Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop

Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation

(2017) Sylvia Torres-Odio et al.   Journal of Neuroinflammation

A20 in Multiple Sclerosis and Parkinson’s Disease: Clue to a Common Dysregulation of Anti-Inflammatory Pathways?

(2017) Simona Perga et al.   NEUROTOXICITY RESEARCH

PINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease

(2017) Francois Mouton-Liger et al.   Frontiers in Molecular Neuroscience

Isolation of primary microglia from the human post-mortem brain: effects of ante- and post-mortem variables

(2017) Mark R. Mizee et al.   Acta Neuropathologica Communications

A novel PINK1- and PARK2-dependent protective neuroimmune pathway in lethal sepsis

(2016) Rui Kang et al.   Autophagy

Fanconi Anemia Proteins Function in Mitophagy and Immunity

(2016) Rhea Sumpter et al.   CELL

Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation

(2016) Diana Matheoud et al.   CELL

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

A simplified approach for efficient isolation of functional microglial cells: Application for modeling neuroinflammatory responsesin vitro

(2016) Julia E. Sepulveda-Diaz et al.   GLIA

MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

(2016) Yan Zhou et al.   Molecular Neurodegeneration

Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation

(2016) Ismail Çimen et al.   Science Translational Medicine

Hepatitis B Virus-Induced Parkin-Dependent Recruitment of Linear Ubiquitin Assembly Complex (LUBAC) to Mitochondria and Attenuation of Innate Immunity

(2016) Mohsin Khan et al.   PLoS Pathogens

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

A20 suppresses vascular inflammation by recruiting proinflammatory signaling molecules to intracellular aggresomes

(2015) Karine Enesa et al.   FASEB JOURNAL

NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients

(2015) Sonja Johann et al.   GLIA

A20 Restricts Ubiquitination of Pro-Interleukin-1β Protein Complexes and Suppresses NLRP3 Inflammasome Activity

(2015) Bao H. Duong et al.   IMMUNITY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Defective mitochondrial fission augments NLRP3 inflammasome activation

(2015) Sangjun Park et al.   Scientific Reports

Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis

(2015) Sean P. Cullen et al.   Cell Reports

Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation

(2015) Prajwal Gurung et al.   Scientific Reports

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Keeping the immune system in check: a role for mitophagy

(2014) Michael Lazarou   IMMUNOLOGY AND CELL BIOLOGY

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

(2014) Lieselotte Vande Walle et al.   NATURE

The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation

(2014) Chinnaswamy Tiruppathi et al.   NATURE IMMUNOLOGY

Tissue- and Cell-Specific Mitochondrial Defect in Parkin-Deficient Mice

(2014) Maria Damiano et al.   PLoS One

PARK2 and proinflammatory/anti-inflammatory cytokine gene interactions contribute to the susceptibility to leprosy: a case–control study of North Indian population

(2014) Rupali Chopra et al.   BMJ Open

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

The ubiquitin ligase parkin mediates resistance to intracellular pathogens

(2013) Paolo S. Manzanillo et al.   NATURE

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

(2013) Gaia Codolo et al.   PLoS One

PARK2 Mediates Interleukin 6 and Monocyte Chemoattractant Protein 1 Production by Human Macrophages

(2013) Louis de Léséleuc et al.   PLoS Neglected Tropical Diseases

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Recognizing the cooperative and independent mitochondrial functions of Parkin and PINK1

(2012) Bethann N. Johnson et al.   CELL CYCLE

Microglial activation of the NLRP3 inflammasome by the priming signals derived from macrophages infected with mycobacteria

(2012) Hye-Mi Lee et al.   GLIA

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β

(2012) Bibhuti B Mishra et al.   NATURE IMMUNOLOGY

The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax

(2012) B. N. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

(2012) Manuela Rossol et al.   Nature Communications

Loss of Braking Signals During Inflammation

(2011) Francesca Gilli   ARCHIVES OF NEUROLOGY

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Glia: Initiators and progressors of pathology in Parkinson's disease

(2011) Glenda M. Halliday et al.   MOVEMENT DISORDERS

Lipopolysaccharide and Tumor Necrosis Factor Regulate Parkin Expression via Nuclear Factor-Kappa B

(2011) Thi A. Tran et al.   PLoS One

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release

(2009) A. K. Berger et al.   HUMAN MOLECULAR GENETICS

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes

(2009) Greta Guarda et al.   NATURE

Translocation Biosensors – Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics

(2009) Verena Fetz et al.   SENSORS

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Differential migration, LPS-induced cytokine, chemokine, and NO expression in immortalized BV-2 and HAPI cell lines and primary microglial cultures

(2008) Ryan J. Horvath et al.   JOURNAL OF NEUROCHEMISTRY

Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration

(2008) T. C. Frank-Cannon et al.   JOURNAL OF NEUROSCIENCE