Emerging concepts in intestinal immune control of obesity-related metabolic disease

Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes

(2021) Evgeny Kiner et al.   NATURE IMMUNOLOGY

Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity

(2020) Abigail Jarret et al.   CELL

Dissociation of Adaptive Thermogenesis from Glucose Homeostasis in Microbiome-Deficient Mice

(2020) Tibor I. Krisko et al.   Cell Metabolism

Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease

(2020) Silvia Sookoian et al.   GUT

Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetes

(2020) Lucas Massier et al.   GUT

The Immune Landscape of Visceral Adipose Tissue During Obesity and Aging

(2020) Saad Khan et al.   Frontiers in Endocrinology

Gut-resident CX3CR1hi macrophages induce tertiary lymphoid structures and IgA response in situ

(2020) Balázs Koscsó et al.   Science Immunology

The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

(2020) Aleksandra Deczkowska et al.   CELL

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity

(2020) Amine Toubal et al.   Nature Communications

Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10

(2019) Olga L. Rojas et al.   CELL

Gut microbial metabolites in obesity, NAFLD and T2DM

(2019) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids

(2019) Kai Wang et al.   Cell Reports

Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue

(2019) Baoguo Li et al.   Cell Reports

c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host–microbiota homeostasis

(2019) Christian Neumann et al.   NATURE IMMUNOLOGY

GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites

(2019) Naoki Morita et al.   NATURE

Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease

(2019) Shun He et al.   NATURE

Spatial and Temporal Mapping of Human Innate Lymphoid Cells Reveals Elements of Tissue Specificity

(2019) Naomi A. Yudanin et al.   IMMUNITY

Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity

(2019) María Martínez-López et al.   IMMUNITY

A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology

(2019) Haiwei Chen et al.   CELL

Gut T Cells Feast on GLP-1 to Modulate Cardiometabolic Disease

(2019) Sue Tsai et al.   Cell Metabolism

Aryl hydrocarbon receptor agonist indigo protects against obesity-related insulin resistance through modulation of intestinal and metabolic tissue immunity

(2019) Yi-Hsuan Lin et al.   INTERNATIONAL JOURNAL OF OBESITY

Comparison of Co-housing and Littermate Methods for Microbiota Standardization in Mouse Models

(2019) Susan J. Robertson et al.   Cell Reports

The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells

(2019) Sara Omenetti et al.   IMMUNITY

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

(2019) Clara Depommier et al.   NATURE MEDICINE

T cell–mediated regulation of the microbiota protects against obesity

(2019) Charisse Petersen et al.   SCIENCE

Innate Lymphoid Cells in the Induction of Obesity

(2019) Takaharu Sasaki et al.   Cell Reports

Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool

(2019) Stefan Jordan et al.   CELL

Structured exercise alters the gut microbiota in humans with overweight and obesity—A randomized controlled trial

(2019) Timo Kern et al.   INTERNATIONAL JOURNAL OF OBESITY

Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth

(2019) Yan Shao et al.   NATURE

ILC2s are the predominant source of intestinal ILC-derived IL-10

(2019) Jennifer K. Bando et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bile acid metabolites control TH17 and Treg cell differentiation

(2019) Saiyu Hang et al.   NATURE

Gut-associated IgA+ immune cells regulate obesity-related insulin resistance

(2019) Helen Luck et al.   Nature Communications

Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids

(2019) Junki Miyamoto et al.   Nature Communications

IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM

(2019) Jason R. Catanzaro et al.   Scientific Reports

How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases

(2019) Wolfgang Kopp   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

(2019) Xinyang Song et al.   NATURE

Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases

(2019) Hao Q. Tran et al.   Nature Communications

Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses

(2018) Shankar S. Iyer et al.   CELL

Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration

(2018) Bjoern O. Schroeder et al.   Cell Host & Microbe

CD1d‐mediated lipid presentation by CD11c + cells regulates intestinal homeostasis

(2018) Julia Sáez de Guinoa et al.   EMBO JOURNAL

Recipient mucosal-associated invariant T cells control GVHD within the colon

(2018) Antiopi Varelias et al.   JOURNAL OF CLINICAL INVESTIGATION

Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression

(2018) Tovah N. Shaw et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metformin improves obesity-associated inflammation by altering macrophages polarization

(2018) Yuanyuan Jing et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Triggering and resolution of inflammation in NASH

(2018) Susanne Schuster et al.   Nature Reviews Gastroenterology & Hepatology

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

(2018) Liping Zhao et al.   SCIENCE

Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

(2018) Christoph A. Thaiss et al.   SCIENCE

Microbial ecology perturbation in human IgA deficiency

(2018) Jehane Fadlallah et al.   Science Translational Medicine

The Intestinal Epithelium: Central Coordinator of Mucosal Immunity

(2018) Joannie M. Allaire et al.   TRENDS IN IMMUNOLOGY

Bilophila wadsworthia aggravates high fat diet induced metabolic dysfunctions in mice

(2018) Jane M. Natividad et al.   Nature Communications

High-Glucose or -Fructose Diet Cause Changes of the Gut Microbiota and Metabolic Disorders in Mice without Body Weight Change

(2018) Moon Do et al.   Nutrients

Computer-guided design of optimal microbial consortia for immune system modulation

(2018) Richard R Stein et al.   eLife

Stereotypic Immune System Development in Newborn Children

(2018) Axel Olin et al.   CELL

Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT

(2018) Jotham Suez et al.   CELL

Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features

(2018) Niv Zmora et al.   CELL

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome

(2018) Jane M. Natividad et al.   Cell Metabolism

Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection

(2018) Sue Tsai et al.   Cell Metabolism

Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements

(2018) Salvatore Fabbiano et al.   Cell Metabolism

IgA Responses to Microbiota

(2018) Jeffrey J. Bunker et al.   IMMUNITY

c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont

(2018) Mo Xu et al.   NATURE

Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography

(2018) Mélanie Deschasaux et al.   NATURE MEDICINE

Regional variation limits applications of healthy gut microbiome reference ranges and disease models

(2018) Yan He et al.   NATURE MEDICINE

Mucosal-Associated Invariant T Cells Improve Nonalcoholic Fatty Liver Disease Through Regulating Macrophage Polarization

(2018) Yanmei Li et al.   Frontiers in Immunology

US Immigration Westernizes the Human Gut Microbiome

(2018) Pajau Vangay et al.   CELL

Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

(2018) Ara Koh et al.   CELL

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

(2018) Lulu Sun et al.   NATURE MEDICINE

Infant diet and maternal gestational weight gain predict early metabolic maturation of gut microbiomes

(2018) Aimee M. Baumann-Dudenhoeffer et al.   NATURE MEDICINE

Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis

(2018) Nicholas A. Scott et al.   Science Translational Medicine

Intestinal Dendritic Cells in Health and Gut Inflammation

(2018) Andrew J. Stagg   Frontiers in Immunology

Gut-Specific Delivery of T-Helper 17 Cells Reduces Obesity and Insulin Resistance in Mice

(2017) Chun-Pyo Hong et al.   GASTROENTEROLOGY

The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids

(2017) Wei Cao et al.   IMMUNITY

Immunologic impact of the intestine in metabolic disease

(2017) Daniel A. Winer et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

(2017) Shabnam Shalapour et al.   NATURE

Feedback control of AHR signalling regulates intestinal immunity

(2017) Chris Schiering et al.   NATURE

A randomized synbiotic trial to prevent sepsis among infants in rural India

(2017) Pinaki Panigrahi et al.   NATURE

Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

(2017) Wei Jia et al.   Nature Reviews Gastroenterology & Hepatology

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

(2017) Rebecca C. Schugar et al.   Cell Reports

Obesity

(2017) Pedro González-Muniesa et al.   Nature Reviews Disease Primers

Gut Microbial Metabolites Fuel Host Antibody Responses

(2016) Myunghoo Kim et al.   Cell Host & Microbe

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis

(2016) Filipe De Vadder et al.   Cell Metabolism

The Intestinal Immune System in Obesity and Insulin Resistance

(2016) Daniel A. Winer et al.   Cell Metabolism

Colonic Pro-inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl2/Ccr2-Dependent Manner

(2016) Yoshinaga Kawano et al.   Cell Metabolism

Mouse and Human Liver Contain Immunoglobulin A–Secreting Cells Originating From Peyer's Patches and Directed Against Intestinal Antigens

(2016) Ludovic Moro-Sibilot et al.   GASTROENTEROLOGY

The aryl hydrocarbon receptor controls cell-fate decisions in B cells

(2016) Bharat Vaidyanathan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43

(2016) W Wu et al.   Mucosal Immunology

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

Antibiotics, birth mode, and diet shape microbiome maturation during early life

(2016) Nicholas A. Bokulich et al.   Science Translational Medicine

Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism

(2016) Renee L. Greer et al.   Nature Communications

AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice

(2016) Jeremy A. Goettel et al.   Cell Reports

Triggering the adaptive immune system with commensal gut bacteria protects against insulin resistance and dysglycemia

(2016) Céline Pomié et al.   Molecular Metabolism

Gut Microbiota Orchestrates Energy Homeostasis during Cold

(2015) Claire Chevalier et al.   CELL

Personalized Nutrition by Prediction of Glycemic Responses

(2015) David Zeevi et al.   CELL

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

(2015) Koji Atarashi et al.   CELL

Jejunal T Cell Inflammation in Human Obesity Correlates with Decreased Enterocyte Insulin Signaling

(2015) Milena Monteiro-Sepulveda et al.   Cell Metabolism

Regulation of Obesity-Related Insulin Resistance with Gut Anti-inflammatory Agents

(2015) Helen Luck et al.   Cell Metabolism

The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease

(2015) Lucile Garidou et al.   Cell Metabolism

Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation

(2015) Valentina Tremaroli et al.   Cell Metabolism

Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling

(2015) Robert Caesar et al.   Cell Metabolism

GLP-1R Agonists Modulate Enteric Immune Responses Through the Intestinal Intraepithelial Lymphocyte GLP-1R

(2015) Bernardo Yusta et al.   DIABETES

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

(2015) Gijs den Besten et al.   DIABETES

Engineered Commensal Bacteria Reprogram Intestinal Cells Into Glucose-Responsive Insulin-Secreting Cells for the Treatment of Diabetes

(2015) Franklin F. Duan et al.   DIABETES

Chronic Exposure to TNFα Impairs Secretion of Glucagon-Like Peptide-1

(2015) Jeffrey Gagnon et al.   ENDOCRINOLOGY

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

Microbiota depletion promotes browning of white adipose tissue and reduces obesity

(2015) Nicolas Suárez-Zamorano et al.   NATURE MEDICINE

Ghrelin Inhibits the Differentiation of T Helper 17 Cells through mTOR/STAT3 Signaling Pathway

(2015) Yanhui Xu et al.   PLoS One

Individual intestinal symbionts induce a distinct population of ROR + regulatory T cells

(2015) E. Sefik et al.   SCIENCE

Proteobacteria: microbial signature of dysbiosis in gut microbiota

(2015) Na-Ri Shin et al.   TRENDS IN BIOTECHNOLOGY

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

(2015) Changtao Jiang et al.   Nature Communications

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

B-1a Lymphocytes Attenuate Insulin Resistance

(2014) Lei Shen et al.   DIABETES

Oral Tolerance Can Be Established via Gap Junction Transfer of Fed Antigens from CX3CR1+ Macrophages to CD103+ Dendritic Cells

(2014) Elisa Mazzini et al.   IMMUNITY

Cholecystokinin octapeptide regulates the differentiation and effector cytokine production of CD4+ T cells in vitro

(2014) Jing-Ge Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity

(2014) Zhongyi Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

(2014) Jonathan R. Brestoff et al.   NATURE

Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

(2014) Xiaoting Wang et al.   NATURE

Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut

(2014) A. M. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis

(2014) A. Mortha et al.   SCIENCE

Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status

(2014) Amandine Everard et al.   Nature Communications

An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

(2013) Na-Ri Shin et al.   GUT

Group 3 Innate Lymphoid Cells Inhibit T-Cell-Mediated Intestinal Inflammation through Aryl Hydrocarbon Receptor Signaling and Regulation of Microflora

(2013) Ju Qiu et al.   IMMUNITY

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut

(2013) S. E. Winter et al.   SCIENCE

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling

(2012) Kento Imajo et al.   Cell Metabolism

Cholecystokinin Plays a Novel Protective Role in Diabetic Kidney Through Anti-inflammatory Actions on Macrophage: Anti-inflammatory Effect of Cholecystokinin

(2012) S. Miyamoto et al.   DIABETES

IL-10 Promotes Production of Intestinal Mucus by Suppressing Protein Misfolding and Endoplasmic Reticulum Stress in Goblet Cells

(2012) Sumaira Z. Hasnain et al.   GASTROENTEROLOGY

An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice

(2012) Na Fei et al.   ISME Journal

Innate immune signaling in defense against intestinal microbes

(2011) Melissa A. Kinnebrew et al.   IMMUNOLOGICAL REVIEWS

Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut

(2011) Jörg H. Fritz et al.   NATURE

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

(2011) Daniel A Winer et al.   NATURE MEDICINE

Adaptive immunity in the host–microbiota dialog

(2010) T Feng et al.   Mucosal Immunology

The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity

(2009) P. Vavassori et al.   JOURNAL OF IMMUNOLOGY

Microbiota and SCFA in Lean and Overweight Healthy Subjects

(2009) Andreas Schwiertz et al.   Obesity

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity

(2008) Tina Rubic et al.   NATURE IMMUNOLOGY

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

(2008) B. S. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA