Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease

(2015) Elizabeta Gjoneska et al.   NATURE

How dependent is synaptic plasticity on microglial phenotype?

(2015) Raasay S. Jones et al.   NEUROPHARMACOLOGY

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

(2015) Carlo Condello et al.   Nature Communications

Post-mortem analysis of neuroinflammatory changes in human Alzheimer’s disease

(2015) Diego Gomez-Nicola et al.   Alzheimers Research & Therapy

Impairment of in vivo calcium signaling in amyloid plaque-associated microglia

(2014) Bianca Brawek et al.   ACTA NEUROPATHOLOGICA

Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration

(2014) Diego Gomez-Nicola et al.   BRAIN

Sustained Inhibition of Receptor Tyrosine Kinases and Macrophage Depletion by PLX3397 and Rapamycin as a Potential New Approach for the Treatment of MPNSTs

(2014) P. P. Patwardhan et al.   CLINICAL CANCER RESEARCH

Differential role of CCR2 in the dynamics of microglia and perivascular macrophages during prion disease

(2014) Diego Gómez-Nicola et al.   GLIA

Antiviral drug ganciclovir is a potent inhibitor of microglial proliferation and neuroinflammation

(2014) Zhaoqing Ding et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pleiotropic effects of extended blockade of CSF1R signaling in adult mice

(2014) K. A. Sauter et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

(2014) Jason D Ulrich et al.   Molecular Neurodegeneration

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Microglial Dynamics and Role in the Healthy and Diseased Brain

(2014) Diego Gomez-Nicola et al.   NEUROSCIENTIST

Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke

(2013) Ting Li et al.   BRAIN

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Alzheimer's Disease Neurodegenerative Biomarkers Are Associated with Decreased Cognitive Function but Not  -Amyloid in Cognitively Normal Older Individuals

(2013) M. Wirth et al.   JOURNAL OF NEUROSCIENCE

Regulation of Microglial Proliferation during Chronic Neurodegeneration

(2013) D. Gomez-Nicola et al.   JOURNAL OF NEUROSCIENCE

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Origin and differentiation of microglia

(2013) Florent Ginhoux et al.   Frontiers in Cellular Neuroscience

Differential cell proliferation in the cortex of the appsweps1de9 alzheimer's disease mouse model

(2012) Willem Kamphuis et al.   GLIA

Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia

(2012) Melanie Greter et al.   IMMUNITY

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling

(2011) D. A. Hume et al.   BLOOD

Soothing the Inflamed Brain: Effect of Non-Steroidal Anti-Inflammatory Drugs on Alzheimers Disease Pathology

(2011) J. J.M. Hoozemans et al.   CNS & Neurological Disorders-Drug Targets

c-FMS inhibitors: a patent review

(2011) Christopher J Burns et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease

(2011) A. Mildner et al.   JOURNAL OF NEUROSCIENCE

The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease

(2011) P. L. McClean et al.   JOURNAL OF NEUROSCIENCE

Interleukin-15 regulates proliferation and self-renewal of adult neural stem cells

(2011) Diego Gómez-Nicola et al.   MOLECULAR BIOLOGY OF THE CELL

3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress

(2011) Sarah M. Rothman et al.   NEUROBIOLOGY OF AGING

Proinflammatory cytokines, sickness behavior, and Alzheimer disease

(2011) C. Holmes et al.   NEUROLOGY

Cytokine expression and microglial activation in progressive supranuclear palsy

(2011) Rafael Fernández-Botrán et al.   PARKINSONISM & RELATED DISORDERS

Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits

(2011) Bryna Erblich et al.   PLoS One

Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes

(2010) Gyungah Jun   ARCHIVES OF NEUROLOGY

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

(2010) Suwen Wei et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The benefits and limitations of animal models for translational research in neurodegenerative diseases

(2010) Mathias Jucker   NATURE MEDICINE

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia

(2009) C. L. Manthey et al.   MOLECULAR CANCER THERAPEUTICS

Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and β-catenin

(2009) Karel Otero et al.   NATURE IMMUNOLOGY

Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia

(2009) Stefan A Grathwohl et al.   NATURE NEUROSCIENCE

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

Consequence of Aβ immunization on the vasculature of human Alzheimer's disease brain

(2008) D. Boche et al.   BRAIN

Interleukin 15 expression in the CNS: Blockade of its activity prevents glial activation after an inflammatory injury

(2008) Diego Gómez-Nicola et al.   GLIA

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

(2008) Paul Edison et al.   NEUROBIOLOGY OF DISEASE