Multikinase Abl/DDR/Src Inhibition Produces Optimal Effects for Tyrosine Kinase Inhibition in Neurodegeneration

Activating Autophagy as a Therapeutic Strategy for Parkinson’s Disease

(2018) Alan J. Fowler et al.   CNS DRUGS

The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson’s disease mouse model

(2018) Saebom Lee et al.   HUMAN MOLECULAR GENETICS

Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy

(2018) Federico Rossari et al.   Journal of Hematology & Oncology

Tau clearance improves astrocytic function and brain glutamate-glutamine cycle

(2018) Michaeline L. Hebron et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The PDGF/PDGFR pathway as a drug target

(2018) Natalia Papadopoulos et al.   MOLECULAR ASPECTS OF MEDICINE

Neuronal c-Abl Overexpression Leads to Neuronal Loss and Neuroinflammation in the Mouse Forebrain

(2018) Sarah D. Schlatterer et al.   JOURNAL OF ALZHEIMERS DISEASE

Diminished Parkin Solubility and Co-Localization with Intraneuronal Amyloid-β are Associated with Autophagic Defects in Alzheimer's Disease

(2018) Irina Lonskaya et al.   JOURNAL OF ALZHEIMERS DISEASE

Pazopanib Reduces Phosphorylated Tau Levels and Alters Astrocytes in a Mouse Model of Tauopathy

(2017) Monica Javidnia et al.   JOURNAL OF ALZHEIMERS DISEASE

Discoidin domain receptor inhibition reduces neuropathology and attenuates inflammation in neurodegeneration models

(2017) Michaeline Hebron et al.   JOURNAL OF NEUROIMMUNOLOGY

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain

(2017) Kassandra Kisler et al.   NATURE NEUROSCIENCE

Altered Subcellular Distribution of c-Abl in Alzheimer's Disease

(2017) Zheng Jing et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau Phosphorylated at Tyrosine 394 is Found in Alzheimer's Disease Tangles and can be a Product of the Abl-Related Kinase, Arg

(2017) Matthew A. Tremblay et al.   JOURNAL OF ALZHEIMERS DISEASE

Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling

(2016) Hua Gao et al.   CELL

Activation of tyrosine kinase c-Abl contributes to α-synuclein–induced neurodegeneration

(2016) Saurav Brahmachari et al.   JOURNAL OF CLINICAL INVESTIGATION

European LeukemiaNet recommendations for the management and avoidance of adverse events of treatment in chronic myeloid leukaemia

(2016) J L Steegmann et al.   LEUKEMIA

Activation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo

(2016) Emily Sempou et al.   Molecular Neurodegeneration

Nilotinib Effects in Parkinson’s disease and Dementia with Lewy bodies

(2016) Fernando Pagan et al.   Journal of Parkinsons Disease

Discoidin domain receptor 1 (DDR1) kinase as target for structure-based drug discovery

(2015) Sandeepkumar Kothiwale et al.   DRUG DISCOVERY TODAY

Parkin Is Dispensable for Mitochondrial Function, but Its Ubiquitin Ligase Activity Is Critical for Macroautophagy and Neurotransmitters: Therapeutic Potential beyond Parkinson's Disease

(2015) Charbel E.-H. Moussa   Neurodegenerative Diseases

Nilotinib and bosutinib modulate pre-plaque alterations of blood immune markers and neuro-inflammation in Alzheimer’s disease models

(2015) I. Lonskaya et al.   NEUROSCIENCE

DDR1 may play a key role in destruction of the blood–brain barrier after cerebral ischemia–reperfusion

(2015) Mingxia Zhu et al.   NEUROSCIENCE RESEARCH

Characterization of Novel Src Family Kinase Inhibitors to Attenuate Microgliosis

(2015) Gunjan D. Manocha et al.   PLoS One

Discoidin domain receptors: a proteomic portrait

(2014) Leo K. Iwai et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Efficacy and safety of radotinib in chronic phase chronic myeloid leukemia patients with resistance or intolerance to BCR-ABL1 tyrosine kinase inhibitors

(2014) S.-H. Kim et al.   HAEMATOLOGICA

Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice

(2014) Chen Wenqiang et al.   HUMAN MOLECULAR GENETICS

Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

(2013) Hyung-Gu Kim et al.   ACS Chemical Biology

Tyrosine kinase inhibition facilitates autophagic SNCA/α-synuclein clearance

(2013) Michaeline L. Hebron et al.   Autophagy

Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance

(2013) Irina Lonskaya et al.   EMBO Molecular Medicine

Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of  -synuclein in Parkinson's disease models

(2013) M. L. Hebron et al.   HUMAN MOLECULAR GENETICS

Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance

(2013) Irina Lonskaya et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis

(2013) Shin H Kang et al.   NATURE NEUROSCIENCE

Neuroprotective Efficacy of a New Brain-Penetrating C-Abl Inhibitor in a Murine Parkinson’s Disease Model

(2013) Syed Z. Imam et al.   PLoS One

Ubiquitination Increases Parkin Activity to Promote Autophagic α-Synuclein Clearance

(2013) Irina Lonskaya et al.   PLoS One

Gender effect on neurodegeneration and myelin markers in an animal model for multiple sclerosis

(2012) Alessandro Massella et al.   BMC NEUROSCIENCE

An update on dual Src/Abl inhibitors

(2012) Francesca Musumeci et al.   Future Medicinal Chemistry

Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson’s disease

(2012) I. Lonskaya et al.   NEUROSCIENCE

A Lipoxin A4 Analog Ameliorates Blood–Brain Barrier Dysfunction and Reduces MMP-9 Expression in a Rat Model of Focal Cerebral Ischemia–Reperfusion Injury

(2011) Yan Wu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

c-Abl in Neurodegenerative Disease

(2011) Sarah D. Schlatterer et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Novel Regulation of Parkin Function through c-Abl-Mediated Tyrosine Phosphorylation: Implications for Parkinson's Disease

(2011) S. Z. Imam et al.   JOURNAL OF NEUROSCIENCE

Expression of the tyrosine kinase discoidin domain receptor 1 (DDR1) in human central nervous system myelin

(2010) Bàrbara Roig et al.   BRAIN RESEARCH

The Src, Syk, and Tec family kinases: Distinct types of molecular switches

(2010) J. Michael Bradshaw   CELLULAR SIGNALLING

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

(2010) H. S. Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extended kinase profile and properties of the protein kinase inhibitor nilotinib

(2009) Paul W. Manley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Discoidin Domain Receptor 1 on Bone Marrow–Derived Cells Promotes Macrophage Accumulation During Atherogenesis

(2009) Christopher Franco et al.   CIRCULATION RESEARCH

A comprehensive target selectivity survey of the BCR-ABL kinase inhibitor INNO-406 by kinase profiling and chemical proteomics in chronic myeloid leukemia cells

(2009) U Rix et al.   LEUKEMIA

The Bcr-Abl kinase inhibitor INNO-406 induces autophagy and different modes of cell death execution in Bcr-Abl-positive leukemias

(2008) Y Kamitsuji et al.   CELL DEATH AND DIFFERENTIATION

Discoidin Domain Receptor 1 ( Ddr1 ) Deletion Decreases Atherosclerosis by Accelerating Matrix Accumulation and Reducing Inflammation in Low-Density Lipoprotein Receptor–Deficient Mice

(2008) Christopher Franco et al.   CIRCULATION RESEARCH

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells

(2008) L L Remsing Rix et al.   LEUKEMIA

Discoidin domain receptor 1 mediates collagen-induced inflammatory activation of microglia in culture

(2007) Min-Chul Seo et al.   JOURNAL OF NEUROSCIENCE RESEARCH