Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain

Dystrophic microglia in late‐onset Alzheimer's disease

(2020) Wolfgang J. Streit et al.   GLIA

Increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged Tupaia belangeri

(2020) Juan D. Rodriguez‐Callejas et al.   GLIA

Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model

(2020) Lynn van Olst et al.   NEUROBIOLOGY OF AGING

Iron Redox Speciation Analysis Using Capillary Electrophoresis Coupled to Inductively Coupled Plasma Mass Spectrometry (CE-ICP-MS)

(2019) Bernhard Michalke et al.   Frontiers in Chemistry

Loss of ferritin-positive microglia relates to increased iron, RNA oxidation, and dystrophic microglia in the brains of aged male marmosets

(2019) Juan de Dios Rodríguez-Callejas et al.   AMERICAN JOURNAL OF PRIMATOLOGY

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Old age increases microglial senescence, exacerbates secondary neuroinflammation, and worsens neurological outcomes after acute traumatic brain injury in mice

(2019) Rodney M. Ritzel et al.   NEUROBIOLOGY OF AGING

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Microglia changes associated to Alzheimer's disease pathology in aged chimpanzees

(2018) Melissa K. Edler et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

A limited capacity for microglial repopulation in the adult brain

(2018) Allison R. Najafi et al.   GLIA

Detergent Insoluble Proteins and Inclusion Body-Like Structures Immunoreactive for PRKDC/DNA-PK/DNA-PKcs, FTL, NNT, and AIFM1 in the Amygdala of Cognitively Impaired Elderly Persons

(2017) Jozsef Gal et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Markers of microglia in post-mortem brain samples from patients with Alzheimer’s disease: a systematic review

(2017) K E Hopperton et al.   MOLECULAR PSYCHIATRY

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

(2017) Thais F Galatro et al.   NATURE NEUROSCIENCE

Soluble phospho-tau from Alzheimer’s disease hippocampus drives microglial degeneration

(2016) Elisabeth Sanchez-Mejias et al.   ACTA NEUROPATHOLOGICA

Microglia in dementia with Lewy bodies

(2016) Wolfgang J. Streit et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia show altered morphology and reduced arborization in human brain during aging and Alzheimer's disease

(2016) Danielle S. Davies et al.   BRAIN PATHOLOGY

Inhomogeneous distribution of Iba-1 characterizes microglial pathology in Alzheimer's disease

(2016) Jasmin Tischer et al.   GLIA

Disease-related microglia heterogeneity in the hippocampus of Alzheimer’s disease, dementia with Lewy bodies, and hippocampal sclerosis of aging

(2015) Adam D Bachstetter et al.   Acta Neuropathologica Communications

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Iron and neurodegeneration in the multiple sclerosis brain

(2013) Simon Hametner et al.   ANNALS OF NEUROLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Transmitting senescence to the cell neighbourhood

(2013) Matthew Hoare et al.   NATURE CELL BIOLOGY

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice

(2013) Marie Orre et al.   NEUROBIOLOGY OF AGING

Microglial pathology in Down syndrome

(2011) Qing-Shan Xue et al.   ACTA NEUROPATHOLOGICA

Neuroinflammation in Alzheimer's disease wanes with age

(2011) Jeroen JM Hoozemans et al.   Journal of Neuroinflammation

Manganese exposure induces microglia activation and dystrophy in the substantia nigra of non-human primates

(2010) Tatyana Verina et al.   NEUROTOXICOLOGY

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity

(2008) Kryslaine O. Lopes et al.   GLIA