Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases

The Quest for Selective Nox Inhibitors and Therapeutics: Challenges, Triumphs and Pitfalls

(2013) Eugenia Cifuentes-Pagano et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration

(2013) Liya Qin et al.   GLIA

Physiological Phenotype and Vulnerability in Parkinson's Disease

(2013) D. J. Surmeier et al.   Cold Spring Harbor Perspectives in Medicine

Targeting NOX enzymes in the central nervous system: therapeutic opportunities

(2012) Silvia Sorce et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting microglia-mediated neurotoxicity: the potential of NOX2 inhibitors

(2012) Michael J. Surace et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NADPH Oxidase and Neurodegeneration

(2012) Marina S. Hernandes et al.   Current Neuropharmacology

Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91 phox subunit of NADPH oxidase

(2012) Qingshan Wang et al.   Journal of Neuroinflammation

NADPH oxidases: novel therapeutic targets for neurodegenerative diseases

(2012) Hui-Ming Gao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration

(2011) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

(2011) Grant R. Drummond et al.   NATURE REVIEWS DRUG DISCOVERY

Neuroinflammation in Parkinson's disease

(2011) Etienne C. Hirsch et al.   PARKINSONISM & RELATED DISORDERS

Reactive microgliosis: extracellular μ-calpain and microglia-mediated dopaminergic neurotoxicity

(2010) Shannon Levesque et al.   BRAIN

p47phoxPhox Homology Domain Regulates Plasma Membrane but Not Phagosome Neutrophil NADPH Oxidase Activation

(2010) Xing Jun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The flavin inhibitor diphenyleneiodonium renders Trichomonas vaginalis resistant to metronidazole, inhibits thioredoxin reductase and flavin reductase, and shuts off hydrogenosomal enzymatic pathways

(2010) David Leitsch et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Liquid Perfluorochemical Inhibits Inducible Nitric Oxide Synthase Expression and Nitric Oxide Formation in Lipopolysaccharide-Treated RAW 264.7 Macrophages

(2009) Li-Ping Chang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Classical Inhibitors of NOX NAD(P)H Oxidases Are Not Specific

(2008) Elisabetta Aldieri et al.   CURRENT DRUG METABOLISM

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

(2008) Hui-Ming Gao et al.   TRENDS IN IMMUNOLOGY