Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci

(2017) Diana Chang et al.   NATURE GENETICS

Inhibiting the Ca 2+ Influx Induced by Human CSF

(2017) Anna Drews et al.   Cell Reports

Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids

(2016) Mathew H. Horrocks et al.   ACS Chemical Neuroscience

Toll-like receptor 2 is increased in neurons in Parkinson’s disease brain and may contribute to alpha-synuclein pathology

(2016) Nicolas Dzamko et al.   ACTA NEUROPATHOLOGICA

Genetics of Parkinson's disease

(2016) Christina M. Lill   MOLECULAR AND CELLULAR PROBES

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Microglia Priming with Aging and Stress

(2016) Anzela Niraula et al.   NEUROPSYCHOPHARMACOLOGY

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

(2016) Marija Iljina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Molecular Mechanisms That Underlie the Dynamic Adaptation of Innate Monocyte Memory to Varying Stimulant Strength of TLR Ligands

(2016) Ruoxi Yuan et al.   Frontiers in Immunology

Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases

(2016) Sarah A. Gagliano et al.   Annals of Clinical and Translational Neurology

Fast Flow Microfluidics and Single-Molecule Fluorescence for the Rapid Characterization of α-Synuclein Oligomers

(2015) Mathew H. Horrocks et al.   ANALYTICAL CHEMISTRY

Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes

(2015) Emmy H. Rannikko et al.   BMC NEUROSCIENCE

Rapid mitochondrial dysfunction mediates TNF-alpha-induced neurotoxicity

(2015) Danielle N. Doll et al.   JOURNAL OF NEUROCHEMISTRY

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

The human transcriptome across tissues and individuals

(2015) M. Mele et al.   SCIENCE

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

(2015) Stefano G. Daniele et al.   Science Signaling

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

(2015) Stefano G. Daniele et al.   Science Signaling

Innate Immune Programing by Endotoxin and Its Pathological Consequences

(2015) Matthew C. Morris et al.   Frontiers in Immunology

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Toll-Like Receptor Expression in the Blood and Brain of Patients and a Mouse Model of Parkinson's Disease

(2015) J. Drouin-Ouellet et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage

(2014) Priyanka Narayan et al.   BIOCHEMISTRY

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

Genetic variability in the regulation of gene expression in ten regions of the human brain

(2014) Adaikalavan Ramasamy et al.   NATURE NEUROSCIENCE

Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

(2014) T. Raj et al.   SCIENCE

Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression

(2014) B. P. Fairfax et al.   SCIENCE

Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson’s disease with dementia and dementia with Lewy bodies compared to Alzheimer’s disease

(2014) Oskar Hansson et al.   Alzheimers Research & Therapy

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

(2013) Gaia Codolo et al.   PLoS One

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

(2013) Changyoun Kim et al.   Nature Communications

Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease

(2013) Carmen Noelker et al.   Scientific Reports

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

Molecular Mechanism Responsible for the Priming of Macrophage Activation

(2012) Hui Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-Like Receptors in Liver Fibrosis: Cellular Crosstalk and Mechanisms

(2012) Ling Yang et al.   Frontiers in Physiology

Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons

(2011) Nadia Stefanova et al.   AMERICAN JOURNAL OF PATHOLOGY

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide

(2011) Priyanka Narayan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Is My Network Module Preserved and Reproducible?

(2011) Peter Langfelder et al.   PLoS Computational Biology

A Versatile Gene-Based Test for Genome-wide Association Studies

(2010) Jimmy Z. Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Detection of elevated levels of  -synuclein oligomers in CSF from patients with Parkinson disease

(2010) T. Tokuda et al.   NEUROLOGY

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS