De novolipogenesis in the liver in health and disease: more than just a shunting yard for glucose

De novo lipogenesis in health and disease

(2014) Fatima Ameer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Prevalence of prediabetes in England from 2003 to 2011: population-based, cross-sectional study

(2014) A. G. Mainous et al.   BMJ Open

Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals

(2013) Howard C. Masuoka et al.   Annals of the New York Academy of Sciences

Zonation of glucose and fatty acid metabolism in the liver: Mechanism and metabolic consequences

(2013) Brenda S. Hijmans et al.   BIOCHIMIE

Hepatic glucose sensing and integrative pathways in the liver

(2013) Maaike H. Oosterveer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Colonic bacterial metabolites and human health

(2013) Wendy R Russell et al.   CURRENT OPINION IN MICROBIOLOGY

The multifaceted role of mTORC1 in the control of lipid metabolism

(2013) Stéphane J H Ricoult et al.   EMBO REPORTS

Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo

(2013) K. H. Williams et al.   ENDOCRINE REVIEWS

Insulin signaling, resistance, and metabolic syndrome: insights from mouse models into disease mechanisms

(2013) Shaodong Guo   JOURNAL OF ENDOCRINOLOGY

Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease

(2013) Yuki Kawano et al.   JOURNAL OF GASTROENTEROLOGY

Role of ceramide in diabetes mellitus: evidence and mechanisms

(2013) Sehamuddin Galadari et al.   Lipids in Health and Disease

Pathogenesis of the Metabolic Syndrome: Insights from Monogenic Disorders

(2013) Rinki Murphy et al.   MEDIATORS OF INFLAMMATION

The SLC2 (GLUT) family of membrane transporters

(2013) Mike Mueckler et al.   MOLECULAR ASPECTS OF MEDICINE

Butyrate-Producing Probiotics Reduce Nonalcoholic Fatty Liver Disease Progression in Rats: New Insight into the Probiotics for the Gut-Liver Axis

(2013) Hitoshi Endo et al.   PLoS One

Fructose as a key player in the development of fatty liver disease

(2013) Metin Basaranoglu   WORLD JOURNAL OF GASTROENTEROLOGY

Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease

(2013) Melania Gaggini et al.   Nutrients

Selective Hepatic Insulin Resistance, VLDL Overproduction, and Hypertriglyceridemia

(2012) Janet D. Sparks et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Intracellular Trafficking and Secretion of VLDL

(2012) Samata Tiwari et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes

(2012) Catherine Arden et al.   BIOCHEMICAL JOURNAL

Nuclear Receptors Reverse McGarry's Vicious Cycle to Insulin Resistance

(2012) David D. Moore   Cell Metabolism

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

(2012) Asami Hagiwara et al.   Cell Metabolism

The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals

(2012) Young-Ah Moon et al.   Cell Metabolism

Prevalence of Prediabetes and Diabetes and Metabolic Profile of Patients With Nonalcoholic Fatty Liver Disease (NAFLD)

(2012) C. Ortiz-Lopez et al.   DIABETES CARE

The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology

(2012) Naga Chalasani et al.   GASTROENTEROLOGY

Liver-Specific Expression of Transcriptionally Active SREBP-1c Is Associated with Fatty Liver and Increased Visceral Fat Mass

(2012) Birgit Knebel et al.   PLoS One

Dissociating fatty liver and diabetes

(2012) Zheng Sun et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hepatic expression and cellular distribution of the glucose transporter family

(2012) Sumera Karim   WORLD JOURNAL OF GASTROENTEROLOGY

Applications of metabolomics for understanding the action of peroxisome proliferator-activated receptors (PPARs) in diabetes, obesity and cancer

(2012) Zsuzsanna Ament et al.   Genome Medicine

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Fatty acid synthase and liver triglyceride metabolism: Housekeeper or messenger?

(2011) Anne P.L. Jensen-Urstad et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Combined Effect of Nonalcoholic Fatty Liver Disease and Impaired Fasting Glucose on the Development of Type 2 Diabetes: A 4-year retrospective longitudinal study

(2011) J. C. Bae et al.   DIABETES CARE

Transcription factors and coactivators controlling nutrient and hormonal regulation of hepatic gluconeogenesis

(2011) Sarawut Jitrapakdee   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate

(2011) Xiaoqing Gan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Missense Mutation inAPOC3within the C-terminal Lipid Binding Domain of Human ApoC-III Results in Impaired Assembly and Secretion of Triacylglycerol-rich Very Low Density Lipoproteins

(2011) Wen Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver

(2011) Renaud Dentin et al.   JOURNAL OF HEPATOLOGY

Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance

(2011) Sung Hee Choi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Fructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome

(2010) Mark J. Dekker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c

(2010) P. Ferré et al.   DIABETES OBESITY & METABOLISM

From the metabolic syndrome to NAFLD or vice versa?

(2010) Ester Vanni et al.   DIGESTIVE AND LIVER DISEASE

Lipid-induced insulin resistance: unravelling the mechanism

(2010) Varman T Samuel et al.   LANCET

The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome

(2010) Jung Sub Lim et al.   Nature Reviews Gastroenterology & Hepatology

The role of the gut microbiota in nonalcoholic fatty liver disease

(2010) Ahmed Abu-Shanab et al.   Nature Reviews Gastroenterology & Hepatology

Recent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion

(2010) Meenakshi Sundaram et al.   Nutrition & Metabolism

Metabolic Effects of Fructose and the Worldwide Increase in Obesity

(2010) Luc Tappy et al.   PHYSIOLOGICAL REVIEWS

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

(2010) Shijie Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis

(2010) C.-W. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In SituLipidomic Analysis of Nonalcoholic Fatty Liver by Cluster TOF-SIMS Imaging

(2009) Delphine Debois et al.   ANALYTICAL CHEMISTRY

Lipid oversupply, selective insulin resistance, and lipotoxicity: Molecular mechanisms

(2009) Jose Antonio Chavez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Enhancement in liver SREBP-1c/PPAR-α ratio and steatosis in obese patients: Correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion

(2009) Paulina Pettinelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator-1 β in the Pathogenesis of Fructose-Induced Insulin Resistance

(2009) Yoshio Nagai et al.   Cell Metabolism

Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance

(2009) Karla F. Leavens et al.   Cell Metabolism

Harmonizing the Metabolic Syndrome

(2009) K.G.M.M. Alberti et al.   CIRCULATION

Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations

(2009) A. Kotronen et al.   DIABETOLOGIA

Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice

(2009) Astrid Spruss et al.   HEPATOLOGY

Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones

(2009) Seong Hwan Hwahng et al.   HEPATOLOGY

Insulin Enhances Post-translational Processing of Nascent SREBP-1c by Promoting Its Phosphorylation and Association with COPII Vesicles

(2009) Chandrahasa R. Yellaturu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diabetes, insulin resistance and sugars

(2009) M. Laville et al.   Obesity Reviews

Liver architecture, cell function, and disease

(2009) Hiromi Ishibashi et al.   Seminars in Immunopathology

Regulation of the fructose transporter GLUT5 in health and disease

(2008) Veronique Douard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

VLDL exits from the endoplasmic reticulum in a specialized vesicle, the VLDL transport vesicle, in rat primary hepatocytes

(2008) Shadab A. Siddiqi   BIOCHEMICAL JOURNAL

Targeting of PKCζ and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide

(2008) Eric Hajduch et al.   BIOCHEMICAL JOURNAL

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Hepatic Stearoyl-CoA Desaturase (SCD)-1 Activity and Diacylglycerol but Not Ceramide Concentrations Are Increased in the Nonalcoholic Human Fatty Liver

(2008) A. Kotronen et al.   DIABETES

Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

(2008) S. M. Reyna et al.   DIABETES

Liver, Muscle, and Adipose Tissue Insulin Action Is Directly Related to Intrahepatic Triglyceride Content in Obese Subjects

(2008) Kevin M. Korenblat et al.   GASTROENTEROLOGY

Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease

(2008) Nobito Higuchi et al.   HEPATOLOGY RESEARCH

Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease

(2008) Naga Chalasani et al.   JOURNAL OF HEPATOLOGY

Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: Role of endotoxin

(2008) Ina Bergheim et al.   JOURNAL OF HEPATOLOGY

Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: A systematic review

(2008) Silvia Sookoian et al.   JOURNAL OF HEPATOLOGY

The Crystal Structure of a Mammalian Fatty Acid Synthase

(2008) T. Maier et al.   SCIENCE