FTY720 Inhibits MPP+-Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
FTY720 Inhibits MPP+-Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation
Authors
Keywords
-
Journal
Journal of Neuroimmune Pharmacology
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-05-08
DOI
10.1007/s11481-019-09843-4
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- IL-33/ST2 plays a critical role in endothelial cell activation and microglia-mediated neuroinflammation modulation
- (2018) Kelei Cao et al. Journal of Neuroinflammation
- NLRP3 inflammasome activation in the thymus of MPTP-induced Parkinsonian mouse model
- (2018) Lu Wen et al. TOXICOLOGY LETTERS
- Evidence that NLRC4 Inflammasome Mediates Apoptotic and Pyroptotic Microglial Death Following Ischemic Stroke
- (2018) Luting Poh et al. BRAIN BEHAVIOR AND IMMUNITY
- NLRP3 inflammasome-dependent pyroptosis is proposed to be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment
- (2018) Lei Yin et al. Journal of Neuroinflammation
- The role of T cells in the pathogenesis of Parkinson’s disease
- (2018) Zhichun Chen et al. PROGRESS IN NEUROBIOLOGY
- Isoliquiritigenin protects against blood‑brain barrier damage and inhibits the secretion of pro-inflammatory cytokines in mice after traumatic brain injury
- (2018) Man Zhang et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Neuroprotective effects of fingolimod in mouse models of Parkinson’s disease
- (2017) Peng Zhao et al. FASEB JOURNAL
- PP2A deactivation is a common event in oral cancer and reactivation by FTY720 shows promising therapeutic potential
- (2017) Bharath K. Velmurugan et al. JOURNAL OF CELLULAR PHYSIOLOGY
- FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation
- (2017) Róisín M. McManus et al. Journal of Neuroimmune Pharmacology
- The Ketone Body β-Hydroxybutyrate Does Not Inhibit Synuclein Mediated Inflammasome Activation in Microglia
- (2017) Vandana Deora et al. Journal of Neuroimmune Pharmacology
- Cross-Talk between Glia, Neurons and Mast Cells in Neuroinflammation Associated with Parkinson’s Disease
- (2017) Duraisamy Kempuraj et al. Journal of Neuroimmune Pharmacology
- The dopamine motive system: implications for drug and food addiction
- (2017) Nora D. Volkow et al. NATURE REVIEWS NEUROSCIENCE
- Cognitive and behavioral disorders in Parkinson’s disease: an update. I: cognitive impairments
- (2017) Costanza Papagno et al. NEUROLOGICAL SCIENCES
- FTY720 (fingolimod) regulates key target genes essential for inflammation in microglial cells as defined by high-resolution mRNA sequencing
- (2017) Amitabh Das et al. NEUROPHARMACOLOGY
- Inflammation and mitochondrial dysfunction: A vicious circle in neurodegenerative disorders?
- (2017) Jack van Horssen et al. NEUROSCIENCE LETTERS
- Characterization of the Anticoagulant and Antithrombotic Properties of the Sphingosine 1-Phosphate Mimetic FTY720
- (2016) Zhen Zhao et al. ACTA HAEMATOLOGICA
- Transforming growth factor-β1 acts via TβR-I on microglia to protect against MPP+-induced dopaminergic neuronal loss
- (2016) Zhan Liu et al. BRAIN BEHAVIOR AND IMMUNITY
- Potential anti-tumor effects of FTY720 associated with PP2A activation: a brief review
- (2016) Ion Cristóbal et al. CURRENT MEDICAL RESEARCH AND OPINION
- Fingolimod ameliorates the development of experimental autoimmune encephalomyelitis by inhibiting Akt–mTOR axis in mice
- (2016) Huiqing Hou et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- PI3k/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-activated microglia
- (2016) Antonia Cianciulli et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- PI3K/AKT signaling mediated by G protein-coupled receptors is involved in neurodegenerative Parkinson's disease (Review)
- (2016) Noriko Nakano et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- FTY720 Attenuates 6-OHDA-Associated Dopaminergic Degeneration in Cellular and Mouse Parkinsonian Models
- (2016) Manru Ren et al. NEUROCHEMICAL RESEARCH
- The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells
- (2016) Md. Mostafizur Rahman et al. Scientific Reports
- The Direct Effects of Fingolimod in the Central Nervous System: Implications for Relapsing Multiple Sclerosis
- (2015) Samuel F. Hunter et al. CNS DRUGS
- Fingolimod induces the transition to a nerve regeneration promoting Schwann cell phenotype
- (2015) André Heinen et al. EXPERIMENTAL NEUROLOGY
- Selective loss of dopaminergic neurons in the substantia nigra pars compacta after systemic administration of MPTP facilitates extinction learning
- (2015) Ken-ichi Kinoshita et al. LIFE SCIENCES
- Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases
- (2015) Yu Tang et al. MOLECULAR NEUROBIOLOGY
- A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
- (2015) Rebecca C Coll et al. NATURE MEDICINE
- Tiagabine Protects Dopaminergic Neurons against Neurotoxins by Inhibiting Microglial Activation
- (2015) Jie Liu et al. Scientific Reports
- Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond
- (2014) Christopher S. Garris et al. IMMUNOLOGY
- Lithium ameliorates lipopolysaccharide-induced microglial activation via inhibition of toll-like receptor 4 expression by activating the PI3K/Akt/FoxO1 pathway
- (2014) Hongquan Dong et al. Journal of Neuroinflammation
- Neurorestorative effect of FTY720 in a rat model of Alzheimer's disease: Comparison with Memantine
- (2013) Fatemeh Hemmati et al. BEHAVIOURAL BRAIN RESEARCH
- Inflammasome activation restrictsLegionella pneumophilareplication in primary microglial cells through flagellin detection
- (2013) Yvan Jamilloux et al. GLIA
- FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease
- (2013) Alba Di Pardo et al. HUMAN MOLECULAR GENETICS
- FTY720 protects neuronal cells from damage induced by human prion protein by inactivating the JNK pathway
- (2013) MYUNG-HEE MOON et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Fingolimod phosphate promotes the neuroprotective effects of microglia
- (2013) Hiromi Noda et al. JOURNAL OF NEUROIMMUNOLOGY
- Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation
- (2013) Celina Wu et al. Journal of Neuroinflammation
- Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1
- (2013) C Rutherford et al. Cell Death & Disease
- FTY720 Improves Functional Recovery after Spinal Cord Injury by Primarily Nonimmunomodulatory Mechanisms
- (2012) Yusuke Norimatsu et al. AMERICAN JOURNAL OF PATHOLOGY
- Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage
- (2012) William B. Rolland et al. EXPERIMENTAL NEUROLOGY
- NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
- (2012) Michael T. Heneka et al. NATURE
- Fingolimod protects cultured cortical neurons against excitotoxic death
- (2012) Luisa Di Menna et al. PHARMACOLOGICAL RESEARCH
- Fingolimod (FTY720) inhibits neuroinflammation and attenuates spontaneous convulsions in lithium-pilocarpine induced status epilepticus in rat model
- (2012) Fei Gao et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Recent Advances in the Genetics of Parkinson's Disease
- (2011) Ian Martin et al. Annual Review of Genomics and Human Genetics
- Fingolimod modulates microglial activation to augment markers of remyelination
- (2011) Samuel J Jackson et al. Journal of Neuroinflammation
- Oral fingolimod (FTY720) in relapsing multiple sclerosis: impact on health-related quality of life in a phase II study
- (2011) X Montalban et al. Multiple Sclerosis Journal
- Neurodegeneration and Inflammation in Parkinson's disease
- (2011) Sudarshan Phani et al. PARKINSONISM & RELATED DISORDERS
- Fingolimod provides long-term protection in rodent models of cerebral ischemia
- (2010) Ying Wei et al. ANNALS OF NEUROLOGY
- A role for mitochondria in NLRP3 inflammasome activation
- (2010) Rongbin Zhou et al. NATURE
- A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis
- (2010) Ludwig Kappos et al. NEW ENGLAND JOURNAL OF MEDICINE
- HDL and sphingosine-1-phosphate activate stat3 in prostate cancer DU145 cells via ERK1/2 and S1P receptors, and promote cell migration and invasion
- (2010) Yoshitaka Sekine et al. PROSTATE
- FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system
- (2009) Volker Brinkmann BRITISH JOURNAL OF PHARMACOLOGY
- Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
- (2009) F. G. Bauernfeind et al. JOURNAL OF IMMUNOLOGY
- The "Down Syndrome Critical Region" Is Sufficient in the Mouse Model to Confer Behavioral, Neurophysiological, and Synaptic Phenotypes Characteristic of Down Syndrome
- (2009) N. P. Belichenko et al. JOURNAL OF NEUROSCIENCE
- Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury
- (2009) Takashi Shichita et al. NATURE MEDICINE
- Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention
- (2009) Malú G. Tansey et al. NEUROBIOLOGY OF DISEASE
- Unregulated mitochondrial GSK3β activity results in NADH:Ubiquinone oxidoreductase deficiency
- (2009) Taj D. King et al. NEUROTOXICITY RESEARCH
- Activation of Sphingosine 1-Phosphate Receptor-1 by FTY720 Is Neuroprotective After Ischemic Stroke in Rats
- (2009) Yu Hasegawa et al. STROKE
- The NALP3 inflammasome is involved in the innate immune response to amyloid-β
- (2008) Annett Halle et al. NATURE IMMUNOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More