The Pathophysiological Role of Microglia in Dynamic Surveillance, Phagocytosis and Structural Remodeling of the Developing CNS

Microglia-glioma cross-talk a two way approach to new strategies against glioma

(2017) Cataldo Arcuri   Frontiers in Bioscience-Landmark

Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging

(2017) Lilach Soreq et al.   Cell Reports

Genetic manipulation of microglia during brain development and disease

(2016) Peter Wieghofer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Histamine regulation of microglia: Gene-environment interaction in the regulation of central nervous system inflammation

(2016) Luciana Frick et al.   BRAIN BEHAVIOR AND IMMUNITY

Prenatal immune activation causes hippocampal synaptic deficits in the absence of overt microglia anomalies

(2016) Sandra Giovanoli et al.   BRAIN BEHAVIOR AND IMMUNITY

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance

(2016) Xianyuan Xiang et al.   EMBO Molecular Medicine

Origin, fate and dynamics of macrophages at central nervous system interfaces

(2016) Tobias Goldmann et al.   NATURE IMMUNOLOGY

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Clearing the corpses: regulatory mechanisms, novel tools, and therapeutic potential of harnessing microglial phagocytosis in the diseased brain

(2016) Amanda Sierra et al.   Neural Regeneration Research

Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS): update on molecular genetics

(2016) Carmen Stabile et al.   NEUROLOGICAL SCIENCES

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

Microglia contact induces synapse formation in developing somatosensory cortex

(2016) Akiko Miyamoto et al.   Nature Communications

Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression

(2016) Dorothy P Schafer et al.   eLife

The end of gating? An introduction to automated analysis of high dimensional cytometry data

(2015) Florian Mair et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli

(2015) James C. Cronk et al.   IMMUNITY

Evidence supporting an altered immune response in ASD

(2015) Jennifer Mead et al.   IMMUNOLOGY LETTERS

Wild-type microglia do not reverse pathology in mouse models of Rett syndrome

(2015) Jieqi Wang et al.   NATURE

What happens to microglial TREM2 in Alzheimer’s disease: Immunoregulatory turned into immunopathogenic?

(2015) L.-F. Lue et al.   NEUROSCIENCE

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Broken or maladaptive? Altered trajectories in neuroinflammation and behavior after early life adversity

(2015) Prabarna Ganguly et al.   Developmental Cognitive Neuroscience

Development of the cerebellum: simple steps to make a 'little brain'

(2014) T. Butts et al.   DEVELOPMENT

Microglia shape corpus callosum axon tract fasciculation: functional impact of prenatal inflammation

(2014) Lorena Pont-Lezica et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Heterogeneous induction of microglia M2a phenotype by central administration of interleukin-4

(2014) Giovanna Pepe et al.   Journal of Neuroinflammation

IL-4 Signaling Drives a Unique Arginase+/IL-1 + Microglia Phenotype and Recruits Macrophages to the Inflammatory CNS: Consequences of Age-Related Deficits in IL-4R  after Traumatic Spinal Cord Injury

(2014) A. M. Fenn et al.   JOURNAL OF NEUROSCIENCE

Microglia Enhance Neurogenesis and Oligodendrogenesis in the Early Postnatal Subventricular Zone

(2014) Y. Shigemoto-Mogami et al.   JOURNAL OF NEUROSCIENCE

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Maternal immune activation and abnormal brain development across CNS disorders

(2014) Irene Knuesel et al.   Nature Reviews Neurology

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes

(2014) Mathias Thelen et al.   NEUROBIOLOGY OF AGING

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

Microglial CR3 Activation Triggers Long-Term Synaptic Depression in the Hippocampus via NADPH Oxidase

(2014) Jingfei Zhang et al.   NEURON

Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice

(2014) Lissandra Castellan Baldan et al.   NEURON

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Membranous lipodystrophy: skeletal findings on CT and MRI

(2014) O. Kenechi Nwawka et al.   SKELETAL RADIOLOGY

Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex

(2014) Benedetta Arnò et al.   Nature Communications

Microglia Modulate Wiring of the Embryonic Forebrain

(2014) Paola Squarzoni et al.   Cell Reports

TREM2Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis

(2014) Janet Cady et al.   JAMA Neurology

Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro

(2013) Vibol Chhor et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial Dysregulation in Psychiatric Disease

(2013) Luciana Romina Frick et al.   Clinical & Developmental Immunology

Human dendritic cell subsets

(2013) Matthew Collin et al.   IMMUNOLOGY

Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members

(2013) Jun Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Local Arginase 1 Activity Is Required for Cutaneous Wound Healing

(2013) Laura Campbell et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Lactadherin/MFG-E8 is essential for microglia-mediated neuronal loss and phagoptosis induced by amyloid β

(2013) Urte Neniskyte et al.   JOURNAL OF NEUROCHEMISTRY

MeCP2 deficiency enhances glutamate release through NF-κB signaling in myeloid derived cells

(2013) Cliona M. O’Driscoll et al.   JOURNAL OF NEUROIMMUNOLOGY

Microglial CD33-Related Siglec-E Inhibits Neurotoxicity by Preventing the Phagocytosis-Associated Oxidative Burst

(2013) J. Claude et al.   JOURNAL OF NEUROSCIENCE

Layer V cortical neurons require microglial support for survival during postnatal development

(2013) Masaki Ueno et al.   NATURE NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Phagocytosis executes delayed neuronal death after focal brain ischemia

(2013) J. J. Neher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

(2013) J. Suzuki et al.   SCIENCE

The effect of glia-glia interactions on oligodendrocyte precursor cell biology during development and in demyelinating diseases

(2013) Diego Clemente et al.   Frontiers in Cellular Neuroscience

Assessing Activation States in Microglia

(2012) Carol A. Colton et al.   CNS & Neurological Disorders-Drug Targets

The immune system and developmental programming of brain and behavior

(2012) Staci D. Bilbo et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Plasminogen activator inhibitor type 1 regulates microglial motility and phagocytic activity

(2012) Hyejin Jeon et al.   Journal of Neuroinflammation

Primary phagocytosis of viable neurons by microglia activated with LPS or Aβ is dependent on calreticulin/LRP phagocytic signalling

(2012) Michael Fricker et al.   Journal of Neuroinflammation

LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein

(2012) Daniel F Marker et al.   Journal of Neuroinflammation

Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice

(2012) Yolanda Diz-Chaves et al.   Journal of Neuroinflammation

MFG-E8 Mediates Primary Phagocytosis of Viable Neurons during Neuroinflammation

(2012) M. Fricker et al.   JOURNAL OF NEUROSCIENCE

Sialic Acid on the Neuronal Glycocalyx Prevents Complement C1 Binding and Complement Receptor-3-Mediated Removal by Microglia

(2012) B. Linnartz et al.   JOURNAL OF NEUROSCIENCE

Peripheral and central inflammation in autism spectrum disorders

(2012) Amaicha Mara Depino   MOLECULAR AND CELLULAR NEUROSCIENCE

Wild-type microglia arrest pathology in a mouse model of Rett syndrome

(2012) Noël C. Derecki et al.   NATURE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Review: Activation patterns of microglia and their identification in the human brain

(2012) D. Boche et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Mutations in a P-Type ATPase Gene Cause Axonal Degeneration

(2012) Xianjun Zhu et al.   PLoS Genetics

Microglial Activation in Young Adults With Autism Spectrum Disorder

(2012) Katsuaki Suzuki et al.   JAMA Psychiatry

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

(2011) Mark L. Hanke et al.   CLINICAL SCIENCE

Synaptic microcircuit dysfunction in genetic models of neurodevelopmental disorders: focus on Mecp2 and Met

(2011) Gordon MG Shepherd et al.   CURRENT OPINION IN NEUROBIOLOGY

TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells

(2011) Hiroaki Ito et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learning

(2011) Kelly Levano et al.   JOURNAL OF NEUROCHEMISTRY

Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes

(2011) Miri Gitik et al.   Journal of Neuroinflammation

Endogenous microglia regulate development of embryonic cortical precursor cells

(2011) Joseph M. Antony et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

(2011) Irina Voineagu et al.   NATURE

Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids

(2011) Rosa Rademakers et al.   NATURE GENETICS

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

Phosphorylated Syk expression is enhanced in Nasu-Hakola disease brains

(2011) Jun-ichi Satoh et al.   NEUROPATHOLOGY

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Microglial Activation and Increased Microglial Density Observed in the Dorsolateral Prefrontal Cortex in Autism

(2010) John T. Morgan et al.   BIOLOGICAL PSYCHIATRY

Fractalkine Attenuates Excito-neurotoxicity via Microglial Clearance of Damaged Neurons and Antioxidant Enzyme Heme Oxygenase-1 Expression

(2010) Mariko Noda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Annexin A1: A Central Player in the Anti-Inflammatory and Neuroprotective Role of Microglia

(2010) S. McArthur et al.   JOURNAL OF IMMUNOLOGY

Alleviation of Neurotoxicity by Microglial Human Siglec-11

(2010) Y. Wang et al.   JOURNAL OF NEUROSCIENCE

Rett Syndrome Microglia Damage Dendrites and Synapses by the Elevated Release of Glutamate

(2010) I. Maezawa et al.   JOURNAL OF NEUROSCIENCE

The myeloid cells of the central nervous system parenchyma

(2010) Richard M. Ransohoff et al.   NATURE

Early-life infection is a vulnerability factor for aging-related glial alterations and cognitive decline

(2010) Staci D. Bilbo   NEUROBIOLOGY OF LEARNING AND MEMORY

Nasu-Hakola disease: The first case reported by Nasu and review

(2010) Minoru Kaneko et al.   NEUROPATHOLOGY

L-Histidine Decarboxylase and Tourette's Syndrome

(2010) A. Gulhan Ercan-Sencicek et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Microglia: biology and pathology

(2009) Manuel B. Graeber et al.   ACTA NEUROPATHOLOGICA

Mass Cytometry: Technique for Real Time Single Cell Multitarget Immunoassay Based on Inductively Coupled Plasma Time-of-Flight Mass Spectrometry

(2009) Dmitry R. Bandura et al.   ANALYTICAL CHEMISTRY

Synapse elimination in the central nervous system

(2009) Masanobu Kano et al.   CURRENT OPINION IN NEUROBIOLOGY

Activation and deactivation of periventricular white matter phagocytes during postnatal mouse development

(2009) Mariya Hristova et al.   GLIA

The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders

(2009) Pat Levitt et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential gene expression in LPS/IFNγ activated microglia and macrophages:in vitroversusin vivo

(2009) Christoph D. Schmid et al.   JOURNAL OF NEUROCHEMISTRY

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and β-catenin

(2009) Karel Otero et al.   NATURE IMMUNOLOGY

Engineering a polarity-sensitive biosensor for time-lapse imaging of apoptotic processes and degeneration

(2009) Yujin E Kim et al.   NATURE METHODS

Non–cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology

(2009) Nurit Ballas et al.   NATURE NEUROSCIENCE

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

(2009) John T. Pesce et al.   PLoS Pathogens

Mechanisms Underlying Development of Visual Maps and Receptive Fields

(2008) Andrew D. Huberman et al.   Annual Review of Neuroscience

MyD88-independent activation of a novel actin-Cdc42/Rac pathway is required for Toll-like receptor-stimulated phagocytosis

(2008) Ling Kong et al.   CELL RESEARCH

Developmental Neuronal Death in Hippocampus Requires the Microglial CD11b Integrin and DAP12 Immunoreceptor

(2008) S. Wakselman et al.   JOURNAL OF NEUROSCIENCE

Toll-Like Receptor 4 Is Involved in Subacute Stress–Induced Neuroinflammation and in the Worsening of Experimental Stroke

(2008) Javier R. Caso et al.   STROKE

From bone marrow to microglia: barriers and avenues

(2008) Nathalie Davoust et al.   TRENDS IN IMMUNOLOGY