Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model

Cumulative Head Impact Exposure Predicts Later-Life Depression, Apathy, Executive Dysfunction, and Cognitive Impairment in Former High School and College Football Players

(2017) Philip H. Montenigro et al.   JOURNAL OF NEUROTRAUMA

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Stream-dependent development of higher visual cortical areas

(2017) Ikuko T Smith et al.   NATURE NEUROSCIENCE

Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal

(2017) Yu-Rong Gao et al.   NEUROIMAGE

It’s Not All Fun and Games: Sports, Concussions, and Neuroscience

(2017) Christopher C. Giza et al.   NEURON

Behavioral Phenotyping Assays for Genetic Mouse Models of Neurodevelopmental, Neurodegenerative, and Psychiatric Disorders

(2017) Stacey J. Sukoff Rizzo et al.   Annual Review of Animal Biosciences

Age of first exposure to American football and long-term neuropsychiatric and cognitive outcomes

(2017) M L Alosco et al.   Translational Psychiatry

Considerations for Experimental Animal Models of Concussion, Traumatic Brain Injury, and Chronic Traumatic Encephalopathy—These Matters Matter

(2017) Mark W. Wojnarowicz et al.   Frontiers in Neurology

TREM2 Function in Alzheimer’s Disease and Neurodegeneration

(2016) Jason D. Ulrich et al.   ACS Chemical Neuroscience

Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration

(2016) Michel Goedert et al.   BRAIN

Glial-endothelial crosstalk regulates blood–brain barrier function

(2016) Lara Cheslow et al.   CURRENT OPINION IN PHARMACOLOGY

Cerebral Vascular Injury in Traumatic Brain Injury

(2016) Kimbra Kenney et al.   EXPERIMENTAL NEUROLOGY

Epileptiform activity and spreading depolarization in the blood–brain barrier-disrupted peri-infarct hippocampus are associated with impaired GABAergic inhibition and synaptic plasticity

(2016) Kristina Lippmann et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Simultaneous monitoring of potassium, glucose and lactate during spreading depolarization in the injured human brain – Proof of principle of a novel real-time neurochemical analysis system, continuous online microdialysis

(2016) Michelle L Rogers et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neural plasticity and behavior - sixty years of conceptual advances

(2016) J. David Sweatt   JOURNAL OF NEUROCHEMISTRY

Blood–Brain Barrier Dysfunction as a Hallmark Pathology in Chronic Traumatic Encephalopathy

(2016) Colin P. Doherty et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Glutamate-Mediated Blood-Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery

(2016) U. Vazana et al.   JOURNAL OF NEUROSCIENCE

Chronic cerebrovascular dysfunction after traumatic brain injury

(2016) Amandine Jullienne et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Additional Post-Concussion Impact Exposure May Affect Recovery in Adolescent Athletes

(2016) Virginia K. Terwilliger et al.   JOURNAL OF NEUROTRAUMA

Altered Neuroinflammation and Behavior after Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease

(2016) Olga Kokiko-Cochran et al.   JOURNAL OF NEUROTRAUMA

Characterisation of interface astroglial scarring in the human brain after blast exposure: a post-mortem case series

(2016) Sharon Baughman Shively et al.   LANCET NEUROLOGY

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

Bidirectional prefrontal-hippocampal interactions support context-guided memory

(2016) Ryan Place et al.   NATURE NEUROSCIENCE

The Molecular Pathophysiology of Concussive Brain Injury – an Update

(2016) Garni Barkhoudarian et al.   Physical Medicine and Rehabilitation Clinics of North America

Tau prions from Alzheimer’s disease and chronic traumatic encephalopathy patients propagate in cultured cells

(2016) Amanda L. Woerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory neuroprotection following traumatic brain injury

(2016) M. V. Russo et al.   SCIENCE

Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits

(2016) Lianyan Huang et al.   Science Translational Medicine

Potential of the Antibody Against cis–Phosphorylated Tau in the Early Diagnosis, Treatment, and Prevention of Alzheimer Disease and Brain Injury

(2016) Kun Ping Lu et al.   JAMA Neurology

Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy

(2016) Jonathan D. Cherry et al.   Acta Neuropathologica Communications

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory

(2016) M. Fá et al.   Scientific Reports

The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy

(2015) Ann C. McKee et al.   ACTA NEUROPATHOLOGICA

Beta-amyloid deposition in chronic traumatic encephalopathy

(2015) Thor D. Stein et al.   ACTA NEUROPATHOLOGICA

Chronic traumatic encephalopathy pathology in a neurodegenerative disorders brain bank

(2015) Kevin F. Bieniek et al.   ACTA NEUROPATHOLOGICA

The Neuropathology of Chronic Traumatic Encephalopathy

(2015) Ann C. McKee et al.   BRAIN PATHOLOGY

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Using transcranial magnetic stimulation to quantify electrophysiological changes following concussive brain injury: A systematic review

(2015) Brendan P Major et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Concussion in Chronic Traumatic Encephalopathy

(2015) Thor D. Stein et al.   Current Pain and Headache Reports

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

(2015) Yuka Atagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke

(2015) M. Kawabori et al.   JOURNAL OF NEUROSCIENCE

A Threshold Shear Force for Calcium Influx in an Astrocyte Model of Traumatic Brain Injury

(2015) Mohammad Mehdi Maneshi et al.   JOURNAL OF NEUROTRAUMA

Epidemiology of mild traumatic brain injury and neurodegenerative disease

(2015) Raquel C. Gardner et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

(2015) Asami Kondo et al.   NATURE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction

(2015) Itai Weissberg et al.   NEUROBIOLOGY OF DISEASE

Age of first exposure to football and later-life cognitive impairment in former NFL players

(2015) J. M. Stamm et al.   NEUROLOGY

Traumatic Brain Injury and the Neuronal Microenvironment: A Potential Role for Neuropathological Mechanotransduction

(2015) Matthew A. Hemphill et al.   NEURON

TREM2 and Risk of Alzheimer’s Disease — Friend or Foe?

(2015) Rudolph E. Tanzi   NEW ENGLAND JOURNAL OF MEDICINE

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

Neurovascular Coupling During Cortical Spreading Depolarization and -Depression

(2015) L. Ostergaard et al.   STROKE

Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?

(2015) Jan Lewerenz et al.   Frontiers in Neuroscience

Repetitive Concussions in Adolescent Athletes – Translating Clinical and Experimental Research into Perspectives on Rehabilitation Strategies

(2015) Bridgette D. Semple et al.   Frontiers in Neurology

Losartan prevents acquired epilepsy via TGF-β signaling suppression

(2014) Guy Bar-Klein et al.   ANNALS OF NEUROLOGY

Microglia Development and Function

(2014) Debasis Nayak et al.   Annual Review of Immunology

Blood–Brain Barrier Imaging in Human Neuropathologies

(2014) Ronel Veksler et al.   ARCHIVES OF MEDICAL RESEARCH

Methodological Issues and Research Recommendations for Prognosis After Mild Traumatic Brain Injury: Results of the International Collaboration on Mild Traumatic Brain Injury Prognosis

(2014) Vicki L. Kristman et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Animal models of sports-related head injury: bridging the gap between pre-clinical research and clinical reality

(2014) Mariana Angoa-Pérez et al.   JOURNAL OF NEUROCHEMISTRY

Abnormal White Matter Integrity Related to Head Impact Exposure in a Season of High School Varsity Football

(2014) Elizabeth M. Davenport et al.   JOURNAL OF NEUROTRAUMA

Gadofosveset-based biomarker of tissue albumin concentration: Technical validation in vitro and feasibility in vivo

(2014) Owen C. Richardson et al.   MAGNETIC RESONANCE IN MEDICINE

Merging pathology with biomechanics using CHIMERA (Closed-Head Impact Model of Engineered Rotational Acceleration): a novel, surgery-free model of traumatic brain injury

(2014) Dhananjay R Namjoshi et al.   Molecular Neurodegeneration

Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations

(2014) Daniela Pietrobon et al.   NATURE REVIEWS NEUROSCIENCE

The New Neurometabolic Cascade of Concussion

(2014) Christopher C. Giza et al.   NEUROSURGERY

Persistent, Long-term Cerebral White Matter Changes after Sports-Related Repetitive Head Impacts

(2014) Jeffrey J. Bazarian et al.   PLoS One

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

Clinical subtypes of chronic traumatic encephalopathy: literature review and proposed research diagnostic criteria for traumatic encephalopathy syndrome

(2014) Philip H Montenigro et al.   Alzheimers Research & Therapy

Imaging Blood-Brain Barrier Dysfunction in Football Players

(2014) Itai Weissberg et al.   JAMA Neurology

The neuropathology of sport

(2013) Ann C. McKee et al.   ACTA NEUROPATHOLOGICA

Clinical correlates in an experimental model of repetitive mild brain injury

(2013) Rebekah Mannix et al.   ANNALS OF NEUROLOGY

Motor system alterations in retired former athletes: the role of aging and concussion history

(2013) Louis De Beaumont et al.   BMC Neurology

Inflammation and white matter degeneration persist for years after a single traumatic brain injury

(2013) Victoria E. Johnson et al.   BRAIN

Consensus statement on concussion in sport: the 4th International Conference on Concussion in Sport held in Zurich, November 2012

(2013) Paul McCrory et al.   BRITISH JOURNAL OF SPORTS MEDICINE

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Changing patterns in the epidemiology of traumatic brain injury

(2013) Bob Roozenbeek et al.   Nature Reviews Neurology

Chronic neuropathologies of single and repetitive TBI: substrates of dementia?

(2013) Douglas H. Smith et al.   Nature Reviews Neurology

The clinical spectrum of sport-related traumatic brain injury

(2013) Barry D. Jordan   Nature Reviews Neurology

Anesthesia and tau pathology

(2013) Robert A. Whittington et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A Neural Circuit for Memory Specificity and Generalization

(2013) W. Xu et al.   SCIENCE

The spectrum of disease in chronic traumatic encephalopathy

(2012) Ann C. McKee et al.   BRAIN

A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury

(2012) M. E. Shenton et al.   Brain Imaging and Behavior

Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer's Disease

(2012) Kazuhiro Nakamura et al.   CELL

American Medical Society for Sports Medicine Position Statement

(2012) Kimberly G. Harmon et al.   CLINICAL JOURNAL OF SPORT MEDICINE

In vitro mechanical strain trauma alters neuronal calcium responses: Implications for posttraumatic epilepsy

(2012) Gene G. Gurkoff et al.   EPILEPSIA

Axonal pathology in traumatic brain injury

(2012) Victoria E. Johnson et al.   EXPERIMENTAL NEUROLOGY

Blood-brain barrier dysfunction, TGFβ signaling, and astrocyte dysfunction in epilepsy

(2012) Uwe Heinemann et al.   GLIA

Biomechanical correlates of symptomatic and asymptomatic neurophysiological impairment in high school football

(2012) Evan L. Breedlove et al.   JOURNAL OF BIOMECHANICS

Repeated Mild Traumatic Brain Injury: Mechanisms of Cerebral Vulnerability

(2012) Mayumi L. Prins et al.   JOURNAL OF NEUROTRAUMA

Neurodegenerative causes of death among retired National Football League players

(2012) E. J. Lehman et al.   NEUROLOGY

The Neuropathology and Neurobiology of Traumatic Brain Injury

(2012) Kaj Blennow et al.   NEURON

The neuroinflammatory response in humans after traumatic brain injury

(2012) C. Smith et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Shear Forces during Blast, Not Abrupt Changes in Pressure Alone, Generate Calcium Activity in Human Brain Cells

(2012) Rea Ravin et al.   PLoS One

Mild traumatic brain injury: a risk factor for neurodegeneration

(2012) Brandon E Gavett et al.   Alzheimers Research & Therapy

Spreading depolarizations have prolonged direct current shifts and are associated with poor outcome in brain trauma

(2011) Jed A. Hartings et al.   BRAIN

Widespread Tau and Amyloid-Beta Pathology Many Years After a Single Traumatic Brain Injury in Humans

(2011) Victoria E. Johnson et al.   BRAIN PATHOLOGY

Head impact exposure in collegiate football players

(2011) Joseph J. Crisco et al.   JOURNAL OF BIOMECHANICS

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

(2011) A. Sydow et al.   JOURNAL OF NEUROSCIENCE

The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease

(2011) Jens P Dreier   NATURE MEDICINE

Chronic traumatic encephalopathy in an Iraqi war veteran with posttraumatic stress disorder who committed suicide

(2011) Bennet Omalu et al.   Neurosurgical Focus

Influence of a Brief Episode of Anesthesia during the Induction of Experimental Brain Trauma on Secondary Brain Damage and Inflammation

(2011) Clara Luh et al.   PLoS One

Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder

(2011) Amy L. Mahan et al.   TRENDS IN NEUROSCIENCES

Position Statement: Definition of Traumatic Brain Injury

(2010) David K. Menon et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Changes in molecular composition of rat medial prefrontal cortex synapses during adolescent development

(2010) Danielle S. Counotte et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Biomechanics of Sport Concussion

(2010) Kevin M. Guskiewicz et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Frequency and Location of Head Impact Exposures in Individual Collegiate Football Players

(2010) Joseph J. Crisco et al.   JOURNAL OF ATHLETIC TRAINING

Temporary Focal Cerebral Ischemia Results in Swollen Astrocytic End-Feet That Compress Microvessels and Lead to Focal Cortical Infarction

(2010) Umeo Ito et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

TDP-43 Proteinopathy and Motor Neuron Disease in Chronic Traumatic Encephalopathy

(2010) Ann C. McKee et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Functionally-Detected Cognitive Impairment in High School Football Players without Clinically-Diagnosed Concussion

(2010) Thomas M. Talavage et al.   JOURNAL OF NEUROTRAUMA

Comparison of Concussive Symptoms, Cognitive Performance, and Psychological Symptoms Between Acute Blast-Versus Nonblast-Induced Mild Traumatic Brain Injury

(2010) Cynthia A. Luethcke et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Biomechanical Properties of Concussions in High School Football

(2010) STEVEN P. BROGLIO et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Glutamate receptors, neurotoxicity and neurodegeneration

(2010) Anthony Lau et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Recommendations for Diagnosing a Mild Traumatic Brain Injury: A National Academy of Neuropsychology Education Paper

(2009) R. M. Ruff et al.   ARCHIVES OF CLINICAL NEUROPSYCHOLOGY

Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury

(2009) Ann C. McKee et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Astrocytic Dysfunction in Epileptogenesis: Consequence of Altered Potassium and Glutamate Homeostasis?

(2009) Y. David et al.   JOURNAL OF NEUROSCIENCE

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Tests to assess motor phenotype in mice: a user's guide

(2009) Simon P. Brooks et al.   NATURE REVIEWS NEUROSCIENCE

Skull Flexure from Blast Waves: A Mechanism for Brain Injury with Implications for Helmet Design

(2009) William C. Moss et al.   PHYSICAL REVIEW LETTERS

Biomechanics of Traumatic Brain Injury: Influences of the Morphologic Heterogeneities of the Cerebral Cortex

(2008) R.J.H. Cloots et al.   ANNALS OF BIOMEDICAL ENGINEERING

Anesthesia-Induced Hyperphosphorylation Detaches 3-Repeat Tau from Microtubules without Affecting Their Stability In Vivo

(2008) E. Planel et al.   JOURNAL OF NEUROSCIENCE