HDAC8 substrate selectivity is determined by long- and short-range interactions leading to enhanced reactivity for full-length histone substrates compared with peptides

General Base–General Acid Catalysis in Human Histone Deacetylase 8

(2016) Sister M. Lucy Gantt et al.   BIOCHEMISTRY

Supramolecular Affinity Labeling of Histone Peptides Containing Trimethyllysine and Its Application to Histone Deacetylase Assays

(2016) Isaiah N. Gober et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure-Based Identification of HDAC8 Non-histone Substrates

(2016) Nawsad Alam et al.   STRUCTURE

Interrogating Substrate Selectivity and Composition of Endogenous Histone Deacetylase Complexes with Chemical Probes

(2015) Alexander Dose et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site specificity analysis of Piccolo NuA4-mediated acetylation for different histone complexes

(2015) Y.-M. Kuo et al.   BIOCHEMICAL JOURNAL

Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8

(2015) Christophe Decroos et al.   BIOCHEMISTRY

FDA Approves New Agent for Multiple Myeloma

(2015) M. P. Fenichel   JNCI-Journal of the National Cancer Institute

Histone Deacetylase Inhibitors in Clinical Studies as Templates for New Anticancer Agents

(2015) Madhusoodanan Mottamal et al.   MOLECULES

KDAC8 substrate specificity quantified by a biologically relevant, label-free deacetylation assay

(2015) Tasha B. Toro et al.   PROTEIN SCIENCE

FDA Approves New Agent for Multiple Myeloma

(2015) M. P. Fenichel   JNCI-Journal of the National Cancer Institute

An Unbiased Approach To Identify Endogenous Substrates of “Histone” Deacetylase 8

(2014) David E. Olson et al.   ACS Chemical Biology

An enzyme-coupled assay measuring acetate production for profiling histone deacetylase specificity

(2014) Noah A. Wolfson et al.   ANALYTICAL BIOCHEMISTRY

Belinostat: First Global Approval

(2014) Raewyn M. Poole   DRUGS

Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance

(2014) Frank J. Kaiser et al.   HUMAN MOLECULAR GENETICS

Synthesis and biological evaluation of a targeted DNA-binding transcriptional activator with HDAC8 inhibitory activity

(2013) Abhijit Saha et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The functional interactome landscape of the human histone deacetylase family

(2013) P. Joshi et al.   Molecular Systems Biology

Quantitating the Specificity and Selectivity of Gcn5-Mediated Acetylation of Histone H3

(2013) Yin-Ming Kuo et al.   PLoS One

Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni

(2013) Martin Marek et al.   PLoS Pathogens

HDAC8 substrates: Histones and beyond

(2012) Noah A. Wolfson et al.   BIOPOLYMERS

HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

(2012) Matthew A. Deardorff et al.   NATURE

A fluorescence-based assay for measuring N-acetyl-1-d-myo-inosityl-2-amino-2-deoxy-α-d-glucopyranoside deacetylase activity

(2011) Xinyi Huang et al.   ANALYTICAL BIOCHEMISTRY

Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors

(2011) Lewis Whitehead et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chatting histone modifications in mammals

(2011) A. Izzo et al.   Briefings in Functional Genomics

Histone H3-K56 acetylation is important for genomic stability in mammals

(2011) Jian Yuan et al.   CELL CYCLE

Structural Basis of the Antiproliferative Activity of Largazole, a Depsipeptide Inhibitor of the Histone Deacetylases

(2011) Kathryn E. Cole et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

HDAC6 α-tubulin deacetylase: A potential therapeutic target in neurodegenerative diseases

(2011) Guoyi Li et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Peptide Arrays Identify Isoform-Selective Substrates for Profiling Endogenous Lysine Deacetylase Activity

(2010) Zachary A. Gurard-Levin et al.   ACS Chemical Biology

Structures of Metal-Substituted Human Histone Deacetylase 8 Provide Mechanistic Inferences on Biological Function,

(2010) Daniel P. Dowling et al.   BIOCHEMISTRY

Histone deacetylases as targets for the treatment of human neurodegenerative diseases

(2010) S.R. D'Mello   DRUG NEWS & PERSPECTIVES

An Acetylation Switch Modulates the Transcriptional Activity of Estrogen-Related Receptor α

(2010) Brian J. Wilson et al.   MOLECULAR ENDOCRINOLOGY

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Combining Mass Spectrometry and Peptide Arrays to Profile the Specificities of Histone Deacetylases

(2009) Zachary A. Gurard-Levin et al.   CHEMBIOCHEM

Activation and Inhibition of Histone Deacetylase 8 by Monovalent Cations

(2009) Stephanie L. Gantt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Method for Genetically Installing Site-Specific Acetylation in Recombinant Histones Defines the Effects of H3 K56 Acetylation

(2009) Heinz Neumann et al.   MOLECULAR CELL

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Inactivation of CREB mediated gene transcription by HDAC8 bound protein phosphatase

(2008) Jingxia Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Activity of HDAC8 Depends on Local and Distal Sequences of Its Peptide Substrates†

(2008) Zachary A. Gurard-Levin et al.   BIOCHEMISTRY

Structural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors†,‡

(2008) Daniel P. Dowling et al.   BIOCHEMISTRY

Genetically encoding Nε-acetyllysine in recombinant proteins

(2008) Heinz Neumann et al.   Nature Chemical Biology

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY