convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting

The Emergence of Universal Immune Receptor T Cell Therapy for Cancer

(2019) Nicholas G. Minutolo et al.   Frontiers in Oncology

Attacking Latent HIV with convertibleCAR-T Cells, a Highly Adaptable Killing Platform

(2019) Eytan Herzig et al.   CELL

CAR T cell therapy for B-cell lymphomas

(2018) Julio C. Chavez et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

(2018) Joseph A. Fraietta et al.   NATURE MEDICINE

Chimeric Antigen Receptor Therapy

(2018) Carl H. June et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

(2018) Jae H. Park et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

(2018) A. J. Davenport et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Switchable CAR-T cells mediate remission in metastatic pancreatic ductal adenocarcinoma

(2018) Deepak Raj et al.   GUT

Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory

(2018) Sophie Viaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor Antigen and Receptor Densities Regulate Efficacy of a Chimeric Antigen Receptor Targeting Anaplastic Lymphoma Kinase

(2017) Alec J. Walker et al.   MOLECULAR THERAPY

A disease-linkedULBP6polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding

(2017) Jianmin Zuo et al.   Science Signaling

A disease-linkedULBP6polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding

(2017) Jianmin Zuo et al.   Science Signaling

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

(2016) Leonardo Morsut et al.   CELL

CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patients

(2016) Cameron J. Turtle et al.   JOURNAL OF CLINICAL INVESTIGATION

Translational Implications for Off-the-shelf Immune Cells Expressing Chimeric Antigen Receptors

(2016) Hiroki Torikai et al.   MOLECULAR THERAPY

Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells

(2016) Lenka V. Hurton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy

(2016) Reza Ghasemi et al.   Nature Communications

Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

(2015) David L. Porter et al.   Science Translational Medicine

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

(2015) E. Sotillo et al.   Cancer Discovery

A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy

(2014) B. Philip et al.   BLOOD

PD-1- and CTLA-4-Based Inhibitory Chimeric Antigen Receptors (iCARs) Divert Off-Target Immunotherapy Responses

(2013) V. D. Fedorov et al.   Science Translational Medicine

Chimeric Antigen Receptor T Cells with Dissociated Signaling Domains Exhibit Focused Antitumor Activity with Reduced Potential for Toxicity In Vivo

(2013) E. Lanitis et al.   Cancer Immunology Research

Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells

(2012) Christopher C Kloss et al.   NATURE BIOTECHNOLOGY

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

(2012) Aaron M Ring et al.   NATURE IMMUNOLOGY

Human NKG2D-ligands: cell biology strategies to ensure immune recognition

(2012) Lola Fernández-Messina et al.   Frontiers in Immunology

A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells

(2011) X. Wang et al.   BLOOD

Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects

(2010) Kannan Gunasekaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineered Fc variant antibodies with enhanced ability to recruit complement and mediate effector functions

(2010) Gregory L. Moore et al.   mAbs

Systematic mutation and thermodynamic analysis of central tyrosine pairs in polyspecific NKG2D receptor interactions

(2010) David J. Culpepper et al.   MOLECULAR IMMUNOLOGY

Structure of the HCMV UL16-MICB Complex Elucidates Select Binding of a Viral Immunoevasin to Diverse NKG2D Ligands

(2010) Steffen Müller et al.   PLoS Pathogens

Regulation of NKG2D ligands: a purposeful but delicate affair

(2008) Thomas Spies   NATURE IMMUNOLOGY