Chaperone-mediated autophagy: machinery, regulation and biological consequences

Compensatory mechanisms and the type of injury determine the fate of cells with impaired macroautophagy

(2014) Rajat Singh et al.   Autophagy

Entering the lysosome through a transient gate by chaperone-mediated autophagy

(2014) Urmi Bandyopadhyay et al.   Autophagy

Early cellular changes after blockage of chaperone-mediated autophagy

(2014) Ashish C. Massey et al.   Autophagy

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets

(2011) Trond Lamark et al.   CELL CYCLE

Ubiquilin at a crossroads in protein degradation pathways

(2010) Cara Rothenberg et al.   Autophagy

Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation

(2010) Yipeng Wang et al.   Autophagy

Chaperone-assisted degradation: multiple paths to destruction

(2010) Nadja Kettern et al.   BIOLOGICAL CHEMISTRY

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

(2010) Verena Arndt et al.   CURRENT BIOLOGY

Eps8 is recruited to lysosomes and subjected to chaperone-mediated autophagy in cancer cells

(2010) Thilo Welsch et al.   EXPERIMENTAL CELL RESEARCH

Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy

(2010) C. Rothenberg et al.   HUMAN MOLECULAR GENETICS

Lysosomal Degradation of α-Synucleinin Vivo

(2010) Sally K. Mak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Identification of Regulators of Chaperone-Mediated Autophagy

(2010) Urmi Bandyopadhyay et al.   MOLECULAR CELL

Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein

(2010) Peter O Bauer et al.   NATURE BIOTECHNOLOGY

Selective autophagy: ubiquitin-mediated recognition and beyond

(2010) Claudine Kraft et al.   NATURE CELL BIOLOGY

Chaperone-mediated autophagy: Molecular mechanisms and physiological relevance

(2010) Samantha J. Orenstein et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

NBR1 co-operates with p62 in selective autophagy of ubiquitinated targets

(2009) Vladimir Kirkin et al.   Autophagy

Ubiquitin ligase complexes: from substrate selectivity to conjugational specificity

(2009) Vanja Nagy et al.   BIOLOGICAL CHEMISTRY

Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways

(2009) Heng Liu et al.   FASEB JOURNAL

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

Chaperone-mediated autophagy in health and disease

(2009) Maria Kon et al.   FEBS LETTERS

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

Quality Control Against Misfolded Proteins in the Cytosol: A Network for Cell Survival

(2009) H. Kubota   JOURNAL OF BIOCHEMISTRY

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

(2009) Leslie Michels Thompson et al.   JOURNAL OF CELL BIOLOGY

Chaperone-mediated autophagy is defective in mucolipidosis type IV

(2009) Bhuvarahamurthy Venugopal et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Neuronal Survival Factor MEF2D by Chaperone-Mediated Autophagy

(2009) Q. Yang et al.   SCIENCE

Parkinson's Disease: To Live or Die by Autophagy

(2009) I. Irrcher et al.   Science Signaling

Chaperone-mediated autophagy: selectivity pays off

(2009) Ana Maria Cuervo   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Proteasome subunits are regulated and expressed in comparable concentrations as a functional cluster

(2008) Youichi Sato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cathepsins: Key modulators of cell death and inflammatory responses

(2008) Sébastien Conus et al.   BIOCHEMICAL PHARMACOLOGY

Autophagy and the ubiquitin-proteasome system: Collaborators in neuroprotection

(2008) Natalia B. Nedelsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies

(2008) Marwan Maalouf et al.   BRAIN RESEARCH REVIEWS

Aberrant Interaction between Parkinson Disease-associated Mutant UCH-L1 and the Lysosomal Receptor for Chaperone-mediated Autophagy

(2008) Tomohiro Kabuta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

(2008) U. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Constitutive Activation of Chaperone-mediated Autophagy in Cells with Impaired Macroautophagy

(2008) Susmita Kaushik et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

(2008) Cong Zhang et al.   NATURE MEDICINE

Dietary factors, hormesis and health

(2007) Mark P. Mattson   AGEING RESEARCH REVIEWS

The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy

(2007) John et al.   Frontiers in Bioscience-Landmark