PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats

Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging

(2020) David Matuskey et al.   ANNALS OF NEUROLOGY

Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

(2020) Ellis Chika Onwordi et al.   Nature Communications

Microglia Heterogeneity in the Single-Cell Era

(2020) Takahiro Masuda et al.   Cell Reports

Mitochondrial Complex 1, Sigma 1, and Synaptic Vesicle 2A in Early Drug‐Naive Parkinson's Disease

(2020) Heather Wilson et al.   MOVEMENT DISORDERS

Deciphering human macrophage development at single-cell resolution

(2020) Zhilei Bian et al.   NATURE

In vivo imaging of synaptic SV2A protein density in healthy and striatal-lesioned rats with [11C]UCB-J PET

(2020) Majken B Thomsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Loss of Presynaptic Terminal Integrity in the Substantia Nigra in Early Parkinson's Disease

(2020) Aline Delva et al.   MOVEMENT DISORDERS

Age- and α-Synuclein-Dependent Degeneration of Dopamine and Noradrenaline Neurons in the Annual Killifish Nothobranchius furzeri

(2019) Hideaki Matsui et al.   Cell Reports

Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration

(2019) Valentina Durante et al.   BRAIN

Defining α-synuclein species responsible for Parkinson disease phenotypes in mice

(2019) Jessica M. Froula et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lower synaptic density is associated with depression severity and network alterations

(2019) Sophie E. Holmes et al.   Nature Communications

Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils

(2019) Joseph R. Patterson et al.   NEUROBIOLOGY OF DISEASE

Behavioral defects associated with amygdala and cortical dysfunction in mice with seeded α-synuclein inclusions

(2019) Lindsay E. Stoyka et al.   NEUROBIOLOGY OF DISEASE

Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates

(2019) Sara Elfarrash et al.   Acta Neuropathologica Communications

α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

(2019) Nolwen L. Rey et al.   Acta Neuropathologica Communications

Nigrostriatal proteasome inhibition impairs dopamine neurotransmission and motor function in minipigs

(2018) Thea P. Lillethorup et al.   EXPERIMENTAL NEUROLOGY

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

(2018) Megan F. Duffy et al.   Journal of Neuroinflammation

ELISA method to detect α-synuclein oligomers in cell and animal models

(2018) Louise Berkhoudt Lassen et al.   PLoS One

Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging

(2018) Ming-Kai Chen et al.   JAMA Neurology

PET imaging of synaptic density: A new tool for investigation of neuropsychiatric diseases

(2018) Zhengxin Cai et al.   NEUROSCIENCE LETTERS

Microglia Response During Parkinson’s Disease: Alpha-Synuclein Intervention

(2018) Sara A. Ferreira et al.   Frontiers in Cellular Neuroscience

Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson’s disease

(2018) Chiara Milanese et al.   Cell Death & Disease

α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration

(2017) Hisham Abdelmotilib et al.   NEUROBIOLOGY OF DISEASE

Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain

(2017) Poonam Thakur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice

(2017) Mantia Karampetsou et al.   Scientific Reports

Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson’s disease

(2017) Jenny-Ann Phan et al.   Scientific Reports

α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration

(2017) Ashley S. Harms et al.   Acta Neuropathologica Communications

Suppression of Map Kinases Inhibits Microglial Activation and Attenuates Neuronal Cell Death Induced by α-Synuclein Protofibrils

(2017) H. Wilms et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Anti-Inflammatory Modulation of Microglia via CD163-Targeted Glucocorticoids Protects Dopaminergic Neurons in the 6-OHDA Parkinson's Disease Model

(2016) Noemie Tentillier et al.   JOURNAL OF NEUROSCIENCE

Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain

(2016) N. B. Nabulsi et al.   JOURNAL OF NUCLEAR MEDICINE

Dopamine synapse is a neuroligin-2–mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures

(2016) Motokazu Uchigashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging synaptic density in the living human brain

(2016) Sjoerd J. Finnema et al.   Science Translational Medicine

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

(2015) Katrina L. Paumier et al.   NEUROBIOLOGY OF DISEASE

Alpha-synuclein spreading in Parkinson’s disease

(2014) Ariadna Recasens et al.   Frontiers in Neuroanatomy

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice

(2013) Nolwen L. Rey et al.   ACTA NEUROPATHOLOGICA

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

(2013) Jeffrey H. Kordower et al.   BRAIN

MHCII Is Required for  -Synuclein-Induced Activation of Microglia, CD4 T Cell Proliferation, and Dopaminergic Neurodegeneration

(2013) A. S. Harms et al.   JOURNAL OF NEUROSCIENCE

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

The interhemispheric connections of the striatum: Implications for Parkinson's disease and drug-induced dyskinesias

(2011) Christopher A. Lieu et al.   BRAIN RESEARCH BULLETIN

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein

(2011) Hoa A. Lam et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat

(2011) Jeffrey H. Kordower et al.   NEUROBIOLOGY OF DISEASE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Are synucleinopathies prion-like disorders?

(2010) Elodie Angot et al.   LANCET NEUROLOGY

Microglia Acquire Distinct Activation Profiles Depending on the Degree of α-Synuclein Neuropathology in a rAAV Based Model of Parkinson's Disease

(2010) Vanesa Sanchez-Guajardo et al.   PLoS One

Lewy body pathology in fetal grafts

(2009) Yaping Chu et al.   Annals of the New York Academy of Sciences

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE