The dual roles of autophagy and the GPCRs-mediating autophagy signaling pathway after cerebral ischemic stroke

PTP1B inhibitor alleviates deleterious microglial activation and neuronal injury after ischemic stroke by modulating the ER stress-autophagy axis via PERK signaling in microglia

(2021) Yu Zhu et al.   Aging-US

Inhibition of PDE1-B by Vinpocetine Regulates Microglial Exosomes and Polarization Through Enhancing Autophagic Flux for Neuroprotection Against Ischemic Stroke

(2021) Jiankun Zang et al.   Frontiers in Cell and Developmental Biology

Microglial PGC-1α protects against ischemic brain injury by suppressing neuroinflammation

(2021) Bin Han et al.   Genome Medicine

Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke

(2021) Zhe-Qi Xu et al.   Frontiers in Pharmacology

Selenium attenuates ischemia/reperfusion injury‑induced damage to the blood‑brain barrier in hyperglycemia through PI3K/AKT/mTOR pathway‑mediated autophagy inhibition

(2021) Biao Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Sex-Specific Differences in Autophagic Responses to Experimental Ischemic Stroke

(2021) Anthony N. Patrizz et al.   Cells

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

β-Arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates

(2020) Jung-A A. Woo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of pH-Sensing Receptor OGR1 (GPR68) Induces ER Stress Via the IRE1α/JNK Pathway in an Intestinal Epithelial Cell Model

(2020) Chiaki Maeyashiki et al.   Scientific Reports

Autophagosome biogenesis: From membrane growth to closure

(2020) Thomas J. Melia et al.   JOURNAL OF CELL BIOLOGY

Mechanisms governing autophagosome biogenesis

(2020) Hitoshi Nakatogawa   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagosome biogenesis and human health

(2020) Tsuyoshi Kawabata et al.   Cell Discovery

PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery

(2020) Ying Tang et al.   Autophagy

Electroacupuncture Alleviates Cerebral Ischemia/Reperfusion Injury in Rats by Histone H4 Lysine 16 Acetylation-Mediated Autophagy

(2020) Shu-Ying Xu et al.   Frontiers in Psychiatry

An online resource for GPCR structure determination and analysis

(2019) Christian Munk et al.   NATURE METHODS

Rapamycin improves the neuroprotection effect of inhibition of NLRP3 inflammasome activation after TBI

(2019) Yuhua Chen et al.   BRAIN RESEARCH

Regulator of G-protein signaling 5 regulates the shift from perivascular to parenchymal pericytes in the chronic phase after stroke

(2019) Michaela Roth et al.   FASEB JOURNAL

The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity

(2019) Lin Gan et al.   NATURE CELL BIOLOGY

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

(2019) Jenna L Jewell et al.   eLife

Autophagy metabolically suppresses CD8+ T cell antitumor immunity

(2019) Gillian Carleton et al.   Autophagy

Protective effects of GPR37 via regulation of inflammation and multiple cell death pathways after ischemic stroke in mice

(2019) Myles R. McCrary et al.   FASEB JOURNAL

Activation of G protein‐coupled receptor 30 protects neurons by regulating autophagy in astrocytes

(2019) Xin‐Shang Wang et al.   GLIA

Activation of G-Protein-Coupled Receptor 30 Protects Neurons against Excitotoxicity through Inhibiting Excessive Autophagy Induced by Glutamate

(2019) Jiao Yue et al.   ACS Chemical Neuroscience

Impaired Autophagy in CD11b + Dendritic Cells Expands CD4 + Regulatory T Cells and Limits Atherosclerosis in Mice

(2019) Marc Clement et al.   CIRCULATION RESEARCH

Autophagy mediates hepatic GRK2 degradation to facilitate glucagon‐induced metabolic adaptation to fasting

(2019) Marta Cruces‐Sande et al.   FASEB JOURNAL

The Molecular Basis of G Protein–Coupled Receptor Activation

(2018) William I. Weis et al.   Annual Review of Biochemistry

Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis

(2018) Yusuke Osonoi et al.   Autophagy

Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke

(2018) Bing Han et al.   Autophagy

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

bFGF plays a neuroprotective role by suppressing excessive autophagy and apoptosis after transient global cerebral ischemia in rats

(2018) Dawei Sun et al.   Cell Death & Disease

Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development

(2018) Sueli Marques et al.   DEVELOPMENTAL CELL

Structural insights into G-protein-coupled receptor allostery

(2018) David M. Thal et al.   NATURE

Loss of Regulator of G-Protein Signaling 5 Leads to Neurovascular Protection in Stroke

(2018) Ilknur Özen et al.   STROKE

GPR119 agonist enhances gefitinib responsiveness through lactate-mediated inhibition of autophagy

(2018) Ji Hye Im et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases

(2018) Jun Ren et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Development, characterization and in vitro evaluation of biodegradable rhein-loaded microparticles for treatment of osteoarthritis

(2017) Carolina Gómez-Gaete et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Sirt3 confers protection against neuronal ischemia by inducing autophagy: Involvement of the AMPK-mTOR pathway

(2017) Shu-Hui Dai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway

(2017) Hyo Jeong Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of the endoplasmic reticulum stress response following cerebral ischemia

(2017) Gina Hadley et al.   International Journal of Stroke

Depletion of microglia exacerbates postischemic inflammation and brain injury

(2017) Wei-Na Jin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pre-ischemia melatonin treatment alleviated acute neuronal injury after ischemic stroke by inhibiting endoplasmic reticulum stress-dependent autophagy via PERK and IRE1 signalings

(2017) Dayun Feng et al.   JOURNAL OF PINEAL RESEARCH

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Mitochondrial function in hypoxic ischemic injury and influence of aging

(2017) P. Benson Ham et al.   PROGRESS IN NEUROBIOLOGY

The Tnfaip8-PE complex is a novel upstream effector in the anti-autophagic action of insulin

(2017) Ji-Soo Kim et al.   Scientific Reports

Sodium hydrosulfide attenuates cerebral ischemia/reperfusion injury by suppressing overactivated autophagy in rats

(2017) Wen-Wu Jiang et al.   FEBS Open Bio

Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury

(2016) Cuicui Xie et al.   Autophagy

Life in lights: Tracking mitochondrial delivery to lysosomes in vivo

(2016) Thomas G. McWilliams et al.   Autophagy

Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis

(2016) Pierre-Michaël Coly et al.   Autophagy

A novel PINK1- and PARK2-dependent protective neuroimmune pathway in lethal sepsis

(2016) Rui Kang et al.   Autophagy

The intersection between growth factors, autophagy and ER stress: A new target to treat neurodegenerative diseases?

(2016) Paula Garcia-Huerta et al.   BRAIN RESEARCH

Time-Dependent Changes in Apoptosis Upon Autophagy Inhibition in Astrocytes Exposed to Oxygen and Glucose Deprivation

(2016) Daniela Kasprowska et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Labeling and Single-Molecule Methods To Monitor G Protein-Coupled Receptor Dynamics

(2016) He Tian et al.   CHEMICAL REVIEWS

Angiotensin(1–7) attenuated Angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H 2 O 2 -activated NLRP3 inflammasome/IL-1β/Smad circuit

(2016) Li-Li Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

MKK3 influences mitophagy and is involved in cigarette smoke-induced inflammation

(2016) Praveen Mannam et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagic flux regulates microglial phenotype according to the time of oxygen-glucose deprivation/reperfusion

(2016) Cong-Yuan Xia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Green Tea Catechin Prevents Hypoxia/Reperfusion-Evoked Oxidative Stress-Regulated Autophagy-Activated Apoptosis and Cell Death in Microglial Cells

(2016) Chang-Mu Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Thiamet G mediates neuroprotection in experimental stroke by modulating microglia/macrophage polarization and inhibiting NF-κB p65 signaling

(2016) Yating He et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mitochondrial translocator protein (TSPO), astrocytes and neuroinflammation

(2016) Wenbin Deng et al.   Neural Regeneration Research

Age-specific localization of NMDA receptors on oligodendrocytes dictates axon function recovery after ischemia

(2016) Selva Baltan   NEUROPHARMACOLOGY

The role of astrocytes in the hypothalamic response and adaptation to metabolic signals

(2016) Julie A. Chowen et al.   PROGRESS IN NEUROBIOLOGY

Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke

(2016) Zhongwu Liu et al.   PROGRESS IN NEUROBIOLOGY

Targeting astrocytes in brain injuries: A translational research approach

(2016) George E. Barreto   PROGRESS IN NEUROBIOLOGY

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke

(2016) Xiao-Yi Xiong et al.   PROGRESS IN NEUROBIOLOGY

The receptor proteins: pivotal roles in selective autophagy

(2015) Zhijie Xu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection

(2015) Elzbieta Janda et al.   Autophagy

Modulation of inflammation by autophagy: Consequences for human disease

(2015) Romana T. Netea-Maier et al.   Autophagy

Regulation on Beclin-1 expression by mTOR in CoCl2-induced HT22 cell ischemia-reperfusion injury

(2015) Tao Yang et al.   BRAIN RESEARCH

Hypoxia induces microglia autophagy and neural inflammation injury in focal cerebral ischemia model

(2015) Zhao Yang et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Autophagy protects human brain microvascular endothelial cells against methylglyoxal-induced injuries, reproducible in a cerebral ischemic model in diabetic rats

(2015) Lili Fang et al.   JOURNAL OF NEUROCHEMISTRY

The Critical Role of Proteolytic Relay through Cathepsins B and E in the Phenotypic Change of Microglia/Macrophage

(2015) J. Ni et al.   JOURNAL OF NEUROSCIENCE

Autophagic flux determination in vivo and ex vivo

(2015) Lorena Esteban-Martínez et al.   METHODS

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(2015) Yao Di et al.   MOLECULAR MEDICINE

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

Mitochondria in autoinflammation: cause, mediator or bystander?

(2015) Robert van der Burgh et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L

(2015) Tao Zhang et al.   eLife

Autophagy in neonatal hypoxia ischemic brain is associated with oxidative stress

(2015) Qing Lu et al.   Redox Biology

Role of autophagy in methylmercury-induced neurotoxicity in rat primary astrocytes

(2014) Fang Yuntao et al.   ARCHIVES OF TOXICOLOGY

Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways

(2014) Ya-Dan Wen et al.   Autophagy

Involvement of autophagy in hypoxic-excitotoxic neuronal death

(2014) Vanessa Ginet et al.   Autophagy

Plant cell remodeling by autophagy

(2014) Jimi Kim et al.   Autophagy

Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury

(2014) Xiangnan Zhang et al.   Autophagy

Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction

(2014) Sandro Huenchuguala et al.   Autophagy

ARRB1/β-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia

(2014) Pei Wang et al.   Autophagy

Posttranslational modification of autophagy-related proteins in macroautophagy

(2014) Yangchun Xie et al.   Autophagy

Rapamycin attenuates mitochondrial dysfunction via activation of mitophagy in experimental ischemic stroke

(2014) Qiang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gβγ interacts with mTOR and promotes its activation

(2014) Evelyn Robles-Molina et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RETRACTED: Rapamycin induces of protective autophagy in vascular endothelial cells exposed to oxygen–glucose deprivation

(2014) Tomasz Urbanek et al.   BRAIN RESEARCH

Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy

(2014) Teng Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

2-Methoxyestradiol Attenuates Autophagy Activation After Global Ischemia

(2014) Xiao-Yu Xin et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

AMP-activated protein kinase is involved in induction of protective autophagy in astrocytes exposed to oxygen-glucose deprivation

(2014) Bożena Gabryel et al.   CELL BIOLOGY INTERNATIONAL

Electrical stimulation of transplanted motoneurons improves motor unit formation

(2014) Yang Liu et al.   JOURNAL OF NEUROPHYSIOLOGY

A combination of four active compounds alleviates cerebral ischemia-reperfusion injury in correlation with inhibition of autophagy and modulation of AMPK/mTOR and JNK pathways

(2014) Zhongshun Guo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Ischemic Preconditioning Provides Neuroprotection by Induction of AMP-Activated Protein Kinase-Dependent Autophagy in a Rat Model of Ischemic Stroke

(2014) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

Down-Regulation of miRNA-30a Alleviates Cerebral Ischemic Injury Through Enhancing Beclin 1-Mediated Autophagy

(2014) Peng Wang et al.   NEUROCHEMICAL RESEARCH

Chronic Oxidative Stress Increases Growth and Tumorigenic Potential of MCF-7 Breast Cancer Cells

(2014) Prathap Kumar S. Mahalingaiah et al.   PLoS One

Hypoxia Induces Autophagic Cell Death through Hypoxia-Inducible Factor 1α in Microglia

(2014) Zhao Yang et al.   PLoS One

Evaluation of the Protective Potential of Brain Microvascular Endothelial Cell Autophagy on Blood–Brain Barrier Integrity During Experimental Cerebral Ischemia–Reperfusion Injury

(2014) Haiying Li et al.   Translational Stroke Research

The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning

(2013) Bo Gao et al.   ACTA PHARMACOLOGICA SINICA

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation Where Autophagy Intersects the Inflammasome

(2013) Mary A. Rodgers et al.   ANTIOXIDANTS & REDOX SIGNALING

β-adrenergic receptor-stimulated lipolysis requires the RAB7-mediated autolysosomal lipid degradation

(2013) Analyn Lizaso et al.   Autophagy

Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway

(2013) Ming-liang Chen et al.   Autophagy

Ca2+in quality control

(2013) Daniel A East et al.   Autophagy

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

(2013) Xiangnan Zhang et al.   Autophagy

Activation of Autophagy Pathway Suppresses the Expression of iNOS, IL6 and Cell Death of LPS-Stimulated Microglia Cells

(2013) Hye-Eun Han et al.   Biomolecules & Therapeutics

Physical exercise improves functional recovery through mitigation of autophagy, attenuation of apoptosis and enhancement of neurogenesis after MCAO in rats

(2013) Liying Zhang et al.   BMC NEUROSCIENCE

Excitotoxic glutamate insults block autophagic flux in hippocampal neurons

(2013) Jacqueline R. Kulbe et al.   BRAIN RESEARCH

Beclin 2 Functions in Autophagy, Degradation of G Protein-Coupled Receptors, and Metabolism

(2013) Congcong He et al.   CELL

Common and divergent functions of Beclin 1 and Beclin 2

(2013) Lorenzo Galluzzi et al.   CELL RESEARCH

Acetylcholine Mediates AMPK-Dependent Autophagic Cytoprotection in H9c2 Cells During Hypoxia/Reoxygenation Injury

(2013) Mei Zhao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy

(2013) Hitoshi Nakatogawa   Essays in Biochemistry

Autophagy Promotes Oligodendrocyte Survival and Function following Dysmyelination in a Long-Lived Myelin Mutant

(2013) C. M. Smith et al.   JOURNAL OF NEUROSCIENCE

Nutrient Sensing, Metabolism, and Cell Growth Control

(2013) Hai-Xin Yuan et al.   MOLECULAR CELL

Class IA PI3K p110β Subunit Promotes Autophagy through Rab5 Small GTPase in Response to Growth Factor Limitation

(2013) Zhixun Dou et al.   MOLECULAR CELL

Minireview: Nutrient Sensing by G Protein-Coupled Receptors

(2013) Eric M. Wauson et al.   MOLECULAR ENDOCRINOLOGY

The regulatory role of NF-κB in autophagy-like cell death after focal cerebral ischemia in mice

(2013) W.-L. Li et al.   NEUROSCIENCE

Propofol prevents cerebral ischemia-triggered autophagy activation and cell death in the rat hippocampus through the NF-κB/p53 signaling pathway

(2013) D.R. Cui et al.   NEUROSCIENCE

Autophagy in the brain of neonates following hypoxia–ischemia shows sex- and region-specific effects

(2013) S.N. Weis et al.   NEUROSCIENCE

Extrasensory perception: Odorant and taste receptors beyond the nose and mouth

(2013) Simon R. Foster et al.   PHARMACOLOGY & THERAPEUTICS

Decreased Autophagy in Rat Heart Induced by Anti-β1-Adrenergic Receptor Autoantibodies Contributes to the Decline in Mitochondrial Membrane Potential

(2013) Li Wang et al.   PLoS One

Targeting annexin A7 by a small molecule suppressed the activity of phosphatidylcholine-specific phospholipase C in vascular endothelial cells and inhibited atherosclerosis in apolipoprotein E−/− mice

(2013) H Li et al.   Cell Death & Disease

Autophagy proteins regulate ERK phosphorylation

(2013) Nuria Martinez-Lopez et al.   Nature Communications

Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia

(2012) Pei Wang et al.   Autophagy

Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning

(2012) Rui Sheng et al.   Autophagy

Anthocyanin Extracts from Black Soybean (Glycine max L.) Protect Human Glial Cells Against Oxygen-Glucose Deprivation by Promoting Autophagy

(2012) Yong-Kwan Kim et al.   Biomolecules & Therapeutics

A Glucagon-Like Peptide-1 Analog Reverses the Molecular Pathology and Cardiac Dysfunction of a Mouse Model of Obesity

(2012) Mohammad Hossein Noyan-Ashraf et al.   CIRCULATION

Excessive Autophagy Contributes to Neuron Death in Cerebral Ischemia

(2012) Ruoyang Shi et al.   CNS Neuroscience & Therapeutics

NF-κB as a Target for Modulating Inflammatory Responses

(2012) Chiara Gasparini et al.   CURRENT PHARMACEUTICAL DESIGN

Autophagy and Its Comprehensive Impact on ALS

(2012) Cheng-yuan Song et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Involvement of Beclin 1 in Engulfment of Apoptotic Cells

(2012) Akimitsu Konishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of autophagy in cardiomyocytes by Ins(1,4,5)P3 and IP3-receptors

(2012) Albert Wong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Novel Role for SHP-2 in Nutrient-Responsive Control of S6 Kinase 1 Signaling

(2012) F. Mercan et al.   MOLECULAR AND CELLULAR BIOLOGY

The G Protein-Coupled Taste Receptor T1R1/T1R3 Regulates mTORC1 and Autophagy

(2012) Eric M. Wauson et al.   MOLECULAR CELL

BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs

(2012) Rebecca Mathew et al.   NATURE

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

(2012) Atsuhiko Ichimura et al.   NATURE

G protein-coupled receptors for energy metabolites as new therapeutic targets

(2012) Clara C. Blad et al.   NATURE REVIEWS DRUG DISCOVERY

The GPCR Network: a large-scale collaboration to determine human GPCR structure and function

(2012) Raymond C. Stevens et al.   NATURE REVIEWS DRUG DISCOVERY

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Expanded indications for stroke thrombolysis—what next?

(2012) Geoffrey A. Donnan et al.   Nature Reviews Neurology

Extracellular Nucleotides Inhibit Insulin Receptor Signaling, Stimulate Autophagy and Control Lipoprotein Secretion

(2012) Cynthia Chatterjee et al.   PLoS One

Inhibition of Autophagy Contributes to Ischemic Postconditioning-Induced Neuroprotection against Focal Cerebral Ischemia in Rats

(2012) Li Gao et al.   PLoS One

Tetracycline Inhibits Local Inflammation Induced by Cerebral Ischemia via Modulating Autophagy

(2012) Yongjun Jiang et al.   PLoS One

Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

(2012) E. C. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G Protein-Coupled Receptor-Mediated Activation of p110  by G   Is Required for Cellular Transformation and Invasiveness

(2012) H. A. Dbouk et al.   Science Signaling

Regulation of the Autophagic Bcl-2/Beclin 1 Interaction

(2012) Jean-Paul Decuypere et al.   Cells

Accumulation of p62 in degenerated spinal cord under chronic mechanical compression

(2011) Fumito Tanabe et al.   Autophagy

Chasing the elusive mammalian microautophagy

(2011) Laura Santambrogio et al.   Autophagy

cAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1

(2011) Hege Ugland et al.   Autophagy

GSK-3β inhibitors suppressed neuroinflammation in rat cortex by activating autophagy in ischemic brain injury

(2011) Xiaogang Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy activation is involved in neuroprotection induced by hyperbaric oxygen preconditioning against focal cerebral ischemia in rats

(2011) Wenjun Yan et al.   BRAIN RESEARCH

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Microautophagy of Cytosolic Proteins by Late Endosomes

(2011) Ranjit Sahu et al.   DEVELOPMENTAL CELL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

GLP-1 Analogs Reduce Hepatocyte Steatosis and Improve Survival by Enhancing the Unfolded Protein Response and Promoting Macroautophagy

(2011) Shvetank Sharma et al.   PLoS One

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Mechanisms and Biology of B-Cell Leukemia/Lymphoma 2/Adenovirus E1B Interacting Protein 3 and Nip-Like Protein X

(2010) Ji Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia

(2010) Ai-Ping Qin et al.   Autophagy

Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia

(2010) Silvia Carloni et al.   Autophagy

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning

(2010) Rui Sheng et al.   Autophagy

Chaperone-mediated autophagy: machinery, regulation and biological consequences

(2010) Wenming Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Gα16 interacts with Class IA phosphatidylinositol 3-kinases and inhibits Akt signaling

(2010) Wendy W.S. Yeung et al.   CELLULAR SIGNALLING

Role of Inositol Trisphosphate Receptors in Autophagy in DT40 Cells

(2010) M. Tariq Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the autophagy protein LC3 by phosphorylation

(2010) Salvatore J. Cherra et al.   JOURNAL OF CELL BIOLOGY

The class IA phosphatidylinositol 3-kinase p110-β subunit is a positive regulator of autophagy

(2010) Zhixun Dou et al.   JOURNAL OF CELL BIOLOGY

Autophagy and protein aggregation after brain ischemia

(2010) Chunli Liu et al.   JOURNAL OF NEUROCHEMISTRY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Gq-coupled Purinergic Receptors Inhibit Insulin-like Growth Factor-I/Phosphoinositide 3-Kinase Pathway-dependent Keratinocyte Migration

(2010) Salma Taboubi et al.   MOLECULAR BIOLOGY OF THE CELL

Exacerbation of ischemia-induced amyloid-β generation by diabetes is associated with autophagy activation in mice brain

(2010) Ting Zhang et al.   NEUROSCIENCE LETTERS

G Protein-Coupled Receptor-Associated Sorting Protein 1 Regulates the Postendocytic Sorting of Seven-Transmembrane-Spanning G Protein-Coupled Receptors

(2010) Elisabeth Moser et al.   PHARMACOLOGY

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond

(2010) Sarah F. Funderburk et al.   TRENDS IN CELL BIOLOGY

Enhancement of Autophagic Flux after Neonatal Cerebral Hypoxia-Ischemia and Its Region-Specific Relationship to Apoptotic Mechanisms

(2009) Vanessa Ginet et al.   AMERICAN JOURNAL OF PATHOLOGY

Postischemic treatment of neonatal cerebral ischemia should target autophagy

(2009) Julien Puyal et al.   ANNALS OF NEUROLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Macroautophagy of the GPR37 orphan receptor and Parkinson disease-associated neurodegeneration

(2009) Daniela Marazziti et al.   Autophagy

The role of autophagy in spinal cord injury

(2009) Haruo Kanno et al.   Autophagy

Activation of autophagy through modulation of 5′-AMP-activated protein kinase protects pancreatic β-cells from high glucose

(2009) Diana Han et al.   BIOCHEMICAL JOURNAL

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1

(2009) J M Vicencio et al.   CELL DEATH AND DIFFERENTIATION

GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell

(2009) L. M. Lauffer et al.   DIABETES

Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1

(2009) Natasha C Chang et al.   EMBO JOURNAL

Induction of macroautophagy by overexpression of the Parkinson’s disease-associated GPR37 receptor

(2009) Daniela Marazziti et al.   FASEB JOURNAL

Molecular Pharmacology of Promiscuous Seven Transmembrane Receptors Sensing Organic Nutrients

(2009) P. Wellendorph et al.   MOLECULAR PHARMACOLOGY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury

(2008) Masato Koike et al.   AMERICAN JOURNAL OF PATHOLOGY

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

High glucose changes extracellular adenosine triphosphate levels in rat retinal cultures

(2008) G. Costa et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels

(2008) Dieter Wicher et al.   NATURE

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

(2008) Chengyu Liang et al.   NATURE CELL BIOLOGY

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

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A new penumbra: transitioning from injury into repair after stroke

(2008) Eng H Lo   NATURE MEDICINE

Protective role of autophagy in neonatal hypoxia–ischemia induced brain injury

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Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: Potential utility in treatment of diabetes and heart disease

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Regulation of GPCRs by Endocytic Membrane Trafficking and Its Potential Implications

(2007) Aylin C. Hanyaloglu et al.   Annual Review of Pharmacology and Toxicology