KATP channels and islet hormone secretion: new insights and controversies

Tolbutamide Controls Glucagon Release From Mouse Islets Differently Than Glucose: Involvement of KATP Channels From Both  -Cells and  -Cells

(2013) R. Cheng-Xue et al.   DIABETES

Regulation of Insulin Secretion in Human Pancreatic Islets

(2012) Patrik Rorsman et al.   Annual Review of Physiology

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

Reduced Insulin Exocytosis in Human Pancreatic  -Cells With Gene Variants Linked to Type 2 Diabetes

(2012) A. H. Rosengren et al.   DIABETES

Regulation of Glucagon Secretion in Normal and Diabetic Human Islets by γ-Hydroxybutyrate and Glycine

(2012) Changhong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Value of Radiologic Interventions and 18F-DOPA PET in Diagnosing and Localizing Focal Congenital Hyperinsulinism: Systematic Review and Meta-Analysis

(2012) Björn A. Blomberg et al.   MOLECULAR IMAGING AND BIOLOGY

The Mitochondrial Ca2+ Uniporter MCU Is Essential for Glucose-Induced ATP Increases in Pancreatic β-Cells

(2012) Andrei I. Tarasov et al.   PLoS One

Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics

(2011) Nicolai M. Doliba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The ATP-Sensitive K+ Channel ABCC8 S1369A Type 2 Diabetes Risk Variant Increases MgATPase Activity

(2011) M. Fatehi et al.   DIABETES

Acute Sulfonylurea Therapy at Disease Onset Can Cause Permanent Remission of KATP-Induced Diabetes

(2011) M. S. Remedi et al.   DIABETES

Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice

(2011) Y. Lee et al.   DIABETES

Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice

(2011) Fabrizio Thorel et al.   DIABETES

Regulation of glucagon secretion by zinc: lessons from the β cell-specific Znt8 knockout mouse model

(2011) A. B. Hardy et al.   DIABETES OBESITY & METABOLISM

Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?

(2011) J. N. Walker et al.   DIABETES OBESITY & METABOLISM

The dual control of insulin secretion by glucose involves triggering and amplifying pathways in β-cells

(2011) Jean-Claude Henquin   DIABETES RESEARCH AND CLINICAL PRACTICE

No beta cell desensitisation after a median of 68 months on glibenclamide therapy in patients with KCNJ11-associated permanent neonatal diabetes

(2011) D. Iafusco et al.   DIABETOLOGIA

In vitro insulin secretion by pancreatic tissue from infants with diazoxide-resistant congenital hyperinsulinism deviates from model predictions

(2011) Jean-Claude Henquin et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical characteristics of recessive and dominant congenital hyperinsulinism due to mutation(s) in the ABCC8/KCNJ11 genes encoding the ATP-sensitive potasium channel in the pancreatic beta cell

(2011) Gönül Öçal et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans

(2011) Rayner Rodriguez-Diaz et al.   NATURE MEDICINE

KATP channel mutations in infants with permanent diabetes diagnosed after 6 months of life

(2011) Oscar RubioCabezas et al.   PEDIATRIC DIABETES

Electrophysiology of pancreatic β-cells in intact mouse islets of Langerhans

(2011) Patrik Rorsman et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

New Uses for Old Drugs: Neonatal Diabetes and Sulphonylureas

(2010) Frances M. Ashcroft   Cell Metabolism

GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-Type Ca2+ Channel-Dependent Exocytosis

(2010) Yang Z. De Marinis et al.   Cell Metabolism

Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in  -Cells Inhibits Glucagon Secretion From Human Islets

(2010) R. Ramracheya et al.   DIABETES

A mutation in KCNJ11 causing human hyperinsulinism (Y12X) results in a glucose-intolerant phenotype in the mouse

(2010) A. Hugill et al.   DIABETOLOGIA

ATP Modulates Interaction of Syntaxin-1A with Sulfonylurea Receptor 1 to Regulate Pancreatic β-Cell KATPChannels

(2010) Youhou Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SYMPOSIUM REVIEW: The role of the KATPchannel in glucose homeostasis in health and disease: more than meets the islet

(2010) James S. McTaggart et al.   JOURNAL OF PHYSIOLOGY-LONDON

Unperturbed islet α-cell function examined in mouse pancreas tissue slices

(2010) Ya-Chi Huang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Muscle Dysfunction Caused by a KATP Channel Mutation in Neonatal Diabetes Is Neuronal in Origin

(2010) R. H. Clark et al.   SCIENCE

Secondary Consequences of β Cell Inexcitability: Identification and Prevention in a Murine Model of KATP-Induced Neonatal Diabetes Mellitus

(2009) Maria Sara Remedi et al.   Cell Metabolism

Insulin Signaling in α Cells Modulates Glucagon Secretion In Vivo

(2009) Dan Kawamori et al.   Cell Metabolism

Coexpression of the Type 2 Diabetes Susceptibility Gene Variants KCNJ11 E23K and ABCC8 S1369A Alter the ATP and Sulfonylurea Sensitivities of the ATP-Sensitive K+ Channel

(2009) K. S.C. Hamming et al.   DIABETES

Kir6.2 Variant E23K Increases ATP-Sensitive K+ Channel Activity and Is Associated With Impaired Insulin Release and Enhanced Insulin Sensitivity in Adults With Normal Glucose Tolerance

(2009) D. T. Villareal et al.   DIABETES

The cAMP Sensor Epac2 Is a Direct Target of Antidiabetic Sulfonylurea Drugs

(2009) C.-L. Zhang et al.   SCIENCE

Glucose and Pharmacological Modulators of ATP-Sensitive K+ Channels Control [Ca2+]c by Different Mechanisms in Isolated Mouse  -Cells

(2008) N. Quoix et al.   DIABETES

Somatostatin Secreted by Islet  -Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

(2008) A. C. Hauge-Evans et al.   DIABETES

Voltage-Gated Ion Channels in Human Pancreatic  -Cells: Electrophysiological Characterization and Role in Insulin Secretion

(2008) M. Braun et al.   DIABETES

Update of mutations in the genes encoding the pancreatic beta-cell KATPchannel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism

(2008) Sarah E. Flanagan et al.   HUMAN MUTATION

Role of the cAMP sensor Epac as a determinant of KATPchannel ATP sensitivity in human pancreatic β-cells and rat INS-1 cells

(2008) Guoxin Kang et al.   JOURNAL OF PHYSIOLOGY-LONDON

KATP-channels and glucose-regulated glucagon secretion

(2008) Patrik Rorsman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM