Toll-like receptor 2 is increased in neurons in Parkinson’s disease brain and may contribute to alpha-synuclein pathology

Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease

(2015) A. Gustot et al.   BIOCHEMICAL JOURNAL

Inflammation is genetically implicated in Parkinson’s disease

(2015) N. Dzamko et al.   NEUROSCIENCE

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

(2015) Stefano G. Daniele et al.   Science Signaling

Sensitive western blotting for detection of endogenous Ser129-phosphorylated α-synuclein in intracellular and extracellular spaces

(2015) Asuka Sasaki et al.   Scientific Reports

Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy

(2015) Changyoun Kim et al.   Cell Reports

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

(2015) Stefano G. Daniele et al.   Science Signaling

Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson’s disease

(2014) Karen E. Murphy et al.   BRAIN

p62 Deficiency Enhances α-Synuclein Pathology in Mice

(2014) Kunikazu Tanji et al.   BRAIN PATHOLOGY

The Role of the Selective Adaptor p62 and Ubiquitin-Like Proteins in Autophagy

(2014) Mónika Lippai et al.   Biomed Research International

Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson’s disease patients

(2014) Karlijn J Doorn et al.   Acta Neuropathologica Communications

The role of inflammation in sporadic and familial Parkinson’s disease

(2013) Michela Deleidi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Toll-Like Receptor 2 Regulates Intestinal Inflammation by Controlling Integrity of the Enteric Nervous System

(2013) Paola Brun et al.   GASTROENTEROLOGY

TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors

(2013) Jeroen van Bergenhenegouwen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

p62/SQSTM1-Dependent Autophagy of Lewy Body-Like α-Synuclein Inclusions

(2013) Yoshihisa Watanabe et al.   PLoS One

Preconditioning of Microglia by α-Synuclein Strongly Affects the Response Induced by Toll-like Receptor (TLR) Stimulation

(2013) Cintia Roodveldt et al.   PLoS One

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

(2013) Changyoun Kim et al.   Nature Communications

Hypothalamic neuronal toll-like receptor 2 protects against age-induced obesity

(2013) Ravid Shechter et al.   Scientific Reports

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

Microglial Activation and Antioxidant Responses Induced by the Parkinson’s Disease Protein α-Synuclein

(2012) Dawn Béraud et al.   Journal of Neuroimmune Pharmacology

Alpha-synuclein and Protein Degradation Systems: a Reciprocal Relationship

(2012) Maria Xilouri et al.   MOLECULAR NEUROBIOLOGY

Therapeutic Effects of Rapamycin on MPTP-Induced Parkinsonism in Mice

(2012) Kangyong Liu et al.   NEUROCHEMICAL RESEARCH

Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease

(2012) Louise M. Collins et al.   NEUROPHARMACOLOGY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line

(2011) Lydia Alvarez-Erviti et al.   NEUROSCIENCE RESEARCH

 -Synuclein Activates Microglia by Inducing the Expressions of Matrix Metalloproteinases and the Subsequent Activation of Protease-Activated Receptor-1

(2010) E.-J. Lee et al.   JOURNAL OF IMMUNOLOGY

Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease

(2010) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

DAMPening Inflammation by Modulating TLR Signalling

(2010) A. M. Piccinini et al.   MEDIATORS OF INFLAMMATION

Rapamycin protects against rotenone-induced apoptosis through autophagy induction

(2009) T. Pan et al.   NEUROSCIENCE

The progression of pathology in longitudinally followed patients with Parkinson’s disease

(2008) Glenda Halliday et al.   ACTA NEUROPATHOLOGICA

Synuclein activates microglia in a model of Parkinson's disease

(2007) Xiaomin Su et al.   NEUROBIOLOGY OF AGING