Autophagy regulation by acetylation—implications for neurodegenerative diseases

Dysregulation of histone acetylation pathways in hippocampus and frontal cortex of Alzheimer's disease patients

(2020) Estelle Schueller et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

SIRT7 depletion inhibits cell proliferation and androgen-induced autophagy by suppressing the AR signaling in prostate cancer

(2020) Mao Ding et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy

(2020) Xu Chen et al.   Molecular Neurodegeneration

Mendelian neurodegenerative disease genes involved in autophagy

(2020) Eleanna Stamatakou et al.   Cell Discovery

Leucine regulates autophagy via acetylation of the mTORC1 component raptor

(2020) Sung Min Son et al.   Nature Communications

Structure, lipid scrambling activity and role in autophagosome formation of ATG9A

(2020) Shintaro Maeda et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion

(2020) Kazuaki Matoba et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The genetic architecture of ALS

(2020) Aleksey Shatunov et al.   NEUROBIOLOGY OF DISEASE

Increase in HDAC9 suppresses myoblast differentiation via epigenetic regulation of autophagy in hypoxia

(2019) Zhang Zhang et al.   Cell Death & Disease

Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing

(2019) Farah H. Siddiqi et al.   Nature Communications

Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB

(2019) Yusha Wang et al.   EMBO REPORTS

Induction of Apoptosis and Autophagy in Breast Cancer Cells by a Novel HDAC8 Inhibitor

(2019) Chang-Fang Chiu et al.   Biomolecules

The ATG conjugation systems in autophagy

(2019) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Frontal Cortex Epigenetic Dysregulation During the Progression of Alzheimer’s Disease

(2018) Laura Mahady et al.   JOURNAL OF ALZHEIMERS DISEASE

Restoring Tip60 HAT/HDAC2 Balance in the Neurodegenerative Brain Relieves Epigenetic Transcriptional Repression and Reinstates Cognition

(2018) Priyalakshmi Panikker et al.   JOURNAL OF NEUROSCIENCE

Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

(2018) Sung Min Son et al.   Cell Metabolism

Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells

(2018) Sara Iachettini et al.   Cell Death & Disease

SIRT5-mediated deacetylation of LDHB promotes autophagy and tumorigenesis in colorectal cancer

(2018) Liang Shi et al.   Molecular Oncology

The many lives of KATs — detectors, integrators and modulators of the cellular environment

(2018) Bilal N. Sheikh et al.   NATURE REVIEWS GENETICS

Functions and mechanisms of non-histone protein acetylation

(2018) Takeo Narita et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of HDAC3 reverses Alzheimer’s disease-related pathologies in vitro and in the 3xTg-AD mouse model

(2018) Karolina J. Janczura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Proteome-wide acetylation dynamics in human cells

(2017) Yekaterina Kori et al.   Scientific Reports

Mammalian Autophagy: How Does It Work?

(2016) Carla F. Bento et al.   Annual Review of Biochemistry

The world of protein acetylation

(2016) Adrian Drazic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders

(2016) Henryk Jęśko et al.   NEUROCHEMICAL RESEARCH

P300/CBP-associated factor (PCAF) inhibits the growth of hepatocellular carcinoma by promoting cell autophagy

(2016) Yu-Li Jia et al.   Cell Death & Disease

The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins

(2016) Michael N. Davies et al.   Cell Reports

Sirtuins: double players in Huntington's disease

(2015) Luana Naia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Therapeutic targeting of autophagy in neurodegenerative and infectious diseases

(2015) David C. Rubinsztein et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ApoE4 and A  Oligomers Reduce BDNF Expression via HDAC Nuclear Translocation

(2015) A. Sen et al.   JOURNAL OF NEUROSCIENCE

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

(2015) Rui Huang et al.   MOLECULAR CELL

HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor Entities

(2015) Emily Koeneke et al.   Cells

Assembly and Interrogation of Alzheimer’s Disease Genetic Networks Reveal Novel Regulators of Progression

(2015) Soline Aubry et al.   PLoS One

Mitochondrial protein acetylation is driven by acetyl-CoA from fatty acid oxidation

(2014) Olga Pougovkina et al.   HUMAN MOLECULAR GENETICS

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone Deacetylase HDAC4 Promotes Gastric Cancer SGC-7901 Cells Progression via p21 Repression

(2014) Zhen-Hua Kang et al.   PLoS One

Histone Acetyltransferase p300 Mediates Histone Acetylation of PS1 and BACE1 in a Cellular Model of Alzheimer's Disease

(2014) Xi Lu et al.   PLoS One

The emerging role of acetylation in the regulation of autophagy

(2013) Ágnes Bánréti et al.   Autophagy

LC3B-II deacetylation by histone deacetylase 6 is involved in serum-starvation-induced autophagic degradation

(2013) Kun-Peng Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS

(2013) Ines Taes et al.   HUMAN MOLECULAR GENETICS

HDAC6 Regulates Mutant SOD1 Aggregation through Two SMIR Motifs and Tubulin Acetylation

(2013) Jozsef Gal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic association of the ULK1 complex with omegasomes during autophagy induction

(2013) E. Karanasios et al.   JOURNAL OF CELL SCIENCE

The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy

(2013) Jens Füllgrabe et al.   NATURE

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Histone deacetylase 10 promotes autophagy-mediated cell survival

(2013) I. Oehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies

(2012) David J. Irwin et al.   BRAIN

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

(2012) Nambirajan Govindarajan et al.   EMBO Molecular Medicine

Histone deacetylase 6 functions as a tumor suppressor by activating c-Jun NH2-terminal kinase-mediated beclin 1-dependent autophagic cell death in liver cancer

(2012) Kwang Hwa Jung et al.   HEPATOLOGY

SIRT1 Protects against  -Synuclein Aggregation by Activating Molecular Chaperones

(2012) G. Donmez et al.   JOURNAL OF NEUROSCIENCE

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tip60 HAT Activity Mediates APP Induced Lethality and Apoptotic Cell Death in the CNS of a Drosophila Alzheimer's Disease Model

(2012) Sheila K. Pirooznia et al.   PLoS One

Histone deacetylases 1 and 2 regulate autophagy flux and skeletal muscle homeostasis in mice

(2012) V. Moresi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

(2012) S.-Y. Lin et al.   SCIENCE

Protein N-terminal acetyltransferases: when the start matters

(2012) Kristian K. Starheim et al.   TRENDS IN BIOCHEMICAL SCIENCES

A comprehensive glossary of autophagy-related molecules and processes (2ndedition)

(2011) Daniel J Klionsky et al.   Autophagy

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity

(2011) A. Giralt et al.   HUMAN MOLECULAR GENETICS

Suppression of aggregate formation of mutant huntingtin potentiates CREB-binding protein sequestration and apoptotic cell death

(2011) Yong-Joon Choi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

(2011) Mali Jiang et al.   NATURE MEDICINE

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway

(2011) Hyunkyung Jeong et al.   NATURE MEDICINE

Pcaf Modulates Polyglutamine Pathology in a Drosophila Model of Huntington’s Disease

(2011) Laszlo Bodai et al.   Neurodegenerative Diseases

Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy

(2011) D. J. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased SOD1 association with chromatin, DNA damage, p53 activation, and apoptosis in a cellular model of SOD1-linked ALS

(2010) Livea F. Barbosa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

microRNA-dependent modulation of histone acetylation in Waldenstrom macroglobulinemia

(2010) A. M. Roccaro et al.   BLOOD

Effects of Longevinex (modified resveratrol) on cardioprotection and its mechanisms of action

(2010) Subhendu Mukherjee et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

(2010) Nirmala Hariharan et al.   CIRCULATION RESEARCH

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

(2010) Joo-Yong Lee et al.   EMBO JOURNAL

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

(2010) C. Rose et al.   HUMAN MOLECULAR GENETICS

Amyotrophic Lateral Sclerosis-associated Proteins TDP-43 and FUS/TLS Function in a Common Biochemical Complex to Co-regulate HDAC6 mRNA

(2010) Sang Hwa Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical and Functional HAT/HDAC Interplay Regulates Protein Acetylation Balance

(2010) Alessia Peserico et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Differential Histone Deacetylase mRNA Expression Patterns in Amyotrophic Lateral Sclerosis

(2010) Claas Janssen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

(2010) Ying Zhao et al.   NATURE CELL BIOLOGY

Mice knock out for the histone acetyltransferase p300/CREB binding protein-associated factor develop a resistance to amyloid toxicity

(2010) F. Duclot et al.   NEUROSCIENCE

CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease

(2010) A. Caccamo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

(2010) Ruth Luthi-Carter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3

(2009) Fiona M. Menzies et al.   BRAIN

Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

(2009) Hyunkyung Jeong et al.   CELL

Elongator Controls the Migration and Differentiation of Cortical Neurons through Acetylation of α-Tubulin

(2009) Catherine Creppe et al.   CELL

Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

(2009) Fabienne C Fiesel et al.   EMBO JOURNAL

Phosphodiesterase type IV inhibition prevents sequestration of CREB binding protein, protects striatal parvalbumin interneurons and rescues motor deficits in the R6/2 mouse model of Huntington’s disease

(2009) Carmela Giampà et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Regulation of Autophagy by the p300 Acetyltransferase

(2009) In Hye Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian macroautophagy at a glance

(2009) B. Ravikumar et al.   JOURNAL OF CELL SCIENCE

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

Genomic investigation of α-synuclein multiplication and parkinsonism

(2008) Owen A. Ross et al.   ANNALS OF NEUROLOGY

Inhibition of histone deacetylase1 induces autophagy

(2008) Meeyeon Oh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

Histone deacetylase 6 interacts with the microtubule-associated protein tau

(2008) Huiping Ding et al.   JOURNAL OF NEUROCHEMISTRY

Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease

(2008) Carl Julien et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

SAHA induces caspase-independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathway

(2008) A Hrzenjak et al.   JOURNAL OF PATHOLOGY

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

(2008) Dohoon Kim et al.   NEURON

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA