The emerging picture of CDK9/P-TEFb: more than 20 years of advances since PITALRE

Synthesis, structure-activity relationship studies and biological evaluation of novel 2,5-disubstituted indole derivatives as anticancer agents

(2016) Hongyu Hu et al.   Chemical Biology & Drug Design

Targeting CDK9: a promising therapeutic opportunity in prostate cancer

(2016) Muhammed H Rahaman et al.   ENDOCRINE-RELATED CANCER

Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy

(2016) Yogesh A. Sonawane et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of tumor-associated macrophages in the Hexim1 and TGFβ/SMAD pathway, and their influence on progression of prostatic adenocarcinoma

(2016) Alev Ok Atılgan et al.   PATHOLOGY RESEARCH AND PRACTICE

Inhibition of cyclin dependent kinase 9 by dinaciclib suppresses cyclin B1 expression and tumor growth in triple negative breast cancer

(2016) Sandeep Rajput et al.   Oncotarget

The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia

(2015) A. Baker et al.   CANCER RESEARCH

CDK11 in TREX/THOC Regulates HIV mRNA 3′ End Processing

(2015) Vladimir Pak et al.   Cell Host & Microbe

Dual Inhibition of Cdc7 and Cdk9 by PHA-767491 Suppresses Hepatocarcinoma Synergistically with 5-Fluorouracil

(2015) Wei Li et al.   CURRENT CANCER DRUG TARGETS

The impact of CDK9 on radiosensitivity, DNA damage repair and cell cycling of HNSCC cancer cells

(2015) KATJA STORCH et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo

(2015) G P Gregory et al.   LEUKEMIA

Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia

(2015) Yuh-Ying Yeh et al.   Oncotarget

MicroRNA-874 inhibits cell proliferation and induces apoptosis in human breast cancer by targeting CDK9

(2014) Ling Wang et al.   FEBS LETTERS

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma

(2014) Chun-Hao Huang et al.   GENES & DEVELOPMENT

A Novel CDK9 Inhibitor Shows Potent Antitumor Efficacy in Preclinical Hematologic Tumor Models

(2014) T. Yin et al.   MOLECULAR CANCER THERAPEUTICS

Cyclin dependent kinase-9 mediated transcriptional de-regulation of cMYC as a critical determinant of endocrine-therapy resistance in breast cancers

(2013) Surojeet Sengupta et al.   BREAST CANCER RESEARCH AND TREATMENT

Selective CDK9 inhibition overcomes TRAIL resistance by concomitant suppression of cFlip and Mcl-1

(2013) J Lemke et al.   CELL DEATH AND DIFFERENTIATION

Adenovirus L-E1A Activates Transcription through Mediator Complex-Dependent Recruitment of the Super Elongation Complex

(2013) S. Vijayalingam et al.   JOURNAL OF VIROLOGY

Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4+ T Lymphocytes

(2013) Uri R. Mbonye et al.   PLoS Pathogens

The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat

(2013) Ursula Schulze-Gahmen et al.   eLife

Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implications for drug design and development

(2012) Valentina Caracciolo et al.   CELL CYCLE

Perspective of Cyclin-dependent kinase 9 (CDK9) as a Drug Target

(2012) Vladimir Krystof et al.   CURRENT PHARMACEUTICAL DESIGN

AZD5438, an Inhibitor of Cdk1, 2, and 9, Enhances the Radiosensitivity of Non-Small Cell Lung Carcinoma Cells

(2012) Pavithra Raghavan et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Androgen Receptor Serine 81 Phosphorylation Mediates Chromatin Binding and Transcriptional Activation

(2012) Shaoyong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II

(2012) Stéphane Larochelle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Estrogen receptor-α recruits P-TEFb to overcome transcriptional pausing in intron 1 of the MYB gene

(2012) Partha Mitra et al.   NUCLEIC ACIDS RESEARCH

Formation of Trans-Activation Competent HIV-1 Rev:RRE Complexes Requires the Recruitment of Multiple Protein Activation Domains

(2012) Dirk Hoffmann et al.   PLoS One

CDK2 Regulates HIV-1 Transcription by Phosphorylation of CDK9 on Serine 90

(2012) Denitra Breuer et al.   Retrovirology

The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor b

(2012) Sonja Baumli et al.   STRUCTURE

Cyclin K goes with Cdk12 and Cdk13

(2012) Jiri Kohoutek et al.   Cell Division

Serine-7 but not serine-5 phosphorylation primes RNA polymerase II CTD for P-TEFb recognition

(2012) Nadine Czudnochowski et al.   Nature Communications

A role for cdk9-cyclin k in maintaining genome integrity

(2011) David S. Yu et al.   CELL CYCLE

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

(2011) D. Blazek et al.   GENES & DEVELOPMENT

Insights into the Phosphoryl Transfer Mechanism of Cyclin-Dependent Protein Kinases from ab Initio QM/MM Free-Energy Studies

(2011) Gregory K. Smith et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Cyclin-dependent kinase inhibitor, P276-00 induces apoptosis in multiple myeloma cells by inhibition of Cdk9-T1 and RNA polymerase II-dependent transcription

(2011) Sonal M. Manohar et al.   LEUKEMIA RESEARCH

Protein Phosphatase-1 Activates CDK9 by Dephosphorylating Ser175

(2011) Tatiana Ammosova et al.   PLoS One

Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin

(2011) N. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

55K isoform of CDK9 associates with Ku70 and is involved in DNA repair

(2010) Hongbing Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases

(2010) Gaetano Romano et al.   CELL CYCLE

Positive transcription elongation factor b (P-TEFb) contributes to dengue virus-stimulated induction of interleukin-8 (IL-8)

(2010) Li-li Li et al.   CELLULAR MICROBIOLOGY

Halogen Bonds Form the Basis for Selective P-TEFb Inhibition by DRB

(2010) Sonja Baumli et al.   CHEMISTRY & BIOLOGY

CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1

(2010) B. Bartkowiak et al.   GENES & DEVELOPMENT

P-TEFb Kinase Complex Phosphorylates Histone H1 to Regulate Expression of Cellular and HIV-1 Genes

(2010) Siobhan K. O'Brien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Proteomics Based on18O Labeling to Determine the Cyclin Dependent Kinase 9 Interactome

(2010) Karel Bezstarosti et al.   JOURNAL OF PROTEOME RESEARCH

Cyclin T1/CDK9 Interacts with Influenza A Virus Polymerase and Facilitates Its Association with Cellular RNA Polymerase II

(2010) J. Zhang et al.   JOURNAL OF VIROLOGY

HIV-1 Tat and Host AFF4 Recruit Two Transcription Elongation Factors into a Bifunctional Complex for Coordinated Activation of HIV-1 Transcription

(2010) Nanhai He et al.   MOLECULAR CELL

CDK9 Regulates AR Promoter Selectivity and Cell Growth through Serine 81 Phosphorylation

(2010) Vicki Gordon et al.   MOLECULAR ENDOCRINOLOGY

Crystal structure of HIV-1 Tat complexed with human P-TEFb

(2010) Tahir H. Tahirov et al.   NATURE

Chemical-genomic dissection of the CTD code

(2010) Joshua R Tietjen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cooperative interaction of transcription termination factors with the RNA polymerase II C-terminal domain

(2010) Bradley M Lunde et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of Hox Gene Activity by Transcriptional Elongation in Drosophila

(2009) Vivek S. Chopra et al.   CURRENT BIOLOGY

CDK9/cyclin complexes modulate endoderm induction by direct interaction with Mix.3/mixer

(2009) Haiqing Zhu et al.   DEVELOPMENTAL DYNAMICS

Phosphorylation of the Yeast Rpb1 C-terminal Domain at Serines 2, 5, and 7

(2009) Minkyu Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective control of gene expression by CDK9 in human cells

(2009) Judit Garriga et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Recruitment of cdk9 to the Immediate-Early Viral Transcriptosomes during Human Cytomegalovirus Infection Requires Efficient Binding to Cyclin T1, a Threshold Level of IE2 86, and Active Transcription

(2009) A. J. Kapasi et al.   JOURNAL OF VIROLOGY

TFIIH-Associated Cdk7 Kinase Functions in Phosphorylation of C-Terminal Domain Ser7 Residues, Promoter-Proximal Pausing, and Termination by RNA Polymerase II

(2009) K. Glover-Cutter et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation of the Transcription Elongation Factor Spt5 by Yeast Bur1 Kinase Stimulates Recruitment of the PAF Complex

(2009) Y. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Functional Evolution of Cyclin-Dependent Kinases

(2009) John H. Doonan et al.   MOLECULAR BIOTECHNOLOGY

The Ess1 Prolyl Isomerase Is Required for Transcription Termination of Small Noncoding RNAs via the Nrd1 Pathway

(2009) Navjot Singh et al.   MOLECULAR CELL

Rtr1 Is a CTD Phosphatase that Regulates RNA Polymerase II during the Transition from Serine 5 to Serine 2 Phosphorylation

(2009) Amber L. Mosley et al.   MOLECULAR CELL

Progression through the RNA Polymerase II CTD Cycle

(2009) Stephen Buratowski   MOLECULAR CELL

Cyclin-dependent kinases: a family portrait

(2009) Marcos Malumbres et al.   NATURE CELL BIOLOGY

P-TEFb- the final frontier

(2009) Jiri Kohoutek   Cell Division

The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation

(2008) Sonja Baumli et al.   EMBO JOURNAL

The Bromodomain Protein Brd4 Stimulates G1Gene Transcription and Promotes Progression to S Phase

(2008) Kazuki Mochizuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatase PPM1A Regulates Phosphorylation of Thr-186 in the Cdk9 T-loop

(2008) Yan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of cdk9 in the Optimization of Expression of the Genes Regulated by ICP22 of Herpes Simplex Virus 1

(2008) L. O. Durand et al.   JOURNAL OF VIROLOGY

Bromodomain Protein Brd4 Regulates Human Immunodeficiency Virus Transcription through Phosphorylation of CDK9 at Threonine 29

(2008) M. Zhou et al.   JOURNAL OF VIROLOGY

Acetylation of Conserved Lysines in the Catalytic Core of Cyclin-Dependent Kinase 9 Inhibits Kinase Activity and Regulates Transcription

(2008) A. Sabo et al.   MOLECULAR AND CELLULAR BIOLOGY

Poised Polymerases: On Your Mark…Get Set…Go!

(2008) David H. Price   MOLECULAR CELL

Drosophila Pgc protein inhibits P-TEFb recruitment to chromatin in primordial germ cells

(2008) Kazuko Hanyu-Nakamura et al.   NATURE

TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb

(2008) A. Gegonne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA