Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin

Bidirectional interactions between curcumin and gut microbiota in transgenic mice with Alzheimer’s disease

(2020) Zhen-Zhen Sun et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: A randomized controlled trial

(2020) Masoud Nouri‐Vaskeh et al.   PHYTOTHERAPY RESEARCH

Mechanistic Differences in the Inhibition of NF-κB by Turmeric and Its Curcuminoid Constituents

(2020) Rebecca L. Edwards et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Highly Bioavailable Forms of Curcumin and Promising Avenues for Curcumin-Based Research and Application: A Review

(2020) Sidney J. Stohs et al.   MOLECULES

You Are What You Eat—The Relationship between Diet, Microbiota, and Metabolic Disorders—A Review

(2020) Małgorzata Moszak et al.   Nutrients

Bioactivity of dietary polyphenols: The role of metabolites

(2019) Simon Vlad Luca et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial

(2019) Saeed Chashmniam et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Dietary Compounds as Epigenetic Modulating Agents in Cancer

(2019) Ángeles Carlos-Reyes et al.   Frontiers in Genetics

Disclosure of complementary medicine use to medical providers: a systematic review and meta-analysis

(2019) H. Foley et al.   Scientific Reports

Curcumin and Resveratrol Regulate Intestinal Bacteria and Alleviate Intestinal Inflammation in Weaned Piglets

(2019) Zhending Gan et al.   MOLECULES

Antitumor effects of curcumin: A lipid perspective

(2019) Mehri Bemani Naeini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metagenomic analysis of microbe-mediated vitamin metabolism in the human gut microbiome

(2019) Promi Das et al.   BMC GENOMICS

Ethnobotany, phytochemistry and traditional uses of Curcuma spp. and pharmacological profile of two important species (C. longa and C. zedoaria): a review

(2019) Zahra Ayati et al.   CURRENT PHARMACEUTICAL DESIGN

Curcumin: New Insights into an Ancient Ingredient against Cancer

(2019) Ella Willenbacher et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protection

(2019) Kathryn Burge et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin for the prevention of myocardial injury following elective percutaneous coronary intervention; a pilot randomized clinical trial

(2019) Naser Aslanabadi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Curcumin C3 complex®/Bioperine® has antineoplastic activity in mesothelioma: an in vitro and in vivo analysis

(2019) Francesco Di Meo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Role of Probiotics in Human Gut Microbiome-Associated Diseases

(2019) Seon-Kyun Kim et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

Curcumin, Gut Microbiota, and Neuroprotection

(2019) Di Meo et al.   Nutrients

Untargeted UPLC-MS metabolomics reveals multiple changes of urine composition in healthy adult volunteers after consumption of curcuma longa L. extract

(2019) Gregorio Peron et al.   FOOD RESEARCH INTERNATIONAL

Protective effect of curcumin on ochratoxin A–induced liver oxidative injury in duck is mediated by modulating lipid metabolism and the intestinal microbiota

(2019) S.S. Zhai et al.   POULTRY SCIENCE

The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy

(2018) Vancheswaran Gopalakrishnan et al.   CANCER CELL

Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment

(2018) Shireen Chikara et al.   CANCER LETTERS

Stool Microbiota Composition Differs in Patients with Stomach, Colon, and Rectal Neoplasms

(2018) Omar Youssef et al.   DIGESTIVE DISEASES AND SCIENCES

Human gut microbiome: hopes, threats and promises

(2018) Patrice D Cani   GUT

Curcumin in turmeric: Basic and clinical evidence for a potential role in analgesia

(2018) U. J. Eke-Okoro et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Effects of curcumin consumption on human chronic diseases: A narrative review of the most recent clinical data

(2018) Maria Mantzorou et al.   PHYTOTHERAPY RESEARCH

The impact of human activities and lifestyles on the interlinked microbiota and health of humans and of ecosystems

(2018) Lucette Flandroy et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Curcumin as a functional food-derived factor: degradation products, metabolites, bioactivity, and future perspectives

(2018) Takanori Tsuda   Food & Function

Role of the gut microbiota in nutrition and health

(2018) Ana M Valdes et al.   BMJ-British Medical Journal

Role of the gut microbiota in nutrition and health

(2018) Ana M Valdes et al.   BMJ-British Medical Journal

The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway

(2018) Chung-Yi Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The efficacy of curcuminoids in improvement of ulcerative colitis symptoms and patients’ self-reported well-being: A randomized double-blind controlled trial

(2018) Mohsen Masoodi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Environment dominates over host genetics in shaping human gut microbiota

(2018) Daphna Rothschild et al.   NATURE

An insight into gut microbiota and its functionalities

(2018) Atanu Adak et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The gut microbiota at the intersection of diet and human health

(2018) Christopher L. Gentile et al.   SCIENCE

In vitro permeability enhancement of curcumin across Caco-2 cells monolayers using electrospun xanthan-chitosan nanofibers

(2018) Adele Faralli et al.   CARBOHYDRATE POLYMERS

Alterations in gut microbiota associated with a cafeteria diet and the physiological consequences in the host

(2017) J M del Bas et al.   INTERNATIONAL JOURNAL OF OBESITY

Curcuminoid Demethylation as an Alternative Metabolism by Human Intestinal Microbiota

(2017) Supawadee Burapan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Therapeutic Potential of Targeting Wnt/β-Catenin Pathway in Treatment of Colorectal Cancer: Rational and Progress

(2017) Afsane Bahrami et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Maternal Infant Microbiome

(2017) Alexis B. Dunn et al.   MCN-The American Journal of Maternal-Child Nursing

Effect of Curcumin on the Diversity of Gut Microbiota in Ovariectomized Rats

(2017) Zhiguo Zhang et al.   Nutrients

Regulative effects of curcumin spice administration on gut microbiota and its pharmacological implications

(2017) Liang Shen et al.   Food & Nutrition Research

Nanoparticle curcumin ameliorates experimental colitis via modulation of gut microbiota and induction of regulatory T cells

(2017) Masashi Ohno et al.   PLoS One

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

(2016) Ajaikumar B Kunnumakkara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Curcumin and tetrahydrocurcumin both prevent osteoarthritis symptoms and decrease the expressions of pro-inflammatory cytokines in estrogen-deficient rats

(2016) Sunmin Park et al.   Genes and Nutrition

Oral bioavailability of curcumin: problems and advancements

(2016) Weidong Liu et al.   JOURNAL OF DRUG TARGETING

Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

(2016) James W. Daily et al.   JOURNAL OF MEDICINAL FOOD

Curcumin improves glucose tolerance via stimulation of glucagon-like peptide-1 secretion

(2016) Masaki Kato et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Curcumin and Health

(2016) Mario Pulido-Moran et al.   MOLECULES

Intestinal Microbiota and Metabolic Diseases: Pharmacological Implications

(2016) Liang Shen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Curcumin suppresses colon cancer cell invasion via AMPK-induced inhibition of NF–κB, uPA activator and MMP9

(2016) Weihua Tong et al.   Oncology Letters

Polyhydroxycurcuminoids but not curcumin upregulate neprilysin and can be applied to the prevention of Alzheimer’s disease

(2016) Po-Ting Chen et al.   Scientific Reports

Curcumin Attenuates Beta-Amyloid-Induced Neuroinflammation via Activation of Peroxisome Proliferator-Activated Receptor-Gamma Function in a Rat Model of Alzheimer's Disease

(2016) Zun-Jing Liu et al.   Frontiers in Pharmacology

Curcumin and tetrahydrocurcumin both prevent osteoarthritis symptoms and decrease the expressions of pro-inflammatory cytokines in estrogen-deficient rats

(2016) Sunmin Park et al.   Genes and Nutrition

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

(2015) Fredrik Bäckhed et al.   Cell Host & Microbe

Curcumin, an active component of turmeric (Curcuma longa), and its effects on health

(2015) Betül Kocaadam et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention

(2015) Rita-Marie T. McFadden et al.   INFLAMMATORY BOWEL DISEASES

The degradation of curcuminoids in a human faecal fermentation model

(2015) Suryani Tan et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Utilizing Food Matrix Effects To Enhance Nutraceutical Bioavailability: Increase of Curcumin Bioaccessibility Using Excipient Emulsions

(2015) Liqiang Zou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Application of ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry to identify curcumin metabolites produced by human intestinal bacteria

(2015) Yan Lou et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Mechanisms and therapeutic effectiveness of lactobacilli

(2015) Alessandro Di Cerbo et al.   JOURNAL OF CLINICAL PATHOLOGY

Association of Neuroprotective Effect of Di-O-Demethylcurcumin on Aβ25–35-Induced Neurotoxicity with Suppression of NF-κB and Activation of Nrf2

(2015) Decha Pinkaew et al.   NEUROTOXICITY RESEARCH

Analgesic Efficacy and Safety of Curcuminoids in Clinical Practice: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2015) Amirhossein Sahebkar et al.   PAIN MEDICINE

The Role of Curcumin Administration in Patients with Major Depressive Disorder: Mini Meta-Analysis of Clinical Trials

(2015) Dalia Al-Karawi et al.   PHYTOTHERAPY RESEARCH

Combining curcumin (C3-complex, Sabinsa) with standard care FOLFOX chemotherapy in patients with inoperable colorectal cancer (CUFOX): study protocol for a randomised control trial

(2015) Glen RB Irving et al.   Trials

Chemoprevention in Gastrointestinal Physiology and Disease. Natural products and microbiome

(2014) Allen K. Greiner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

Flavonoids in modulation of cell survival signalling pathways

(2014) Mohammad Lukman Mansuri et al.   Genes and Nutrition

Curcumin attenuates inflammatory responses by suppressing TLR4-mediated NF-κB signaling pathway in lipopolysaccharide-induced mastitis in mice

(2014) Yunhe Fu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics

(2014) Rachel N. Carmody et al.   JOURNAL OF CLINICAL INVESTIGATION

Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury

(2014) Hai-tao Zhu et al.   Journal of Neuroinflammation

Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study

(2014) Yasuaki Nakagawa et al.   JOURNAL OF ORTHOPAEDIC SCIENCE

Oral Supplementation with Non-Absorbable Antibiotics or Curcumin Attenuates Western Diet-Induced Atherosclerosis and Glucose Intolerance in LDLR−/− Mice – Role of Intestinal Permeability and Macrophage Activation

(2014) Siddhartha S. Ghosh et al.   PLoS One

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Dietary intervention impact on gut microbial gene richness

(2013) Aurélie Cotillard et al.   NATURE

Non-alcoholic steatohepatitis: a microbiota-driven disease

(2013) Alexander R. Moschen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Chemopreventative effects of tetrahydrocurcumin on human diseases

(2013) Jia-Ching Wu et al.   Food & Function

Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials

(2012) Subash C. Gupta et al.   AAPS Journal

Lipopolysaccharide Causes an Increase in Intestinal Tight Junction Permeability in Vitro and in Vivo by Inducing Enterocyte Membrane Expression and Localization of TLR-4 and CD14

(2012) Shuhong Guo et al.   AMERICAN JOURNAL OF PATHOLOGY

Curcumin-From Molecule to Biological Function

(2012) Tuba Esatbeyoglu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

(2012) Daniele Del Rio et al.   ANTIOXIDANTS & REDOX SIGNALING

Curcumin uptake and metabolism

(2012) Manfred Metzler et al.   BIOFACTORS

Conundrum and Therapeutic Potential of Curcumin in Drug Delivery

(2012) Anil Kumar et al.   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

Metabolism and permeability of curcumin in cultured Caco-2 cells

(2012) Julia S. Dempe et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Multitargeting by turmeric, the golden spice: From kitchen to clinic

(2012) Subash C. Gupta et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Diversity, stability and resilience of the human gut microbiota

(2012) Catherine A. Lozupone et al.   NATURE

The effects of black pepper on the intestinal absorption and hepatic metabolism of drugs

(2011) Hyo-Kyung Han   Expert Opinion on Drug Metabolism & Toxicology

B-Group vitamin production by lactic acid bacteria - current knowledge and potential applications

(2011) J.G. LeBlanc et al.   JOURNAL OF APPLIED MICROBIOLOGY

Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism

(2011) A. Hassaninasab et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Gut Microbiota and Endocannabinoid System Tone in Obese and Diabetic Leptin-Resistant Mice: Impact on Apelin Regulation in Adipose Tissue

(2011) Lucie Geurts et al.   Frontiers in Microbiology

Curcumin in Cancer Chemoprevention: Molecular Targets, Pharmacokinetics, Bioavailability, and Clinical Trials

(2010) Adeeb Shehzad et al.   ARCHIV DER PHARMAZIE

Role of the gut microbiota in defining human health

(2010) Kei E Fujimura et al.   Expert Review of Anti-Infective Therapy

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease

(2010) T. Ahmed et al.   NEUROSCIENCE

Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer

(2009) J. Shaikh et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Rapid Analysis of Curcumin and Curcumin Metabolites in Rat Biomatrices Using a Novel Ultraperformance Liquid Chromatography (UPLC) Method

(2009) Timothy H. Marczylo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Protective effect of curcumin against intracerebral streptozotocin induced impairment in memory and cerebral blood flow

(2009) Himani Awasthi et al.   LIFE SCIENCES

Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator

(2008) Y. Jiao et al.   BLOOD

Curcumin: From ancient medicine to current clinical trials

(2008) H. Hatcher et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

(2008) N. Dhillon et al.   CLINICAL CANCER RESEARCH

Microbes in Gastrointestinal Health and Disease

(2008) Andrew S. Neish   GASTROENTEROLOGY

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets

(2008) Bharat B. Aggarwal et al.   TRENDS IN PHARMACOLOGICAL SCIENCES