Flap Endonuclease 1

Sequential Posttranslational Modifications Program FEN1 Degradation during Cell-Cycle Progression

(2012) Zhigang Guo et al.   MOLECULAR CELL

Intrinsic coupling of lagging-strand synthesis to chromatin assembly

(2012) Duncan J. Smith et al.   NATURE

DNA base excision repair: a mechanism of trinucleotide repeat expansion

(2012) Yuan Liu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Msh2-Msh3 Interferes with Okazaki Fragment Processing to Promote Trinucleotide Repeat Expansions

(2012) Athena Kantartzis et al.   Cell Reports

Functional FEN1 genetic variants contribute to risk of hepatocellular carcinoma, esophageal cancer, gastric cancer and colorectal cancer

(2011) L. Liu et al.   CARCINOGENESIS

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

(2011) Susan E. Tsutakawa et al.   CELL

The changing view of Dna2

(2011) Lata Balakrishnan et al.   CELL CYCLE

It’s all about flaps

(2011) Peter M. Burgers   CELL CYCLE

Inviability of aDNA2deletion mutant is due to the DNA damage checkpoint

(2011) Martin E. Budd et al.   CELL CYCLE

PCNA directs type 2 RNase H activity on DNA replication and repair substrates

(2011) Doryen Bubeck et al.   NUCLEIC ACIDS RESEARCH

Okazaki fragment maturation: nucleases take centre stage

(2011) L. Zheng et al.   Journal of Molecular Cell Biology

Eukaryotic Lagging Strand DNA Replication Employs a Multi-pathway Mechanism That Protects Genome Integrity

(2010) Lata Balakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complementary Roles for Exonuclease 1 and Flap Endonuclease 1 in Maintenance of Triplet Repeats

(2010) Aarthy C. Vallur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dna2 Exhibits a Unique Strand End-dependent Helicase Function

(2010) Lata Balakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flap Endonuclease 1 Mechanism Analysis Indicates Flap Base Binding Prior to Threading

(2010) Jason W. Gloor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Alternative Pathway for Okazaki Fragment Processing

(2010) Jason E. Pike et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding

(2010) Zhigang Guo et al.   Nature Chemical Biology

Mechanisms of trinucleotide repeat instability during human development

(2010) Cynthia T. McMurray   NATURE REVIEWS GENETICS

Functional regulation of FEN1 nuclease and its link to cancer

(2010) L. Zheng et al.   NUCLEIC ACIDS RESEARCH

Distinct Activities of Exonuclease 1 and Flap Endonuclease 1 at Telomeric G4 DNA

(2010) Aarthy C. Vallur et al.   PLoS One

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

(2010) R. T. Pomerantz et al.   SCIENCE

Evidence for a role of FEN1 in maintaining mitochondrial DNA integrity

(2009) Lidza Kalifa et al.   DNA REPAIR

Ribonuclease H: the enzymes in eukaryotes

(2009) Susana M. Cerritelli et al.   FEBS Journal

C-Terminal Flap Endonuclease (rad27) Mutations: Lethal Interactions With a DNA Ligase I Mutation (cdc9-p) and Suppression by Proliferating Cell Nuclear Antigen (POL30) in Saccharomyces cerevisiae

(2009) K. K. Karanja et al.   GENETICS

FunctionalFEN1polymorphisms are associated with DNA damage levels and lung cancer risk

(2009) Ming Yang et al.   HUMAN MUTATION

Acetylation of Dna2 Endonuclease/Helicase and Flap Endonuclease 1 by p300 Promotes DNA Stability by Creating Long Flap Intermediates

(2009) Lata Balakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordination between Polymerase β and FEN1 Can Modulate CAG Repeat Expansion

(2009) Yuan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dna2 is a structure-specific nuclease, with affinity for 5′-flap intermediates

(2009) Jason A. Stewart et al.   NUCLEIC ACIDS RESEARCH

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Early-Onset Lymphoma and Extensive Embryonic Apoptosis in Two Domain-Specific Fen1 Mice Mutants

(2008) E. Larsen et al.   CANCER RESEARCH

Effect of polyamine deficiency on proteins involved in Okazaki fragment maturation

(2008) V JOHANSSON et al.   CELL BIOLOGY INTERNATIONAL

Flap Endonuclease 1 Contributes to Telomere Stability

(2008) Abhishek Saharia et al.   CURRENT BIOLOGY

Human Flap Endonuclease I Is in Complex with Telomerase and Is Required for Telomerase-mediated Telomere Maintenance

(2008) Shilpa Sampathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long Patch Base Excision Repair in Mammalian Mitochondrial Genomes

(2008) Bartosz Szczesny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-stranded DNA-binding Proteinin VitroEliminates the Orientation-dependent Impediment to Polymerase Passage on CAG/CTG Repeats

(2008) Emmanuelle Delagoutte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Removal of Oxidative DNA Damage via FEN1-Dependent Long-Patch Base Excision Repair in Human Cell Mitochondria

(2008) P. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Nucleolar Localization and Dynamic Roles of Flap Endonuclease 1 in Ribosomal DNA Replication and Damage Repair

(2008) Z. Guo et al.   MOLECULAR AND CELLULAR BIOLOGY

Flap endonuclease 1 and its role in eukaryotic DNA metabolism

(2008) Zh. K. Nazarkina et al.   MOLECULAR BIOLOGY