Modulation of cellular processes by histone and non-histone protein acetylation

Targeting ACSS2 with a transition state mimetic inhibits triple-negative breast cancer growth

(2021) Katelyn D. Miller et al.   CANCER RESEARCH

Autophagy regulation by acetylation—implications for neurodegenerative diseases

(2021) Sung Min Son et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Acute perturbation strategies in interrogating RNA polymerase II elongation factor function in gene expression

(2021) Bin Zheng et al.   GENES & DEVELOPMENT

SIRT7-dependent deacetylation of NPM promotes p53 stabilization following UV-induced genotoxic stress

(2021) Alessandro Ianni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies

(2021) Mariesa J. Slaughter et al.   Cell Reports

Safety and Efficacy of Bromodomain and Extra-Terminal Inhibitors for the Treatment of Hematological Malignancies and Solid Tumors: A Systematic Study of Clinical Trials

(2021) Yanli Sun et al.   Frontiers in Pharmacology

Impaired Regulation of Histone Methylation and Acetylation Underlies Specific Neurodevelopmental Disorders

(2021) Merrick S. Fallah et al.   Frontiers in Genetics

What do Transcription Factors Interact With?

(2021) Haining Chen et al.   JOURNAL OF MOLECULAR BIOLOGY

Co-condensation between transcription factor and coactivator p300 modulates transcriptional bursting kinetics

(2021) Liang Ma et al.   MOLECULAR CELL

Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis

(2021) Aliaksandra Radzisheuskaya et al.   MOLECULAR CELL

Functional mechanisms and abnormalities of the nuclear lamina

(2021) Adam Karoutas et al.   NATURE CELL BIOLOGY

Histone modifications form a cell-type-specific chromosomal bar code that persists through the cell cycle

(2021) John A. Halsall et al.   Scientific Reports

The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway

(2021) He Huang et al.   Science Advances

Understanding the Function of Mammalian Sirtuins and Protein Lysine Acylation

(2021) Miao Wang et al.   Annual Review of Biochemistry

Reducing acetylated tau is neuroprotective in brain injury

(2021) Min-Kyoo Shin et al.   CELL

Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release

(2021) Takeo Narita et al.   MOLECULAR CELL

H3K27ac bookmarking promotes rapid post-mitotic activation of the pluripotent stem cell program without impacting 3D chromatin reorganization

(2021) Bobbie Pelham-Webb et al.   MOLECULAR CELL

Histone acetylation dynamics modulates chromatin conformation and allele-specific interactions at oncogenic loci

(2021) Stephanie Sungalee et al.   NATURE GENETICS

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice

(2021) Benjamin Caballero et al.   Nature Communications

Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes

(2021) Nazar Mashtalir et al.   SCIENCE

Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains

(2020) Tamta Arakhamia et al.   CELL

Circadian Clocks Make Metabolism Run

(2020) Flore Sinturel et al.   JOURNAL OF MOLECULAR BIOLOGY

Hat1-Dependent Lysine Acetylation Targets Diverse Cellular Functions

(2020) Paula A. Agudelo Garcia et al.   JOURNAL OF PROTEOME RESEARCH

Compartmentalized acyl-CoA metabolism and roles in chromatin regulation

(2020) Sophie Trefely et al.   Molecular Metabolism

Further delineation of the clinical spectrum of KAT6B disorders and allelic series of pathogenic variants

(2020) Li Xin Zhang et al.   GENETICS IN MEDICINE

Revealing Dynamic Protein Acetylation across Subcellular Compartments

(2020) Josue Baeza et al.   JOURNAL OF PROTEOME RESEARCH

How RNA-Binding Proteins Interact with RNA: Molecules and Mechanisms

(2020) Meredith Corley et al.   MOLECULAR CELL

Chromatin Hyperacetylation Impacts Chromosome Folding by Forming a Nuclear Subcompartment

(2020) Celeste D. Rosencrance et al.   MOLECULAR CELL

Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate

(2020) Steven Zhao et al.   NATURE

Chromatin as a key consumer in the metabolite economy

(2020) Katharine L. Diehl et al.   Nature Chemical Biology

Release of promoter–proximal paused Pol II in response to histone deacetylase inhibition

(2020) Roshan Vaid et al.   NUCLEIC ACIDS RESEARCH

Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate

(2020) Cecilia Pessoa Rodrigues et al.   Science Advances

Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma

(2020) Michael A. Gillette et al.   CELL

Intergenerationally Maintained Histone H4 Lysine 16 Acetylation Is Instructive for Future Gene Activation

(2020) Maria Samata et al.   CELL

Metabolites Regulate Cell Signaling and Growth via Covalent Modification of Proteins

(2020) Gianluca Figlia et al.   DEVELOPMENTAL CELL

Exploring the Influence of Cell Metabolism on Cell Fate through Protein Post-translational Modifications

(2020) Oscar A. Tarazona et al.   DEVELOPMENTAL CELL

Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation

(2020) Hyeseon Kang et al.   GENES & DEVELOPMENT

Lysine acetylation regulates the RNA binding, subcellular localization and inclusion formation of FUS

(2020) Alexandra Arenas et al.   HUMAN MOLECULAR GENETICS

Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature

(2020) Bilal N. Sheikh et al.   NATURE CELL BIOLOGY

Diverse nucleosome Site-Selectivity among histone deacetylase complexes

(2020) Zhipeng A Wang et al.   eLife

De Novo KAT5 Variants Cause a Syndrome with Recognizable Facial Dysmorphisms, Cerebellar Atrophy, Sleep Disturbance, and Epilepsy

(2020) Jonathan Humbert et al.   AMERICAN JOURNAL OF HUMAN GENETICS

An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease

(2020) Raffaella Nativio et al.   NATURE GENETICS

The evolving metabolic landscape of chromatin biology and epigenetics

(2020) Ziwei Dai et al.   NATURE REVIEWS GENETICS

Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therapeutic Strategies

(2020) Richard C. Centore et al.   TRENDS IN GENETICS

Breaths, Twists, and Turns of Atomistic Nucleosomes

(2020) Jan Huertas et al.   JOURNAL OF MOLECULAR BIOLOGY

Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation

(2020) Marc A. J. Morgan et al.   NATURE GENETICS

NAD+ metabolism and its roles in cellular processes during ageing

(2020) Anthony J. Covarrubias et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses

(2020) Ryan Houston et al.   PLOS BIOLOGY

Divide and Rule: Phase Separation in Eukaryotic Genome Functioning

(2020) Sergey V. Razin et al.   Cells

Enhancer-promoter communication: hubs or loops?

(2020) Bomyi Lim et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Cul4-Ddb1 ubiquitin ligases facilitate DNA replication-coupled sister chromatid cohesion through regulation of cohesin acetyltransferase Esco2

(2019) Haitao Sun et al.   PLoS Genetics

Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule

(2019) Sabrina Chriett et al.   Scientific Reports

Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism

(2019) Xiawei Cheng et al.   MOLECULAR CELL

Kat6b Modulates Oct4 and Nanog Binding to Chromatin in Embryonic Stem Cells and Is Required for Efficient Neural Differentiation

(2019) María Soledad Cosentino et al.   JOURNAL OF MOLECULAR BIOLOGY

Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease

(2019) Hisayuki Amano et al.   Cell Metabolism

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

(2019) Frank Madeo et al.   Cell Metabolism

Acetylation & Co: an expanding repertoire of histone acylations regulates chromatin and transcription

(2019) Claire E. Barnes et al.   Essays in Biochemistry

NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling

(2019) Sudhir Chowdhry et al.   NATURE

Effects of α-tubulin acetylation on microtubule structure and stability

(2019) Lisa Eshun-Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of alternative splicing by p300-mediated acetylation of splicing factors

(2019) Ahmad Siam et al.   RNA

Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription

(2019) Vivek Behera et al.   Cell Reports

Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity

(2019) Jeffrey M Alexander et al.   eLife

Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2

(2019) Aaron J. Plys et al.   GENES & DEVELOPMENT

From discoveries in ageing research to therapeutics for healthy ageing

(2019) Judith Campisi et al.   NATURE

BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity

(2019) P. Khoueiry et al.   Epigenetics & Chromatin

Lysine/RNA-interactions drive and regulate biomolecular condensation

(2019) Tina Ukmar-Godec et al.   Nature Communications

Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function

(2019) Nora Yucel et al.   Cell Reports

Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters

(2019) Nikolai Petkau et al.   eLife

Molecular basis for hierarchical histone de-β-hydroxybutyrylation by SIRT3

(2019) Xingrun Zhang et al.   Cell Discovery

SIRT7 regulates the nuclear export of NF-κB p65 by deacetylating Ran

(2019) Shihab U. Sobuz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Histone H3K27 acetylation precedes active transcription during zebrafish zygotic genome activation as revealed by live-cell analysis

(2019) Yuko Sato et al.   DEVELOPMENT

The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing

(2019) Jean-Pierre Etchegaray et al.   MOLECULAR CELL

Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics

(2019) Xiucong Bao et al.   MOLECULAR CELL

HDAC7 regulates histone 3 lysine 27 acetylation and transcriptional activity at super-enhancer-associated genes in breast cancer stem cells

(2019) Corrado Caslini et al.   ONCOGENE

RNAi-mediated depletion of the NSL complex subunits leads to abnormal chromosome segregation and defective centrosome duplication in Drosophila mitosis

(2019) Gera A. Pavlova et al.   PLoS Genetics

Organization of Chromatin by Intrinsic and Regulated Phase Separation

(2019) Bryan A. Gibson et al.   CELL

The Control Centers of Biomolecular Phase Separation: How Membrane Surfaces, PTMs, and Active Processes Regulate Condensation

(2019) Wilton T. Snead et al.   MOLECULAR CELL

Alcohol metabolism contributes to brain histone acetylation

(2019) P. Mews et al.   NATURE

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

The NSL complex maintains nuclear architecture stability via lamin A/C acetylation

(2019) Adam Karoutas et al.   NATURE CELL BIOLOGY

Determinants of enhancer and promoter activities of regulatory elements

(2019) Robin Andersson et al.   NATURE REVIEWS GENETICS

Bromodomain biology and drug discovery

(2019) Nilesh Zaware et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity

(2019) Mercedes Dávalos-Salas et al.   Nature Communications

Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability

(2019) Lin Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome

(2018) Brian T. Weinert et al.   CELL

Impairment of an Endothelial NAD + -H 2 S Signaling Network Is a Reversible Cause of Vascular Aging

(2018) Abhirup Das et al.   CELL

Overexpressed HDAC8 in cervical cancer cells shows functional redundancy of tubulin deacetylation with HDAC6

(2018) G. R. Vanaja et al.   Cell Communication and Signaling

Ketone bodies as epigenetic modifiers

(2018) Hai-Bin Ruan et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Disruption of Epithelial HDAC3 in Intestine Prevents Diet-Induced Obesity in Mice

(2018) Jordan Whitt et al.   GASTROENTEROLOGY

Recognition of histone acetylation by the GAS41 YEATS domain promotes H2A.Z deposition in non-small cell lung cancer

(2018) Chih-Chao Hsu et al.   GENES & DEVELOPMENT

Revealing the protein propionylation activity of the histone acetyltransferase MOF (males absent on the first)

(2018) Zhen Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic localization of α-tubulin acetyltransferase ATAT1 through the cell cycle in human fibroblastic KD cells

(2018) Yoko Nekooki-Machida et al.   Medical Molecular Morphology

Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease

(2018) Raffaella Nativio et al.   NATURE NEUROSCIENCE

Sirtuin activators and inhibitors: Promises, achievements, and challenges

(2018) Han Dai et al.   PHARMACOLOGY & THERAPEUTICS

Metabolic regulation of transcription through compartmentalized NAD+biosynthesis

(2018) Keun Woo Ryu et al.   SCIENCE

SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis

(2018) Matthias Muhar et al.   SCIENCE

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Mediator and RNA polymerase II clusters associate in transcription-dependent condensates

(2018) Won-Ki Cho et al.   SCIENCE

Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals

(2018) Anne K. Voss et al.   BIOESSAYS

Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

(2018) Sung Min Son et al.   Cell Metabolism

Study of mitotic chromatin supports a model of bookmarking by histone modifications and reveals nucleosome deposition patterns

(2018) Elisheva Javasky et al.   GENOME RESEARCH

Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II

(2018) Huasong Lu et al.   NATURE

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

(2018) Jonathan B. Baell et al.   NATURE

Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape

(2018) Paul Adrian Ginno et al.   Nature Communications

Probing the Function of Metazoan Histones with a Systematic Library of H3 and H4 Mutants

(2018) Weimin Zhang et al.   DEVELOPMENTAL CELL

Chromatin conformation and transcriptional activity are permissive regulators of DNA replication initiation in Drosophila

(2018) Robin L. Armstrong et al.   GENOME RESEARCH

Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation

(2018) Roubina Tatavosian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nε-lysine acetylation in the endoplasmic reticulum – a novel cellular mechanism that regulates proteostasis and autophagy

(2018) Mark A. Farrugia et al.   JOURNAL OF CELL SCIENCE

Acetylation of intrinsically disordered regions regulates phase separation

(2018) Makoto Saito et al.   Nature Chemical Biology

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brains

(2018) Hans-Ulrich Klein et al.   NATURE NEUROSCIENCE

A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex

(2018) Sarah J. Marzi et al.   NATURE NEUROSCIENCE

The many lives of KATs — detectors, integrators and modulators of the cellular environment

(2018) Bilal N. Sheikh et al.   NATURE REVIEWS GENETICS

Functions and mechanisms of non-histone protein acetylation

(2018) Takeo Narita et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A changing paradigm of transcriptional memory propagation through mitosis

(2018) Katherine C. Palozola et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sex-specific phenotypes of histone H4 point mutants establish dosage compensation as the critical function of H4K16 acetylation in Drosophila

(2018) Ömer Copur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Replication Control During Drosophila Development: Insights into the Onset of S Phase, Replication Initiation, and Fork Progression

(2017) Brian L. Hua et al.   GENETICS

HDAC8 substrate selectivity is determined by long- and short-range interactions leading to enhanced reactivity for full-length histone substrates compared with peptides

(2017) Carol Ann Castañeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of a High-fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels

(2017) Alessandro Carrer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KATapulting toward Pluripotency and Cancer

(2017) Calley L. Hirsch et al.   JOURNAL OF MOLECULAR BIOLOGY

Lysine acetylation in mitochondria: From inventory to function

(2017) Fabian Hosp et al.   MITOCHONDRION

The emerging picture of CDK9/P-TEFb: more than 20 years of advances since PITALRE

(2017) Nikolas Ferreira dos Santos Paparidis et al.   Molecular BioSystems

SAGA Is a General Cofactor for RNA Polymerase II Transcription

(2017) Tiago Baptista et al.   MOLECULAR CELL

CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis

(2017) Ran Lin et al.   MOLECULAR CELL

CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II

(2017) Ann Boija et al.   MOLECULAR CELL

BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment

(2017) Georg E. Winter et al.   MOLECULAR CELL

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

(2017) Loren M. Lasko et al.   NATURE

KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase

(2017) Yugang Wang et al.   NATURE

Phase separation drives heterochromatin domain formation

(2017) Amy R. Strom et al.   NATURE

Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory

(2017) Philipp Mews et al.   NATURE

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

(2017) Adam G. Larson et al.   NATURE

The impact of cellular metabolism on chromatin dynamics and epigenetics

(2017) Michael A. Reid et al.   NATURE CELL BIOLOGY

Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes

(2017) Cedric R. Clapier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitotic transcription and waves of gene reactivation during mitotic exit

(2017) Katherine C. Palozola et al.   SCIENCE

Expanding the Reader Landscape of Histone Acylation

(2017) Abid Khan et al.   STRUCTURE

Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair

(2017) Hiroyuki Niida et al.   Nature Communications

Characterization of histone acylations links chromatin modifications with metabolism

(2017) Johayra Simithy et al.   Nature Communications

Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features

(2017) Martin Pannek et al.   Nature Communications

Non-enzymatic N -acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S -acetylated Thiol Intermediate Sensitive to Glyoxalase II

(2017) Andrew M. James et al.   Cell Reports

KAT-Independent Gene Regulation by Tip60 Promotes ESC Self-Renewal but Not Pluripotency

(2017) Diwash Acharya et al.   Cell Reports

Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation

(2017) Vinay Bulusu et al.   Cell Reports

SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice

(2017) Fang Wang et al.   Cell Reports

Regulation of Serine-Threonine Kinase Akt Activation by NAD + -Dependent Deacetylase SIRT7

(2017) Jia Yu et al.   Cell Reports

Mitotic post-translational modifications of histones promote chromatin compaction in vitro

(2017) Alisa Zhiteneva et al.   Open Biology

DNA Replication Control During Drosophila Development: Insights into the Onset of S Phase, Replication Initiation, and Fork Progression

(2017) Brian L. Hua et al.   GENETICS

MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells

(2016) B. N. Sheikh et al.   BLOOD

MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria

(2016) Aindrila Chatterjee et al.   CELL

Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle

(2016) David W. Frederick et al.   Cell Metabolism

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

(2016) Kathryn F. Mills et al.   Cell Metabolism

A hyperactive transcriptional state marks genome reactivation at the mitosis–G1 transition

(2016) Chris C.-S. Hsiung et al.   GENES & DEVELOPMENT

Chromatin dynamics during DNA replication

(2016) Raz Bar-Ziv et al.   GENOME RESEARCH

KATching-Up on Small Molecule Modulators of Lysine Acetyltransferases

(2016) Roman P. Simon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Atomistic Simulation of Stacked Nucleosome Core Particles: Tail Bridging, the H4 Tail, and Effect of Hydrophobic Forces

(2016) Suman Saurabh et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Site-Specific Identification of Lysine Acetylation Stoichiometries in Mammalian Cells

(2016) Tong Zhou et al.   JOURNAL OF PROTEOME RESEARCH

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

(2016) Zhongyu Xie et al.   MOLECULAR CELL

Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation

(2016) Fei Mo et al.   Nature Chemical Biology

Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2

(2016) Xiaozhe Xiong et al.   Nature Chemical Biology

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic regulation of gene expression through histone acylations

(2016) Benjamin R. Sabari et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PCAF-mediated acetylation of transcriptional factor HOXB9 suppresses lung adenocarcinoma progression by targeting oncogenic protein JMJD6

(2016) Junhu Wan et al.   NUCLEIC ACIDS RESEARCH

The CSRP2BP histone acetyltransferase drives smooth muscle gene expression

(2016) Yanlin Ma et al.   NUCLEIC ACIDS RESEARCH

Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

(2016) Sushabhan Sadhukhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosensor reveals multiple sources for mitochondrial NAD+

(2016) X. A. Cambronne et al.   SCIENCE

Mutations that prevent or mimic persistent post-translational modifications of the histone H3 globular domain cause lethality and growth defects in Drosophila

(2016) Hillary K. Graves et al.   Epigenetics & Chromatin

KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification

(2016) Marjorie Fournier et al.   Nature Communications

Sirtuin 1 Promotes Deacetylation of Oct4 and Maintenance of Naive Pluripotency

(2016) Eric O. Williams et al.   Cell Reports

Acetylation Reader Proteins: Linking Acetylation Signaling to Genome Maintenance and Cancer

(2016) Fade Gong et al.   PLoS Genetics

Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health

(2016) David Ríos-Covián et al.   Frontiers in Microbiology

Site-Specific Reactivity of Nonenzymatic Lysine Acetylation

(2015) Josue Baeza et al.   ACS Chemical Biology

Kinetic and Structural Basis for Acyl-Group Selectivity and NAD+ Dependence in Sirtuin-Catalyzed Deacylation

(2015) Jessica L. Feldman et al.   BIOCHEMISTRY

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

(2015) Zachary T. Schug et al.   CANCER CELL

Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells

(2015) Arieh Moussaieff et al.   Cell Metabolism

Esco1 Acetylates Cohesin via a Mechanism Different from That of Esco2

(2015) Masashi Minamino et al.   CURRENT BIOLOGY

Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions

(2015) B. T. Weinert et al.   EMBO JOURNAL

Chromatin Unfolding by Epigenetic Modifications Explained by Dramatic Impairment of Internucleosome Interactions: A Multiscale Computational Study

(2015) Rosana Collepardo-Guevara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Global and Specific Responses of the Histone Acetylome to Systematic Perturbation

(2015) Christian Feller et al.   MOLECULAR CELL

An Interactive Database for the Assessment of Histone Antibody Specificity

(2015) Scott B. Rothbart et al.   MOLECULAR CELL

The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine

(2015) Jean-Pierre Etchegaray et al.   NATURE CELL BIOLOGY

Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization

(2015) Shangyu Hong et al.   NATURE MEDICINE

Sox2 Deacetylation by Sirt1 Is Involved in Mouse Somatic Reprogramming

(2015) Wen-Li Mu et al.   STEM CELLS

Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers

(2015) F. F. Wagner et al.   Chemical Science

Comprehensive Catalog of Currently Documented Histone Modifications

(2015) Yingming Zhao et al.   Cold Spring Harbor Perspectives in Biology

An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis

(2015) Sylvain Meunier et al.   Nature Communications

Histone Deacetylases Positively Regulate Transcription through the Elongation Machinery

(2015) Celeste B. Greer et al.   Cell Reports

An Unbiased Approach To Identify Endogenous Substrates of “Histone” Deacetylase 8

(2014) David E. Olson et al.   ACS Chemical Biology

Changing the Selectivity of p300 by Acetyl-CoA Modulation of Histone Acetylation

(2014) Ryan A. Henry et al.   ACS Chemical Biology

Histone deacetylase 8 regulates cortactin deacetylation and contraction in smooth muscle tissues

(2014) Jia Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases

(2014) Tomoyuki Mashimo et al.   CELL

Acetate Dependence of Tumors

(2014) Sarah A. Comerford et al.   CELL

Sirtuin 4 Is a Lipoamidase Regulating Pyruvate Dehydrogenase Complex Activity

(2014) Rommel A. Mathias et al.   CELL

Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation

(2014) Joyce V. Lee et al.   Cell Metabolism

Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

(2014) Minjia Tan et al.   Cell Metabolism

Nucleosome Structure and Function

(2014) Robert K. McGinty et al.   CHEMICAL REVIEWS

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

(2014) B. J. North et al.   EMBO JOURNAL

Protein Acetylation and Acetyl Coenzyme A Metabolism in Budding Yeast

(2014) Luciano Galdieri et al.   EUKARYOTIC CELL

The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription

(2014) Jacques Bonnet et al.   GENES & DEVELOPMENT

Naphthoquinone-mediated Inhibition of Lysine Acetyltransferase KAT3B/p300, Basis for Non-toxic Inhibitor Synthesis

(2014) Mohankrishna Dalvoy Vasudevarao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia

(2014) David G. Cotter et al.   JOURNAL OF CLINICAL INVESTIGATION

Histone Methylation Has Dynamics Distinct from Those of Histone Acetylation in Cell Cycle Reentry from Quiescence

(2014) P. Mews et al.   MOLECULAR AND CELLULAR BIOLOGY

NEDD9 Regulates Actin Dynamics through Cortactin Deacetylation in an AURKA/HDAC6–Dependent Manner

(2014) Varvara K. Kozyreva et al.   MOLECULAR CANCER RESEARCH

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

(2014) Guillermo Mariño et al.   MOLECULAR CELL

Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae

(2014) B. T. Weinert et al.   Molecular Systems Biology

Regulation of RNA polymerase II activation by histone acetylation in single living cells

(2014) Timothy J. Stasevich et al.   NATURE

BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones

(2014) Tomohiko Kanno et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells

(2014) Shereen Jamaladdin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Cascade of Histone Modifications Induces Chromatin Condensation in Mitosis

(2014) Bryan J. Wilkins et al.   SCIENCE

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Distinct and Predictive Histone Lysine Acetylation Patterns at Promoters, Enhancers, and Gene Bodies

(2014) Nisha Rajagopal et al.   G3-Genes Genomes Genetics

Identification of ‘erasers’ for lysine crotonylated histone marks using a chemical proteomics approach

(2014) Xiucong Bao et al.   eLife

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

(2013) Matthew J. Rardin et al.   Cell Metabolism

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

Intracellular distribution of human SIRT7 and mapping of the nuclear/nucleolar localization signal

(2013) Shashi Kiran et al.   FEBS Journal

Histone Acetyltransferase 1 Promotes Homologous Recombination in DNA Repair by Facilitating Histone Turnover

(2013) Xiaohan Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Widespread and Enzyme-independentNϵ-Acetylation andNϵ-Succinylation of Proteins in the Chemical Conditions of the Mitochondrial Matrix

(2013) Gregory R. Wagner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of a Dynamic Interaction between Two Microtubule-binding Proteins, EB1 and TIP150, by the Mitotic p300/CBP-associated Factor (PCAF) Orchestrates Kinetochore Microtubule Plasticity and Chromosome Stability during Mitosis

(2013) Tarsha Ward et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of the nucleosome acidic patch in modulating higher order chromatin structure

(2013) A. A. Kalashnikova et al.   Journal of the Royal Society Interface

Acetylation of RNA Polymerase II Regulates Growth-Factor-Induced Gene Transcription in Mammalian Cells

(2013) Sebastian Schröder et al.   MOLECULAR CELL

SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase

(2013) Gaëlle Laurent et al.   MOLECULAR CELL

Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli

(2013) Brian T. Weinert et al.   MOLECULAR CELL

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

(2013) Jeongsoon Park et al.   MOLECULAR CELL

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

MOZ increases p53 acetylation and premature senescence through its complex formation with PML

(2013) S. Rokudai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways

(2013) M. J. Rardin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

(2013) C. B. Peek et al.   SCIENCE

αTAT1 is the major α-tubulin acetyltransferase in mice

(2013) Nereo Kalebic et al.   Nature Communications

Lysine Succinylation Is a Frequently Occurring Modification in Prokaryotes and Eukaryotes and Extensively Overlaps with Acetylation

(2013) Brian T. Weinert et al.   Cell Reports

Histone Deacetylase 2 (HDAC2) Regulates Chromosome Segregation and Kinetochore Function via H4K16 Deacetylation during Oocyte Maturation in Mouse

(2013) Pengpeng Ma et al.   PLoS Genetics

Lysine acetylation in the lumen of the ER: A novel and essential function under the control of the UPR

(2012) Mariana Pehar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Connecting Threads: Epigenetics and Metabolism

(2012) Sayako Katada et al.   CELL

Metabolic Regulation of Epigenetics

(2012) Chao Lu et al.   Cell Metabolism

SIRT3 Functions in the Nucleus in the Control of Stress-Related Gene Expression

(2012) T. Iwahara et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

(2012) Matthew F. Barber et al.   NATURE

The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB

(2012) Elisabeth Ziesché et al.   NUCLEIC ACIDS RESEARCH

EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis

(2012) P. Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combinatorial Patterning of Chromatin Regulators Uncovered by Genome-wide Location Analysis in Human Cells

(2011) Oren Ram et al.   CELL

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes

(2011) Ling Cai et al.   MOLECULAR CELL

Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation

(2011) Rui Zhao et al.   NATURE CELL BIOLOGY

Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes

(2011) J. M. Lamonica et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Proteome-Wide Mapping of the Drosophila Acetylome Demonstrates a High Degree of Conservation of Lysine Acetylation

(2011) B. T. Weinert et al.   Science Signaling

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

Hdac3 Is Essential for the Maintenance of Chromatin Structure and Genome Stability

(2010) Srividya Bhaskara et al.   CANCER CELL

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Emphasizing the positive: A role for histone deacetylases in transcriptional activation

(2010) Oliver M. Dovey et al.   CELL CYCLE

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

(2010) Carles Cantó et al.   Cell Metabolism

Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains

(2010) Nicolas Reynoird et al.   EMBO JOURNAL

The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates

(2010) Meritxell Orpinell et al.   EMBO JOURNAL

Gcn5 regulates the dissociation of SWI/SNF from chromatin by acetylation of Swi2/Snf2

(2010) J.-H. Kim et al.   GENES & DEVELOPMENT

HDAC3 Is Negatively Regulated by the Nuclear Protein DBC1

(2010) Claudia C. S. Chini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

The effects of histone H4 tail acetylations on cation-induced chromatin folding and self-association

(2010) Abdollah Allahverdi et al.   NUCLEIC ACIDS RESEARCH

Structure and binding of the H4 histone tail and the effects of lysine 16 acetylation

(2010) Darren Yang et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Global turnover of histone post-translational modifications and variants in human cells

(2010) Barry M Zee et al.   Epigenetics & Chromatin

Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl-CoA/acetate metabolism

(2009) Yukie Yoshii et al.   CANCER SCIENCE

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL

The maternal-to-zygotic transition: a play in two acts

(2009) W. Tadros et al.   DEVELOPMENT

BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis

(2009) Eunhee Choi et al.   EMBO JOURNAL

Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes

(2009) Lei Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subunit Composition and Substrate Specificity of a MOF-containing Histone Acetyltransferase Distinct from the Male-specific Lethal (MSL) Complex

(2009) Yong Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53

(2009) D. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition

(2008) Katrina L Bogan et al.   Annual Review of Nutrition

Probing Nucleosome Function: A Highly Versatile Library of Synthetic Histone H3 and H4 Mutants

(2008) Junbiao Dai et al.   CELL

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

Tissue-specific regulation of SIRT1 by calorie restriction

(2008) D. Chen et al.   GENES & DEVELOPMENT

Molecular Architecture of Quartet MOZ/MORF Histone Acetyltransferase Complexes

(2008) M. Ullah et al.   MOLECULAR AND CELLULAR BIOLOGY

The Double-Histone-Acetyltransferase Complex ATAC Is Essential for Mammalian Development

(2008) S. Guelman et al.   MOLECULAR AND CELLULAR BIOLOGY

The structural basis of protein acetylation by the p300/CBP transcriptional coactivator

(2008) Xin Liu et al.   NATURE

Combinatorial patterns of histone acetylations and methylations in the human genome

(2008) Zhibin Wang et al.   NATURE GENETICS

A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation

(2008) Shima Nakanishi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY