUROPSYCHOPHARMACOLOGY

Dynamic plasticity: The role of glucocorticoids, brain-derived neurotrophic factor and other trophic factors

(2012) J.D. Gray et al.   NEUROSCIENCE

Alterations in the expression of PSA-NCAM and synaptic proteins in the dorsolateral prefrontal cortex of psychiatric disorder patients

(2012) Javier Gilabert-Juan et al.   NEUROSCIENCE LETTERS

Are We Getting Closer to Valid Translational Models for Major Depression?

(2012) O. Berton et al.   SCIENCE

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

(2012) R. S. Duman et al.   SCIENCE

Microglia: actively surveying and shaping neuronal circuit structure and function

(2012) Hiroaki Wake et al.   TRENDS IN NEUROSCIENCES

Coffee Consumption and Depression Risk

(2011) Seth A. Berkowitz   ARCHIVES OF INTERNAL MEDICINE

Dysfunction of Astrocyte Connexins 30 and 43 in Dorsal Lateral Prefrontal Cortex of Suicide Completers

(2011) Carl Ernst et al.   BIOLOGICAL PSYCHIATRY

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

(2011) Nanxin Li et al.   BIOLOGICAL PSYCHIATRY

Activation of serotonin receptors promotes microglial injury-induced motility but attenuates phagocytic activity

(2011) Grietje Krabbe et al.   BRAIN BEHAVIOR AND IMMUNITY

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

The role(s) of astrocytes and astrocyte activity in neurometabolism, neurovascular coupling, and the production of functional neuroimaging signals

(2011) Chase R. Figley et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

ATP receptors gate microglia signaling in neuropathic pain

(2011) Tuan Trang et al.   EXPERIMENTAL NEUROLOGY

A morphometric study of glia and neurons in the anterior cingulate cortex in mood disorder

(2011) Rebecca A. Gittins et al.   JOURNAL OF AFFECTIVE DISORDERS

Long Term Potentiation Is Impaired in Membrane Glycoprotein CD200-deficient Mice

(2011) Derek A. Costello et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction

(2011) Nelson Rebola et al.   JOURNAL OF NEUROCHEMISTRY

Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide

(2011) Angela W Corona et al.   Journal of Neuroinflammation

Regulation of microglia by ionotropic glutamatergic and GABAergic neurotransmission

(2011) Wai T. Wong et al.   Neuron Glia Biology

Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activation

(2011) Young C. Chung et al.   NEUROPHARMACOLOGY

Stress and anxiety: Structural plasticity and epigenetic regulation as a consequence of stress

(2011) Bruce S. McEwen et al.   NEUROPHARMACOLOGY

Astrocytic Hypertrophy in Anterior Cingulate White Matter of Depressed Suicides

(2011) Susana G Torres-Platas et al.   NEUROPSYCHOPHARMACOLOGY

Gap Junction Dysfunction in the Prefrontal Cortex Induces Depressive-Like Behaviors in Rats

(2011) Jian-Dong Sun et al.   NEUROPSYCHOPHARMACOLOGY

Brain-derived neurotrophic factor (BDNF) infusion restored astrocytic plasticity in the hippocampus of a rat model of depression

(2011) Yuanyuan Ye et al.   NEUROSCIENCE LETTERS

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Microglial Morphology and Dynamic Behavior Is Regulated by Ionotropic Glutamatergic and GABAergic Neurotransmission

(2011) Aurora M. Fontainhas et al.   PLoS One

Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission

(2011) O. Pascual et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism

(2011) F. Ros-Bernal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Amygdala astrocyte reduction in subjects with major depressive disorder but not bipolar disorder

(2010) Lori L Altshuler et al.   BIPOLAR DISORDERS

Hippocampal astrocytes are necessary for antidepressant treatment of learned helplessness rats

(2010) Masaaki Iwata et al.   HIPPOCAMPUS

Glial and glutamatergic markers in depression, alcoholism, and their comorbidity

(2010) José Javier Miguel-Hidalgo et al.   JOURNAL OF AFFECTIVE DISORDERS

Antidepressants act on glial cells: SSRIs and serotonin elicit astrocyte calcium signaling in the mouse prefrontal cortex

(2010) Carola G. Schipke et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Long-term potentiation depends on release of d-serine from astrocytes

(2010) Christian Henneberger et al.   NATURE

Glia: The many ways to modulate synaptic plasticity

(2010) S. Ben Achour et al.   NEUROCHEMISTRY INTERNATIONAL

Blockade of Astrocytic Glutamate Uptake in Rats Induces Signs of Anhedonia and Impaired Spatial Memory

(2010) Anita J Bechtholt-Gompf et al.   NEUROPSYCHOPHARMACOLOGY

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Neuroplasticity Regulation by Noradrenaline in Mammalian Brain

(2009) Aude Marzo et al.   Current Neuropharmacology

Astrocyte-Derived MCP-1 Mediates Neuroprotective Effects of Noradrenaline

(2009) J. L. M. Madrigal et al.   JOURNAL OF NEUROSCIENCE

Up-regulation of GLT-1 severely impairs LTD at mossy fibre-CA3 synapses

(2009) Azar Omrani et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Multifaceted Profile of Activated Microglia

(2009) Marina A. Lynch   MOLECULAR NEUROBIOLOGY

Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss

(2009) Michael M. Halassa et al.   NEURON

The Role of the Tripartite Glutamatergic Synapse in the Pathophysiology and Therapeutics of Mood Disorders

(2009) Rodrigo Machado-Vieira et al.   NEUROSCIENTIST

Global Brain Gene Expression Analysis Links Glutamatergic and GABAergic Alterations to Suicide and Major Depression

(2009) Adolfo Sequeira et al.   PLoS One

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors

(2008) Mounira Banasr et al.   BIOLOGICAL PSYCHIATRY

Potential Therapeutic Interest of Adenosine A2A Receptors in Psychiatric Disorders

(2008) Rodrigo Cunha et al.   CURRENT PHARMACEUTICAL DESIGN

Serum markers support disease-specific glial pathology in major depression

(2008) Matthias L. Schroeter et al.   JOURNAL OF AFFECTIVE DISORDERS

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE

Coupling of Neural Activity to Blood Flow in Olfactory Glomeruli Is Mediated by Astrocytic Pathways

(2008) Gabor C. Petzold et al.   NEURON

Requirement of AQP4 for Antidepressive Efficiency of Fluoxetine: Implication in Adult Hippocampal Neurogenesis

(2008) Hui Kong et al.   NEUROPSYCHOPHARMACOLOGY

Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression

(2008) Anteneh M. Feyissa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission

(2008) N. Rouach et al.   SCIENCE

Corticosteroid receptors and neuroplasticity

(2007) Nuno Sousa et al.   BRAIN RESEARCH REVIEWS

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

Different cellular sources and different roles of adenosine: A1 receptor-mediated inhibition through astrocytic-driven volume transmission and synapse-restricted A2A receptor-mediated facilitation of plasticity

(2007) Rodrigo A. Cunha   NEUROCHEMISTRY INTERNATIONAL

Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide

(2006) Johann Steiner et al.   JOURNAL OF PSYCHIATRIC RESEARCH