Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes

Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications

(2019) Michele Longo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes

(2019) Jingli Lu et al.   Frontiers in Immunology

Innate Immune Control of Adipose Tissue Homeostasis

(2019) Harry Kane et al.   TRENDS IN IMMUNOLOGY

Anti-interleukin-1 treatment in patients with rheumatoid arthritis and type 2 diabetes (TRACK): A multicentre, open-label, randomised controlled trial

(2019) Piero Ruscitti et al.   PLOS MEDICINE

An Integrated View of Immunometabolism

(2018) Yun Sok Lee et al.   CELL

Insulin-stimulated glucose uptake in skeletal muscle, adipose tissue and liver: a positron emission tomography study

(2018) Miikka-Juhani Honka et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Translational and clinical advances in JAK-STAT biology: The present and future of jakinibs

(2018) Massimo Gadina et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mast cells participate in chronic low-grade inflammation within adipose tissue

(2018) P. Żelechowska et al.   Obesity Reviews

Innate immune cells in the adipose tissue

(2018) Kyoung-Jin Chung et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

JAK/STAT – Emerging Players in Metabolism

(2018) David W. Dodington et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

High glucose induces inflammatory responses in HepG2 cells via the oxidative stress-mediated activation of NF-κB, and MAPK pathways in HepG2 cells

(2018) Ghodratollah Panahi et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Parallels in Immunometabolic Adipose Tissue Dysfunction with Ageing and Obesity

(2018) William Trim et al.   Frontiers in Immunology

Metformin and Autoimmunity: A “New Deal” of an Old Drug

(2018) Francesco Ursini et al.   Frontiers in Immunology

IL-6 signalling pathways and the development of type 2 diabetes

(2018) Mohamad Akbari et al.   INFLAMMOPHARMACOLOGY

Association between insulin resistance and the development of cardiovascular disease

(2018) Valeska Ormazabal et al.   Cardiovascular Diabetology

The epidemiology of obesity

(2018) Yu Chung Chooi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Impaired Adipogenesis and Dysfunctional Adipose Tissue in Human Hypertrophic Obesity

(2018) Ann Hammarstedt et al.   PHYSIOLOGICAL REVIEWS

Role of the HIF‐1α/Nur77 axis in the regulation of the tyrosine hydroxylase expression by insulin in PC12 cells

(2018) Francesca Fiory et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Obesity Pathogenesis: An Endocrine Society Scientific Statement

(2017) Michael W Schwartz et al.   ENDOCRINE REVIEWS

Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity

(2017) Selma Boulenouar et al.   IMMUNITY

Foundations of Immunometabolism and Implications for Metabolic Health and Disease

(2017) Gökhan S. Hotamisligil   IMMUNITY

Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk

(2017) Allison B. Goldfine et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of innate and adaptive immunity in obesity-associated metabolic disease

(2017) Tracey McLaughlin et al.   JOURNAL OF CLINICAL INVESTIGATION

Adapting to obesity with adipose tissue inflammation

(2017) Shannon M. Reilly et al.   Nature Reviews Endocrinology

Biological control of appetite: A daunting complexity

(2017) Paul S. MacLean et al.   Obesity

Relationships of serum high-sensitivity C-reactive protein and body size with insulin resistance in a Japanese cohort

(2017) Hirokazu Uemura et al.   PLoS One

Elevated C-reactive protein, interleukin 6, tumor necrosis factor alpha and glycemic load associated with type 2 diabetes mellitus in rural Thais: a cross-sectional study

(2017) Chanchira Phosat et al.   BMC Endocrine Disorders

How does obesity lead to insulin resistance?

(2017) Chan Hee J Choi et al.   eLife

Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity

(2017) Gregory A. Raciti et al.   Scientific Reports

Adipose extracellular matrix remodelling in obesity and insulin resistance

(2016) De Lin et al.   BIOCHEMICAL PHARMACOLOGY

Pathologic endoplasmic reticulum stress induced by glucotoxic insults inhibits adipocyte differentiation and induces an inflammatory phenotype

(2016) Michele Longo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity

(2016) Faidon Magkos et al.   Cell Metabolism

Energy balance, body composition, sedentariness and appetite regulation: pathways to obesity

(2016) M. Hopkins et al.   CLINICAL SCIENCE

Adipose Cell Size and Regional Fat Deposition as Predictors of Metabolic Response to Overfeeding in Insulin-Resistant and Insulin-Sensitive Humans

(2016) Tracey McLaughlin et al.   DIABETES

Adipose Recruitment and Activation of Plasmacytoid Dendritic Cells Fuel Metaflammation

(2016) Amrit Raj Ghosh et al.   DIABETES

Multiple benefits of targeting inflammation in the treatment of type 2 diabetes

(2016) Marc Y. Donath   DIABETOLOGIA

IL-1β at the crossroad between rheumatoid arthritis and type 2 diabetes: may we kill two birds with one stone?

(2016) Roberto Giacomelli et al.   Expert Review of Clinical Immunology

The JAK/STAT pathway in obesity and diabetes

(2016) Esteban N. Gurzov et al.   FEBS Journal

Adipose Tissue Dendritic Cells Are Independent Contributors to Obesity-Induced Inflammation and Insulin Resistance

(2016) Kae Won Cho et al.   JOURNAL OF IMMUNOLOGY

Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants

(2016)   LANCET

SYSTEMIC INTERLEUKIN 1β INHIBITION IN PROLIFERATIVE DIABETIC RETINOPATHY

(2016) Marc Stahel et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

The Macrophage Switch in Obesity Development

(2016) Angela Castoldi et al.   Frontiers in Immunology

Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders

(2016) Sung Sik Choe et al.   Frontiers in Endocrinology

Rg3 Improves Mitochondrial Function and the Expression of Key Genes Involved in Mitochondrial Biogenesis in C2C12 Myotubes

(2016) Min Joo Kim et al.   Diabetes & Metabolism Journal

Insulin Sensitizing and Anti-Inflammatory Effects of Thiazolidinediones Are Heightened in Obese Patients

(2016) Yonah B. Esterson et al.   JOURNAL OF INVESTIGATIVE MEDICINE

IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance

(2015) Dov B. Ballak et al.   CYTOKINE

The non-canonical NF-κB pathway is induced by cytokines in pancreatic beta cells and contributes to cell death and proinflammatory responses in vitro

(2015) Kira Meyerovich et al.   DIABETOLOGIA

Glucose-induced expression of the homeotic transcription factor Prep1 is associated with histone post-translational modifications in skeletal muscle

(2015) Marco Ciccarelli et al.   DIABETOLOGIA

Diets Containing α-Linolenic (ω3) or Oleic (ω9) Fatty Acids Rescues Obese Mice From Insulin Resistance

(2015) V. Oliveira et al.   ENDOCRINOLOGY

Activated Kupffer cells inhibit insulin sensitivity in obese mice

(2015) Michaela Tencerova et al.   FASEB JOURNAL

Physiological adaptations to weight loss and factors favouring weight regain

(2015) F L Greenway   INTERNATIONAL JOURNAL OF OBESITY

Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages

(2015) Beth Kelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cell biology of fat expansion

(2015) Joseph M. Rutkowski et al.   JOURNAL OF CELL BIOLOGY

Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective

(2015) David Albuquerque et al.   MOLECULAR GENETICS AND GENOMICS

Regulation of metabolism by the innate immune system

(2015) Denise E. Lackey et al.   Nature Reviews Endocrinology

From neutrophils to macrophages: differences in regional adipose tissue depots

(2015) V. Dam et al.   Obesity Reviews

The IL-1 Pathway in Type 2 Diabetes and Cardiovascular Complications

(2015) Christian Herder et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Intersection of mTOR and STAT signaling in immunity

(2015) Diana Saleiro et al.   TRENDS IN IMMUNOLOGY

NLRP3 inflammasome and its inhibitors: a review

(2015) Bo-Zong Shao et al.   Frontiers in Pharmacology

TRAIL protects against endothelium injury in diabetes via Akt-eNOS signaling

(2014) Min Liu et al.   ATHEROSCLEROSIS

The interleukin-1 receptor antagonist anakinra improves endothelial dysfunction in streptozotocin-induced diabetic rats

(2014) Susana Vallejo et al.   Cardiovascular Diabetology

Adipocyte Inflammation Is Essential for Healthy Adipose Tissue Expansion and Remodeling

(2014) Ingrid Wernstedt Asterholm et al.   Cell Metabolism

Characterization of Distinct Subpopulations of Hepatic Macrophages in HFD/Obese Mice

(2014) Hidetaka Morinaga et al.   DIABETES

Adipocyte-specific deficiency of Janus kinase (JAK) 2 in mice impairs lipolysis and increases body weight, and leads to insulin resistance with ageing

(2014) Sally Yu Shi et al.   DIABETOLOGIA

Crosstalk between Adipocytes and Immune Cells in Adipose Tissue Inflammation and Metabolic Dysregulation in Obesity

(2014) Jin Young Huh et al.   MOLECULES AND CELLS

Targeting inflammation in the treatment of type 2 diabetes: time to start

(2014) Marc Y. Donath   NATURE REVIEWS DRUG DISCOVERY

Insulin Resistance is Associated with MCP1-Mediated Macrophage Accumulation in Skeletal Muscle in Mice and Humans

(2014) David Patsouris et al.   PLoS One

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

T cell responses: naïve to memory and everything in between

(2013) Nathan D. Pennock et al.   ADVANCES IN PHYSIOLOGY EDUCATION

Involvement of mast cells in adipose tissue fibrosis

(2013) Shizuka Hirai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes

(2013) Allison B. Goldfine   ANNALS OF INTERNAL MEDICINE

Salicylate (Salsalate) in Patients With Type 2 Diabetes

(2013) Allison B. Goldfine   ANNALS OF INTERNAL MEDICINE

Inflammasomes and Metabolic Disease

(2013) Jorge Henao-Mejia et al.   Annual Review of Physiology

Adipose tissue plasticity from WAT to BAT and in between

(2013) Yun-Hee Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance

(2013) Byung-Cheol Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The role of JAK–STAT signaling in adipose tissue function

(2013) Allison J. Richard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation

(2013) Xiaoyuan Xu et al.   Cell Metabolism

Adipose Natural Regulatory B Cells Negatively Control Adipose Tissue Inflammation

(2013) Satoshi Nishimura et al.   Cell Metabolism

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

(2013) Stephen P. Gray et al.   CIRCULATION

Endothelial Loss and Repair in the Vascular Complications of Diabetes

(2013) Richard E. Gilbert   CIRCULATION JOURNAL

Reduced Adipose Tissue Macrophage Content Is Associated With Improved Insulin Sensitivity in Thiazolidinedione-Treated Diabetic Humans

(2013) S. Koppaka et al.   DIABETES

The Impact of Salsalate Treatment on Serum Levels of Advanced Glycation End Products in Type 2 Diabetes

(2013) Joshua I. Barzilay et al.   DIABETES CARE

Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1  Antibody, in Patients With Type 2 Diabetes

(2013) J. Sloan-Lancaster et al.   DIABETES CARE

Association of Subclinical Inflammation With Polyneuropathy in the Older Population: KORA F4 study

(2013) C. Herder et al.   DIABETES CARE

Expression of anti-inflammatory macrophage genes within skeletal muscle correlates with insulin sensitivity in human obesity and type 2 diabetes

(2013) L. N. Fink et al.   DIABETOLOGIA

Local proliferation of macrophages in adipose tissue during obesity-induced inflammation

(2013) Julia Haase et al.   DIABETOLOGIA

Adipocyte Mitochondrial Function Is Reduced in Human Obesity Independent of Fat Cell Size

(2013) Xiao Yin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Immune Regulation in Obesity-Associated Adipose Inflammation

(2013) J. M. Han et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial dysfunction and the inflammatory response

(2013) María J. López-Armada et al.   MITOCHONDRION

Disruption of JAK2 in Adipocytes Impairs Lipolysis and Improves Fatty Liver in Mice With Elevated GH

(2013) Sarah M. Nordstrom et al.   MOLECULAR ENDOCRINOLOGY

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

(2013) Shannon M Reilly et al.   NATURE MEDICINE

Pro-Inflammatory macrophages increase in skeletal muscle of high fat-Fed mice and correlate with metabolic risk markers in humans

(2013) Lisbeth N. Fink et al.   Obesity

Hypoxia and Adipose Tissue Function and Dysfunction in Obesity

(2013) Paul Trayhurn   PHYSIOLOGICAL REVIEWS

B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile

(2013) J. DeFuria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance

(2013) Triantafyllos Chavakis et al.   THROMBOSIS AND HAEMOSTASIS

Chronic inflammation role in the obesity-diabetes association: a case-cohort study

(2013) Vivian C Luft et al.   Diabetology & Metabolic Syndrome

Mechanisms of Inflammatory Responses in Obese Adipose Tissue

(2012) Shengyi Sun et al.   Annual Review of Nutrition

Mitochondrial dysfunction increases inflammatory responsiveness to cytokines in normal human chondrocytes

(2012) Carlos Vaamonde-García et al.   ARTHRITIS AND RHEUMATISM

Cellular and molecular mechanisms of mitochondrial function

(2012) Laura D. Osellame et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with Type 2 Diabetes

(2012) Kui-Kai Lau et al.   Cardiovascular Diabetology

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages

(2012) Nicolas J Pillon et al.   Cell Communication and Signaling

The Inflammasome Puts Obesity in the Danger Zone

(2012) Rinke Stienstra et al.   Cell Metabolism

Akt3 Deficiency in Macrophages Promotes Foam Cell Formation and Atherosclerosis in Mice

(2012) Liang Ding et al.   Cell Metabolism

Novel roles for insulin receptor (IR) in adipocytes and skeletal muscle cells via new and unexpected substrates

(2012) Latha Ramalingam et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c+ Cells in Adipose Tissue and Liver

(2012) M. Stefanovic-Racic et al.   DIABETES

Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients

(2012) A. Bertola et al.   DIABETES

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes

(2012) C. Cavelti-Weder et al.   DIABETES CARE

Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production

(2012) Lydia Lynch et al.   IMMUNITY

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

(2012) Daniela Cipolletta et al.   NATURE

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

(2012) Saswata Talukdar et al.   NATURE MEDICINE

Metformin, an Antidiabetic Agent Reduces Growth of Cutaneous Squamous Cell Carcinoma by Targeting mTOR Signaling Pathway†

(2012) Sandeep C. Chaudhary et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

(2012) S. A. Hawley et al.   SCIENCE

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Depot-Specific Differences and Insufficient Subcutaneous Adipose Tissue Angiogenesis in Human Obesity

(2011) Olga Gealekman et al.   CIRCULATION

Mitochondrial DNA and inflammatory diseases

(2011) Germaine Escames et al.   HUMAN GENETICS

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

(2011) Daniel A Winer et al.   NATURE MEDICINE

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

(2011) Helga Ellingsgaard et al.   NATURE MEDICINE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153

(2011) N. WU et al.   NEOPLASMA

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages, Meta-Inflammation, and Immuno-Metabolism

(2011) Haim Shapiro et al.   TheScientificWorldJOURNAL

Emerging roles of JAK–STAT signaling pathways in adipocytes

(2011) Allison J. Richard et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes

(2010) Sarah Hummasti et al.   CIRCULATION RESEARCH

Control of Macrophage Activation and Function by PPARs

(2010) Ajay Chawla   CIRCULATION RESEARCH

C-C Chemokine Receptor 2 (CCR2) Regulates the Hepatic Recruitment of Myeloid Cells That Promote Obesity-Induced Hepatic Steatosis

(2010) A. E. Obstfeld et al.   DIABETES

The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytes

(2010) Qinkai Li et al.   FEBS LETTERS

TNF-α Antagonism with Etanercept Decreases Glucose and Increases the Proportion of High Molecular Weight Adiponectin in Obese Subjects with Features of the Metabolic Syndrome

(2010) Takara L. Stanley et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Apocynin restores endothelial dysfunction in streptozotocin diabetic rats through regulation of nitric oxide synthase and NADPH oxidase expressions

(2010) Murat Olukman et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus

(2010) Inge A. M. van den Oever et al.   MEDIATORS OF INFLAMMATION

FFA-Induced Adipocyte Inflammation and Insulin Resistance: Involvement of ER Stress and IKKβ Pathways

(2010) Ping Jiao et al.   Obesity

The Relationship of Omental and Subcutaneous Adipocyte Size to Metabolic Disease in Severe Obesity

(2010) Jean O'Connell et al.   PLoS One

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity

(2010) Olga T. Hardy et al.   Surgery for Obesity and Related Diseases

Toll-like receptors: linking inflammation to metabolism

(2010) A. Christine Könner et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action

(2009) Vijayalakshmi Varma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Transcriptional Control of Mitochondrial Biogenesis and Function

(2009) M. Benjamin Hock et al.   Annual Review of Physiology

Sensing pathogens and danger signals by the inflammasome

(2009) Joao HF Pedra et al.   CURRENT OPINION IN IMMUNOLOGY

Endoplasmic Reticulum Stress: Another Link Between Obesity and Insulin Resistance/Inflammation?

(2009) G. Boden   DIABETES

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

(2009) R. A. DeFronzo et al.   DIABETES CARE

Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes

(2009) C. M. Larsen et al.   DIABETES CARE

Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I

(2009) Marianne Böni-Schnetzler et al.   ENDOCRINOLOGY

Activated Ask1-MKK4-p38MAPK/JNK Stress Signaling Pathway in Human Omental Fat Tissue May Link Macrophage Infiltration to Whole-Body Insulin Sensitivity

(2009) Matthias Blüher et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Degradation of IRS1 leads to impaired glucose uptake in adipose tissue of the type 2 diabetes mouse model TALLYHO/Jng

(2009) Yun Wang et al.   JOURNAL OF ENDOCRINOLOGY

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

(2009) Jian Liu et al.   NATURE MEDICINE

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

The role of interleukins in insulin resistance and type 2 diabetes mellitus

(2009) Bruno Fève et al.   Nature Reviews Endocrinology

Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue

(2008) Jun Yin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes

(2008) Allison B. Goldfine et al.   CTS-Clinical and Translational Science

Hypoxia Decreases Insulin Signaling Pathways in Adipocytes

(2008) C. Regazzetti et al.   DIABETES

Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle

(2008) I. Nieto-Vazquez et al.   DIABETES

Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss

(2008) M. F. Gregor et al.   DIABETES

Acute Modulation of Toll-Like Receptors by Insulin

(2008) H. Ghanim et al.   DIABETES CARE

Cytokines and β-Cell Biology: from Concept to Clinical Translation

(2008) Marc Y. Donath et al.   ENDOCRINE REVIEWS

Dendritic Cells In Vivo: A Key Target for a New Vaccine Science

(2008) Ralph M. Steinman   IMMUNITY

Metformin inhibits TNF-α-induced IκB kinase phosphorylation, IκB-α degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation

(2008) Nan-Lan Huang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Endoplasmic Reticulum Stress Markers Are Associated with Obesity in Nondiabetic Subjects

(2008) Neeraj K. Sharma et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Increased Interleukin (IL)-1β Messenger Ribonucleic Acid Expression in β-Cells of Individuals with Type 2 Diabetes and Regulation of IL-1β in Human Islets by Glucose and Autostimulation

(2008) Marianne Böni-Schnetzler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice

(2008) I. Murano et al.   JOURNAL OF LIPID RESEARCH

Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding

(2008) Vered Elgazar-Carmon et al.   JOURNAL OF LIPID RESEARCH

Requirements of calcium fluxes and ERK kinase activation for glucose- and interleukin-1β-induced β-cell apoptosis

(2008) Hongqiang Fei et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Inducible Toll-like Receptor and NF-κB Regulatory Pathway Expression in Human Adipose Tissue

(2008) Olga I. Vitseva et al.   Obesity

Interleukin-6 regulates pancreatic  -cell mass expansion

(2008) H. Ellingsgaard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

(2008) G. Sabio et al.   SCIENCE