Visceral adipose tissue Tregs and the cells that nurture them

Sex-specific adipose tissue imprinting of regulatory T cells

(2020) Ajithkumar Vasanthakumar et al.   NATURE

Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches

(2019) Madelene W. Dahlgren et al.   IMMUNITY

Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction

(2019) Lisa Schmidleithner et al.   IMMUNITY

Identification of a mesenchymal progenitor cell hierarchy in adipose tissue

(2019) David Merrick et al.   SCIENCE

The Transcriptional Regulator Id2 Is Critical for Adipose-Resident Regulatory T Cell Differentiation, Survival, and Function

(2019) Adolfo B. Frias et al.   JOURNAL OF IMMUNOLOGY

TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases

(2019) Bi-Huei Yang et al.   Cell Reports

Distinct immunocyte-promoting and adipocyte-generating stromal components coordinate adipose tissue immune and metabolic tenors

(2019) Raul German Spallanzani et al.   Science Immunology

Stromal cells maintain immune cell homeostasis in adipose tissue via production of interleukin-33

(2019) T. Mahlakõiv et al.   Science Immunology

TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the Distinctive Fat-Treg Phenotype

(2018) Chaoran Li et al.   CELL

Deconstructing Adipogenesis Induced by β3-Adrenergic Receptor Activation with Single-Cell Expression Profiling

(2018) Rayanne B. Burl et al.   Cell Metabolism

Peripheral PDGFRα+gp38+mesenchymal cells support the differentiation of fetal liver–derived ILC2

(2018) Satoshi Koga et al.   JOURNAL OF EXPERIMENTAL MEDICINE

γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis

(2018) Ayano C. Kohlgruber et al.   NATURE IMMUNOLOGY

A stromal cell population that inhibits adipogenesis in mammalian fat depots

(2018) Petra C. Schwalie et al.   NATURE

Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice

(2018) Chelsea Hepler et al.   eLife

A Unique Population: Adipose-Resident Regulatory T Cells

(2018) Qin Zeng et al.   Frontiers in Immunology

Cutting Edge: Dynamic Expression of Id3 Defines the Stepwise Differentiation of Tissue-Resident Regulatory T Cells

(2018) Jenna M. Sullivan et al.   JOURNAL OF IMMUNOLOGY

Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance

(2018) Jérôme Gilleron et al.   Cell Reports

IL-33/ST2 Axis in Organ Fibrosis

(2018) Ourania S. Kotsiou et al.   Frontiers in Immunology

Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family

(2017) Corinne Cayrol et al.   IMMUNOLOGICAL REVIEWS

Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes

(2017) Sook Kyung Chang et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells

(2017) Tuo Deng et al.   Nature Communications

Distinct Blood and Visceral Adipose Tissue Regulatory T Cell and Innate Lymphocyte Profiles Characterize Obesity and Colorectal Cancer

(2017) Gloria Donninelli et al.   Frontiers in Immunology

Characterization of stromal vascular fraction and adipose stem cells from subcutaneous, preperitoneal and visceral morbidly obese human adipose tissue depots

(2017) Karina Ribeiro Silva et al.   PLoS One

Tissue Tregs

(2016) Marisella Panduro et al.   Annual Review of Immunology

Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice

(2016) Lavanya Vishvanath et al.   Cell Metabolism

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells

(2016) Wilson Kuswanto et al.   IMMUNITY

Interleukin 33 is a guardian of barriers and a local alarmin

(2016) Nikolas T Martin et al.   NATURE IMMUNOLOGY

On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver

(2016) Igor Theurl et al.   NATURE MEDICINE

Lower omental t-regulatory cell count is associated with higher fasting glucose and lower β-cell function in adults with obesity

(2016) Lauren E. Gyllenhammer et al.   Obesity

Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation

(2016) Lucy H. Jackson-Jones et al.   Nature Communications

Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice

(2015) Dmitriy Kolodin et al.   Cell Metabolism

Using a 3D Culture System to Differentiate Visceral Adipocytes In Vitro

(2015) Margo P. Emont et al.   ENDOCRINOLOGY

Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation

(2015) Ari B. Molofsky et al.   IMMUNITY

IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance

(2015) Jonathan M. Han et al.   JOURNAL OF IMMUNOLOGY

Depletion of fat-resident Treg cells prevents age-associated insulin resistance

(2015) Sagar P. Bapat et al.   NATURE

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells

(2015) Ajithkumar Vasanthakumar et al.   NATURE IMMUNOLOGY

Adipocyte progenitor cells initiate monocyte chemoattractant protein-1-mediated macrophage accumulation in visceral adipose tissue

(2015) Jennifer L. Kaplan et al.   Molecular Metabolism

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

IL-21 Is a Major Negative Regulator of IRF4-Dependent Lipolysis Affecting Tregs in Adipose Tissue and Systemic Insulin Sensitivity

(2014) Marta Fabrizi et al.   DIABETES

The alarmin IL-33 promotes regulatory T-cell function in the intestine

(2014) Chris Schiering et al.   NATURE

Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source

(2014) You-Ying Chau et al.   NATURE CELL BIOLOGY

Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue

(2014) Lydia Lynch et al.   NATURE IMMUNOLOGY

Appearance and disappearance of the mRNA signature characteristic of Tregcells in visceral adipose tissue: Age, diet, and PPARγ effects

(2014) Daniela Cipolletta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Special Population of Regulatory T Cells Potentiates Muscle Repair

(2013) Dalia Burzyn et al.   CELL

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

(2013) Ari B. Molofsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Modulation of adipose tissue inflammation by FOXP3+ Treg cells, IL-10, and TGF-β in metabolically healthy class III obese individuals

(2013) Solange Pereira et al.   NUTRITION

Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance

(2013) S. J. Priceman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zfp423 Expression Identifies Committed Preadipocytes and Localizes to Adipose Endothelial and Perivascular Cells

(2012) Rana K. Gupta et al.   Cell Metabolism

Mesenchymal Stromal Cells: New Directions

(2012) Armand Keating   Cell Stem Cell

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

(2012) Daniela Cipolletta et al.   NATURE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Female Mice are Protected against High-Fat Diet Induced Metabolic Syndrome and Increase the Regulatory T Cell Population in Adipose Tissue

(2012) Ulrika S. Pettersson et al.   PLoS One

Sex differences in human adipose tissues – the biology of pear shape

(2012) Kalypso Karastergiou et al.   Biology of Sex Differences

The clinical importance of visceral adiposity: a critical review of methods for visceral adipose tissue analysis

(2011) A Shuster et al.   BRITISH JOURNAL OF RADIOLOGY

Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy

(2011) Kathrin Eller et al.   DIABETES

Visceral Adipose Inflammation in Obesity Is Associated with Critical Alterations in Tregulatory Cell Numbers

(2011) Jeffrey Deiuliis et al.   PLoS One

Interleukin-33 Induces Protective Effects in Adipose Tissue Inflammation During Obesity in Mice

(2010) Ashley M. Miller et al.   CIRCULATION RESEARCH

Inflammation Correlates With Markers of T-Cell Subsets Including Regulatory T Cells in Adipose Tissue From Obese Patients

(2010) Maximilian Zeyda et al.   Obesity

Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice

(2010) Y. Ilan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex and Depot Differences in Adipocyte Insulin Sensitivity and Glucose Metabolism

(2009) Y. Macotela et al.   DIABETES

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE