Functional mechanisms and abnormalities of the nuclear lamina

Local rewiring of genome–nuclear lamina interactions by transcription

(2020) Laura Brueckner et al.   EMBO JOURNAL

Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria

(2020) Kohta Ikegami et al.   DEVELOPMENTAL CELL

LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation

(2020) Alexander von Appen et al.   NATURE

Mechanisms generating cancer genome complexity from a single cell division error

(2020) Neil T. Umbreit et al.   SCIENCE

Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome

(2020) Florian Köhler et al.   Genome Medicine

Nuclear Membrane Rupture and Its Consequences

(2020) John Maciejowski et al.   Annual Review of Cell and Developmental Biology

R-Loops Enhance Polycomb Repression at a Subset of Developmental Regulator Genes

(2019) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

Nuclear accumulation of UBC9 contributes to SUMOylation of lamin A/C and nucleophagy in response to DNA damage

(2019) Yunong Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Promoter-Intrinsic and Local Chromatin Features Determine Gene Repression in LADs

(2019) Christ Leemans et al.   CELL

Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest

(2019) Sangkyun Cho et al.   DEVELOPMENTAL CELL

Genome–lamina interactions are established de novo in the early mouse embryo

(2019) Máté Borsos et al.   NATURE

The Role of Transcription Factors and Nuclear Pore Proteins in Controlling the Spatial Organization of the Yeast Genome

(2019) Donna Garvey Brickner et al.   DEVELOPMENTAL CELL

Chromatin targeting of nuclear pore proteins induces chromatin decondensation

(2019) Terra M. Kuhn et al.   JOURNAL OF CELL BIOLOGY

Heterochromatin drives compartmentalization of inverted and conventional nuclei

(2019) Martin Falk et al.   NATURE

H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis

(2019) Andrey Poleshko et al.   eLife

The liquid state of FG-nucleoporins mimics permeability barrier properties of nuclear pore complexes

(2019) Giorgia Celetti et al.   JOURNAL OF CELL BIOLOGY

Core Components of the Nuclear Pore Bind Distinct States of Chromatin and Contribute to Polycomb Repression

(2019) Alejandro Gozalo et al.   MOLECULAR CELL

The NSL complex maintains nuclear architecture stability via lamin A/C acetylation

(2019) Adam Karoutas et al.   NATURE CELL BIOLOGY

Nuclear Lamin B1 Interactions With Chromatin During the Circadian Cycle Are Uncoupled From Periodic Gene Expression

(2019) Annaël Brunet et al.   Frontiers in Genetics

Smurf2 regulates stability and the autophagic-lysosomal turnover of lamin A and its disease-associated form progerin

(2018) Aurora Paola Borroni et al.   AGING CELL

Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal

(2018) Thomas J. Mitchell et al.   CELL

Nuclear envelope rupture: little holes, big openings

(2018) Emily M .Hatch   CURRENT OPINION IN CELL BIOLOGY

Lamins Organize the Global Three-Dimensional Genome from the Nuclear Periphery

(2018) Xiaobin Zheng et al.   MOLECULAR CELL

DNA methylation loss in late-replicating domains is linked to mitotic cell division

(2018) Wanding Zhou et al.   NATURE GENETICS

Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin

(2018) Manuel Rodríguez-Paredes et al.   Nature Communications

OGT (O-GlcNAc Transferase) Selectively Modifies Multiple Residues Unique to Lamin A

(2018) Dan Simon et al.   Cells

Nuclear envelope assembly defects link mitotic errors to chromothripsis

(2018) Shiwei Liu et al.   NATURE

PP2A-B55 promotes nuclear envelope reformation after mitosis in Drosophila

(2018) Haytham Mehsen et al.   JOURNAL OF CELL BIOLOGY

Massive reshaping of genome–nuclear lamina interactions during oncogene-induced senescence

(2017) Christelle Lenain et al.   GENOME RESEARCH

Lamins in the nuclear interior − life outside the lamina

(2017) Nana Naetar et al.   JOURNAL OF CELL SCIENCE

Phase separation drives heterochromatin domain formation

(2017) Amy R. Strom et al.   NATURE

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

(2017) Adam G. Larson et al.   NATURE

Identification of H3K4me1-associated proteins at mammalian enhancers

(2017) Andrea Local et al.   NATURE GENETICS

Nuclear topology modulates the mutational landscapes of cancer genomes

(2017) Kyle S Smith et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis

(2017) Peter Ly et al.   TRENDS IN CELL BIOLOGY

Nuclear topology modulates the mutational landscapes of cancer genomes

(2017) Kyle S Smith et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

(2016) Alejandro Ocampo et al.   CELL

Epigenetic transcriptional memory

(2016) Agustina D’Urso et al.   CURRENT GENETICS

The genomic characteristics and cellular origin of chromothripsis

(2016) Zuzana Storchová et al.   CURRENT OPINION IN CELL BIOLOGY

Causes and consequences of nuclear envelope alterations in tumour progression

(2016) Emily S. Bell et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Nucleoporin-mediated regulation of cell identity genes

(2016) Arkaitz Ibarra et al.   GENES & DEVELOPMENT

A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha

(2016) Kevin Gesson et al.   GENOME RESEARCH

Nuclear envelope rupture is induced by actin-based nucleus confinement

(2016) Emily M. Hatch et al.   JOURNAL OF CELL BIOLOGY

A Disease or Not a Disease? Aging As a Pathology

(2016) Timothy V. Gladyshev et al.   TRENDS IN MOLECULAR MEDICINE

Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory

(2016) Agustina D'Urso et al.   eLife

Anchoring a Leviathan: How the Nuclear Membrane Tethers the Genome

(2016) Rafal Czapiewski et al.   Frontiers in Genetics

Chromothripsis: A New Mechanism for Rapid Karyotype Evolution

(2015) Mitchell L. Leibowitz et al.   Annual Review of Genetics

Nuclear lamins are not required for lamina-associated domain organization in mouse embryonic stem cells

(2015) M. Amendola et al.   EMBO REPORTS

The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing

(2015) Filipe V. Jacinto et al.   GENES & DEVELOPMENT

Nuclear pore proteins and the control of genome functions

(2015) Arkaitz Ibarra et al.   GENES & DEVELOPMENT

Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins

(2015) Jennifer C. Harr et al.   JOURNAL OF CELL BIOLOGY

Identification of lamin B–regulated chromatin regions based on chromatin landscapes

(2015) Xiaobin Zheng et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

Nuclear architecture dictates HIV-1 integration site selection

(2015) Bruna Marini et al.   NATURE

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Acetylation site specificities of lysine deacetylase inhibitors in human cells

(2015) Christian Schölz et al.   NATURE BIOTECHNOLOGY

Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles

(2015) William M. Aumiller et al.   Nature Chemistry

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair

(2015) Shrestha Ghosh et al.   Cell Reports

Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin

(2015) Amy R Vandiver et al.   GENOME BIOLOGY

Distinct features of lamin A-interacting chromatin domains mapped by ChIP-sequencing from sonicated or micrococcal nuclease-digested chromatin

(2015) Eivind G Lund et al.   Nucleus

Distinct features of lamin A-interacting chromatin domains mapped by ChIP-sequencing from sonicated or micrococcal nuclease-digested chromatin

(2015) Eivind G Lund et al.   Nucleus

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

(2014) Amnon Buxboim et al.   CURRENT BIOLOGY

Nuclear position dictates DNA repair pathway choice

(2014) Charlène Lemaître et al.   GENES & DEVELOPMENT

Breaching the nuclear envelope in development and disease

(2014) Emily Hatch et al.   JOURNAL OF CELL BIOLOGY

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

Interphase phosphorylation of lamin A

(2014) V. Kochin et al.   JOURNAL OF CELL SCIENCE

Chromatin decondensation is sufficient to alter nuclear organization in embryonic stem cells

(2014) Pierre Therizols et al.   SCIENCE

Nucleoporin Nup98 Associates with Trx/MLL and NSL Histone-Modifying Complexes and Regulates Hox Gene Expression

(2014) Pau Pascual-Garcia et al.   Cell Reports

MOF-associated complexes ensure stem cell identity and Xist repression

(2014) Tomasz Chelmicki et al.   eLife

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Chromatin Position Effects Assayed by Thousands of Reporters Integrated in Parallel

(2013) Waseem Akhtar et al.   CELL

Single-Cell Dynamics of Genome-Nuclear Lamina Interactions

(2013) Jop Kind et al.   CELL

Criteria for Inference of Chromothripsis in Cancer Genomes

(2013) Jan O. Korbel et al.   CELL

When Lamins Go Bad: Nuclear Structure and Disease

(2013) Katherine H. Schreiber et al.   CELL

Partners and post-translational modifications of nuclear lamins

(2013) Dan N. Simon et al.   CHROMOSOMA

Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements

(2013) C.-Z. Zhang et al.   GENES & DEVELOPMENT

β-Globin cis-elements determine differential nuclear targeting through epigenetic modifications

(2013) Qian Bian et al.   JOURNAL OF CELL BIOLOGY

Emerin in health and disease

(2013) Adam J. Koch et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A Conserved Role for Human Nup98 in Altering Chromatin Structure and Promoting Epigenetic Transcriptional Memory

(2013) William H. Light et al.   PLOS BIOLOGY

Chromothripsis and Focal Copy Number Alterations Determine Poor Outcome in Malignant Melanoma

(2012) D. Hirsch et al.   CANCER RESEARCH

Lamin A/C protein is overexpressed in tissue-invading prostate cancer and promotes prostate cancer cell growth, migration and invasion through the PI3K/AKT/PTEN pathway

(2012) Lu Kong et al.   CARCINOGENESIS

Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome

(2012) R. P. McCord et al.   GENOME RESEARCH

Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence

(2012) W. Meuleman et al.   GENOME RESEARCH

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Lamin A tail modification by SUMO1 is disrupted by familial partial lipodystrophy–causing mutations

(2012) Dan N. Simon et al.   MOLECULAR BIOLOGY OF THE CELL

Nuclear pore complex composition: a new regulator of tissue-specific and developmental functions

(2012) Marcela Raices et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets

(2012) J. F. Alfaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear lamin functions and disease

(2012) Veronika Butin-Israeli et al.   TRENDS IN GENETICS

Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation

(2011) Vanja Pekovic et al.   AGING CELL

Cancer Genomes Evolve by Pulverizing Single Chromosomes

(2011) Matthew Meyerson et al.   CELL

The role of nuclear lamin B1 in cell proliferation and senescence

(2011) T. Shimi et al.   GENES & DEVELOPMENT

Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains

(2011) Benjamin P Berman et al.   NATURE GENETICS

The lamin protein family

(2011) Travis A Dittmer et al.   GENOME BIOLOGY

Lamin A and lamin C form homodimers and coexist in higher complex forms both in the nucleoplasmic fraction and in the lamina of cultured human cells

(2011) Thorsten Kolb et al.   Nucleus

Posttranslational arginine methylation of lamin A/C during myoblast fusion

(2010) Su-Jin Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Chromatin-Bound Nuclear Pore Components Regulate Gene Expression in Higher Eukaryotes

(2010) Maya Capelson et al.   CELL

Nucleoporins Directly Stimulate Expression of Developmental and Cell-Cycle Genes Inside the Nucleoplasm

(2010) Bernike Kalverda et al.   CELL

Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion

(2010) Sandra Krull et al.   EMBO JOURNAL

Phosphorylation statuses at different residues of lamin B2, B1, and A/C dynamically and independently change throughout the cell cycle

(2010) Takahisa Kuga et al.   EXPERIMENTAL CELL RESEARCH

Interaction of a DNA Zip Code with the Nuclear Pore Complex Promotes H2A.Z Incorporation and INO1 Transcriptional Memory

(2010) William H. Light et al.   MOLECULAR CELL

Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells

(2010) Michael H. A. Schmitz et al.   NATURE CELL BIOLOGY

Nuclear Pore Proteins Nup153 and Megator Define Transcriptionally Active Regions in the Drosophila Genome

(2010) Juan M. Vaquerizas et al.   PLoS Genetics

Gene loops function to maintain transcriptional memory through interaction with the nuclear pore complex

(2009) Sue Mei Tan-Wong et al.   GENES & DEVELOPMENT

Role of A-type lamins in signaling, transcription, and chromatin organization

(2009) Vicente Andrés et al.   JOURNAL OF CELL BIOLOGY

Ageing-related chromatin defects through loss of the NURD complex

(2009) Gianluca Pegoraro et al.   NATURE CELL BIOLOGY

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

(2009) E. Lieberman-Aiden et al.   SCIENCE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies

(2008) Yu-Qian Zhang et al.   JOURNAL OF CELL BIOLOGY

A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence

(2008) R. Ileng Kumaran et al.   JOURNAL OF CELL BIOLOGY

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

(2008) Lars Guelen et al.   NATURE

Transcriptional repression mediated by repositioning of genes to the nuclear lamina

(2008) K. L. Reddy et al.   NATURE

Loss of nucleoplasmic LAP2α–lamin A complexes causes erythroid and epidermal progenitor hyperproliferation

(2008) Nana Naetar et al.   NATURE CELL BIOLOGY

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY