Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology
Authors
Keywords
disease-associated microglia (DAM), CSF1R, Alzheimer's disease, APP/PS1
Journal
Cell Reports
Volume 35, Issue 10, Pages 109228
Publisher
Elsevier BV
Online
2021-06-08
DOI
10.1016/j.celrep.2021.109228
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Dystrophic microglia in late‐onset Alzheimer's disease
- (2020) Wolfgang J. Streit et al. GLIA
- Astrocyte senescence promotes glutamate toxicity in cortical neurons
- (2020) Chandani Limbad et al. PLoS One
- Human fetal microglia acquire homeostatic immune-sensing properties early in development
- (2020) L. Kracht et al. SCIENCE
- Targeting Microglial Population Dynamics in Alzheimer’s Disease: Are We Ready for a Potential Impact on Immune Function?
- (2020) Maria Martin-Estebane et al. Frontiers in Cellular Neuroscience
- Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model
- (2019) Peisu Zhang et al. NATURE NEUROSCIENCE
- A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment
- (2019) Hannah Van Hove et al. NATURE NEUROSCIENCE
- Transcriptome signature of cellular senescence
- (2019) Gabriel Casella et al. NUCLEIC ACIDS RESEARCH
- CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
- (2019) Renzo Mancuso et al. BRAIN
- Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model
- (2019) Elizabeth Spangenberg et al. Nature Communications
- A story of birth and death: Insights into the formation and dynamics of the microglial population
- (2018) Katharine Askew et al. BRAIN BEHAVIOR AND IMMUNITY
- Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease
- (2018) Justyna Sosna et al. Molecular Neurodegeneration
- The Evolving Dialogue of Microglia and Neurons in Alzheimer’s Disease: Microglia as Necessary Transducers of Pathology
- (2018) E. Simon et al. NEUROSCIENCE
- Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
- (2018) Tyler J. Bussian et al. NATURE
- The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
- (2017) Susanne Krasemann et al. IMMUNITY
- Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain
- (2017) Katharine Askew et al. Cell Reports
- Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution
- (2017) Hansruedi Mathys et al. Cell Reports
- Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology
- (2016) Adrian Olmos-Alonso et al. BRAIN
- Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology
- (2016) Elizabeth E. Spangenberg et al. BRAIN
- Immunosenescence of microglia and macrophages: impact on the ageing central nervous system
- (2016) Khalil S. Rawji et al. BRAIN
- Dark microglia: A new phenotype predominantly associated with pathological states
- (2016) Kanchan Bisht et al. GLIA
- CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves
- (2016) Anna Martínez-Muriana et al. Scientific Reports
- Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening
- (2015) Divya D. A. Raj et al. AGING CELL
- TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
- (2015) Yaming Wang et al. CELL
- USP18 lack in microglia causes destructive interferonopathy of the mouse brain
- (2015) T. Goldmann et al. EMBO JOURNAL
- Microglial numbers attain adult levels after undergoing a rapid decrease in cell number in the third postnatal week
- (2015) Maria Nikodemova et al. JOURNAL OF NEUROIMMUNOLOGY
- Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice
- (2015) Nabil N. Dagher et al. Journal of Neuroinflammation
- Telomere dysfunction reduces microglial numbers without fully inducing an aging phenotype
- (2015) Asif Manzoor Khan et al. NEUROBIOLOGY OF AGING
- Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques
- (2015) Carlo Condello et al. Nature Communications
- featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
- (2013) Y. Liao et al. BIOINFORMATICS
- Regulation of Microglial Proliferation during Chronic Neurodegeneration
- (2013) D. Gomez-Nicola et al. JOURNAL OF NEUROSCIENCE
- Smart-seq2 for sensitive full-length transcriptome profiling in single cells
- (2013) Simone Picelli et al. NATURE METHODS
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
- (2010) F. Ginhoux et al. SCIENCE
- Critical pathways in cellular senescence and immortalization revealed by gene expression profiling
- (2008) A L Fridman et al. ONCOGENE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now