- Home
- Publications
- Publication Search
- Publication Details
Title
Engineering living therapeutics with synthetic biology
Authors
Keywords
-
Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 20, Issue 12, Pages 941-960
Publisher
Springer Science and Business Media LLC
Online
2021-10-08
DOI
10.1038/s41573-021-00285-3
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The therapeutic landscape for cells engineered with chimeric antigen receptors
- (2020) Matthew MacKay et al. NATURE BIOTECHNOLOGY
- Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies
- (2020) Candice R. Gurbatri et al. Science Translational Medicine
- State of the art in CAR T cell therapy for CD19+ B cell malignancies
- (2020) Matthew J. Frigault et al. JOURNAL OF CLINICAL INVESTIGATION
- Quantitative Control of Gene-Engineered T-Cell Activity through the Covalent Attachment of Targeting Ligands to a Universal Immune Receptor
- (2020) Nicholas G. Minutolo et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Genetic circuit design automation for the gut resident species Bacteroides thetaiotaomicron
- (2020) Mao Taketani et al. NATURE BIOTECHNOLOGY
- The human tumor microbiome is composed of tumor type–specific intracellular bacteria
- (2020) Deborah Nejman et al. SCIENCE
- Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity
- (2020) Daniel S. Leventhal et al. Nature Communications
- Developing a new class of engineered live bacterial therapeutics to treat human diseases
- (2020) Mark R. Charbonneau et al. Nature Communications
- Safety Aspects of Genetically Modified Lactic Acid Bacteria
- (2020) Tina Vida Plavec et al. Microorganisms
- Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In Vivo
- (2020) Sarah A. Richman et al. MOLECULAR THERAPY
- Automated design of thousands of nonrepetitive parts for engineering stable genetic systems
- (2020) Ayaan Hossain et al. NATURE BIOTECHNOLOGY
- Thermal Control of Engineered T-cells
- (2020) Mohamad H. Abedi et al. ACS Synthetic Biology
- convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting
- (2020) Kyle E. Landgraf et al. Communications Biology
- Gut microbial metabolites as multi-kingdom intermediates
- (2020) Kimberly A. Krautkramer et al. NATURE REVIEWS MICROBIOLOGY
- An Automated Model Test System for Systematic Development and Improvement of Gene Expression Models
- (2020) Alexander C. Reis et al. ACS Synthetic Biology
- Discriminatory Power of Combinatorial Antigen Recognition in Cancer T Cell Therapies
- (2020) Ruth Dannenfelser et al. Cell Systems
- Precise T cell recognition programs designed by transcriptionally linking multiple receptors
- (2020) Jasper Z. Williams et al. SCIENCE
- Engineering of lactic acid bacteria for delivery of therapeutic proteins and peptides
- (2019) Tina Vida Plavec et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans
- (2019) Caroline B. Kurtz et al. Science Translational Medicine
- Total eclipses and the heart
- (2019) Luis Campos SCIENCE
- Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting
- (2019) Shivani Srivastava et al. CANCER CELL
- A compact synthetic pathway rewires cancer signaling to therapeutic effector release
- (2019) Hokyung K. Chung et al. SCIENCE
- Expanding the Toolbox of Broad Host-Range Transcriptional Terminators for Proteobacteria through Metagenomics
- (2019) Vanesa Amarelle et al. ACS Synthetic Biology
- Modulation of chimeric antigen receptor surface expression by a small molecule switch
- (2019) Alexandre Juillerat et al. BMC BIOTECHNOLOGY
- Overcoming genetic heterogeneity in industrial fermentations
- (2019) Peter Rugbjerg et al. NATURE BIOTECHNOLOGY
- Programmable bacteria induce durable tumor regression and systemic antitumor immunity
- (2019) Sreyan Chowdhury et al. NATURE MEDICINE
- Streamlined Genetic Manipulation of Diverse Bacteroides and Parabacteroides Isolates from the Human Gut Microbiota
- (2019) Leonor García-Bayona et al. mBio
- Multi-antigen-targeted chimeric antigen receptor T cells for cancer therapy
- (2019) Xiao Han et al. Journal of Hematology & Oncology
- The Role of Protein Engineering in Biomedical Applications of Mammalian Synthetic Biology
- (2019) Daniel Bojar et al. Small
- Artificial signaling in mammalian cells enabled by prokaryotic two-component system
- (2019) Alain Mazé et al. Nature Chemical Biology
- Engineered E. coli Nissle 1917 for the delivery of matrix-tethered therapeutic domains to the gut
- (2019) Pichet Praveschotinunt et al. Nature Communications
- Logic-gated approaches to extend the utility of chimeric antigen receptor T-cell technology
- (2018) Lisa M. Ebert et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses
- (2018) Jang Hwan Cho et al. CELL
- Clinical use of lentiviral vectors
- (2018) Michael C. Milone et al. LEUKEMIA
- Metagenomic mining of regulatory elements enables programmable species-selective gene expression
- (2018) Nathan I Johns et al. NATURE METHODS
- Designing cell function: assembly of synthetic gene circuits for cell biology applications
- (2018) Mingqi Xie et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Mechanogenetics for the remote and noninvasive control of cancer immunotherapy
- (2018) Yijia Pan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Programming gene and engineered-cell therapies with synthetic biology
- (2018) Tasuku Kitada et al. SCIENCE
- An ingestible bacterial-electronic system to monitor gastrointestinal health
- (2018) Mark Mimee et al. SCIENCE
- Enhancing the Potency and Specificity of Engineered T Cells for Cancer Treatment
- (2018) Sujita Sukumaran et al. Cancer Discovery
- Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria
- (2018) Vincent M Isabella et al. NATURE BIOTECHNOLOGY
- Programmable protein circuits in living cells
- (2018) Xiaojing J. Gao et al. SCIENCE
- Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques
- (2018) Matthew A. Bochenek et al. Nature Biomedical Engineering
- Temporal development of the gut microbiome in early childhood from the TEDDY study
- (2018) Christopher J. Stewart et al. NATURE
- Design of fast proteolysis-based signaling and logic circuits in mammalian cells
- (2018) Tina Fink et al. Nature Chemical Biology
- Engineering Microbial Living Therapeutics: The Synthetic Biology Toolbox
- (2018) Danielle B. Pedrolli et al. TRENDS IN BIOTECHNOLOGY
- Preclinical Development of Bivalent Chimeric Antigen Receptors Targeting Both CD19 and CD22
- (2018) Haiying Qin et al. Molecular Therapy-Oncolytics
- Engineering mammalian cells for disease diagnosis and treatment
- (2018) Ana P Teixeira et al. CURRENT OPINION IN BIOTECHNOLOGY
- Engineering bacterial thiosulfate and tetrathionate sensors for detecting gut inflammation
- (2017) Kristina N‐M Daeffler et al. Molecular Systems Biology
- Therapeutic T cell engineering
- (2017) Michel Sadelain et al. NATURE
- Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation
- (2017) David T Riglar et al. NATURE BIOTECHNOLOGY
- Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates
- (2017) Joshua C. Doloff et al. NATURE MATERIALS
- Delivery technologies for genome editing
- (2017) Hao Yin et al. NATURE REVIEWS DRUG DISCOVERY
- CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond
- (2017) ZeNan L. Chang et al. TRENDS IN MOLECULAR MEDICINE
- Genomic alterations of ERBB receptors in cancer: clinical implications
- (2017) Rosalin Mishra et al. Oncotarget
- An oxygen sensitive self-decision making engineered CAR T-cell
- (2017) Alexandre Juillerat et al. Scientific Reports
- Fundamental Design Principles for Transcription-Factor-Based Metabolite Biosensors
- (2017) Ahmad A. Mannan et al. ACS Synthetic Biology
- Intestinal Anti-inflammatory Effects of Outer Membrane Vesicles from Escherichia coli Nissle 1917 in DSS-Experimental Colitis in Mice
- (2017) María-José Fábrega et al. Frontiers in Microbiology
- Automated Design of Synthetic Cell Classifier Circuits Using a Two-Step Optimization Strategy
- (2017) Pejman Mohammadi et al. Cell Systems
- Antimicrobial Probiotics Reduce Salmonella enterica in Turkey Gastrointestinal Tracts
- (2017) Brittany Forkus et al. Scientific Reports
- Armored CAR T-cells: utilizing cytokines and pro-inflammatory ligands to enhance CAR T-cell anti-tumour efficacy
- (2016) Oladapo O. Yeku et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- An engineered Lactococcus lactis strain exerts significant immune responses through efficient expression and delivery of Helicobacter pylori Lpp20 antigen
- (2016) Rongguang Zhang et al. BIOTECHNOLOGY LETTERS
- Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits
- (2016) Kole T. Roybal et al. CELL
- A review of food-grade vectors in lactic acid bacteria: from the laboratory to their application
- (2016) José Maria Landete CRITICAL REVIEWS IN BIOTECHNOLOGY
- Modular engineering of cellular signaling proteins and networks
- (2016) Russell M Gordley et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape
- (2016) Meenakshi Hegde et al. JOURNAL OF CLINICAL INVESTIGATION
- Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies
- (2016) Marco Ruella et al. JOURNAL OF CLINICAL INVESTIGATION
- A synthetic biology-based device prevents liver injury in mice
- (2016) Peng Bai et al. JOURNAL OF HEPATOLOGY
- Synchronized cycles of bacterial lysis for in vivo delivery
- (2016) M. Omar Din et al. NATURE
- Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates
- (2016) Arturo J Vegas et al. NATURE BIOTECHNOLOGY
- The microbiome in early life: implications for health outcomes
- (2016) Sabrina Tamburini et al. NATURE MEDICINE
- Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies
- (2016) David T. Rodgers et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synthetic gene network restoring endogenous pituitary–thyroid feedback control in experimental Graves’ disease
- (2016) Pratik Saxena et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- -cell-mimetic designer cells provide closed-loop glycemic control
- (2016) M. Xie et al. SCIENCE
- Genetic circuit design automation
- (2016) A. A. K. Nielsen et al. SCIENCE
- Antibiotics, birth mode, and diet shape microbiome maturation during early life
- (2016) Nicholas A. Bokulich et al. Science Translational Medicine
- Metabolic Burden: Cornerstones in Synthetic Biology and Metabolic Engineering Applications
- (2016) Gang Wu et al. TRENDS IN BIOTECHNOLOGY
- Switching CAR T cells on and off: a novel modular platform for retargeting of T cells to AML blasts
- (2016) M Cartellieri et al. Blood Cancer Journal
- Quantitative Analyses of Core Promoters Enable Precise Engineering of Regulated Gene Expression in Mammalian Cells
- (2016) Christopher Ede et al. ACS Synthetic Biology
- T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells
- (2016) E. Zah et al. Cancer Immunology Research
- Examination of the foreign body response to biomaterials by nonlinear intravital microscopy
- (2016) Eleonora Dondossola et al. Nature Biomedical Engineering
- Prosthetic gene networks as an alternative to standard pharmacotherapies for metabolic disorders
- (2015) Boon Chin Heng et al. CURRENT OPINION IN BIOTECHNOLOGY
- TRUCKs: the fourth generation of CARs
- (2015) Markus Chmielewski et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Safety and Survival With GVAX Pancreas Prime and Listeria Monocytogenes–Expressing Mesothelin (CRS-207) Boost Vaccines for Metastatic Pancreatic Cancer
- (2015) Dung T. Le et al. JOURNAL OF CLINICAL ONCOLOGY
- Oral Immunization with a RecombinantLactococcus lactis–Expressing HIV-1 Antigen on Group AStreptococcusPilus Induces Strong Mucosal Immunity in the Gut
- (2015) Venkateswarlu Chamcha et al. JOURNAL OF IMMUNOLOGY
- Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates
- (2015) Omid Veiseh et al. NATURE MATERIALS
- The pharmacology of second-generation chimeric antigen receptors
- (2015) Sjoukje J. C. van der Stegen et al. NATURE REVIEWS DRUG DISCOVERY
- Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip
- (2015) Hyun Jung Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Remote control of therapeutic T cells through a small molecule-gated chimeric receptor
- (2015) C.-Y. Wu et al. SCIENCE
- Implantable synthetic cytokine converter cells with AND-gate logic treat experimental psoriasis
- (2015) Lina Schukur et al. Science Translational Medicine
- Detection of pathological biomarkers in human clinical samples via amplifying genetic switches and logic gates
- (2015) Alexis Courbet et al. Science Translational Medicine
- Programmable probiotics for detection of cancer in urine
- (2015) Tal Danino et al. Science Translational Medicine
- The recombinant Lactococcus lactis oral vaccine induces protection against C. difficile spore challenge in a mouse model
- (2015) Shanguang Guo et al. VACCINE
- Programming a Human Commensal Bacterium, Bacteroides thetaiotaomicron, to Sense and Respond to Stimuli in the Murine Gut Microbiota
- (2015) Mark Mimee et al. Cell Systems
- Efficient search, mapping, and optimization of multi-protein genetic systems in diverse bacteria
- (2014) I. Farasat et al. Molecular Systems Biology
- Principles of genetic circuit design
- (2014) Jennifer A N Brophy et al. NATURE METHODS
- Engineering adeno-associated viruses for clinical gene therapy
- (2014) Melissa A. Kotterman et al. NATURE REVIEWS GENETICS
- A brief history of synthetic biology
- (2014) D. Ewen Cameron et al. NATURE REVIEWS MICROBIOLOGY
- Programmable bacteria detect and record an environmental signal in the mammalian gut
- (2014) Jonathan W. Kotula et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Programming Controlled Adhesion of E. coli to Target Surfaces, Cells, and Tumors with Synthetic Adhesins
- (2014) Carlos Piñero-Lambea et al. ACS Synthetic Biology
- Experimental models of the gut microbiome
- (2013) Koen Venema et al. BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY
- Phase 1b, multicenter, single blinded, placebo-controlled, sequential dose escalation study to assess the safety and tolerability of topically applied AG013 in subjects with locally advanced head and neck cancer receiving induction chemotherapy
- (2013) Sewanti Atul Limaye et al. CANCER
- T Lymphocytes Expressing a CD16 Signaling Receptor Exert Antibody-Dependent Cancer Cell Killing
- (2013) K. Kudo et al. CANCER RESEARCH
- Probiotic Bacteria Reduce Salmonella Typhimurium Intestinal Colonization by Competing for Iron
- (2013) Elisa Deriu et al. Cell Host & Microbe
- Oncology Meets Immunology: The Cancer-Immunity Cycle
- (2013) Daniel S. Chen et al. IMMUNITY
- Combinational Targeting Offsets Antigen Escape and Enhances Effector Functions of Adoptively Transferred T Cells in Glioblastoma
- (2013) Meenakshi Hegde et al. MOLECULAR THERAPY
- Treatment of Metastatic Renal Cell Carcinoma With CAIX CAR-engineered T cells: Clinical Evaluation and Management of On-target Toxicity
- (2013) Cor HJ Lamers et al. MOLECULAR THERAPY
- Inducible control of gene expression with destabilized Cre
- (2013) Richard Sando et al. NATURE METHODS
- KATP channels and islet hormone secretion: new insights and controversies
- (2013) Frances M. Ashcroft et al. Nature Reviews Endocrinology
- PD-1- and CTLA-4-Based Inhibitory Chimeric Antigen Receptors (iCARs) Divert Off-Target Immunotherapy Responses
- (2013) V. D. Fedorov et al. Science Translational Medicine
- Cell-Based Therapeutics: The Next Pillar of Medicine
- (2013) M. A. Fischbach et al. Science Translational Medicine
- MET: A Critical Player in Tumorigenesis and Therapeutic Target
- (2013) C. R. Graveel et al. Cold Spring Harbor Perspectives in Biology
- Chimeric Antigen Receptor T Cells with Dissociated Signaling Domains Exhibit Focused Antitumor Activity with Reduced Potential for Toxicity In Vivo
- (2013) E. Lanitis et al. Cancer Immunology Research
- A Synthetic Biology Framework for Programming Eukaryotic Transcription Functions
- (2012) Ahmad S. Khalil et al. CELL
- Redirecting Gene-Modified T Cells toward Various Cancer Types Using Tagged Antibodies
- (2012) K. Tamada et al. CLINICAL CANCER RESEARCH
- Dual Targeting of ErbB2 and MUC1 in Breast Cancer Using Chimeric Antigen Receptors Engineered to Provide Complementary Signaling
- (2012) Scott Wilkie et al. JOURNAL OF CLINICAL IMMUNOLOGY
- Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells
- (2012) Christopher C Kloss et al. NATURE BIOTECHNOLOGY
- Foundations for the design and implementation of synthetic genetic circuits
- (2012) Adrian L. Slusarczyk et al. NATURE REVIEWS GENETICS
- In Vivo Gene Expression Dynamics of Tumor-Targeted Bacteria
- (2012) Tal Danino et al. ACS Synthetic Biology
- Genetic Circuits in Salmonella typhimurium
- (2012) Arthur Prindle et al. ACS Synthetic Biology
- A Live-Attenuated Listeria Vaccine (ANZ-100) and a Live-Attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase I Studies of Safety and Immune Induction
- (2011) D. T. Le et al. CLINICAL CANCER RESEARCH
- IL-22 and TNF-α represent a key cytokine combination for epidermal integrity during infection withCandida albicans
- (2011) Stefanie Eyerich et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Attenuated Listeria monocytogenes vaccine vectors expressing Influenza A nucleoprotein: preclinical evaluation and oral inoculation of volunteers
- (2011) Paul V. Johnson et al. MICROBIOLOGY AND IMMUNOLOGY
- Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy
- (2011) Antonio Di Stasi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Synthetic Biology: Integrated Gene Circuits
- (2011) N. Nandagopal et al. SCIENCE
- Multi-Input RNAi-Based Logic Circuit for Identification of Specific Cancer Cells
- (2011) Z. Xie et al. SCIENCE
- Inflammatory Bowel Disease
- (2010) Arthur Kaser et al. Annual Review of Immunology
- Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1 , and TNF- Recapitulates Some Features of Psoriasis
- (2010) K. Guilloteau et al. JOURNAL OF IMMUNOLOGY
- A tunable dual-promoter integrator for targeting of cancer cells
- (2010) Lior Nissim et al. Molecular Systems Biology
- A functional metagenomic approach for expanding the synthetic biology toolbox for biomass conversion
- (2010) Morten OA Sommer et al. Molecular Systems Biology
- Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2
- (2010) Richard A Morgan et al. MOLECULAR THERAPY
- T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis
- (2010) Maria R Parkhurst et al. MOLECULAR THERAPY
- Robust multicellular computing using genetically encoded NOR gates and chemical ‘wires’
- (2010) Alvin Tamsir et al. NATURE
- Self-sufficient control of urate homeostasis in mice by a synthetic circuit
- (2010) Christian Kemmer et al. NATURE BIOTECHNOLOGY
- Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model
- (2010) F. Duan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reprogramming Cellular Behavior with RNA Controllers Responsive to Endogenous Proteins
- (2010) S. J. Culler et al. SCIENCE
- Genetically modified Bifidobacterium displaying Salmonella-antigen protects mice from lethal challenge of Salmonella Typhimurium in a murine typhoid fever model
- (2010) Sakura Yamamoto et al. VACCINE
- The Prioritization of Cancer Antigens: A National Cancer Institute Pilot Project for the Acceleration of Translational Research
- (2009) M. A. Cheever et al. CLINICAL CANCER RESEARCH
- Pathogenesis of cognitive dysfunction in phenylketonuria: Review of hypotheses☆
- (2009) M.J. de Groot et al. MOLECULAR GENETICS AND METABOLISM
- Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis
- (2009) K Vandenbroucke et al. Mucosal Immunology
- Diversity-based, model-guided construction of synthetic gene networks with predicted functions
- (2009) Tom Ellis et al. NATURE BIOTECHNOLOGY
- Construction and Characterization of an Attenuated Listeria monocytogenes Strain for Clinical Use in Cancer Immunotherapy
- (2008) A. Wallecha et al. Clinical and Vaccine Immunology
- The Barrier of Hypoglycemia in Diabetes
- (2008) P. E. Cryer DIABETES
- Clinical use of E. coli Nissle 1917 in inflammatory bowel disease
- (2008) Michael Schultz INFLAMMATORY BOWEL DISEASES
- A fast, robust and tunable synthetic gene oscillator
- (2008) Jesse Stricker et al. NATURE
- Chemical control of protein stability and function in living mice
- (2008) Laura A Banaszynski et al. NATURE MEDICINE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started