Aging Microglia—Phenotypes, Functions and Implications for Age-Related Neurodegenerative Diseases

Microglia Demonstrate Age-Dependent Interaction with Amyloid-β Fibrils

(2018) Angela Marie Floden et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity

(2017) Eva Czirr et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging

(2017) Lilach Soreq et al.   Cell Reports

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

(2017) Katharine Askew et al.   Cell Reports

Microglia show altered morphology and reduced arborization in human brain during aging and Alzheimer's disease

(2016) Danielle S. Davies et al.   BRAIN PATHOLOGY

Young microglia restore amyloid plaque clearance of aged microglia

(2016) Anna Daria et al.   EMBO JOURNAL

Inhomogeneous distribution of Iba-1 characterizes microglial pathology in Alzheimer's disease

(2016) Jasmin Tischer et al.   GLIA

Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina

(2016) Xu Wang et al.   JOURNAL OF NEUROSCIENCE

The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming

(2016) Laura K. Fonken et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

Origin, fate and dynamics of macrophages at central nervous system interfaces

(2016) Tobias Goldmann et al.   NATURE IMMUNOLOGY

Age-related myelin degradation burdens the clearance function of microglia during aging

(2016) Shima Safaiyan et al.   NATURE NEUROSCIENCE

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

The age-related neuroinflammatory environment promotes macrophage activation, which negatively impacts synaptic function

(2016) Derek A. Costello et al.   NEUROBIOLOGY OF AGING

Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus

(2016) Nicholas H. Varvel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset

(2016) Juan D. Rodriguez-Callejas et al.   Frontiers in Aging Neuroscience

Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model

(2016) Annika Scheffold et al.   Acta Neuropathologica Communications

Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes

(2015) Corinna Bliederhaeuser et al.   ACTA NEUROPATHOLOGICA

Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening

(2015) Divya D. A. Raj et al.   AGING CELL

TGFβ1 inhibits IFNγ-mediated microglia activation and protects mDA neurons from IFNγ-driven neurotoxicity

(2015) Xiaolai Zhou et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Brain region-specific gene expression profiles in freshly isolated rat microglia

(2015) Karlijn J. Doorn et al.   Frontiers in Cellular Neuroscience

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

(2015) Carlo Condello et al.   Nature Communications

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody

(2015) Wenjie Luo et al.   Scientific Reports

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

(2015) Inge R Holtman et al.   Acta Neuropathologica Communications

Age-dependent changes on TGFβ1 Smad3 pathway modify the pattern of microglial cell activation

(2014) Juan E. Tichauer et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia shape corpus callosum axon tract fasciculation: functional impact of prenatal inflammation

(2014) Lorena Pont-Lezica et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Pattern recognition receptors and central nervous system repair

(2014) Kristina A. Kigerl et al.   EXPERIMENTAL NEUROLOGY

TGFβ1 increases microglia-mediated engulfment of apoptotic cells via upregulation of the milk fat globule-EGF factor 8

(2014) Björn Spittau et al.   GLIA

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Priming of microglia in a DNA-repair deficient model of accelerated aging

(2014) Divya D.A. Raj et al.   NEUROBIOLOGY OF AGING

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Toll-Like Receptors 2, -3 and -4 Prime Microglia but not Astrocytes Across Central Nervous System Regions for ATP-Dependent Interleukin-1β Release

(2014) Laura Facci et al.   Scientific Reports

Microglia Modulate Wiring of the Embryonic Forebrain

(2014) Paola Squarzoni et al.   Cell Reports

The genetics of Alzheimer's disease

(2014) Eva Bagyinszky et al.   Clinical Interventions in Aging

Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke

(2013) Ting Li et al.   BRAIN

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson’s disease

(2013) Y Tang et al.   CELL DEATH AND DIFFERENTIATION

Unique transcriptome signature of mouse microglia

(2013) Clara Beutner et al.   GLIA

Regulation of Microglial Proliferation during Chronic Neurodegeneration

(2013) D. Gomez-Nicola et al.   JOURNAL OF NEUROSCIENCE

Layer V cortical neurons require microglial support for survival during postnatal development

(2013) Masaki Ueno et al.   NATURE NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation

(2013) Wenxin Ma et al.   NEUROBIOLOGY OF AGING

Aging enhances classical activation but mitigates alternative activation in the central nervous system

(2013) Daniel C. Lee et al.   NEUROBIOLOGY OF AGING

Distinct activation profiles in microglia of different ages: A systematic study in isolated embryonic to aged microglial cultures

(2013) A.Y. Lai et al.   NEUROSCIENCE

Preconditioning of Microglia by α-Synuclein Strongly Affects the Response Induced by Toll-like Receptor (TLR) Stimulation

(2013) Cintia Roodveldt et al.   PLoS One

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Distribution of microglia in the postnatal murine nigrostriatal system

(2012) Ahmed Sharaf et al.   CELL AND TISSUE RESEARCH

The Soothing Touch: Microglial Contact Influences Neuronal Excitability

(2012) Aude Panatier et al.   DEVELOPMENTAL CELL

Differential cell proliferation in the cortex of the appsweps1de9 alzheimer's disease mouse model

(2012) Willem Kamphuis et al.   GLIA

Endogenous transforming growth factor-beta promotes quiescence of primary microglia in vitro

(2012) Björn Spittau et al.   GLIA

Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia

(2012) Melanie Greter et al.   IMMUNITY

TGFβ signalling plays an important role in IL4-induced alternative activation of microglia

(2012) Xiaolai Zhou et al.   Journal of Neuroinflammation

Deficiency of the Microglial Receptor CX3CR1 Impairs Postnatal Functional Development of Thalamocortical Synapses in the Barrel Cortex

(2012) M. Hoshiko et al.   JOURNAL OF NEUROSCIENCE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment

(2011) Heather D VanGuilder et al.   Journal of Neuroinflammation

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Age-related alterations in the dynamic behavior of microglia

(2010) Mausam R. Damani et al.   AGING CELL

Microglial activation and age-related dopaminergic neurodegeneration in MPTP-treated SAMP8 mice

(2010) Jing Liu et al.   BRAIN RESEARCH

Microglial activation in healthy aging

(2010) Alie Schuitemaker et al.   NEUROBIOLOGY OF AGING

Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function

(2010) eMalick G. Njie et al.   NEUROBIOLOGY OF AGING

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia

(2009) Stefan A Grathwohl et al.   NATURE NEUROSCIENCE

Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease

(2008) Luigi Zecca et al.   ACTA NEUROPATHOLOGICA

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

(2008) Christopher J. Henry et al.   BRAIN BEHAVIOR AND IMMUNITY

Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in monkeys

(2008) Nicholas M. Kanaan et al.   GLIA

Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS

(2008) Alexander H. de Haas et al.   GLIA