Chromatin as a key consumer in the metabolite economy

Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3

(2019) Lorna A. Farrelly et al.   NATURE

Role of Advanced Glycation End-products in Carcinogenesis and their Therapeutic Implications

(2019) David Schröter et al.   CURRENT PHARMACEUTICAL DESIGN

Acetylation & Co: an expanding repertoire of histone acylations regulates chromatin and transcription

(2019) Claire E. Barnes et al.   Essays in Biochemistry

Biogenic Amines: Signals Between Commensal Microbiota and Gut Physiology

(2019) Nobuyuki Sudo   Frontiers in Endocrinology

Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics

(2019) Xiucong Bao et al.   MOLECULAR CELL

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Chromatin and Metabolism

(2018) Tamaki Suganuma et al.   Annual Review of Biochemistry

Metabolic regulation of chromatin modifications and gene expression

(2018) Juan Manuel Schvartzman et al.   JOURNAL OF CELL BIOLOGY

p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis

(2018) He Huang et al.   MOLECULAR CELL

Regulation of chromatin and gene expression by metabolic enzymes and metabolites

(2018) Xinjian Li et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic regulation of transcription through compartmentalized NAD+biosynthesis

(2018) Keun Woo Ryu et al.   SCIENCE

Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation

(2018) Sharanya Sivanand et al.   TRENDS IN BIOCHEMICAL SCIENCES

Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks

(2018) James J. Galligan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Supramolecular assembly of KAT2A with succinyl-CoA for histone succinylation

(2018) Yugang Wang et al.   Cell Discovery

Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks

(2018) Eric C. Greenwald et al.   CHEMICAL REVIEWS

Beyond histone acetylation—writing and erasing histone acylations

(2018) Shuai Zhao et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A Metabolic Function for Phospholipid and Histone Methylation

(2017) Cunqi Ye et al.   MOLECULAR CELL

Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis

(2017) Shumeng Liu et al.   MOLECULAR CELL

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination

(2017) Sharanya Sivanand et al.   MOLECULAR CELL

Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction

(2017) Weier Qi et al.   NATURE MEDICINE

Histone propionylation is a mark of active chromatin

(2017) Adam F Kebede et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Guanine glycation repair by DJ-1/Park7 and its bacterial homologs

(2017) Gilbert Richarme et al.   SCIENCE

Characterization of histone acylations links chromatin modifications with metabolism

(2017) Johayra Simithy et al.   Nature Communications

Histone propionylation is a mark of active chromatin

(2017) Adam F Kebede et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation

(2017) Vinay Bulusu et al.   Cell Reports

Histone Adduction and Its Functional Impact on Epigenetics

(2016) James J. Galligan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Quantifying the Influence of the Crowded Cytoplasm on Small Molecule Diffusion

(2016) Peter M. Kekenes-Huskey et al.   JOURNAL OF PHYSICAL CHEMISTRY B

SIRT2 Reverses 4-Oxononanoyl Lysine Modification on Histones

(2016) Jing Jin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

(2016) Zhongyu Xie et al.   MOLECULAR CELL

Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters

(2016) Afsaneh Goudarzi et al.   MOLECULAR CELL

Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain

(2016) Yuanyuan Li et al.   MOLECULAR CELL

Structure of p300 in complex with acyl-CoA variants

(2016) Zuzanna Kaczmarska et al.   Nature Chemical Biology

Metabolic regulation of gene expression through histone acylations

(2016) Benjamin R. Sabari et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis?

(2016) Roman M. Stilling et al.   NEUROCHEMISTRY INTERNATIONAL

Epigenetics and Human Disease

(2016) Huda Y. Zoghbi et al.   Cold Spring Harbor Perspectives in Biology

Structural basis for acyl-group discrimination by human Gcn5L2

(2016) Alison E. Ringel et al.   Acta Crystallographica Section D-Structural Biology

Accumulation of isolevuglandin-modified protein in normal and fibrotic lung

(2016) Stacey Mont et al.   Scientific Reports

Site-Specific Reactivity of Nonenzymatic Lysine Acetylation

(2015) Josue Baeza et al.   ACS Chemical Biology

DJ-1 as a human oncogene and potential therapeutic target

(2015) Ji Cao et al.   BIOCHEMICAL PHARMACOLOGY

Nutrient-Sensing Mechanisms across Evolution

(2015) Lynne Chantranupong et al.   CELL

Metabolic pathway compartmentalization: an underappreciated opportunity?

(2015) Annalisa Zecchin et al.   CURRENT OPINION IN BIOTECHNOLOGY

The nuclear pore complex - structure and function at a glance

(2015) G. Kabachinski et al.   JOURNAL OF CELL SCIENCE

High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet

(2015) Xiaojing Liu et al.   MOLECULAR & CELLULAR PROTEOMICS

Serine and SAM Responsive Complex SESAME Regulates Histone Modification Crosstalk by Sensing Cellular Metabolism

(2015) Shanshan Li et al.   MOLECULAR CELL

Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation

(2015) Benjamin R. Sabari et al.   MOLECULAR CELL

Critical Role of Histone Turnover in Neuronal Transcription and Plasticity

(2015) Ian Maze et al.   NEURON

Nuclear pyruvate kinase M2 complex serves as a transcriptional coactivator of arylhydrocarbon receptor

(2015) Shun Matsuda et al.   NUCLEIC ACIDS RESEARCH

3-Deoxyglucosone: A Potential Glycating Agent Accountable for Structural Alteration in H3 Histone Protein through Generation of Different AGEs

(2015) Jalaluddin M. Ashraf et al.   PLoS One

Methylglyoxal, the dark side of glycolysis

(2015) Igor Allaman et al.   Frontiers in Neuroscience

Levuglandin Forms Adducts with Histone H4 in a Cyclooxygenase-2-Dependent Manner, Altering Its Interaction with DNA

(2014) Erica J. Carrier et al.   BIOCHEMISTRY

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation

(2014) Joyce V. Lee et al.   Cell Metabolism

Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

(2014) Minjia Tan et al.   Cell Metabolism

Physicochemical analysis of structural alteration and advanced glycation end products generation during glycation of H2A histone by 3-deoxyglucosone

(2014) Jalaluddin M. Ashraf et al.   IUBMB LIFE

The Undernourished Neonatal Mouse Metabolome Reveals Evidence of Liver and Biliary Dysfunction, Inflammation, and Oxidative Stress

(2014) Geoffrey A. Preidis et al.   JOURNAL OF NUTRITION

Stable Histone Adduction by 4-Oxo-2-nonenal: A Potential Link between Oxidative Stress and Epigenetics

(2014) James J. Galligan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark

(2014) Lunzhi Dai et al.   Nature Chemical Biology

The Warburg effect then and now: From cancer to inflammatory diseases

(2013) Eva M. Palsson-McDermott et al.   BIOESSAYS

High-fat diet induces changes in adipose tissue trans-4-oxo-2-nonenal and trans-4-hydroxy-2-nonenal levels in a depot-specific manner

(2013) Eric K. Long et al.   FREE RADICAL BIOLOGY AND MEDICINE

Widespread and Enzyme-independentNϵ-Acetylation andNϵ-Succinylation of Proteins in the Chemical Conditions of the Mitochondrial Matrix

(2013) Gregory R. Wagner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncometabolites: linking altered metabolism with cancer

(2013) Ming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Transglutaminase-mediated transamidation of serotonin, dopamine and noradrenaline to fibronectin: Evidence for a general mechanism of monoaminylation

(2012) René Hummerich et al.   FEBS LETTERS

Lysine Succinylation and Lysine Malonylation in Histones

(2012) Zhongyu Xie et al.   MOLECULAR & CELLULAR PROTEOMICS

Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation

(2012) N. Shyh-Chang et al.   SCIENCE

Glycation and oxidation of histones H2B and H1: in vitro study and characterization by mass spectrometry

(2011) Sofia Guedes et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

(2011) Minjia Tan et al.   CELL

Metabolic Biomarkers of Prenatal Disorders: An Exploratory NMR Metabonomics Study of Second Trimester Maternal Urine and Blood Plasma

(2011) Sílvia O. Diaz et al.   JOURNAL OF PROTEOME RESEARCH

Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes

(2011) Ling Cai et al.   MOLECULAR CELL

Minireview: New Roles for Peripheral Dopamine on Metabolic Control and Tumor Growth: Let’s Seek the Balance

(2010) Blanca Rubí et al.   ENDOCRINOLOGY

Gut microbiome-derived metabolites characterize a peculiar obese urinary metabotype

(2010) R Calvani et al.   INTERNATIONAL JOURNAL OF OBESITY

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Metabolic Compartmentation – A System Level Property of Muscle Cells

(2008) Valdur Saks et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Symbiotic gut microbes modulate human metabolic phenotypes

(2008) M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA