Regulation Where Autophagy Intersects the Inflammasome

A Key Role for Redox Signaling in Rapid P2X7 Receptor-Induced IL-1  Processing in Human Monocytes

(2014) J. Hewinson et al.   JOURNAL OF IMMUNOLOGY

The CARD plays a critical role in ASC foci formation and inflammasome signalling

(2012) Martina Proell et al.   BIOCHEMICAL JOURNAL

Ubiquitination and phosphorylation in the regulation of NOD2 signaling and NOD2-mediated disease

(2012) Justine T. Tigno-Aranjuez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization

(2012) Anwari Akhter et al.   IMMUNITY

The NLRP12 Inflammasome Recognizes Yersinia pestis

(2012) Gregory I. Vladimer et al.   IMMUNITY

An NLRP7-Containing Inflammasome Mediates Recognition of Microbial Lipopeptides in Human Macrophages

(2012) Sonal Khare et al.   IMMUNITY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy

(2012) Yu Lei et al.   IMMUNITY

Activation of the Nlrp1b Inflammasome by Reduction of Cytosolic ATP

(2012) Kuo-Chieh Liao et al.   INFECTION AND IMMUNITY

NLRX1 does not inhibit MAVS-dependent antiviral signalling

(2012) Fraser Soares et al.   Innate Immunity

Critical role of AIM2 in Mycobacterium tuberculosis infection

(2012) H. Saiga et al.   INTERNATIONAL IMMUNOLOGY

Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

(2012) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation and Structure of a NAIP5-NLRC4 Inflammasome Induced by Direct Interactions with Conserved N- and C-terminal Regions of Flagellin

(2012) Els F. Halff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome

(2012) Gloria Lopez-Castejon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Dual Role for Receptor-interacting Protein Kinase 2 (RIP2) Kinase Activity in Nucleotide-binding Oligomerization Domain 2 (NOD2)-dependent Autophagy

(2012) Craig R. Homer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll or Interleukin-1 Receptor (TIR) Domain-containing Adaptor Inducing Interferon-β (TRIF)-mediated Caspase-11 Protease Production Integrates Toll-like Receptor 4 (TLR4) Protein- and Nlrp3 Inflammasome-mediated Host Defense against Enteropathogens

(2012) Prajwal Gurung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Nitric Oxide Inhibits the NLRP3 Inflammasome

(2012) E. Hernandez-Cuellar et al.   JOURNAL OF IMMUNOLOGY

NLRP1-Dependent Pyroptosis Leads to Acute Lung Injury and Morbidity in Mice

(2012) M. Kovarova et al.   JOURNAL OF IMMUNOLOGY

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

(2012) Rune Busk Damgaard et al.   MOLECULAR CELL

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

(2012) Bénédicte F. Py et al.   MOLECULAR CELL

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

(2012) Petr Broz et al.   NATURE

Phosphorylation of NLRC4 is critical for inflammasome activation

(2012) Yan Qu et al.   NATURE

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Sensing and reacting to microbes through the inflammasomes

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Proteolytic Processing of Nlrp1b Is Required for Inflammasome Activity

(2012) Bradley C. Frew et al.   PLoS Pathogens

Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome

(2012) Jonathan L. Levinsohn et al.   PLoS Pathogens

NLRX1/NOD5 deficiency does not affect MAVS signalling

(2011) M Rebsamen et al.   CELL DEATH AND DIFFERENTIATION

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2

(2011) T. S. Plantinga et al.   GUT

NLRX1 Negatively Regulates TLR-Induced NF-κB Signaling by Targeting TRAF6 and IKK

(2011) Xiaojun Xia et al.   IMMUNITY

NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways

(2011) Irving C. Allen et al.   IMMUNITY

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VDAC, a multi-functional mitochondrial protein as a pharmacological target

(2011) Varda Shoshan-Barmatz et al.   MITOCHONDRION

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Caspase-1 Dependent IL-1β Secretion Is Critical for Host Defense in a Mouse Model of Chlamydia pneumoniae Lung Infection

(2011) Kenichi Shimada et al.   PLoS One

CARD8 and NLRP1 Undergo Autoproteolytic Processing through a ZU5-Like Domain

(2011) Andrea D'Osualdo et al.   PLoS One

Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity

(2011) J.-D. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Asc Modulates the Function of NLRC4 in Response to Infection of Macrophages by Legionella pneumophila

(2011) C. L. Case et al.   mBio

Human NLRP3 inflammasome activation is Nox1-4 independent

(2010) R. van Bruggen et al.   BLOOD

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing

(2010) Petr Broz et al.   Cell Host & Microbe

The complex interplay of NOD-like receptors and the autophagy machinery in the pathophysiology of Crohn disease

(2010) Susanne Billmann-Born et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

(2010) Sarah Kim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Reactive oxygen species-independent activation of the IL-1  inflammasome in cells from patients with chronic granulomatous disease

(2010) F. L. van de Veerdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

(2010) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

When autophagy meets viruses: a double-edged sword with functions in defense and offense

(2010) Hee Jin Kim et al.   Seminars in Immunopathology

Inflammasomes and autoimmunity

(2010) Patrick J. Shaw et al.   TRENDS IN MOLECULAR MEDICINE

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

(2009) Amy G. Hise et al.   Cell Host & Microbe

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

(2009) Eric M Cooper et al.   EMBO JOURNAL

Mechanisms of interleukin-1β release

(2009) Claudia Eder   IMMUNOBIOLOGY

Anthrax Lethal Toxin Triggers the Formation of a Membrane-Associated Inflammasome Complex in Murine Macrophages

(2009) A. M. Nour et al.   INFECTION AND IMMUNITY

Crystal Structure of Procaspase-1 Zymogen Domain Reveals Insight into Inflammatory Caspase Autoactivation

(2009) J. Michael Elliott et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specificity of the BRISC Deubiquitinating Enzyme Is Not Due to Selective Binding to Lys63-linked Polyubiquitin

(2009) Eric M. Cooper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

MyD88 and Trif Target Beclin 1 to Trigger Autophagy in Macrophages

(2008) Chong-Shan Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRX1 is a regulator of mitochondrial antiviral immunity

(2008) Chris B. Moore et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

NOX enzymes and Toll-like receptor signaling

(2008) Eric Ogier-Denis et al.   Seminars in Immunopathology