Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers

A Key Role for Lysine Residues in Amyloid β-Protein Folding, Assembly, and Toxicity

(2012) Sharmistha Sinha et al.   ACS Chemical Neuroscience

Comparison of Three Amyloid Assembly Inhibitors: The Sugar scyllo-Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01

(2012) Sharmistha Sinha et al.   ACS Chemical Neuroscience

Modulating Self-Assembly of Amyloidogenic Proteins as a Therapeutic Approach for Neurodegenerative Diseases: Strategies and Mechanisms

(2012) Tingyu Liu et al.   ChemMedChem

A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo

(2012) Shubhangi Prabhudesai et al.   Neurotherapeutics

2011 Alzheimer’s disease facts and figures

(2011)   Alzheimers & Dementia

Peroxynitrite-Induced Nitrative and Oxidative Modifications Alter Tau Filament Formation

(2011) Laurel Vana et al.   BIOCHEMISTRY

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

(2011) Sharmistha Sinha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction

(2011) S. Fusco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

Synaptic degeneration in Alzheimer’s disease

(2009) Thomas Arendt   ACTA NEUROPATHOLOGICA

Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau

(2009) Wenkai Li et al.   JOURNAL OF NEUROCHEMISTRY

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

The role of tau in neurodegeneration

(2009) Tania F Gendron et al.   Molecular Neurodegeneration

Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's disease

(2009) Fanchon Bourasset et al.   NEUROPHARMACOLOGY

Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity

(2009) K. Usui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversal of long-term dendritic spine alterations in Alzheimer disease models

(2009) D. L. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model

(2008) Chiho Hirata-Fukae et al.   BRAIN RESEARCH

Molecular Clip and Tweezer Introduce New Mechanisms of Enzyme Inhibition

(2008) Peter Talbiersky et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A genome-wide panel of congenic mice reveals widespread epistasis of behavior quantitative trait loci

(2008) G D Gale et al.   MOLECULAR PSYCHIATRY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Escaping amyloid fate

(2008) Blake E Roberts et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Effect of a ΔK280 Mutation on the Unfolded State of a Microtubule-Binding Repeat in Tau

(2008) Austin Huang et al.   PLoS Computational Biology

Cytochrome P450 and Chemical Toxicology

(2007) F. Peter Guengerich   CHEMICAL RESEARCH IN TOXICOLOGY

Cell Signaling and Nuclear Receptors: New Opportunities for Molecular Pharmaceuticals in Liver Disease

(2007) Jeff L. Staudinger et al.   MOLECULAR PHARMACEUTICS

On the nucleation of amyloid β-protein monomer folding

(2005) Noel D. Lazo et al.   PROTEIN SCIENCE