A combination of four active compounds alleviates cerebral ischemia-reperfusion injury in correlation with inhibition of autophagy and modulation of AMPK/mTOR and JNK pathways

The kinase triad, AMPK, mTORC1 and ULK1, maintains energy and nutrient homoeostasis

(2013) Elaine A. Dunlop et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Ruscogenin reduces cerebral ischemic injury via NF-κB-mediated inflammatory pathway in the mouse model of experimental stroke

(2013) Teng Guan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Involvement of the dual-specificity phosphatase M3/6 in c-Jun N-terminal kinase inactivation following cerebral ischemia in the rat hippocampus

(2013) ZheRen Huang et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Ischemic post-conditioning facilitates brain recovery after stroke by promoting Akt/mTOR activity in nude rats

(2013) Rong Xie et al.   JOURNAL OF NEUROCHEMISTRY

Function of the master energy regulator adenosine monophosphate-activated protein kinase in stroke

(2013) Bharti Manwani et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Hypoxic Preconditioning Attenuates Neuronal Cell Death by Preventing MEK/ERK Signaling Pathway Activation after Transient Global Cerebral Ischemia in Adult Rats

(2013) Lixuan Zhan et al.   MOLECULAR NEUROBIOLOGY

Chronological changes and effects of AMP-activated kinase in the hippocampal CA1 region after transient forebrain ischemia in gerbils

(2013) Han Ga Wi Nam et al.   NEUROLOGICAL RESEARCH

Expression analysis of genes involved in TLR2-related signaling pathway: Inflammation and apoptosis after ischemic brain injury

(2013) L. Winters et al.   NEUROSCIENCE

A Polypill for All? Critical Review of the Polypill Literature for Primary Prevention of Cardiovascular Disease and Stroke

(2012) Katherine M Carey et al.   ANNALS OF PHARMACOTHERAPY

Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia

(2012) Pei Wang et al.   Autophagy

Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage

(2012) Maria Teresa Viscomi et al.   Autophagy

Beclin1: A role in membrane dynamics and beyond

(2012) Ellen Wirawan et al.   Autophagy

Inhibition of NF-κB activation is associated with anti-inflammatory and anti-apoptotic effects of Ginkgolide B in a mouse model of cerebral ischemia/reperfusion injury

(2012) Jin-Hua Gu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Beta-asarone attenuates ischemia–reperfusion-induced autophagy in rat brains via modulating JNK, p-JNK, Bcl-2 and Beclin 1

(2012) Lin Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ginsenoside Rb1 Prevents MPP+-Induced Apoptosis in PC12 Cells by Stimulating Estrogen Receptors with Consequent Activation of ERK1/2, Akt and Inhibition of SAPK/JNK, p38 MAPK

(2012) Ryo Hashimoto et al.   Evidence-based Complementary and Alternative Medicine

Cerebralcare Granule® attenuates blood–brain barrier disruption after middle cerebral artery occlusion in rats

(2012) Ping Huang et al.   EXPERIMENTAL NEUROLOGY

Deficits in auditory, cognitive, and motor processing following reversible middle cerebral artery occlusion in mice

(2012) Dongnhu T. Truong et al.   EXPERIMENTAL NEUROLOGY

Treatment of rats with pioglitazone in the reperfusion phase of focal cerebral ischemia: A preclinical stroke trial

(2012) Juraj Culman et al.   EXPERIMENTAL NEUROLOGY

Diosgenin down-regulates NF-κB p65/p50 and p38MAPK pathways and attenuates acute lung injury induced by lipopolysaccharide in mice

(2012) Mengyu Gao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ginsenoside Rg1 inhibits autophagy in H9c2 cardiomyocytes exposed to hypoxia/reoxygenation

(2012) Zi-Long Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Schizandrin Protects Primary Rat Cortical Cell Cultures from Glutamate-Induced Apoptosis by Inhibiting Activation of the MAPK Family and the Mitochondria Dependent Pathway

(2012) Meng-Shiou Lee et al.   MOLECULES

Astragaloside IV protects against focal cerebral ischemia/reperfusion injury correlating to suppression of neutrophils adhesion-related molecules

(2012) Min Li et al.   NEUROCHEMISTRY INTERNATIONAL

NAD+ administration decreases ischemic brain damage partially by blocking autophagy in a mouse model of brain ischemia

(2012) Chaobo Zheng et al.   NEUROSCIENCE LETTERS

Propofol Prevents Autophagic Cell Death following Oxygen and Glucose Deprivation in PC12 Cells and Cerebral Ischemia-Reperfusion Injury in Rats

(2012) Derong Cui et al.   PLoS One

CXCR4 Antagonist AMD3100 Protects Blood–Brain Barrier Integrity and Reduces Inflammatory Response After Focal Ischemia in Mice

(2012) Jun Huang et al.   STROKE

Neuronal autophagy in cerebral ischemia

(2012) Feng Xu et al.   Neuroscience Bulletin

Death and survival of neuronal and astrocytic cells in ischemic brain injury: a role of autophagy

(2011) Min Xu et al.   ACTA PHARMACOLOGICA SINICA

AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation

(2011) Libin Shang et al.   Autophagy

Intranasal Ginsenoside Rb1 Targets the Brain and Ameliorates Cerebral Ischemia/Reperfusion Injury in Rats

(2011) Tingting Lu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Autophagy: for better or for worse

(2011) Ellen Wirawan et al.   CELL RESEARCH

Safety evaluation of steroidal saponin DT-13 isolated from the tuber of Liriope muscari (Decne.) Baily

(2011) Shengtang Ma et al.   FOOD AND CHEMICAL TOXICOLOGY

The new P2Y-like receptor G protein-coupled receptor 17 mediates acute neuronal injury and late microgliosis after focal cerebral ischemia in rats

(2011) B. Zhao et al.   NEUROSCIENCE

The Development of an Immunohistochemical Method to Detect the Autophagy-Associated Protein LC3-II in Human Tumor Xenografts

(2011) Sarah V. Holt et al.   TOXICOLOGIC PATHOLOGY

Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview

(2010) Maryam Mehrpour et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Pharmacokinetics, tissue distribution, metabolism, and excretion of ginsenoside Rg1 in rats

(2010) Liang Feng et al.   ARCHIVES OF PHARMACAL RESEARCH

Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia

(2010) Ai-Ping Qin et al.   Autophagy

In vivo imaging of autophagy in a mouse stroke model

(2010) FengFeng Tian et al.   Autophagy

Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning

(2010) Rui Sheng et al.   Autophagy

DJ-1, a cancer and Parkinson’s disease associated protein, regulates autophagy through JNK pathway in cancer cells

(2010) Haigang Ren et al.   CANCER LETTERS

Crosstalk between apoptosis and autophagy within the Beclin 1 interactome

(2010) Maria Chiara Maiuri et al.   EMBO JOURNAL

New Hierarchical Phosphorylation Pathway of the Translational Repressor eIF4E-binding Protein 1 (4E-BP1) in Ischemia-Reperfusion Stress

(2010) María I. Ayuso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotection in acute ischemic stroke - current status

(2010) E. Auriel et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Brain microvascular endothelial cells mediate neuroprotective effects on ischemia/reperfusion neurons

(2010) Qian Hua et al.   JOURNAL OF ETHNOPHARMACOLOGY

Autophagy: assays and artifacts

(2010) Sandra Barth et al.   JOURNAL OF PATHOLOGY

Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-κB activation

(2010) Qian Liu et al.   NEUROCHEMISTRY INTERNATIONAL

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Neuroprotective effect of ginsenoside Rb1 on glutamate-induced neurotoxicity: With emphasis on autophagy

(2010) Zhaoyao Chen et al.   NEUROSCIENCE LETTERS

What Is the Future of Stroke Prevention?: Debate: Polypill Versus Personalized Risk Factor Modification

(2010) W. N. Kernan et al.   STROKE

RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats

(2009) Yong-qiu Zheng et al.   ACTA PHARMACOLOGICA SINICA

Anti-hypoxic effect of ginsenoside Rbl on neonatal rat cardiomyocytes is mediated through the specific activation of glucose transporter-4 ex vivo

(2009) Hong-liang Kong et al.   ACTA PHARMACOLOGICA SINICA

Postischemic treatment of neonatal cerebral ischemia should target autophagy

(2009) Julien Puyal et al.   ANNALS OF NEUROLOGY

Autophagy in hypoxia-ischemia induced brain injury: Evidences and speculations

(2009) Walter Balduini et al.   Autophagy

Adenovirus-mediated brain-derived neurotrophic factor expression regulated by hypoxia response element protects brain from injury of transient middle cerebral artery occlusion in mice

(2009) Qindong Shi et al.   NEUROSCIENCE LETTERS

Limited role of the c-Jun N-terminal kinase pathway in a neonatal rat model of cerebral hypoxia-ischemia

(2008) Vanessa Ginet et al.   JOURNAL OF NEUROCHEMISTRY

Possible Mechanism of the Anti-inflammatory Activity of Ruscogenin: Role of Intercellular Adhesion Molecule-1 and Nuclear Factor-κB

(2008) Ya-Lin Huang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Schizandrin Protects Primary Cultures of Rat Cortical Cells From Glutamate-Induced Excitotoxicity

(2008) Hao-Yuan Cheng et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Neuroprotection for ischemic stroke: Past, present and future

(2008) Myron D. Ginsberg   NEUROPHARMACOLOGY

Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death

(2007) A. Rami et al.   NEUROBIOLOGY OF DISEASE