PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery

Extracellular Vesicle-Mediated Delivery of CircSCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models

(2020) Li Yang et al.   CIRCULATION

Beclin1‐driven autophagy modulates the inflammatory response of microglia via NLRP3

(2019) Judith Houtman et al.   EMBO JOURNAL

Exploring and comparing adverse events between PARP inhibitors

(2019) Christopher J LaFargue et al.   LANCET ONCOLOGY

Research Progress on PARP14 as a Drug Target

(2019) Wei Qin et al.   Frontiers in Pharmacology

Protease-independent action of tissue plasminogen activator in brain plasticity and neurological recovery after ischemic stroke

(2019) Hongjian Pu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circular RNA TLK1 aggravates neuronal injury and neurological deficits after ischemic stroke via miR-335-3p/TIPARP

(2019) Fangfang Wu et al.   JOURNAL OF NEUROSCIENCE

Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain–barrier disruption after ischemic stroke

(2019) An-Qi Chen et al.   Cell Death & Disease

Microglia Biology: One Century of Evolving Concepts

(2019) Marco Prinz et al.   CELL

Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells

(2019) Ioanna Plastira et al.   Frontiers in Cellular Neuroscience

Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke

(2018) Bing Han et al.   Autophagy

Exosomes from MiR-30d-5p-ADSCs Reverse Acute Ischemic Stroke-Induced, Autophagy-Mediated Brain Injury by Promoting M2 Microglial/Macrophage Polarization

(2018) Mei Jiang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Erythrocyte-Inspired Discoidal Polymeric Nanoconstructs Carrying Tissue Plasminogen Activator for the Enhanced Lysis of Blood Clots

(2018) Marianna Colasuonno et al.   ACS Nano

PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis

(2017) Partha Mukhopadhyay et al.   JOURNAL OF HEPATOLOGY

Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

(2017) I. Plastira et al.   Journal of Neuroinflammation

The biphasic function of microglia in ischemic stroke

(2017) Yuanyuan Ma et al.   PROGRESS IN NEUROBIOLOGY

PARP, transcription and chromatin modeling

(2017) Melanija Posavec Marjanović et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PARP activity and inhibition in fetal and adult oligodendrocyte precursor cells: Effect on cell survival and differentiation

(2017) Vito A. Baldassarro et al.   Stem Cell Research

Inhibiting Histone Deacetylase 2 (HDAC2) Promotes Functional Recovery From Stroke

(2017) Ying Tang et al.   Journal of the American Heart Association

PARP inhibitors in ovarian cancer: evidence, experience and clinical potential

(2017) Tarra Evans et al.   Therapeutic Advances in Medical Oncology

Small Molecule Microarray Based Discovery of PARP14 Inhibitors

(2016) Bo Peng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis and autophagy: Implications for methamphetamine-mediated neurotoxicity

(2016) Yuan Zhang et al.   Autophagy

Autophagic flux regulates microglial phenotype according to the time of oxygen-glucose deprivation/reperfusion

(2016) Cong-Yuan Xia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Green Tea Catechin Prevents Hypoxia/Reperfusion-Evoked Oxidative Stress-Regulated Autophagy-Activated Apoptosis and Cell Death in Microglial Cells

(2016) Chang-Mu Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target

(2016) Li Du et al.   MOLECULAR NEUROBIOLOGY

Nuclear ADP-Ribosylation and Its Role in Chromatin Plasticity, Cell Differentiation, and Epigenetics

(2015) Michael O. Hottiger   Annual Review of Biochemistry

PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression

(2014) M. B. Iqbal et al.   BLOOD

Interaction of nNOS with PSD-95 Negatively Controls Regenerative Repair after Stroke

(2014) C.-X. Luo et al.   JOURNAL OF NEUROSCIENCE

Inhibition of a SNARE-Sensitive Pathway in Astrocytes Attenuates Damage following Stroke

(2013) D. J. Hines et al.   JOURNAL OF NEUROSCIENCE

Therapeutic applications of PARP inhibitors: Anticancer therapy and beyond

(2013) Nicola J. Curtin et al.   MOLECULAR ASPECTS OF MEDICINE

Tankyrase-targeted therapeutics: expanding opportunities in the PARP family

(2012) Jenna L. Riffell et al.   NATURE REVIEWS DRUG DISCOVERY

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

(2012) Bryan A. Gibson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GSK-3β inhibitors suppressed neuroinflammation in rat cortex by activating autophagy in ischemic brain injury

(2011) Xiaogang Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Distinct Role of Medium Spiny Neurons and Cholinergic Interneurons in the D2/A2A Receptor Interaction in the Striatum: Implications for Parkinson's Disease

(2011) A. Tozzi et al.   JOURNAL OF NEUROSCIENCE

LPA Receptors: Subtypes and Biological Actions

(2010) Ji Woong Choi et al.   Annual Review of Pharmacology and Toxicology

PARP-14 Functions as a Transcriptional Switch for Stat6-dependent Gene Activation

(2010) Purvi Mehrotra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke

(2010) Andrew N. Clarkson et al.   NATURE