Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

LncRNAs and miRNAs participate in determination of response of cancer cells to cisplatin

(2021) Mohammad Taheri et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Xanthatin synergizes with cisplatin to suppress homologous recombination through JAK2/STAT4/BARD1 axis in human NSCLC cells

(2021) Jian Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dual relationship between long non-coding RNAs and STAT3 signaling in different cancers: New insight to proliferation and metastasis

(2021) Milad Ashrafizadeh et al.   LIFE SCIENCES

Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota

(2021) Umair Shabbir et al.   Nutrients

Curcumin Nanoparticle Enhances the Anticancer Effect of Cisplatin by Inhibiting PI3K/AKT and JAK/STAT3 Pathway in Rat Ovarian Carcinoma Induced by DMBA

(2021) Ni Made Dwi Sandhiutami et al.   Frontiers in Pharmacology

The Effect of Curcumin Nanoparticles on Cisplatin-Induced Cardiotoxicity in Male Wistar Albino Rats

(2021) Yasser A. Khadrawy et al.   Cardiovascular Toxicology

Curcumin suppresses tumor growth of gemcitabine-resistant non-small cell lung cancer by regulating lncRNA-MEG3 and PTEN signaling

(2021) L. Gao et al.   Clinical & Translational Oncology

Curcumin Efficacy in a Serum/glucose Deprivation-induced Neuronal PC12 Injury Model

(2021) Tahereh Farkhondeh et al.   Current Molecular Pharmacology

Curcumin and cardiovascular diseases: Focus on cellular targets and cascades

(2021) Ali Mohammad Pourbagher-Shahri et al.   BIOMEDICINE & PHARMACOTHERAPY

Effects of cisplatin and acacetin on total antioxidant status, apoptosis and expression of OCTN3 in mouse testis

(2021) Ali Ghanbari et al.   BIOTECHNIC & HISTOCHEMISTRY

Biomedical application of chitosan-based nanoscale delivery systems: Potential usefulness in siRNA delivery for cancer therapy

(2021) Milad Ashrafizadeh et al.   CARBOHYDRATE POLYMERS

RNA Expression of DNA Damage Response Genes in Muscle-Invasive Bladder Cancer: Influence on Outcome and Response to Adjuvant Cisplatin-Based Chemotherapy

(2021) Jonas Herrmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies

(2021) Sepideh Mirzaei et al.   MOLECULES

The salutary action of melatonin and betaine, given singly or concomitantly, on cisplatin-induced nephrotoxicity in mice

(2021) Mohammed Al Za’abi et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Triggered Drug Release From Liposomes: Exploiting the Outer and Inner Tumor Environment

(2021) Marina Santiago Franco et al.   Frontiers in Oncology

Melatonin protects rats testes against bleomycin, etoposide, and cisplatin-induced toxicity via mitigating nitro-oxidative stress and apoptosis

(2021) Mojtaba Moradi et al.   BIOMEDICINE & PHARMACOTHERAPY

Long non-coding RNAs in the doxorubicin resistance of cancer cells

(2021) Saeed Ashrafizaveh et al.   CANCER LETTERS

Small interfering RNA (siRNA) to target genes and molecular pathways in glioblastoma therapy: Current status with an emphasis on delivery systems

(2021) Sepideh Mirzaei et al.   LIFE SCIENCES

Employing siRNA tool and its delivery platforms in suppressing cisplatin resistance: Approaching to a new era of cancer chemotherapy

(2021) Sepideh Mirzaei et al.   LIFE SCIENCES

A Systematic Review Assessing Clinical Utility of Curcumin with a Focus on Cancer Prevention

(2021) Lynne Howells et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Curcumin–cisplatin chemotherapy: A novel strategy in promoting chemotherapy efficacy and reducing side effects

(2021) Yaseen Hussain et al.   PHYTOTHERAPY RESEARCH

Therapeutic Effects of Curcumin against Bladder Cancer: A Review of Possible Molecular Pathways

(2020) Milad Ashrafizadeh et al.   Anti-Cancer Agents in Medicinal Chemistry

MicroRNA‐31 weakens cisplatin resistance of medulloblastoma cells via NF‐κB and PI3K/AKT pathways

(2020) Hui Ma et al.   BIOFACTORS

Curcumin therapeutic modulation of the Wnt signaling pathway

(2020) Amirhossein Sahebkar et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Curcumin-Mediated Apoptotic Cell Death in Papillary Thyroid Cancer and Cancer Stem-Like Cells through Targeting of the JAK/STAT3 Signaling Pathway

(2020) Abdul Q. Khan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Thymoquinone and curcumin combination protects cisplatin-induced kidney injury, nephrotoxicity by attenuating NFκB, KIM-1 and ameliorating Nrf2/HO-1 signalling

(2020) Majed Al Fayi et al.   JOURNAL OF DRUG TARGETING

Curcumin diminishes cisplatin-induced apoptosis and mitochondrial oxidative stress through inhibition of TRPM2 channel signaling pathway in mouse optic nerve

(2020) Dilek Özkaya et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

New Paradigms to Assess Consequences of Long-Term, Low-Dose Curcumin Exposure in Lung Cancer Cells

(2020) Gintare Smagurauskaite et al.   MOLECULES

Pantoprazole abrogated cisplatin-induced nephrotoxicity in mice via suppression of inflammation, apoptosis, and oxidative stress

(2020) Raed S. Ismail et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Curcumin suppresses the proliferation and tumorigenicity of Cal27 by modulating cancer associated fibroblasts of TSCC

(2020) Pengfei Ba et al.   ORAL DISEASES

Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: A randomized controlled trial

(2020) Masoud Nouri‐Vaskeh et al.   PHYTOTHERAPY RESEARCH

The dual role of curcumin and ferulic acid in counteracting chemoresistance and cisplatin-induced ototoxicity

(2020) Fabiola Paciello et al.   Scientific Reports

Comparative nephroprotective effects of curcumin and etoricoxib against cisplatin-induced acute kidney injury in rats

(2020) Marwa Abd El-Kader et al.   ACTA HISTOCHEMICA

Apatinib suppresses tumor progression and enhances cisplatin sensitivity in esophageal cancer via the Akt/β-catenin pathway

(2020) Bin Wei et al.   Cancer Cell International

Co-Delivery of Curcumin and Cisplatin to Enhance Cytotoxicity of Cisplatin Using Lipid-Chitosan Hybrid Nanoparticles

(2020) Muhammad Muzamil Khan et al.   International Journal of Nanomedicine

Mitochondria participate in chemoresistance to cisplatin in human ovarian cancer cells

(2020) Luca X Zampieri et al.   MOLECULAR CANCER RESEARCH

Highly Bioavailable Forms of Curcumin and Promising Avenues for Curcumin-Based Research and Application: A Review

(2020) Sidney J. Stohs et al.   MOLECULES

Curcumin nanoparticles ameliorate hepatotoxicity and nephrotoxicity induced by cisplatin in rats

(2020) Mayada M. El-Gizawy et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Curcumin: an inflammasome silencer

(2020) Shima Hassanzadeh et al.   PHARMACOLOGICAL RESEARCH

Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives

(2020) Srimanta Patra et al.   SEMINARS IN CANCER BIOLOGY

Dexmedetomidine attenuates cisplatin-induced cognitive impairment by modulating miR-429-3p expression in rats

(2020) Chang Li et al.   3 Biotech

Possible Protective Effects of Curcumin via Modulating of Androgen Receptor (AR) and Oct2 Gene Alterations in Cisplatin‐Induced Testicular Toxicity in Rat

(2020) Amin Abdollahzade Fard et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

DhHP-6 ameliorates hepatic oxidative stress and insulin resistance in type 2 diabetes mellitus through the PI3K/AKT and AMPK pathway

(2020) Kai Wang et al.   BIOCHEMICAL JOURNAL

MiR-34c downregulation leads to SOX4 overexpression and cisplatin resistance in nasopharyngeal carcinoma

(2020) Pierre-Antoine Bissey et al.   BMC CANCER

A novel effect of Aprepitant: Protection for cisplatin-induced nephrotoxicity and hepatotoxicity

(2020) Harun Un et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oral co-delivery nanoemulsion of 5-fluorouracil and curcumin for synergistic effects against liver cancer

(2020) Pu Guo et al.   Expert Opinion on Drug Delivery

Crocin attenuates cisplatin-induced hepatotoxicity via TLR4/NF-κBp50 signaling and BAMBI modulation of TGF-β activity: Involvement of miRNA-9 and miRNA-29

(2020) L.H. Khedr et al.   FOOD AND CHEMICAL TOXICOLOGY

ASB16-AS1 up-regulated and phosphorylated TRIM37 to activate NF-κB pathway and promote proliferation, stemness, and cisplatin resistance of gastric cancer

(2020) Tao Fu et al.   Gastric Cancer

Sophoridine inhibits lung cancer cell growth and enhances cisplatin sensitivity through activation of the p53 and Hippo signaling pathways

(2020) Lingling Zhu et al.   GENE

Novel lncRNA XLOC_032768 alleviates cisplatin-induced apoptosis and inflammatory response of renal tubular epithelial cells through TNF-α

(2020) Xiangjun Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gliclazide attenuates cisplatin‐induced nephrotoxicity through inhibiting NF‐κB and caspase‐3 activity

(2020) Fatemeh Taghizadeh et al.   IUBMB LIFE

LncRNA KCNQ1OT1 is a key factor in the reversal effect of curcumin on cisplatin resistance in the colorectal cancer cells

(2020) Zhi-hai Zheng et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Tocilizumab potentiates cisplatin cytotoxicity and targets cancer stem cells in triple‐negative breast cancer

(2020) Noura N. Alraouji et al.   MOLECULAR CARCINOGENESIS

A Co-Delivery System of Curcumin and p53 for Enhancing the Sensitivity of Drug-Resistant Ovarian Cancer Cells to Cisplatin

(2020) Xinli Guo et al.   MOLECULES

Combination of Curcumin and Metformin Inhibits Cell Growth and Induces Apoptosis without Affecting the Cell Cycle in LNCaP Prostate Cancer Cell Line

(2020) Seyed Sadegh Eslami et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

The Role of the Curcumin for Inducing Apoptosis in Acute Lymphoblastic Leukemia Cells: A Systematic Review

(2020) Hossein Khadem Haghighian et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Apigenin Enhanced Antitumor Effect of Cisplatin in Lung Cancer via Inhibition of Cancer Stem Cells

(2020) Yunxia Li et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Curcumin downregulates the PI3K–AKT–mTOR pathway and inhibits growth and progression in head and neck cancer cells

(2020) Gabriel Alvares Borges et al.   PHYTOTHERAPY RESEARCH

MK2206 Enhances Cisplatin-Induced Cytotoxicity and Apoptosis in Testicular Cancer Through Akt Signaling Pathway Inhibition

(2020) Dingqi Sun et al.   Translational Oncology

Combination Therapy of Lung Cancer Using Layer-by-Layer Cisplatin Prodrug and Curcumin Co-Encapsulated Nanomedicine

(2020) Yuan Hong et al.   Drug Design Development and Therapy

Curcumin Derivative C086 Combined with Cisplatin Inhibits Proliferation of Osteosarcoma Cells

(2020) Xi Jiang et al.   MEDICAL SCIENCE MONITOR

Curcumin and blood lipid levels: an updated systematic review and meta-analysis of randomised clinical trials

(2020) Farhad Saeedi et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Current Strategies to Combat Cisplatin-Induced Ototoxicity

(2020) Dehong Yu et al.   Frontiers in Pharmacology

Methyl-Cantharidimide (MCA) Has Anticancer Efficacy in ABCB1- and ABCG2-Overexpressing and Cisplatin Resistant Cancer Cells

(2020) Yi-Dong Li et al.   Frontiers in Oncology

STAT3 Pathway in Gastric Cancer: Signaling, Therapeutic Targeting and Future Prospects

(2020) Milad Ashrafizadeh et al.   Biology-Basel

The ameliorative effects of methylene blue on testicular damage induced by cisplatin in rats

(2020) Fatemeh Gholami Jourabi et al.   ANDROLOGIA

Clinical effects of curcumin in enhancing cancer therapy: A systematic review

(2020) Kamran Mansouri et al.   BMC CANCER

Protective effects of nucleosides‐rich extract from Cordyceps cicadae against cisplatin induced testicular damage

(2020) Ling Wang et al.   CHEMISTRY & BIODIVERSITY

Curcumin Regulates ERCC1 Expression and Enhances Oxaliplatin Sensitivity in Resistant Colorectal Cancer Cells through Its Effects on miR-409-3p

(2020) Wei Han et al.   Evidence-based Complementary and Alternative Medicine

Epigallocatechin‑3‑gallate inhibits self‑renewal ability of lung cancer stem‑like cells through inhibition of CLOCK

(2020) Pan Jiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Obstacles against the Marketing of Curcumin as a Drug

(2020) Kambiz Hassanzadeh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Polysulfide and Hydrogen Sulfide Ameliorate Cisplatin-Induced Nephrotoxicity and Renal Inflammation through Persulfidating STAT3 and IKKβ

(2020) Hai-Jian Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PPAR-α Deletion Attenuates Cisplatin Nephrotoxicity by Modulating Renal Organic Transporters MATE-1 and OCT-2

(2020) Leandro Ceotto Freitas-Lima et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Peptide-functionalized liposomes as therapeutic and diagnostic tools for cancer treatment

(2020) Jafrin Jobayer Sonju et al.   JOURNAL OF CONTROLLED RELEASE

Antioxidant effect of acetyl-l-carnitine against cisplatin-induced cardiotoxicity

(2020) Serdar Bayrak et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Curcumin Alleviates the Side Effects of Cisplatin on Gastric Emptying of Mice by Inhibiting the Signal Changes of Acetylcholine and Interstitial Cells of Cajal

(2020) Hui Li et al.   JOURNAL OF MEDICINAL FOOD

Curcumin in cancer therapy: A novel adjunct for combination chemotherapy with paclitaxel and alleviation of its adverse effects

(2020) Milad Ashrafizadeh et al.   LIFE SCIENCES

Epigallocatechin-3-gallate mobilizes intracellular Ca2+ in prostate cancer cells through combined Ca2+ entry and Ca2+-induced Ca2+ release

(2020) Carla Marchetti et al.   LIFE SCIENCES

The role of curcumin/curcuminoids during gastric cancer chemotherapy: A systematic review of non-clinical study

(2020) Masoud Najafi et al.   LIFE SCIENCES

Apoptosis, autophagy and atherosclerosis: relationships and the role of Hsp27

(2020) Ruiting Shan et al.   PHARMACOLOGICAL RESEARCH

Sensing the scent of death: Modulation of microRNAs by Curcumin in gastrointestinal cancers

(2020) Milad Ashrafizadeh et al.   PHARMACOLOGICAL RESEARCH

Melatonin Provides Protection Against Cisplatin-Induced Ovarian Damage and Loss of Fertility in Mice

(2020) Wanying Shan et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Nrf2 activation protects auditory hair cells from cisplatin-induced ototoxicity independent on mitochondrial ROS production

(2020) Weijian Zhang et al.   TOXICOLOGY LETTERS

ATF4-mediated autophagy-dependent glycolysis plays an important role in attenuating apoptosis induced by Cr (VI) in A549 cells

(2020) Zeyun Gao et al.   TOXICOLOGY LETTERS

PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers

(2020) Rui Liu et al.   Cell Death & Disease

Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy

(2020) Milad Ashrafizadeh et al.   ACS Combinatorial Science

Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin

(2020) Beatrice Scazzocchio et al.   Nutrients

The Effect of Resveratrol or Curcumin on Head and Neck Cancer Cells Sensitivity to the Cytotoxic Effects of Cisplatin

(2020) Marinela Bostan et al.   Nutrients

ALKBH5 inhibited cell proliferation and sensitized bladder cancer cells to cisplatin by m6A-CK2α mediated glycolysis

(2020) Hao Yu et al.   Molecular Therapy-Nucleic Acids

Synergistic anti-liver cancer effects of curcumin and total ginsenosides

(2020) Zhe Deng et al.   World Journal of Gastrointestinal Oncology

Pre-clinical investigation of STAT3 pathway in bladder cancer: Paving the way for clinical translation

(2020) Sepideh Mirzaei et al.   BIOMEDICINE & PHARMACOTHERAPY

Curcumin and Its Derivatives as Theranostic Agents in Alzheimer’s Disease: The Implication of Nanotechnology

(2020) Umair Shabbir et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resveratrol and artemisinin eudragit-coated liposomes: A strategy to tackle intestinal tumors

(2020) Carla Caddeo et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

ATF4 ‐modified serum exosomes derived from osteoarthritic mice inhibit osteoarthritis by inducing autophagy

(2020) Yan Wang et al.   IUBMB LIFE

Intercalation of curcumin into liposomal chemotherapeutic agent augments apoptosis in breast cancer cells

(2020) Reza Mahmoudi et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Naringin attenuates cisplatin‐ and aminoglycoside‐induced hair cell injury in the zebrafish lateral line via multiple pathways

(2020) Ming Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Neuroprotective Effect of Mesna on Cisplatin-Induced Neurotoxicity: Behavioral, Electrophysiological, and Molecular Studies

(2020) Hakimeh Saadati et al.   NEUROTOXICITY RESEARCH

Synthesis Characterization of Platinum (IV) Complex Curcumin Backboned Polyprodrugs: In Vitro Drug Release Anticancer Activity

(2020) Honglei Zhang et al.   Polymers

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

(2020) Milad Ashrafizadeh et al.   Frontiers in Pharmacology

BCL2L10 Is Overexpressed in Melanoma Downstream of STAT3 and Promotes Cisplatin and ABT-737 Resistance

(2020) María Josefina Quezada et al.   Cancers

Lung cancer cells and their sensitivity/resistance to cisplatin chemotherapy: Role of microRNAs and upstream mediators

(2020) Milad Ashrafizadeh et al.   CELLULAR SIGNALLING

Enhanced anti-cancer activity by localized delivery of curcumin form PVA/CNCs hydrogel membranes: Preparation and in vitro bioevaluation

(2020) Yasmein Hussein et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Curcumin and inflammatory bowel diseases: From in vitro studies to clinical trials

(2020) Farzaneh Fallahi et al.   MOLECULAR IMMUNOLOGY

Targeted Codelivery of an Antigen and Dual Agonists by Hybrid Nanoparticles for Enhanced Cancer Immunotherapy

(2019) Linhua Zhang et al.   NANO LETTERS

Lycopene, sulforaphane, quercetin, and curcumin applied together show improved antiproliferative potential in colon cancer cells in vitro

(2019) Ewa Langner et al.   JOURNAL OF FOOD BIOCHEMISTRY

New insights into designing hybrid nanoparticles for lung cancer: Diagnosis and treatment

(2019) Fatemeh Mottaghitalab et al.   JOURNAL OF CONTROLLED RELEASE

Delineation of proapoptotic signaling of anthracene-shelled M2L4 metallacapsules and their synergistic activity with curcumin in cisplatin-sensitive and resistant tumor cell lines

(2019) Rositsa Mihaylova et al.   INVESTIGATIONAL NEW DRUGS

Metformin attenuates cisplatin-induced genotoxicity and apoptosis in rat bone marrow cells

(2019) Mohsen Cheki et al.   DRUG AND CHEMICAL TOXICOLOGY

Cisplatin: The first metal based anticancer drug

(2019) Sumit Ghosh   BIOORGANIC CHEMISTRY

Recent Advances in Models, Mechanisms, Biomarkers, and Interventions in Cisplatin-Induced Acute Kidney Injury

(2019) Sara J. Holditch et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evaluating the Anti-cancer Efficacy of a Synthetic Curcumin Analog on Human Melanoma Cells and Its Interaction with Standard Chemotherapeutics

(2019) Krishan Parashar et al.   MOLECULES

Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia

(2019) Shilpa Kuttikrishnan et al.   Frontiers in Oncology

Investigation of Astaxanthin Effect on Cisplatin Ototoxicity in Rats by Using Otoacoustic Emission, Total Antioxidant Capacity, and Histopathological Methods

(2019) M. Emrah Kınal et al.   ENT-EAR NOSE & THROAT JOURNAL

Curcumin C3 complex®/Bioperine® has antineoplastic activity in mesothelioma: an in vitro and in vivo analysis

(2019) Francesco Di Meo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Robust Microfluidic Technology and New Lipid Composition for Fabrication of Curcumin-Loaded Liposomes: Effect on the Anticancer Activity and Safety of Cisplatin

(2019) Nobuhito Hamano et al.   MOLECULAR PHARMACEUTICS

Curcumin activates the Nrf2 pathway and induces cellular protection against oxidative injury

(2019) Milad Ashrafizadeh et al.   CURRENT MOLECULAR MEDICINE

Arsenic trioxide and curcumin attenuate cisplatin-induced renal fibrosis in rats through targeting Hedgehog signaling

(2019) Abdalkareem Omar Maghmomeh et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Curcumin, Gut Microbiota, and Neuroprotection

(2019) Di Meo et al.   Nutrients

Curcumin enhances cisplatin-induced human laryngeal squamous cancer cell death through activation of TRPM2 channel and mitochondrial oxidative stress

(2019) Sinem Gökçe Kütük et al.   Scientific Reports

Evaluation of the protective effects of amifostine and melatonin against cisplatin induced testis injury via oxidative stress and apoptosis in rats

(2019) Huseyin Eren et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Doxorubicin and cisplatin induced cognitive impairment: The possible mechanisms and interventions

(2019) Benjamin Ongnok et al.   EXPERIMENTAL NEUROLOGY

Curcumin attenuates cognitive impairment by enhancing autophagy in chemotherapy

(2019) Li-Tao Yi et al.   NEUROBIOLOGY OF DISEASE

Curcumin sensitizes lymphoma cells to DNA damage agents through regulating Rad51-dependent homologous recombination

(2018) Qian Zhao et al.   BIOMEDICINE & PHARMACOTHERAPY

Cisplatin and curcumin co-loaded nano-liposomes for the treatment of hepatocellular carcinoma

(2018) Yao Cheng et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Metal chelating ability and antioxidant properties of Curcumin-metal complexes – A DFT approach

(2018) C. Pitchumani Violet Mary et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Protective effects of amifostine, curcumin, and melatonin against cisplatin-induced acute kidney injury

(2018) Filiz Mercantepe et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Curcumin ameliorates cisplatin-induced cystopathy via activating NRF2 pathway

(2018) Yun Peng Shao et al.   NEUROUROLOGY AND URODYNAMICS

Phytosome complex of curcumin as complementary therapy of advanced pancreatic cancer improves safety and efficacy of gemcitabine: Results of a prospective phase II trial

(2018) Davide Pastorelli et al.   PHARMACOLOGICAL RESEARCH

The clinical efficacy of curcumin-containing nutraceuticals: An overview of systematic reviews

(2018) Ester Pagano et al.   PHARMACOLOGICAL RESEARCH

Curcumin enhances cisplatin sensitivity of human NSCLC cell lines through influencing Cu-Sp1-CTR1 regulatory loop

(2018) Wei Zhang et al.   PHYTOMEDICINE

Effects of curcumin consumption on human chronic diseases: A narrative review of the most recent clinical data

(2018) Maria Mantzorou et al.   PHYTOTHERAPY RESEARCH

Curcumin increases breast cancer cell sensitivity to cisplatin by decreasing FEN1 expression

(2018) Jiao Zou et al.   Oncotarget

Neuropathic Pain: Delving into the Oxidative Origin and the Possible Implication of Transient Receptor Potential Channels

(2018) Cristina Carrasco et al.   Frontiers in Physiology

A phase 1 dose-escalation study on the safety, tolerability and activity of liposomal curcumin (Lipocurc™) in patients with locally advanced or metastatic cancer

(2018) Richard Greil et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Effect of curcumin nanoparticles on the cisplatin-induced neurotoxicity in rat

(2018) Yasser A. Khadrawy et al.   DRUG AND CHEMICAL TOXICOLOGY

Curcumin relieved cisplatin-induced kidney inflammation through inhibiting Mincle-maintained M1 macrophage phenotype

(2018) Rui-zhi Tan et al.   PHYTOMEDICINE

Modulatory effect of curcumin against genotoxicity and oxidative stress induced by cisplatin and methotrexate in male mice

(2017) Noha Ibrahim Said Salem et al.   FOOD AND CHEMICAL TOXICOLOGY

Curcumin prevents cisplatin-induced renal alterations in mitochondrial bioenergetics and dynamic

(2017) Bibiana Ortega-Domínguez et al.   FOOD AND CHEMICAL TOXICOLOGY

Curcumin Alleviates the Functional Gastrointestinal Disorders of Mice In Vivo

(2017) Jing Yu et al.   JOURNAL OF MEDICINAL FOOD

TNF-α, IL-6 and IL-10 expressions, responsible for disparity in action of curcumin against cisplatin-induced nephrotoxicity in rats

(2017) Parveen Kumar et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mitochondrial Quality Control and Disease: Insights into Ischemia-Reperfusion Injury

(2017) Anthony R. Anzell et al.   MOLECULAR NEUROBIOLOGY

Curcumin: A potentially powerful tool to reverse cisplatin-induced toxicity

(2017) Ramin Rezaee et al.   PHARMACOLOGICAL RESEARCH

Synergistic anticancer effect of curcumin and chemotherapy regimen FP in human gastric cancer MGC-803 cells

(2017) Bin He et al.   Oncology Letters

Irinotecan and 5-fluorouracil-co-loaded, hyaluronic acid-modified layer-by-layer nanoparticles for targeted gastric carcinoma therapy

(2017) Zhuanglei Gao et al.   Drug Design Development and Therapy

Curcumin Ameliorates Cisplatin-Induced Nephrotoxicity and Potentiates Its Anticancer Activity in SD Rats: Potential Role of Curcumin in Breast Cancer Chemotherapy

(2017) Parveen Kumar et al.   Frontiers in Pharmacology

Thermo-Sensitive TRP Channels: Novel Targets for Treating Chemotherapy-Induced Peripheral Pain

(2017) Mustafa Nazıroğlu et al.   Frontiers in Physiology

Sensitizing nanoparticle based platinum(IV) drugs by curcumin for better chemotherapy

(2016) Xiang Kang et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Intraperitoneal curcumin and vitamin E combination for the treatment of cisplatin-induced ototoxicity in rats

(2016) Harun Soyalıç et al.   INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY

Hedgehog Gli signalling in kidney fibrosis

(2016) Rafael Kramann   NEPHROLOGY DIALYSIS TRANSPLANTATION

Curcumin counteracts cisplatin-induced nephrotoxicity by preventing renal tubular cell apoptosis

(2016) Yeter Topcu-Tarladacalisir et al.   RENAL FAILURE

Proteome-Wide Profiling of Targets of Cysteine reactive Small Molecules by Using Ethynyl Benziodoxolone Reagents

(2015) Daniel Abegg et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

YY1 suppresses FEN1 over-expression and drug resistance in breast cancer

(2015) Jianwei Wang et al.   BMC CANCER

Molecular targets for anticancer redox chemotherapy and cisplatin-induced ototoxicity: the role of curcumin on pSTAT3 and Nrf-2 signalling

(2015) A R Fetoni et al.   BRITISH JOURNAL OF CANCER

Comparative study of curcumin and curcumin formulated in a solid dispersion: Evaluation of their antigenotoxic effects

(2015) Leonardo Meneghin Mendonça et al.   GENETICS AND MOLECULAR BIOLOGY

Sirtuin 3–dependent mitochondrial dynamic improvements protect against acute kidney injury

(2015) Marina Morigi et al.   JOURNAL OF CLINICAL INVESTIGATION

Curcumin alleviates cisplatin-induced learning and memory impairments

(2015) Mehmet Oz et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines

(2015) PUTERI BAHARUDDIN et al.   ONCOLOGY REPORTS

The renoprotective effect of curcumin in cisplatin-induced nephrotoxicity

(2015) Sıddık Ugur et al.   RENAL FAILURE

Cancer Stem Cell Division: When the Rules of Asymmetry Are Broken

(2015) Subhas Mukherjee et al.   STEM CELLS AND DEVELOPMENT

Effects of curcumin in pediatric epithelial liver tumors: inhibition of tumor growth and alpha-fetoprotein in vitro and in vivo involving the NFkappaB- and the beta-catenin pathways

(2015) Nicola Bortel et al.   Oncotarget

Liposome encapsulated curcumin-difluorinated (CDF) inhibits the growth of cisplatin resistant head and neck cancer stem cells

(2015) Saroj K. Basak et al.   Oncotarget

Curcumin Ameliorates Functional and Structural Abnormalities in Cisplatin-induced Neuropathy

(2015) Sithiporn Agthong et al.   Experimental Neurobiology

Reversal of Resistance towards Cisplatin by Curcumin in Cervical Cancer Cells

(2014) Madhumita Roy et al.   Asian Pacific Journal of Cancer Prevention

Comparative In Vivo Evaluations of Curcumin and Its Analog Difluorinated Curcumin Against Cisplatin-Induced Nephrotoxicity

(2014) Kazim Sahin et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Hepatoprotective effect of curcumin and alpha-tocopherol against cisplatin-induced oxidative stress

(2014) Sarawoot Palipoch et al.   BMC Complementary and Alternative Medicine

Curcumin-enhanced chemosensitivity of FDA-approved platinum (II)-based anti-cancer drugs involves downregulation of nuclear endonuclease G and NF-κB as well as induction of apoptosis and G2/M arrest

(2014) Ying-Ti Wang et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Mechanisms of cell uptake and toxicity of the anticancer drug cisplatin

(2014) Nasma D. Eljack et al.   Metallomics

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

Attenuation of Cisplatin Ototoxicity by Otoprotective Effects of Nanoencapsulated Curcumin and Dexamethasone in a Guinea Pig Model

(2014) Pezhman Salehi et al.   OTOLOGY & NEUROTOLOGY

Curcuma Longa (Curcumin) Decreases In Vivo Cisplatin-Induced Ototoxicity Through Heme Oxygenase-1 Induction

(2014) Anna R. Fetoni et al.   OTOLOGY & NEUROTOLOGY

A Novel Curcumin Analog (H-4073) Enhances the Therapeutic Efficacy of Cisplatin Treatment in Head and Neck Cancer

(2014) Bhavna Kumar et al.   PLoS One

Curcumin Promotes Apoptosis, Increases Chemosensitivity, and Inhibits Nuclear Factor κB in Esophageal Adenocarcinoma

(2014) Wibisono Hartojo et al.   Translational Oncology

Curcumin reverses cisplatin resistance in cisplatin-resistant lung caner cells by inhibiting FA/BRCA pathway

(2014) Ping Chen et al.   TUMOR BIOLOGY

The Protective Effect of Curcumin on Hepatotoxicity and Ultrastructural Damage Induced by Cisplatin

(2014) Ying Wang et al.   ULTRASTRUCTURAL PATHOLOGY

Flap Endonuclease 1

(2013) Lata Balakrishnan et al.   Annual Review of Biochemistry

Layer-by-layer coated lipid–polymer hybrid nanoparticles designed for use in anticancer drug delivery

(2013) Thiruganesh Ramasamy et al.   CARBOHYDRATE POLYMERS

Curcumin-loaded nanoparticles enhance apoptotic cell death of U2OS human osteosarcoma cells through the Akt-Bad signaling pathway

(2013) SHU-FEN PENG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology

(2013) Ming Zhan et al.   KIDNEY INTERNATIONAL

SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress

(2013) Sadhana A. Samant et al.   MOLECULAR AND CELLULAR BIOLOGY

Acute effects of diesel exhaust particles and cisplatin on oxidative stress in cultured human kidney (HEK 293) cells, and the influence of curcumin thereon

(2013) Mostafa I. Waly et al.   TOXICOLOGY IN VITRO

The importance of interstitial cells of cajal in the gastrointestinal tract

(2013) OthmanA Al-Shboul   Saudi Journal of Gastroenterology

Role of the Human High-Affinity Copper Transporter in Copper Homeostasis Regulation and Cisplatin Sensitivity in Cancer Chemotherapy

(2012) M. T. Kuo et al.   CANCER RESEARCH

Curcumin ameliorates cisplatin-induced nephrotoxicity by inhibiting renal inflammation in mice

(2012) Masaaki Ueki et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Curcumin reduces cisplatin-induced neurotoxicity in NGF-differentiated PC12 cells

(2012) Leonardo Meneghin Mendonça et al.   NEUROTOXICOLOGY

Cancer cachexia: impact, mechanisms and emerging treatments

(2012) Vanessa C. Vaughan et al.   Journal of Cachexia Sarcopenia and Muscle

Sensitization of Head and Neck Cancer to Cisplatin Through the Use of a Novel Curcumin Analog

(2011) Waleed M. Abuzeid et al.   ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY

HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition

(2011) Karuppaiyah Selvendiran et al.   CANCER BIOLOGY & THERAPY

BMI1 as a novel target for drug discovery in cancer

(2011) Liangxian Cao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Use of a Short Peptide as a Building Block in the Layer-by-Layer Assembly of Biomolecules on Polymeric Surfaces

(2011) Dewi P. Go et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Synergistic Effect of Curcumin and Cisplatin via Down-Regulation of Thymidine Phosphorylase and Excision Repair Cross-Complementary 1 (ERCC1)

(2011) M.-S. Tsai et al.   MOLECULAR PHARMACOLOGY

Effect of Curcumin on Cisplatin- and Oxaliplatin-Induced Oxidative Stress in Human Embryonic Kidney (HEK) 293 Cells

(2011) Mostafa I. Waly et al.   RENAL FAILURE

Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects

(2011) Ana-Maria Florea et al.   Cancers

Transtympanic Administration of Short Interfering (si)RNA for the NOX3 Isoform of NADPH Oxidase Protects Against Cisplatin-Induced Hearing Loss in the Rat

(2010) Debashree Mukherjea et al.   ANTIOXIDANTS & REDOX SIGNALING

Enhancing Tumor-Specific Uptake of the Anticancer Drug Cisplatin with a Copper Chelator

(2010) Seiko Ishida et al.   CANCER CELL

Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: Differential cytotoxicity in healthy and cancer cells

(2010) Karuppaiyah Selvendiran et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evaluation of curcumin and cisplatin-induced DNA damage in PC12 cells by the alkaline comet assay

(2010) Leonardo Meneghin Mendonça et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Cancer stem cells: the theory and perspectives in cancer therapy

(2010) Justyna Gil et al.   JOURNAL OF APPLIED GENETICS

Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells

(2010) Murali Mohan Yallapu et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Roles of NADPH Oxidases in Cisplatin-Induced Reactive Oxygen Species Generation and Ototoxicity

(2010) H.-J. Kim et al.   JOURNAL OF NEUROSCIENCE

Curcumin Enhances the Effect of Cisplatin in Suppression of Head and Neck Squamous Cell Carcinoma via Inhibition of IKK  Protein of the NF B Pathway

(2010) V. M. Duarte et al.   MOLECULAR CANCER THERAPEUTICS

Anticancer Efficacy of a Difluorodiarylidenyl Piperidone (HO-3867) in Human Ovarian Cancer Cells and Tumor Xenografts

(2010) K. Selvendiran et al.   MOLECULAR CANCER THERAPEUTICS

Cisplatin-induced gastrointestinal dysmotility is aggravated after chronic administration in the rat. Comparison with pica

(2010) P. A. Cabezos et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth

(2010) Murali M Yallapu et al.   Journal of Ovarian Research

Curcumin Sensitizes Lung Cancer Cells to Cisplatin-Induced Apoptosis Through Superoxide Anion-Mediated Bcl-2 Degradation

(2009) Pithi Chanvorachote et al.   CANCER INVESTIGATION

Cell-cycle inhibition and apoptosis induced by curcumin and cisplatin or oxaliplatin in human ovarian carcinoma cells

(2009) M. Montopoli et al.   CELL PROLIFERATION

Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways

(2009) Y. O. Ilbey et al.   HUMAN REPRODUCTION

Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells

(2009) Maha H. Elamin et al.   MOLECULAR CARCINOGENESIS

GLI3 Repressor Controls Nephron Number via Regulation of Wnt11 and Ret in Ureteric Tip Cells

(2009) Jason E. Cain et al.   PLoS One

Cisplatin Ototoxicity and Protection: Clinical and Experimental Studies

(2009) Leonard P Rybak et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

(2008) N. Dhillon et al.   CLINICAL CANCER RESEARCH

Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies

(2008) N. Pabla et al.   KIDNEY INTERNATIONAL

Transcription Factor Sp1 Plays an Important Role in the Regulation of Copper Homeostasis in Mammalian Cells

(2008) I.-S. Song et al.   MOLECULAR PHARMACOLOGY

A Calcium Influx Pathway Regulated Separately by Oxidative Stress and ADP-Ribose in TRPM2 Channels: Single Channel Events

(2008) Mustafa Nazıroğlu et al.   NEUROCHEMICAL RESEARCH