Nε-lysine acetylation in the endoplasmic reticulum – a novel cellular mechanism that regulates proteostasis and autophagy

Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype

(2018) Yajing Peng et al.   AGING CELL

ER‐to‐lysosome‐associated degradation of proteasome‐resistant ATZ polymers occurs via receptor‐mediated vesicular transport

(2018) Ilaria Fregno et al.   EMBO JOURNAL

Lysine acetylation in mitochondria: From inventory to function

(2017) Fabian Hosp et al.   MITOCHONDRION

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination

(2017) Sharanya Sivanand et al.   MOLECULAR CELL

The winding path of protein methylation research: milestones and new frontiers

(2017) Jernej Murn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation

(2017) Vinay Bulusu et al.   Cell Reports

A SUMO-acetyl switch in PXR biology

(2016) Wenqi Cui et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The world of protein acetylation

(2016) Adrian Drazic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Improved proteostasis in the secretory pathway rescues Alzheimer’s disease in the mouse

(2016) Yajing Peng et al.   BRAIN

S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model

(2016) Pingting Liu et al.   Disease Models & Mechanisms

Atg9A trafficking through the recycling endosomes is required for autophagosome formation

(2016) Kenta Imai et al.   JOURNAL OF CELL SCIENCE

Increased expression of AT-1/SLC33A1 causes an autistic-like phenotype in mice by affecting dendritic branching and spine formation

(2016) Rikki Hullinger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Huppke-Brendel syndrome in a seven months old boy with a novel 2-bp deletion in SLC33A1

(2016) Shwetha Chiplunkar et al.   METABOLIC BRAIN DISEASE

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

On keeping the right ER size

(2016) Sebastian Schuck   NATURE CELL BIOLOGY

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

(2016) Fiorenza Fumagalli et al.   NATURE CELL BIOLOGY

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Reticulophagy and nucleophagy: New findings and unsolved issues

(2015) Hitoshi Nakatogawa et al.   Autophagy

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

Emerging roles of lysine methylation on non-histone proteins

(2015) Xi Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Acetyl-CoA and the regulation of metabolism: mechanisms and consequences

(2015) Lei Shi et al.   CURRENT OPINION IN CELL BIOLOGY

Identification and Functional Analysis of a SLC33A1: c.339T>G (p.Ser113Arg) Variant in the Original SPG42 Family

(2015) Fei Mao et al.   HUMAN MUTATION

Autophagy and neurodegeneration

(2015) Rebecca A. Frake et al.   JOURNAL OF CLINICAL INVESTIGATION

Development of autophagy inducers in clinical medicine

(2015) Beth Levine et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacologic agents targeting autophagy

(2015) Helin Vakifahmetoglu-Norberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy: a druggable process that is deregulated in aging and human disease

(2015) Guido Kroemer   JOURNAL OF CLINICAL INVESTIGATION

Essential role for autophagy in life span extension

(2015) Frank Madeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Receptors for selective recycling

(2015) David C. Rubinsztein   NATURE

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

(2015) Keisuke Mochida et al.   NATURE

Protein acetylation in metabolism — metabolites and cofactors

(2015) Keir J. Menzies et al.   Nature Reviews Endocrinology

Protein lysine acetylation in bacteria: Current state of the art

(2015) Tassadit Ouidir et al.   PROTEOMICS

Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation

(2015) Sean J. Humphrey et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

(2014) Gopinath Sutendra et al.   CELL

Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation

(2014) Joyce V. Lee et al.   Cell Metabolism

The Endoplasmic Reticulum-based Acetyltransferases, ATase1 and ATase2, Associate with the Oligosaccharyltransferase to Acetylate Correctly Folded Polypeptides

(2014) Yun Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-Translational Regulation of CD133 by ATase1/ATase2-Mediated Lysine Acetylation

(2014) Anthony B. Mak et al.   JOURNAL OF MOLECULAR BIOLOGY

Deficient Import of Acetyl-CoA into the ER Lumen Causes Neurodegeneration and Propensity to Infections, Inflammation, and Cancer

(2014) Y. Peng et al.   JOURNAL OF NEUROSCIENCE

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intracellular Long-Chain Acyl CoAs Activate TRPV1 Channels

(2014) Yi Yu et al.   PLoS One

Vesicle-mediated export from the ER: COPII coat function and regulation

(2013) Jennifer G. D'Arcangelo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Protein quality control and elimination of protein waste: The role of the ubiquitin–proteasome system

(2013) Ingo Amm et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

C6orf89encodes three distinct HDAC enhancers that function in the nucleolus, the golgi and the midbody

(2013) Vasiliki S. Lalioti et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Enhanced autophagy ameliorates cardiac proteinopathy

(2013) Md. Shenuarin Bhuiyan et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Mutations in SLC33A1 Cause a Lethal Autosomal-Recessive Disorder with Congenital Cataracts, Hearing Loss, and Low Serum Copper and Ceruloplasmin

(2012) Peter Huppke et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ATP-citrate lyase: A mini-review

(2012) Melanie Chypre et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lysine acetylation in the lumen of the ER: A novel and essential function under the control of the UPR

(2012) Mariana Pehar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lysine Acetylation Is Widespread on Proteins of Diverse Function and Localization in the Protozoan Parasite Toxoplasma gondii

(2012) Victoria Jeffers et al.   EUKARYOTIC CELL

Proteomic Assessment Shows That Many Endoplasmic Reticulum (ER)-resident Proteins Are Targeted by Nϵ-Lysine Acetylation in the Lumen of the Organelle and Predicts Broad Biological Impact

(2012) Mariana Pehar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SLC33A1/AT-1 Protein Regulates the Induction of Autophagy Downstream of IRE1/XBP1 Pathway

(2012) Mariana Pehar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Inhibition of the Acetyltransferases ATase1 and ATase2 Reduces β-Secretase (BACE1) Levels and Aβ Generation

(2012) Yun Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic Analysis of Lysine Acetylation Sites in Rat Tissues Reveals Organ Specificity and Subcellular Patterns

(2012) Alicia Lundby et al.   Cell Reports

A Discovery Resource of Rare Copy Number Variations in Individuals with Autism Spectrum Disorder

(2012) Aparna Prasad et al.   G3-Genes Genomes Genetics

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism

(2011) Stephan J. Sanders et al.   NEURON

Proteins of Diverse Function and Subcellular Location Are Lysine Acetylated in Arabidopsis

(2011) I. Finkemeier et al.   PLANT PHYSIOLOGY

Phosphorylation in Protein-Protein Binding: Effect on Stability and Function

(2011) Hafumi Nishi et al.   STRUCTURE

Molecular Identification of NAT8 as the Enzyme That Acetylates CysteineS-Conjugates to Mercapturic Acids

(2010) Maria Veiga-da-Cunha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability

(2010) M. C. Jonas et al.   JOURNAL OF CELL SCIENCE

Atg9A Protein, an Autophagy-related Membrane Protein, Is Localized in the Neurons of Mouse Brains

(2010) Hirosumi Tamura et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Membrane Delivery to the Yeast Autophagosome from the Golgi–Endosomal System

(2010) Yohei Ohashi et al.   MOLECULAR BIOLOGY OF THE CELL

Protein Quality Control in the Cytosol and the Endoplasmic Reticulum: Brothers in Arms

(2010) Alexander Buchberger et al.   MOLECULAR CELL

XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy

(2009) Soledad Matus et al.   Autophagy

SUMOylation and cell signalling

(2009) Artemisia M. Andreou et al.   Biotechnology Journal

ER exit sites - Localization and control of COPII vesicle formation

(2009) Annika Budnik et al.   FEBS LETTERS

Autophagy for the avoidance of neurodegeneration

(2009) F. Madeo et al.   GENES & DEVELOPMENT

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

(2009) C. Hetz et al.   GENES & DEVELOPMENT

Regulation of Autophagy by the p300 Acetyltransferase

(2009) In Hye Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

(2009) T. Saitoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Missense Mutation in SLC33A1, which Encodes the Acetyl-CoA Transporter, Causes Autosomal-Dominant Spastic Paraplegia (SPG42)

(2008) Pengfei Lin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Two Endoplasmic Reticulum (ER)/ER Golgi Intermediate Compartment-based Lysine Acetyltransferases Post-translationally Regulate BACE1 Levels

(2008) Mi Hee Ko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice

(2008) Fiona Pickford et al.   JOURNAL OF CLINICAL INVESTIGATION

Hereditary spastic paraplegia: clinical features and pathogenetic mechanisms

(2008) Sara Salinas et al.   LANCET NEUROLOGY

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA