Inflammation in obesity, diabetes, and related disorders

MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice

(2021) Wei Ying et al.   Cell Metabolism

Epigenetic Regulation of Kupffer Cell Function in Health and Disease

(2021) Hunter Bennett et al.   Frontiers in Immunology

Chronic tissue inflammation and metabolic disease

(2021) Yun Sok Lee et al.   GENES & DEVELOPMENT

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

An update on the regulatory mechanisms of NLRP3 inflammasome activation

(2021) Seungwha Paik et al.   Cellular & Molecular Immunology

Associations among adipose tissue immunology, inflammation and exosomes and insulin sensitivity in people with obesity and nonalcoholic fatty liver disease

(2021) Anja Fuchs et al.   GASTROENTEROLOGY

IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial

(2021) Paul M Ridker et al.   LANCET

Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity

(2021) Andrew D. Hildreth et al.   NATURE IMMUNOLOGY

Emerging concepts in intestinal immune control of obesity-related metabolic disease

(2021) Saad Khan et al.   Nature Communications

Innate Immunity in Diabetic Wound Healing: Focus on the Mastermind Hidden in Chronic Inflammatory

(2021) Kang Geng et al.   Frontiers in Pharmacology

Obesity in Humans Is Characterized by Gut Inflammation as Shown by Pro-Inflammatory Intestinal Macrophage Accumulation

(2021) Theresa V. Rohm et al.   Frontiers in Immunology

Dietary fructose improves intestinal cell survival and nutrient absorption

(2021) Samuel R. Taylor et al.   NATURE

Diet-regulated production of PDGFcc by macrophages controls energy storage

(2021) Nehemiah Cox et al.   SCIENCE

Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes

(2021) Naureen Javeed et al.   Cell Reports

“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis

(2021) Mark A. Febbraio et al.   Cell Metabolism

Molecular aspects of fructose metabolism and metabolic disease

(2021) Mark A. Herman et al.   Cell Metabolism

Innate immunity in diabetic kidney disease

(2020) Sydney C. W. Tang et al.   Nature Reviews Nephrology

Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes

(2020) Federica Zatterale et al.   Frontiers in Physiology

Postprandial Hypoglycemia in Patients after Gastric Bypass Surgery Is Mediated by Glucose-Induced IL-1β

(2020) Matthias Hepprich et al.   Cell Metabolism

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis

(2020) Jason S. Seidman et al.   IMMUNITY

Visceral adipose tissue Tregs and the cells that nurture them

(2020) Chaoran Li et al.   IMMUNOLOGICAL REVIEWS

Type 3 Diabetes and Its Role Implications in Alzheimer’s Disease

(2020) Thuy Trang Nguyen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate

(2020) Steven Zhao et al.   NATURE

Potential therapeutic applications of the gut microbiome in obesity: from brain function to body detoxification

(2020) Béatrice S.-Y. Choi et al.   INTERNATIONAL JOURNAL OF OBESITY

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity

(2020) Amine Toubal et al.   Nature Communications

Dietary Regulation of Immunity

(2020) Aileen H. Lee et al.   IMMUNITY

Gut microbiota in human metabolic health and disease

(2020) Yong Fan et al.   NATURE REVIEWS MICROBIOLOGY

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

Pharmacologic Targeting of Hypoxia-Inducible Factors

(2019) Gregg L. Semenza   Annual Review of Pharmacology and Toxicology

Anti-Inflammatory Therapy with Canakinumab for the Prevention of Hospitalization for Heart Failure

(2019) Brendan M. Everett et al.   CIRCULATION

High-fructose corn syrup enhances intestinal tumor growth in mice

(2019) Marcus D. Goncalves et al.   SCIENCE

IL-1 inhibition improves insulin resistance and adipokines in rheumatoid arthritis patients with comorbid type 2 diabetes

(2019) Piero Ruscitti et al.   MEDICINE

Spatial and Temporal Mapping of Human Innate Lymphoid Cells Reveals Elements of Tissue Specificity

(2019) Naomi A. Yudanin et al.   IMMUNITY

Treatment of type 2 diabetes by targeting interleukin-1: a meta-analysis of 2921 patients

(2019) Yachana Kataria et al.   Seminars in Immunopathology

Islet inflammation in type 2 diabetes

(2019) Marianne Böni-Schnetzler et al.   Seminars in Immunopathology

Chronic low-grade inflammation in polycystic ovary syndrome: is there a (patho)-physiological role for interleukin-1?

(2019) Milica Popovic et al.   Seminars in Immunopathology

Novel Insights into Sensorimotor and Cardiovascular Autonomic Neuropathy from Recent-Onset Diabetes and Population-Based Cohorts

(2019) Christian Herder et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Exosomes

(2019) D. Michiel Pegtel et al.   Annual Review of Biochemistry

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

The role of inflammation in diabetic eye disease

(2019) Marina Mesquida et al.   Seminars in Immunopathology

Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity

(2019) Hongdong Wang et al.   Nature Communications

Innate Lymphoid Cells in the Induction of Obesity

(2019) Takaharu Sasaki et al.   Cell Reports

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

(2019) Marco Orecchioni et al.   Frontiers in Immunology

Metabolically healthy obesity: facts and fantasies

(2019) Gordon I. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Interorgan communication by exosomes, adipose tissue, and adiponectin in metabolic syndrome

(2019) Shunbun Kita et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatocyte-Derived Extracellular Vesicles Promote Endothelial Inflammation and Atherogenesis via microRNA-1

(2019) Fangjie Jiang et al.   JOURNAL OF HEPATOLOGY

Treatment of type 2 diabetes with the designer cytokine IC7Fc

(2019) Maria Findeisen et al.   NATURE

Mechanisms of hypoxia signalling: new implications for nephrology

(2019) Johannes Schödel et al.   Nature Reviews Nephrology

Innate Immune Control of Adipose Tissue Homeostasis

(2019) Harry Kane et al.   TRENDS IN IMMUNOLOGY

Anti-interleukin-1 treatment in patients with rheumatoid arthritis and type 2 diabetes (TRACK): A multicentre, open-label, randomised controlled trial

(2019) Piero Ruscitti et al.   PLOS MEDICINE

Brain cell type–specific enhancer–promoter interactome maps and disease-risk association

(2019) Alexi Nott et al.   SCIENCE

Gut-associated IgA+ immune cells regulate obesity-related insulin resistance

(2019) Helen Luck et al.   Nature Communications

Targeting Intestinal Macrophages as a Potential Therapeutic Option in Obesity

(2018) THERESA V. ROHM et al.   DIABETES

Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes

(2018) Alexander J. Lakhter et al.   DIABETOLOGIA

Role of Inflammation in Diabetic Retinopathy

(2018) Anne Rübsam et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interleukin-1 Antagonism in Men with Metabolic Syndrome and Low Testosterone − A Randomized Clinical Trial

(2018) Fahim Ebrahimi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Recipient mucosal-associated invariant T cells control GVHD within the colon

(2018) Antiopi Varelias et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes

(2018) Brendan M. Everett et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial

(2018) Paul M Ridker et al.   LANCET

Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment

(2018) Héctor F. Escobar-Morreale   Nature Reviews Endocrinology

Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue

(2018) David A. Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion

(2018) Marianne Böni-Schnetzler et al.   Cell Reports

Expanded Regulatory T Cells Induce Alternatively Activated Monocytes With a Reduced Capacity to Expand T Helper-17 Cells

(2018) Marco Romano et al.   Frontiers in Immunology

Microglia and CNS Interleukin-1: Beyond Immunological Concepts

(2018) Xiaoyu Liu et al.   Frontiers in Neurology

The role of IL-1 in postprandial fatigue

(2018) Louise L. Lehrskov et al.   Molecular Metabolism

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

(2018) Michael P. Murphy et al.   CELL

Rationale and design of the Virginia Commonwealth University-Anakinra Remodeling Trial-3 (VCU-ART3): A randomized, placebo-controlled, double-blinded, multicenter study

(2018) Benjamin W. Van Tassell et al.   CLINICAL CARDIOLOGY

A Systemic Inflammatory Signature Reflecting Crosstalk Between Innate and Adaptive Immunity Is Associated With Incident Polyneuropathy: KORA F4/FF4 Study

(2018) Christian Herder et al.   DIABETES

Emerging biomarkers, tools, and treatments for diabetic polyneuropathy

(2018) Gidon J Bönhof et al.   ENDOCRINE REVIEWS

Global Perspectives on Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis

(2018) Zobair Younossi et al.   HEPATOLOGY

Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity

(2018) Wei Ying et al.   Cell Metabolism

Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial

(2018) Anne-Sophie Wedell-Neergaard et al.   Cell Metabolism

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

(2018) Mark A. Febbraio et al.   Cell Metabolism

General and Abdominal Obesity and Incident Distal Sensorimotor Polyneuropathy: Insights Into Inflammatory Biomarkers as Potential Mediators in the KORA F4/FF4 Cohort

(2018) Sabrina Schlesinger et al.   DIABETES CARE

Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics

(2018) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Low-Dose Methotrexate for the Prevention of Atherosclerotic Events

(2018) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hyperphosphorylation of Tau Associates With Changes in Its Function Beyond Microtubule Stability

(2018) Alejandra D. Alonso et al.   Frontiers in Cellular Neuroscience

Intestinal Dendritic Cells in Health and Gut Inflammation

(2018) Andrew J. Stagg   Frontiers in Immunology

Gut-Specific Delivery of T-Helper 17 Cells Reduces Obesity and Insulin Resistance in Mice

(2017) Chun-Pyo Hong et al.   GASTROENTEROLOGY

Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity

(2017) Selma Boulenouar et al.   IMMUNITY

Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production

(2017) Elise Dalmas et al.   IMMUNITY

Inhibitory Effects of Toll-Like Receptor 4, NLRP3 Inflammasome, and Interleukin-1β on White Adipocyte Browning

(2017) Meshail Okla et al.   INFLAMMATION

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Role of innate and adaptive immunity in obesity-associated metabolic disease

(2017) Tracey McLaughlin et al.   JOURNAL OF CLINICAL INVESTIGATION

Skeletal muscle insulin resistance: role of mitochondria and other ROS sources

(2017) Sergio Di Meo et al.   JOURNAL OF ENDOCRINOLOGY

Prevalence of type 2 diabetes and impaired fasting glucose in patients affected by rheumatoid arthritis

(2017) Piero Ruscitti et al.   MEDICINE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance

(2017) Ruth C. R. Meex et al.   Nature Reviews Endocrinology

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Poor clinical response in rheumatoid arthritis is the main risk factor for diabetes development in the short-term: A 1-year, single-centre, longitudinal study

(2017) Piero Ruscitti et al.   PLoS One

Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis

(2017) Shuyang Traub et al.   Cell Reports

The Pathophysiological Role of Microglia in Dynamic Surveillance, Phagocytosis and Structural Remodeling of the Developing CNS

(2017) Cataldo Arcuri et al.   Frontiers in Molecular Neuroscience

Mechanisms of Alzheimer’s Disease Pathogenesis and Prevention: The Brain, Neural Pathology, N-methyl-D-aspartate Receptors, Tau Protein and Other Risk Factors

(2017) Sayad Kocahan et al.   Clinical Psychopharmacology and Neuroscience

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation

(2017) Harsh R. Desai et al.   Scientific Reports

The Role of Inflammation in β-cell Dedifferentiation

(2017) Thierry M. Nordmann et al.   Scientific Reports

Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance

(2016) Pingping Li et al.   CELL

Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity

(2016) Byung-Cheol Lee et al.   Cell Metabolism

Colonic Pro-inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl2/Ccr2-Dependent Manner

(2016) Yoshinaga Kawano et al.   Cell Metabolism

HIF-1α in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance

(2016) Akiko Takikawa et al.   DIABETES

Macrophage Proliferation Sustains Adipose Tissue Inflammation in Formerly Obese Mice

(2016) Brian F. Zamarron et al.   DIABETES

Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance

(2016) Timothy E. O’Sullivan et al.   IMMUNITY

Adipose Tissue Hypoxia, Inflammation, and Fibrosis in Obese Insulin-Sensitive and Obese Insulin-Resistant Subjects

(2016) Helen M. Lawler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy

(2016) K. Shahzad et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Altered Interleukin-10 Signaling in Skeletal Muscle Regulates Obesity-Mediated Inflammation and Insulin Resistance

(2016) Sezin Dagdeviren et al.   MOLECULAR AND CELLULAR BIOLOGY

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes

(2016) Steven P. Marso et al.   NEW ENGLAND JOURNAL OF MEDICINE

SYSTEMIC INTERLEUKIN 1β INHIBITION IN PROLIFERATIVE DIABETIC RETINOPATHY

(2016) Marc Stahel et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Local proliferation initiates macrophage accumulation in adipose tissue during obesity

(2016) C Zheng et al.   Cell Death & Disease

Comparative Safety of Interleukin-1 Blockade With Anakinra in Patients With ST-Segment Elevation Acute Myocardial Infarction (from the VCU-ART and VCU-ART2 Pilot Studies)

(2015) Antonio Abbate et al.   AMERICAN JOURNAL OF CARDIOLOGY

Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α–Dependent Senescence-Associated Secretory PhenotypeSignificance

(2015) Sarah E. Gardner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

De novolipogenesis in the liver in health and disease: more than just a shunting yard for glucose

(2015) Francis W. B. Sanders et al.   BIOLOGICAL REVIEWS

Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells

(2015) Claudiane Guay et al.   Cell Communication and Signaling

Jejunal T Cell Inflammation in Human Obesity Correlates with Decreased Enterocyte Insulin Signaling

(2015) Milena Monteiro-Sepulveda et al.   Cell Metabolism

Regulation of Obesity-Related Insulin Resistance with Gut Anti-inflammatory Agents

(2015) Helen Luck et al.   Cell Metabolism

Blocking IL-6 trans-Signaling Prevents High-Fat Diet-Induced Adipose Tissue Macrophage Recruitment but Does Not Improve Insulin Resistance

(2015) Michael J. Kraakman et al.   Cell Metabolism

Monocytes from patients with rheumatoid arthritis and type 2 diabetes mellitus display an increased production of interleukin (IL)-1β via the nucleotide-binding domain and leucine-rich repeat containing family pyrin 3(NLRP3)-inflammasome activation: a pos

(2015) P. Ruscitti et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

One week treatment with the IL-1 receptor antagonist anakinra leads to a sustained improvement in insulin sensitivity in insulin resistant patients with type 1 diabetes mellitus

(2015) Edwin J.P. van Asseldonk et al.   CLINICAL IMMUNOLOGY

Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects

(2015) Mariëtte R. Boon et al.   CLINICAL SCIENCE

Monounsaturated Fatty Acid–Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome–Mediated IL-1β Secretion and Insulin Resistance Despite Obesity

(2015) Orla M. Finucane et al.   DIABETES

Mast cells infiltrate pancreatic islets in human type 1 diabetes

(2015) Luisa Martino et al.   DIABETOLOGIA

The Origin of Tissue-Resident Macrophages: When an Erythro-myeloid Progenitor Is an Erythro-myeloid Progenitor

(2015) Elisa Gomez Perdiguero et al.   IMMUNITY

Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance

(2015) I M Khan et al.   INTERNATIONAL JOURNAL OF OBESITY

Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects

(2015) Javier Traba et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Depletion of fat-resident Treg cells prevents age-associated insulin resistance

(2015) Sagar P. Bapat et al.   NATURE

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

(2015) Felix M Wensveen et al.   NATURE IMMUNOLOGY

Innate immunity in Alzheimer's disease

(2015) Michael T Heneka et al.   NATURE IMMUNOLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes

(2015) Pingping Li et al.   NATURE MEDICINE

Regulation of metabolism by the innate immune system

(2015) Denise E. Lackey et al.   Nature Reviews Endocrinology

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

(2015) Bernard Zinman et al.   NEW ENGLAND JOURNAL OF MEDICINE

The dynamics of monocytes and microglia in Alzheimer’s disease

(2015) Peter Thériault et al.   Alzheimers Research & Therapy

High Fat Diet Causes Depletion of Intestinal Eosinophils Associated with Intestinal Permeability

(2015) Andrew M. F. Johnson et al.   PLoS One

Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients

(2014) Kosuke Kamata et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

(2014) Hayato Nakagawa et al.   CANCER CELL

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

(2014) Yun Sok Lee et al.   CELL

Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity

(2014) Prabhakara R. Nagareddy et al.   Cell Metabolism

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

(2014) Mario Kratz et al.   Cell Metabolism

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

(2014) Shinya U. Amano et al.   Cell Metabolism

Adipocyte Inflammation Is Essential for Healthy Adipose Tissue Expansion and Remodeling

(2014) Ingrid Wernstedt Asterholm et al.   Cell Metabolism

Interleukin-6 blockade in ocular inflammatory diseases

(2014) M. Mesquida et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Anakinra treatment in patients with gout and type 2 diabetes

(2014) Antonio Vitale et al.   CLINICAL RHEUMATOLOGY

Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes

(2014) Teresa Rodriguez-Calvo et al.   DIABETES

Angiotensin II Induces Interleukin-1β–Mediated Islet Inflammation and β-Cell Dysfunction Independently of Vasoconstrictive Effects

(2014) Nadine S. Sauter et al.   DIABETES

Characterization of Distinct Subpopulations of Hepatic Macrophages in HFD/Obese Mice

(2014) Hidetaka Morinaga et al.   DIABETES

T Cell–Derived IL-22 Amplifies IL-1β–Driven Inflammation in Human Adipose Tissue: Relevance to Obesity and Type 2 Diabetes

(2014) Elise Dalmas et al.   DIABETES

Ocular Anti-VEGF Therapy for Diabetic Retinopathy: The Role of VEGF in the Pathogenesis of Diabetic Retinopathy

(2014) Rafael Simó et al.   DIABETES CARE

The interleukin-1 receptor antagonist anakinra improves first-phase insulin secretion and insulinogenic index in subjects with impaired glucose tolerance

(2014) P. C. M. van Poppel et al.   DIABETES OBESITY & METABOLISM

Association of proinflammatory cytokines and islet resident leucocytes with islet dysfunction in type 2 diabetes

(2014) Matthew J. Butcher et al.   DIABETOLOGIA

IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice

(2014) Clara Y. Westwell-Roper et al.   DIABETOLOGIA

Myokines in insulin resistance and type 2 diabetes

(2014) Kristin Eckardt et al.   DIABETOLOGIA

Islet amyloid formation is an important determinant for inducing islet inflammation in high-fat-fed human IAPP transgenic mice

(2014) Daniel T. Meier et al.   DIABETOLOGIA

Macrophages in intestinal homeostasis and inflammation

(2014) Calum C. Bain et al.   IMMUNOLOGICAL REVIEWS

Transplantation of mesenchymal stem cells recruits trophic macrophages to induce pancreatic beta cell regeneration in diabetic mice

(2014) Xiaocang Cao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Global toll-like receptor 4 knockout results in decreased renal inflammation, fibrosis and podocytopathy

(2014) Ishwarlal Jialal et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

(2014) Xiaoting Wang et al.   NATURE

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

(2014) Calum C Bain et al.   NATURE IMMUNOLOGY

Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress

(2014) Sumaira Z Hasnain et al.   NATURE MEDICINE

Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity

(2014) Bhama Ramkhelawon et al.   NATURE MEDICINE

Targeting inflammation in the treatment of type 2 diabetes: time to start

(2014) Marc Y. Donath   NATURE REVIEWS DRUG DISCOVERY

Effect of extracellular vesicles of human adipose tissue on insulin signaling in liver and muscle cells

(2014) Mariëtte E.G. Kranendonk et al.   Obesity

TLR4 Activation Promotes Podocyte Injury and Interstitial Fibrosis in Diabetic Nephropathy

(2014) Jin Ma et al.   PLoS One

Insulin Resistance is Associated with MCP1-Mediated Macrophage Accumulation in Skeletal Muscle in Mice and Humans

(2014) David Patsouris et al.   PLoS One

M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7

(2014) Xiangwei Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of interleukins in obesity: implications for metabolic disease

(2014) Mark A. Febbraio   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes

(2013) Allison B. Goldfine   ANNALS OF INTERNAL MEDICINE

Salicylate (Salsalate) in Patients With Type 2 Diabetes

(2013) Allison B. Goldfine   ANNALS OF INTERNAL MEDICINE

Neuroimmune Guidance Cue Semaphorin 3E Is Expressed in Atherosclerotic Plaques and Regulates Macrophage Retention

(2013) Amarylis Wanschel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation

(2013) Xiaoyuan Xu et al.   Cell Metabolism

Semaphorin3E-Induced Inflammation Contributes to Insulin Resistance in Dietary Obesity

(2013) Ippei Shimizu et al.   Cell Metabolism

Infliximab in the Treatment of Crohn Disease and Type 1 Diabetes

(2013) K. Timper et al.   DIABETES CARE

Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1  Antibody, in Patients With Type 2 Diabetes

(2013) J. Sloan-Lancaster et al.   DIABETES CARE

Association of Subclinical Inflammation With Polyneuropathy in the Older Population: KORA F4 study

(2013) C. Herder et al.   DIABETES CARE

A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance

(2013) A. B. Goldfine et al.   DIABETOLOGIA

Local proliferation of macrophages in adipose tissue during obesity-induced inflammation

(2013) Julia Haase et al.   DIABETOLOGIA

Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?

(2013) Pura Muñoz-Cánoves et al.   FEBS Journal

Origins and Functional Specialization of Macrophages and of Conventional and Monocyte-Derived Dendritic Cells in Mouse Skin

(2013) Samira Tamoutounour et al.   IMMUNITY

Immune Regulation in Obesity-Associated Adipose Inflammation

(2013) J. M. Han et al.   JOURNAL OF IMMUNOLOGY

Testosterone and insulin resistance in the metabolic syndrome and T2DM in men

(2013) Preethi M. Rao et al.   Nature Reviews Endocrinology

Pro-Inflammatory macrophages increase in skeletal muscle of high fat-Fed mice and correlate with metabolic risk markers in humans

(2013) Lisbeth N. Fink et al.   Obesity

Involvement of Endoplasmic Reticulum Stress in Albuminuria Induced Inflammasome Activation in Renal Proximal Tubular Cells

(2013) Li Fang et al.   PLoS One

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

A Nonsynonymous Polymorphism in Semaphorin 3A as a Risk Factor for Human Unexplained Cardiac Arrest with Documented Ventricular Fibrillation

(2013) Yukiko Nakano et al.   PLoS Genetics

A Ceramide-Centric View of Insulin Resistance

(2012) Jose A. Chavez et al.   Cell Metabolism

Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

(2012) Kosei Eguchi et al.   Cell Metabolism

Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes

(2012) C. Cavelti-Weder et al.   DIABETES CARE

Effect of anti-IL-1β antibody (canakinumab) on insulin secretion rates in impaired glucose tolerance or type 2 diabetes: results of a randomized, placebo-controlled trial

(2012) A. Rissanen et al.   DIABETES OBESITY & METABOLISM

CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis

(2012) Samira Tamoutounour et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Usefulness of the Vitreous Fluid Analysis in the Translational Research of Diabetic Retinopathy

(2012) Olga Simó-Servat et al.   MEDIATORS OF INFLAMMATION

Selective Inhibition of Hypoxia-Inducible Factor 1  Ameliorates Adipose Tissue Dysfunction

(2012) K. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors

(2012) C C Bain et al.   Mucosal Immunology

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

(2012) Daniela Cipolletta et al.   NATURE

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

(2012) Saswata Talukdar et al.   NATURE MEDICINE

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inducible MicroRNA-223 Down-Regulation Promotes TLR-Triggered IL-6 and IL-1β Production in Macrophages by Targeting STAT3

(2012) Qingyun Chen et al.   PLoS One

High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway

(2012) Kyung-Ah Kim et al.   PLoS One

Relation of depot-specific adipose inflammation to insulin resistance in human obesity

(2012) S J Bigornia et al.   Nutrition & Diabetes

Salsalate improves glycemic control in patients with newly diagnosed type 2 diabetes

(2011) Elham Faghihimani et al.   ACTA DIABETOLOGICA

β-Cell Loss and β-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition

(2011) Catherine A. Jurgens et al.   AMERICAN JOURNAL OF PATHOLOGY

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

(2011) Joshua A. Smith et al.   BRAIN RESEARCH BULLETIN

Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet-Fed Mice

(2011) C. Jiang et al.   DIABETES

Increased Macrophage Migration Into Adipose Tissue in Obese Mice

(2011) D. Y. Oh et al.   DIABETES

Lack of Interleukin-1 Receptor I (IL-1RI) Protects Mice From High-Fat Diet-Induced Adipose Tissue Inflammation Coincident With Improved Glucose Homeostasis

(2011) F. C. McGillicuddy et al.   DIABETES

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Effect of Diacerein on Insulin Secretion and Metabolic Control in Drug-Naive Patients With Type 2 Diabetes: A randomized clinical trial

(2011) M. G. Ramos-Zavala et al.   DIABETES CARE

Inhibition of IL-1  Improves Fatigue in Type 2 Diabetes

(2011) C. Cavelti-Weder et al.   DIABETES CARE

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

(2011) Jacques Amar et al.   EMBO Molecular Medicine

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease

(2011) Chia-Hsiung Chen et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Association Between Disease-Modifying Antirheumatic Drugs and Diabetes Risk in Patients With Rheumatoid Arthritis and Psoriasis

(2011) Daniel H. Solomon   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Regulation of VEGF expression in human retinal cells by cytokines: Implications for the role of inflammation in age-related macular degeneration

(2011) Chandrasekharam N. Nagineni et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Treatment with Anakinra Improves Disposition Index But Not Insulin Sensitivity in Nondiabetic Subjects with the Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study

(2011) Edwin J. P. van Asseldonk et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity, inflammation, and liver cancer

(2011) Beicheng Sun et al.   JOURNAL OF HEPATOLOGY

Deficiency of the Leukotriene B4 Receptor, BLT-1, Protects against Systemic Insulin Resistance in Diet-Induced Obesity

(2011) M. Spite et al.   JOURNAL OF IMMUNOLOGY

Toll-Like Receptor 4 Promotes Tubular Inflammation in Diabetic Nephropathy

(2011) M. Lin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

(2011) Helga Ellingsgaard et al.   NATURE MEDICINE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Diabetes mellitus risk in rheumatoid arthritis: Reduced incidence with anti-tumor necrosis factor α therapy

(2011) Jana l. Antohe et al.   ARTHRITIS CARE & RESEARCH

Interleukin-1 Blockade With Anakinra to Prevent Adverse Cardiac Remodeling After Acute Myocardial Infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot Study)

(2010) Antonio Abbate et al.   AMERICAN JOURNAL OF CARDIOLOGY

Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation

(2010) Claire Barbier de La Serre et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Dynamic, M2-Like Remodeling Phenotypes of CD11c+ Adipose Tissue Macrophages During High-Fat Diet-Induced Obesity in Mice

(2010) M. E. Shaul et al.   DIABETES

C-C Chemokine Receptor 2 (CCR2) Regulates the Hepatic Recruitment of Myeloid Cells That Promote Obesity-Induced Hepatic Steatosis

(2010) A. E. Obstfeld et al.   DIABETES

Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity

(2010) J. M. Wentworth et al.   DIABETES

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

(2010) M. Igoillo-Esteve et al.   DIABETOLOGIA

Reduced Oxygenation in Human Obese Adipose Tissue Is Associated with Impaired Insulin Suppression of Lipolysis

(2010) Magdalena Pasarica et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

TNF-α Antagonism with Etanercept Decreases Glucose and Increases the Proportion of High Molecular Weight Adiponectin in Obese Subjects with Features of the Metabolic Syndrome

(2010) Takara L. Stanley et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

(2010) A. Vilaysane et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases

(2010) Olav A. Gressner et al.   LIVER INTERNATIONAL

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Differential release of chromatin-bound IL-1  discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation

(2010) I. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

(2010) J. R. Swann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action

(2009) Vijayalakshmi Varma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle

(2009) E.-G. Hong et al.   DIABETES

Subclinical Inflammation and Diabetic Polyneuropathy: MONICA/KORA Survey F3 (Augsburg, Germany)

(2009) C. Herder et al.   DIABETES CARE

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

(2009) R. A. DeFronzo et al.   DIABETES CARE

Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes

(2009) C. M. Larsen et al.   DIABETES CARE

Islet-associated macrophages in type 2 diabetes

(2009) S. J. Richardson et al.   DIABETOLOGIA

Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I

(2009) Marianne Böni-Schnetzler et al.   ENDOCRINOLOGY

Rheumatoid arthritis

(2009) Lars Klareskog et al.   LANCET

Hypoxia-Inducible Factor 1  Induces Fibrosis and Insulin Resistance in White Adipose Tissue

(2009) N. Halberg et al.   MOLECULAR AND CELLULAR BIOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat

(2009) J. A. Ehses et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota

(2009) Y. Cong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, Inhibits Apoptosis in Experimental Acute Myocardial Infarction

(2008) Antonio Abbate et al.   CIRCULATION

Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes

(2008) Allison B. Goldfine et al.   CTS-Clinical and Translational Science

UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators

(2008) D. Thomas Rutkowski et al.   DEVELOPMENTAL CELL

Reduced Adipose Tissue Oxygenation in Human Obesity: Evidence for Rarefaction, Macrophage Chemotaxis, and Inflammation Without an Angiogenic Response

(2008) M. Pasarica et al.   DIABETES

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice

(2008) S. Franckhauser et al.   DIABETOLOGIA

The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomised double-blind placebo-controlled study

(2008) J. Koska et al.   DIABETOLOGIA

Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice

(2008) I. Murano et al.   JOURNAL OF LIPID RESEARCH

Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance

(2008) T. Bolmont et al.   JOURNAL OF NEUROSCIENCE

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

(2008) Bente K. Pedersen et al.   PHYSIOLOGICAL REVIEWS

Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species

(2007) Yongzhong Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

(2007) Puneet Puri et al.   GASTROENTEROLOGY