Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease

Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration

(2016) E. G. Gentry et al.   JOURNAL OF NEUROSCIENCE

Assessment of disease-related cognitive impairments using the novel object recognition (NOR) task in rodents

(2015) Ben Grayson et al.   BEHAVIOURAL BRAIN RESEARCH

Water Dispersion Interactions Strongly Influence Simulated Structural Properties of Disordered Protein States

(2015) Stefano Piana et al.   JOURNAL OF PHYSICAL CHEMISTRY B

AAV.shRNA-mediated downregulation of ROCK2 attenuates degeneration of dopaminergic neurons in toxin-induced models of Parkinson's disease in vitro and in vivo

(2015) Kim-Ann Saal et al.   NEUROBIOLOGY OF DISEASE

Olfactory Dysfunction and Neurotransmitter Disturbance in Olfactory Bulb of Transgenic Mice Expressing Human A53T Mutant α-Synuclein

(2015) Sufang Zhang et al.   PLoS One

Rho Kinase Inhibition by Fasudil in the Striatal 6-Hydroxydopamine Lesion Mouse Model of Parkinson Disease

(2014) Lars Tatenhorst et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The neurobiological basis of cognitive impairment in Parkinson's disease

(2014) Glenda M. Halliday et al.   MOVEMENT DISORDERS

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

Inhibition of the microglial response is essential for the neuroprotective effects of Rho-kinase inhibitors on MPTP-induced dopaminergic cell death

(2014) Ana Borrajo et al.   NEUROPHARMACOLOGY

ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS

(2014) J C Koch et al.   Cell Death & Disease

Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation

(2014) Diana F. Lázaro et al.   PLoS Genetics

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease

(2013) Jens Wagner et al.   ACTA NEUROPATHOLOGICA

Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis

(2013) Lars Tönges et al.   GLIA

Evaluation of Rho-Kinase Activity in Mice Brain Using N-[11C]Methyl-hydroxyfasudil with Positron Emission Tomography

(2013) Junko Taniguchi et al.   MOLECULAR IMAGING AND BIOLOGY

The Function of α-Synuclein

(2013) Jacob T. Bendor et al.   NEURON

Behavioral Characterization of A53T Mice Reveals Early and Late Stage Deficits Related to Parkinson’s Disease

(2013) Katrina L. Paumier et al.   PLoS One

Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease

(2012) L. Tonges et al.   BRAIN

Cognitive deficits in a mouse model of pre-manifest Parkinson’s disease

(2012) Iddo Magen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Curcumin Prevents Aggregation in α-Synuclein by Increasing Reconfiguration Rate

(2012) Basir Ahmad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identifying prodromal Parkinson's disease: Pre-Motor disorders in Parkinson's disease

(2012) Ronald B. Postuma et al.   MOVEMENT DISORDERS

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Involvement of microglial RhoA/Rho-Kinase pathway activation in the dopaminergic neuron death. Role of angiotensin via angiotensin type 1 receptors

(2012) Begoña Villar-Cheda et al.   NEUROBIOLOGY OF DISEASE

ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo

(2012) Carlos Barcia et al.   Scientific Reports

Role of C-terminal negative charges and tyrosine residues in fibril formation of α-synuclein

(2012) Yasutaka Izawa et al.   Brain and Behavior

Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, α-Synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms

(2011) Daniel F. Tardiff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conserved C-Terminal Charge Exerts a Profound Influence on the Aggregation Rate of α-Synuclein

(2011) Katerina Levitan et al.   JOURNAL OF MOLECULAR BIOLOGY

Population-based case–control study of cognitive function in early Parkinson's disease (NEDICES)

(2011) Julián Benito-León et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Use of viral vectors to create animal models for Parkinson's disease

(2011) Karin Löw et al.   NEUROBIOLOGY OF DISEASE

Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models

(2011) L. Lyon et al.   PSYCHOPHARMACOLOGY

ROCKing regeneration: Rho kinase inhibition as molecular target for neurorestoration

(2011) Lars Tönges   Frontiers in Molecular Neuroscience

Automated quantitative gait analysis in animal models of movement disorders

(2010) Caroline Vandeputte et al.   BMC NEUROSCIENCE

Ventricular enlargement and mild cognitive impairment in early Parkinson's disease

(2010) Turi O. Dalaker et al.   MOVEMENT DISORDERS

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models

(2009) L. J. Su et al.   Disease Models & Mechanisms

Y-27632 improves rotarod performance and reduces huntingtin levels in R6/2 mice

(2009) Mei Li et al.   NEUROBIOLOGY OF DISEASE

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY