Interorgan communication by exosomes, adipose tissue, and adiponectin in metabolic syndrome

Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation

(2019) Yong Pan et al.   JOURNAL OF CLINICAL INVESTIGATION

Adiponectin promotes muscle regeneration through binding to T-cadherin

(2019) Yoshimitsu Tanaka et al.   Scientific Reports

A lipase-independent pathway of lipid release and immune modulation by adipocytes

(2019) Stephen E. Flaherty et al.   SCIENCE

Obesity needs to be put into a much wider context

(2019) Sabine Kleinert et al.   LANCET

Altered Extracellular Vesicle Concentration, Cargo and Function in Diabetes Mellitus

(2018) David W. Freeman et al.   DIABETES

Serum exosomes mediate delivery of arginase 1 as a novel mechanism for endothelial dysfunction in diabetes

(2018) Huina Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceramides – Lipotoxic Inducers of Metabolic Disorders

(2018) Bhagirath Chaurasia et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State

(2018) Clair Crewe et al.   CELL

Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016–40 for 195 countries and territories

(2018) Kyle J Foreman et al.   LANCET

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

Adiponectin association with T-cadherin protects against neointima proliferation and atherosclerosis

(2017) Yuya Fujishima et al.   FASEB JOURNAL

The unique prodomain of T-cadherin plays a key role in adiponectin binding with the essential extracellular cadherin repeats 1 and 2

(2017) Shiro Fukuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pet10p is a yeast perilipin that stabilizes lipid droplets and promotes their assembly

(2017) Qiang Gao et al.   JOURNAL OF CELL BIOLOGY

Inflammatory mechanisms linking obesity and metabolic disease

(2017) Alan R. Saltiel et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Phosphatidylserine-Derived Negative Surface Charges in the Recognition and Uptake of Intravenously Injected B16BL6-Derived Exosomes by Macrophages

(2017) Akihiro Matsumoto et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells

(2017) Akiko Takahashi et al.   Nature Communications

Bone marrow adipocytes

(2017) Mark C. Horowitz et al.   Adipocyte

Impact of lysosome status on extracellular vesicle content and release

(2016) Erez Eitan et al.   AGEING RESEARCH REVIEWS

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Role of Adiponectin in Coronary Heart Disease RiskNovelty and Significance

(2016) Maria Carolina Borges et al.   CIRCULATION RESEARCH

Autophagy Is Dispensable for Macrophage-Mediated Lipid Homeostasis in Adipose Tissue

(2016) Ambar Grijalva et al.   DIABETES

Effect of exosome isolation methods on physicochemical properties of exosomes and clearance of exosomes from the blood circulation

(2016) Takuma Yamashita et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

CDH13 Polymorphisms are Associated with Adiponectin Levels and Metabolic Syndrome Traits Independently of Visceral Fat Mass

(2016) Aya Kitamoto et al.   Journal of Atherosclerosis and Thrombosis

ExtraPEG: A Polyethylene Glycol-Based Method for Enrichment of Extracellular Vesicles

(2016) Mark A. Rider et al.   Scientific Reports

Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis

(2015) Jonathan Y. Xia et al.   Cell Metabolism

Positive Feedback Regulation Between Adiponectin and T-Cadherin Impacts Adiponectin Levels in Tissue and Plasma of Male Mice

(2015) Keisuke Matsuda et al.   ENDOCRINOLOGY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Perilipin-related protein regulates lipid metabolism inC. elegans

(2015) Ahmed Ali Chughtai et al.   PeerJ

Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction

(2014) L. Barile et al.   CARDIOVASCULAR RESEARCH

Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling

(2014) T Yabu et al.   CELL DEATH AND DIFFERENTIATION

Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction

(2014) William P. Cawthorn et al.   Cell Metabolism

Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium

(2014) Nicholette D. Palmer et al.   DIABETES

Plasma Exosome MicroRNA Profiling Unravels a New Potential Modulator of Adiponectin Pathway in Diabetes: Effect of Glycemic Control

(2014) Donato Santovito et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Quantitative and stoichiometric analysis of the microRNA content of exosomes

(2014) J. R. Chevillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adiponectin Regulates Bone Mass via Opposite Central and Peripheral Mechanisms through FoxO1

(2013) Daisuke Kajimura et al.   Cell Metabolism

Genetic Variation in CDH13 Is Associated With Lower Plasma Adiponectin Levels but Greater Adiponectin Sensitivity in East Asian Populations

(2013) H. Gao et al.   DIABETES

Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes

(2013) H. Yaghootkar et al.   DIABETES

T-cadherin Is Essential for Adiponectin-mediated Revascularization

(2013) Jennifer L. Parker-Duffen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

(2013) Yuki Takahashi et al.   JOURNAL OF BIOTECHNOLOGY

Adipokines: A link between obesity and cardiovascular disease

(2013) Kazuto Nakamura et al.   Journal of Cardiology

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

(2013) Fatih Arslan et al.   Stem Cell Research

Contribution of glucocorticoid–mineralocorticoid receptor pathway on the obesity-related adipocyte dysfunction

(2012) Ayumu Hirata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exosomes Mediate the Cytoprotective Action of Mesenchymal Stromal Cells on Hypoxia-Induced Pulmonary Hypertension

(2012) Changjin Lee et al.   CIRCULATION

Relationship between serum adiponectin levels and age in healthy subjects and patients with type 2 diabetes

(2012) Yoshinari Obata et al.   CLINICAL ENDOCRINOLOGY

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

(2012) Zari Dastani et al.   PLoS Genetics

A Variant Upstream of the CDH13 Adiponectin Receptor Gene and Metabolic Syndrome in Swedes

(2011) Cristiano Fava et al.   AMERICAN JOURNAL OF CARDIOLOGY

Secretion of adipokines by human adipose tissue in vivo: partitioning between capillary and lymphatic transport

(2011) Norman E. Miller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Genome-Wide Association Study Reveals a Quantitative Trait Locus of Adiponectin on CDH13 That Predicts Cardiometabolic Outcomes

(2011) C.-M. Chung et al.   DIABETES

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

CDH13gene coding t-cadherin influences variations in plasma adiponectin levels in the Japanese population

(2011) Hiroko Morisaki et al.   HUMAN MUTATION

Serum high-molecular-weight adiponectin as a marker for the evaluation and care of subjects with metabolic syndrome and related disorders

(2011) Hiroshi Hirose et al.   Journal of Atherosclerosis and Thrombosis

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid droplets as fat storage organelles inCaenorhabditis elegans

(2011) Ho Yi Mak   JOURNAL OF LIPID RESEARCH

Identification and Validation of Novel Adipokines Released from Primary Human Adipocytes

(2011) Stefan Lehr et al.   MOLECULAR & CELLULAR PROTEOMICS

Adipokines: A treasure trove for the discovery of biomarkers for metabolic disorders

(2011) Stefan Lehr et al.   Proteomics Clinical Applications

T-cadherin (Cdh13) in association with pancreatic β-cell granules contributes to second phase insulin secretion

(2011) Björn Tyrberg et al.   Islets

Adiponectin Concentrations: A Genome-wide Association Study

(2010) Sun Ha Jee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1–ADIPOQ

(2010) Ying Wu et al.   HUMAN MOLECULAR GENETICS

Beta-blockers modify the prognostic value of adiponectin in chronic heart failure

(2010) An M. Van Berendoncks et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy

(2010) Tian Tian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

T-cadherin is critical for adiponectin-mediated cardioprotection in mice

(2010) Martin S. Denzel et al.   JOURNAL OF CLINICAL INVESTIGATION

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

(2010) Masato Iwabu et al.   NATURE

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

Mammalian Neutral Sphingomyelinases: Regulation and Roles in Cell Signaling Responses

(2010) Bill X. Wu et al.   NEUROMOLECULAR MEDICINE

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

(2010) Ruenn Chai Lai et al.   Stem Cell Research

Cellular Internalization of Exosomes Occurs Through Phagocytosis

(2010) Du Feng et al.   TRAFFIC

Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice

(2009) Ayumu Hirata et al.   CARDIOVASCULAR RESEARCH

Effect of Carvedilol on Plasma Adiponectin Concentration in Patients With Chronic Heart Failure

(2009) Masayuki Yamaji et al.   CIRCULATION JOURNAL

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Natriuretic Peptides Enhance the Production of Adiponectin in Human Adipocytes and in Patients With Chronic Heart Failure

(2009) Osamu Tsukamoto et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Adiponectin multimer distribution in patients with familial combined hyperlipidemia

(2008) Tim B. Koenen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Adipocyte as an Endocrine Cell

(2008) Nils Halberg et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Association of adiponectin with adverse outcome in coronary artery disease patients: results from the AtheroGene study

(2008) R. Schnabel et al.   EUROPEAN HEART JOURNAL