Untangling senescent and damage‐associated microglia in the aging and diseased brain
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Title
Untangling senescent and damage‐associated microglia in the aging and diseased brain
Authors
Keywords
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Journal
FEBS Journal
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2021-12-07
DOI
10.1111/febs.16315
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Note: Only part of the references are listed.- Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice
- (2021) Mikolaj Ogrodnik et al. AGING CELL
- Traumatic brain injury causes chronic cortical inflammation and neuronal dysfunction mediated by microglia
- (2021) Kristina G. Witcher et al. JOURNAL OF NEUROSCIENCE
- Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease
- (2021) Akira Sobue et al. Acta Neuropathologica Communications
- Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain
- (2021) Ryan K. Shahidehpour et al. NEUROBIOLOGY OF AGING
- The effect of aged microglia on synaptic impairment and its relevance in neurodegenerative diseases
- (2021) Juan José Triviño et al. NEUROCHEMISTRY INTERNATIONAL
- Senescent Microglia: The Key to the Ageing Brain?
- (2021) Eleanor K. Greenwood et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Algorithmic assessment of cellular senescence in experimental and clinical specimens
- (2021) J. Kohli et al. Nature Protocols
- Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline
- (2021) Sara Rojas-Vázquez et al. Frontiers in Neuroscience
- One-Year Prospective Study of Plasma Biomarkers From CNS in Patients With Mild Traumatic Brain Injury
- (2021) Gerard Janez Brett Clarke et al. Frontiers in Neurology
- Early onset senescence and cognitive impairment in a murine model of repeated mTBI
- (2021) Nicole Schwab et al. Acta Neuropathologica Communications
- Cellular senescence at the crossroads of inflammation and Alzheimer's disease
- (2021) Ana Guerrero et al. TRENDS IN NEUROSCIENCES
- Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology
- (2021) Yanling Hu et al. Cell Reports
- Association of traumatic brain injury with dementia and memory decline in older adults in the United States
- (2020) Leslie Grasset et al. Alzheimers & Dementia
- Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain
- (2020) Tamas Kiss et al. GeroScience
- Senolytic drugs: from discovery to translation
- (2020) J. L. Kirkland et al. JOURNAL OF INTERNAL MEDICINE
- Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts
- (2020) Wei Chen et al. Frontiers in Genetics
- Tauopathy: A common mechanism for neurodegeneration and Brain Aging
- (2019) Pampa Saha et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Emergence of Microglia Bearing Senescence Markers During Paralysis Progression in a Rat Model of Inherited ALS
- (2019) Emiliano Trias et al. Frontiers in Aging Neuroscience
- Senescence-associated-β-galactosidase staining following traumatic brain injury in the mouse cerebrum
- (2019) Tadasuke Tominaga et al. PLoS One
- Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution
- (2019) Takahiro Masuda et al. NATURE
- L1 drives IFN in senescent cells and promotes age-associated inflammation
- (2019) Marco De Cecco et al. NATURE
- Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model
- (2019) Peisu Zhang et al. NATURE NEUROSCIENCE
- Old age increases microglial senescence, exacerbates secondary neuroinflammation, and worsens neurological outcomes after acute traumatic brain injury in mice
- (2019) Rodney M. Ritzel et al. NEUROBIOLOGY OF AGING
- The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques
- (2019) Carlo Sala Frigerio et al. Cell Reports
- Single-cell transcriptomic profiling of the aging mouse brain
- (2019) Methodios Ximerakis et al. NATURE NEUROSCIENCE
- Ageing as a risk factor for neurodegenerative disease
- (2019) Yujun Hou et al. Nature Reviews Neurology
- Time-Dependent Changes in Microglia Transcriptional Networks Following Traumatic Brain Injury
- (2019) Saef Izzy et al. Frontiers in Cellular Neuroscience
- Cellular Senescence: Defining a Path Forward
- (2019) Vassilis Gorgoulis et al. CELL
- Traumatic brain injury triggers APP and Tau cleavage by delta-secretase, mediating Alzheimer’s disease pathology
- (2019) Zhourui Wu et al. PROGRESS IN NEUROBIOLOGY
- DNA repair deficiency and senescence in concussed professional athletes involved in contact sports
- (2019) Nicole Schwab et al. Acta Neuropathologica Communications
- Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model
- (2018) Chad A Tagge et al. BRAIN
- High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease
- (2018) Dunja Mrdjen et al. IMMUNITY
- Persistent Infiltration and Impaired Response of Peripherally-Derived Monocytes after Traumatic Brain Injury in the Aged Brain
- (2018) Austin Chou et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives
- (2018) Darren J. Baker et al. JOURNAL OF CLINICAL INVESTIGATION
- Traumatic brain injury history and progression from mild cognitive impairment to Alzheimer disease.
- (2018) Christian LoBue et al. NEUROPSYCHOLOGY
- The Evolving Dialogue of Microglia and Neurons in Alzheimer’s Disease: Microglia as Necessary Transducers of Pathology
- (2018) E. Simon et al. NEUROSCIENCE
- Hallmarks of Cellular Senescence
- (2018) Alejandra Hernandez-Segura et al. TRENDS IN CELL BIOLOGY
- Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models
- (2018) Brad A. Friedman et al. Cell Reports
- Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease
- (2018) Shankar J. Chinta et al. Cell Reports
- Telomere length and advanced diffusion MRI as biomarkers for repetitive mild traumatic brain injury in adolescent rats
- (2018) David K. Wright et al. NeuroImage-Clinical
- The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease
- (2018) Olga N. Kokiko-Cochran et al. Frontiers in Immunology
- Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis
- (2018) Shashank Masaldan et al. Redox Biology
- Tau protein aggregation is associated with cellular senescence in the brain
- (2018) Nicolas Musi et al. AGING CELL
- Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures
- (2018) Carole Sousa et al. EMBO REPORTS
- Microglia heterogeneity along a spatio-temporal axis: More questions than answers
- (2018) Aymeric Silvin et al. GLIA
- Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
- (2018) Tyler J. Bussian et al. NATURE
- Senescence and senotherapeutics: a new field in cancer therapy
- (2018) Vassilios Myrianthopoulos et al. PHARMACOLOGY & THERAPEUTICS
- Fisetin is a senotherapeutic that extends health and lifespan
- (2018) Matthew J. Yousefzadeh et al. EBioMedicine
- Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice
- (2018) Monica R. P. Elmore et al. AGING CELL
- Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes
- (2018) Timothy R. Hammond et al. IMMUNITY
- Phenotypic and functional differences between senescent and aged murine microglia
- (2018) Milan R. Stojiljkovic et al. NEUROBIOLOGY OF AGING
- The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
- (2017) Susanne Krasemann et al. IMMUNITY
- Microglia in Alzheimer’s disease
- (2017) David V. Hansen et al. JOURNAL OF CELL BIOLOGY
- Longitudinal Study of Postconcussion Syndrome: Not Everyone Recovers
- (2017) Carmen Hiploylee et al. JOURNAL OF NEUROTRAUMA
- Markers of microglia in post-mortem brain samples from patients with Alzheimer’s disease: a systematic review
- (2017) K E Hopperton et al. MOLECULAR PSYCHIATRY
- Senescent cells: an emerging target for diseases of ageing
- (2017) Bennett G. Childs et al. NATURE REVIEWS DRUG DISCOVERY
- Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease
- (2017) Fabio A. Zucca et al. PROGRESS IN NEUROBIOLOGY
- Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution
- (2017) Hansruedi Mathys et al. Cell Reports
- Aging Microglia—Phenotypes, Functions and Implications for Age-Related Neurodegenerative Diseases
- (2017) Björn Spittau Frontiers in Aging Neuroscience
- Microglial Activation in Traumatic Brain Injury
- (2017) Cornelius K. Donat et al. Frontiers in Aging Neuroscience
- Cellular Senescence: A Translational Perspective
- (2017) James L. Kirkland et al. EBioMedicine
- Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
- (2016) Yi Zhu et al. AGING CELL
- Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease
- (2016) Willem Kamphuis et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology
- (2016) Adrian Olmos-Alonso et al. BRAIN
- Dark microglia: A new phenotype predominantly associated with pathological states
- (2016) Kanchan Bisht et al. GLIA
- Microglial/Macrophage Polarization Dynamics following Traumatic Brain Injury
- (2016) Alok Kumar et al. JOURNAL OF NEUROTRAUMA
- Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
- (2016) Darren J. Baker et al. NATURE
- Age-related myelin degradation burdens the clearance function of microglia during aging
- (2016) Shima Safaiyan et al. NATURE NEUROSCIENCE
- A polarizing question: do M1 and M2 microglia exist?
- (2016) Richard M Ransohoff NATURE NEUROSCIENCE
- TREM2 variants: new keys to decipher Alzheimer disease pathogenesis
- (2016) Marco Colonna et al. NATURE REVIEWS NEUROSCIENCE
- The use of telomere length as a predictive biomarker for injury prognosis in juvenile rats following a concussion/mild traumatic brain injury
- (2016) Harleen Hehar et al. NEUROBIOLOGY OF DISEASE
- Complement and microglia mediate early synapse loss in Alzheimer mouse models
- (2016) S. Hong et al. SCIENCE
- Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues
- (2016) EA Georgakopoulou et al. Aging-US
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases
- (2015) Yu Tang et al. MOLECULAR NEUROBIOLOGY
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- (2015) Jianhui Chang et al. NATURE MEDICINE
- Cellular senescence in aging and age-related disease: from mechanisms to therapy
- (2015) Bennett G Childs et al. NATURE MEDICINE
- Age- and location-related changes in microglial function
- (2015) Rodney M. Ritzel et al. NEUROBIOLOGY OF AGING
- Origin of Microglia: Current Concepts and Past Controversies
- (2015) Florent Ginhoux et al. Cold Spring Harbor Perspectives in Biology
- Distinct p21 requirements for regulating normal and self-reactive T cells through IFN-γ production
- (2015) Lidia Daszkiewicz et al. Scientific Reports
- Disease-related microglia heterogeneity in the hippocampus of Alzheimer’s disease, dementia with Lewy bodies, and hippocampal sclerosis of aging
- (2015) Adam D Bachstetter et al. Acta Neuropathologica Communications
- Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis
- (2015) Inge R Holtman et al. Acta Neuropathologica Communications
- An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
- (2014) Marco Demaria et al. DEVELOPMENTAL CELL
- Macrophagic and microglial responses after focal traumatic brain injury in the female rat
- (2014) L Turtzo et al. Journal of Neuroinflammation
- Necessary and Sufficient Role for a Mitosis Skip in Senescence Induction
- (2014) Yoshikazu Johmura et al. MOLECULAR CELL
- Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
- (2014) Saul A Villeda et al. NATURE MEDICINE
- Microglial priming in neurodegenerative disease
- (2014) V. Hugh Perry et al. Nature Reviews Neurology
- Expression and clinical significance of non-phagocytic cell oxidase 2 and 4 after human traumatic brain injury
- (2014) Zhen Li et al. NEUROLOGICAL SCIENCES
- Coordinated Gene Expression of Neuroinflammatory and Cell Signaling Markers in Dorsolateral Prefrontal Cortex during Human Brain Development and Aging
- (2014) Christopher T. Primiani et al. PLoS One
- Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors
- (2014) L. Katsimpardi et al. SCIENCE
- Is pathological aging a successful resistance against amyloid-beta or preclinical Alzheimer’s disease?
- (2014) Melissa E Murray et al. Alzheimers Research & Therapy
- Homeostatic and injury-induced microglia behavior in the aging brain
- (2013) Jasmin K. Hefendehl et al. AGING CELL
- Inhibition of Akt/mTOR Signaling by the Dietary Flavonoid Fisetin
- (2013) Deeba Syed et al. Anti-Cancer Agents in Medicinal Chemistry
- Inflammation and white matter degeneration persist for years after a single traumatic brain injury
- (2013) Victoria E. Johnson et al. BRAIN
- Iron deposits in the chronically inflamed central nervous system and contributes to neurodegeneration
- (2013) Hjalte Holm Andersen et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Microglia/Macrophage Polarization Dynamics in White Matter after Traumatic Brain Injury
- (2013) Guohua Wang et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Progressive Neurodegeneration After Experimental Brain Trauma
- (2013) David J. Loane et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Transcranial amelioration of inflammation and cell death after brain injury
- (2013) Theodore L. Roth et al. NATURE
- Identification of a unique TGF-β–dependent molecular and functional signature in microglia
- (2013) Oleg Butovsky et al. NATURE NEUROSCIENCE
- M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
- (2013) Veronique E Miron et al. NATURE NEUROSCIENCE
- Microglia: New Roles for the Synaptic Stripper
- (2013) Helmut Kettenmann et al. NEURON
- Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature
- (2013) T. Wyss-Coray et al. Cold Spring Harbor Perspectives in Medicine
- Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response
- (2012) Diana Jurk et al. AGING CELL
- Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices
- (2012) Marie-Ève Tremblay et al. GLIA
- Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline
- (2012) Johannes vom Berg et al. NATURE MEDICINE
- Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states
- (2012) Alok Kumar et al. NEUROBIOLOGY OF AGING
- A2E accumulation influences retinal microglial activation and complement regulation
- (2012) Wenxin Ma et al. NEUROBIOLOGY OF AGING
- Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
- (2012) Dorothy P. Schafer et al. NEURON
- Review: Microglia of the aged brain: primed to be activated and resistant to regulation
- (2012) D. M. Norden et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Astrocyte Senescence as a Component of Alzheimer’s Disease
- (2012) Rekha Bhat et al. PLoS One
- Temporal Changes in Cell Marker Expression and Cellular Infiltration in a Controlled Cortical Impact Model in Adult Male C57BL/6 Mice
- (2012) Xuemei Jin et al. PLoS One
- Chronic Traumatic Encephalopathy in Blast-Exposed Military Veterans and a Blast Neurotrauma Mouse Model
- (2012) L. E. Goldstein et al. Science Translational Medicine
- Inflammation after trauma: Microglial activation and traumatic brain injury
- (2011) Anil F. Ramlackhansingh et al. ANNALS OF NEUROLOGY
- Age related changes in microglial phenotype vary between CNS regions: Grey versus white matter differences
- (2011) Adam D. Hart et al. BRAIN BEHAVIOR AND IMMUNITY
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- Alzheimer's Disease and Non-Demented High Pathology Control Nonagenarians: Comparing and Contrasting the Biochemistry of Cognitively Successful Aging
- (2011) Chera L. Maarouf et al. PLoS One
- Age-related alterations in the dynamic behavior of microglia
- (2010) Mausam R. Damani et al. AGING CELL
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- Senescence-associated beta-galactosidase activity expression in aging hippocampal neurons
- (2010) Yi-Qun Geng et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury
- (2010) Kenji Dohi et al. Journal of Neuroinflammation
- Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease
- (2010) Brandy L. Wilkinson et al. NEUROBIOLOGY OF AGING
- The role of microglia in central nervous system immunity and glioma immunology
- (2009) Isaac Yang et al. JOURNAL OF CLINICAL NEUROSCIENCE
- Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines
- (2008) Christopher J. Henry et al. BRAIN BEHAVIOR AND IMMUNITY
- Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity
- (2008) Kryslaine O. Lopes et al. GLIA
- Moderate and severe traumatic brain injury in adults
- (2008) Andrew IR Maas et al. LANCET NEUROLOGY
- Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology
- (2008) Terrence Town et al. NATURE MEDICINE
- Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice
- (2007) Heping Xu et al. AGING CELL
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