The AAA+ superfamily: a review of the structural and mechanistic principles of these molecular machines

A chemical genetics approach to examine the functions of AAA proteins

(2021) Tommaso Cupido et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction

(2021) Subu Subramanian et al.   eLife

Mechanistic insight into substrate processing and allosteric inhibition of human p97

(2021) Man Pan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Extreme parsimony in ATP consumption by 20S complexes in the global disassembly of single SNARE complexes

(2021) Changwon Kim et al.   Nature Communications

Evidence for a novel overlapping coding sequence in POLG initiated at a CUG start codon

(2020) Yousuf A. Khan et al.   BMC GENETICS

Processive extrusion of polypeptide loops by a Hsp100 disaggregase

(2020) Mario J. Avellaneda et al.   NATURE

Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein

(2020) Wai Kwan Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Bcs1 AAA-ATPase suggests an airlock-like translocation mechanism for folded proteins

(2020) Lukas Kater et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding

(2020) Julia R Kardon et al.   eLife

A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

(2020) Zev A Ripstein et al.   eLife

AAA+ proteins

(2020) Thiago V. Seraphim et al.   CURRENT BIOLOGY

Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis

(2020) Kyle E. Lopez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for distinct operational modes and protease activation in AAA+ protease Lon

(2020) Mia Shin et al.   Science Advances

Sorafenib as an Inhibitor of RUVBL2

(2020) Nardin Nano et al.   Biomolecules

The AAA+ ATPase Msp1 is a processive protein translocase with robust unfoldase activity

(2020) Dominic T. Castanzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

(2020) Juraj Ahel et al.   eLife

ClpL is a functionally active tetradecameric AAA+ chaperone, distinct from hexameric/dodecameric ones

(2020) Gyuhee Kim et al.   FASEB JOURNAL

Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch

(2020) Christl Gaubitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sigma 54-Regulated Transcription Is Associated with Membrane Reorganization and Type III Secretion Effectors during Conversion to Infectious Forms of Chlamydia trachomatis

(2020) Katelyn R. Soules et al.   mBio

The Cryo-EM structure of AAV2 Rep68 in complex with ssDNA reveals a malleable AAA+ machine that can switch between oligomeric states

(2020) Vishaka Santosh et al.   NUCLEIC ACIDS RESEARCH

The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein

(2020) Xinglei Liu et al.   Nature Communications

Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase

(2020) Fabian Zimmermann et al.   Science Advances

Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7

(2019) Yu-Hua Lo et al.   Nature Communications

Designing a chemical inhibitor for the AAA protein spastin using active site mutations

(2019) Tommaso Cupido et al.   Nature Chemical Biology

Physical Basis for the Loading of a Bacterial Replicative Helicase onto DNA

(2019) Ernesto Arias-Palomo et al.   MOLECULAR CELL

The AAA+ ATPase/ubiquitin ligase mysterin stabilizes cytoplasmic lipid droplets

(2019) Munechika Sugihara et al.   JOURNAL OF CELL BIOLOGY

AAA+ protein-based technologies to counter neurodegenerative disease

(2019) Zachary M. March et al.   BIOPHYSICAL JOURNAL

Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality

(2019) Jo Ishizawa et al.   CANCER CELL

Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease

(2019) Cristina Puchades et al.   MOLECULAR CELL

An allosteric network in spastin couples multiple activities required for microtubule severing

(2019) Colby R. Sandate et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Cdc48 segregase in the act of unfolding an authentic substrate

(2019) Ian Cooney et al.   SCIENCE

Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding

(2019) Edward C. Twomey et al.   SCIENCE

Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC

(2019) Neha Nirwan et al.   Nature Communications

DNA translocation mechanism of the MCM complex and implications for replication initiation

(2019) Martin Meagher et al.   Nature Communications

The AAA + ATPase TorsinA polymerizes into hollow helical tubes with 8.5 subunits per turn

(2019) F. Esra Demircioglu et al.   Nature Communications

Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor

(2019) Célia Deville et al.   Cell Reports

Structural basis for power stroke vs. Brownian ratchet mechanisms of motor proteins

(2019) Wonmuk Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the complex of the interaction domains of Escherichia coli DnaB helicase and DnaC helicase loader: structural basis implying a distortion-accumulation mechanism for the DnaB ring opening caused by DnaC binding

(2019) Koji Nagata et al.   JOURNAL OF BIOCHEMISTRY

The molecular principles governing the activity and functional diversity of AAA+ proteins

(2019) Cristina Puchades et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-EM structure of the ClpXP protein degradation machinery

(2019) Christos Gatsogiannis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Shaping the Nascent Ribosome: AAA-ATPases in Eukaryotic Ribosome Biogenesis

(2019) Prattes et al.   Biomolecules

Insights into the mechanism and regulation of the CbbQO-type Rubisco activase, a MoxR AAA+ ATPase

(2019) Yi-Chin Candace Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common Mode of Remodeling AAA ATPases p97/CDC48 by Their Disassembling Cofactors ASPL/PUX1

(2019) Sofia Banchenko et al.   STRUCTURE

Structural basis of nucleosome assembly by the Abo1 AAA+ ATPase histone chaperone

(2019) Carol Cho et al.   Nature Communications

The Role of ClpP Protease in Bacterial Pathogenesis and Human Diseases

(2018) Vaibhav Bhandari et al.   ACS Chemical Biology

Structure and Function of the 26S Proteasome

(2018) Jared A.M. Bard et al.   Annual Review of Biochemistry

Molecular Mechanisms of Fast Neurotransmitter Release

(2018) Axel T. Brunger et al.   Annual Review of Biophysics

Dissecting Substrate Specificities of the Mitochondrial AFG3L2 Protease

(2018) Bojian Ding et al.   BIOCHEMISTRY

VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling

(2018) Johannes van den Boom et al.   MOLECULAR CELL

The cytoplasmic dynein transport machinery and its many cargoes

(2018) Samara L. Reck-Peterson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1–Npl4

(2018) Nicholas O. Bodnar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An atypical N-ethylmaleimide sensitive factor enables the viability of nematode-resistantRhg1soybeans

(2018) Adam M. Bayless et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1–Npl4

(2018) Nicholas O. Bodnar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Malaria parasite translocon structure and mechanism of effector export

(2018) Chi-Min Ho et al.   NATURE

Structure of the origin recognition complex bound to DNA replication origin

(2018) Ningning Li et al.   NATURE

Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13

(2018) Claudio Alfieri et al.   NATURE

Structural principles of SNARE complex recognition by the AAA+ protein NSF

(2018) K Ian White et al.   eLife

The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair

(2018) Justin L. Sparks et al.   CELL

The AAA ATPase Afg1 preserves mitochondrial fidelity and cellular health by maintaining mitochondrial matrix proteostasis

(2018) Edward M. Germany et al.   JOURNAL OF CELL SCIENCE

Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome

(2018) Yuanchen Dong et al.   NATURE

Hexameric assembly of the AAA+ protein McrB is necessary for GTPase activity

(2018) Neha Nirwan et al.   NUCLEIC ACIDS RESEARCH

Cryo-EM structures of the archaeal PAN-proteasome reveal an around-the-ring ATPase cycle

(2018) Parijat Majumder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP-dependent force generation and membrane scission by ESCRT-III and Vps4

(2018) Johannes Schöneberg et al.   SCIENCE

Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis–driven translocation

(2018) Andres H. de la Peña et al.   SCIENCE

The CryoEM structure of the Saccharomyces cerevisiae ribosome maturation factor Rea1

(2018) Piotr Sosnowski et al.   eLife

ATAD2 in cancer: a pharmacologically challenging but tractable target

(2017) Muzammal Hussain et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Covalently linked HslU hexamers support a probabilistic mechanism that links ATP hydrolysis to protein unfolding and translocation

(2017) Vladimir Baytshtok et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Programmed Ribosomal Frameshifting Generates a Copper Transporter and a Copper Chaperone from the Same Gene

(2017) Sezen Meydan et al.   MOLECULAR CELL

Functions of bromodomain-containing proteins and their roles in homeostasis and cancer

(2017) Takao Fujisawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-EM structures of the human INO80 chromatin-remodeling complex

(2017) Ricardo J. Aramayo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Katanin spiral and ring structures shed light on power stroke for microtubule severing

(2017) Elena Zehr et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18

(2017) Ying Lai et al.   NEURON

Effect of directional pulling on mechanical protein degradation by ATP-dependent proteolytic machines

(2017) Adrian O. Olivares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy

(2017) Emily E. Blythe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104

(2017) Stephanie N. Gates et al.   SCIENCE

Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing

(2017) Cristina Puchades et al.   SCIENCE

Cryo-EM structures of the ATP-bound Vps4E233Q hexamer and its complex with Vta1 at near-atomic resolution

(2017) Shan Sun et al.   Nature Communications

Cryo-EM structures of the human INO80 chromatin-remodeling complex

(2017) Ricardo J. Aramayo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Katanin spiral and ring structures shed light on power stroke for microtubule severing

(2017) Elena Zehr et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets

(2017) Han Han et al.   eLife

Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase

(2017) Nicole Monroe et al.   eLife

Diversity of DNA Replication in the Archaea

(2017) Darya Ausiannikava et al.   Genes

Review: The lord of the rings: Structure and mechanism of the sliding clamp loader

(2016) Brian A. Kelch   BIOPOLYMERS

The life cycle of the 26S proteasome: from birth, through regulation and function and onto its death

(2016) Ido Livneh et al.   CELL RESEARCH

Novel CLPB mutation in a patient with 3-methylglutaconic aciduria causing severe neurological involvement and congenital neutropenia

(2016) Ayca Kiykim et al.   CLINICAL IMMUNOLOGY

Torsins Are Essential Regulators of Cellular Lipid Metabolism

(2016) Micheline Grillet et al.   DEVELOPMENTAL CELL

Structural and Functional Characterization of Programmed Ribosomal Frameshift Signals in West Nile Virus Strains Reveals High Structural Plasticity Amongcis-Acting RNA Elements

(2016) Christine Moomau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines

(2016) Nicole Monroe et al.   JOURNAL OF MOLECULAR BIOLOGY

Ablation of Programmed −1 Ribosomal Frameshifting in Venezuelan Equine Encephalitis Virus Results in Attenuated Neuropathogenicity

(2016) Joseph A. Kendra et al.   JOURNAL OF VIROLOGY

Substrate-translocating loops regulate mechanochemical coupling and power production in AAA+ protease ClpXP

(2016) Piere Rodriguez-Aliaga et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

2.3 A resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition

(2016) S. Banerjee et al.   SCIENCE

Substrate-translocating loops regulate mechanochemical coupling and power production in AAA+ protease ClpXP

(2016) Piere Rodriguez-Aliaga et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insights into the Escherichia coli lysine decarboxylases and molecular determinants of interaction with the AAA+ ATPase RavA

(2016) Eaazhisai Kandiah et al.   Scientific Reports

Fundamental Characteristics of AAA+ Protein Family Structure and Function

(2016) Justin M. Miller et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia

(2016) F Esra Demircioglu et al.   eLife

Mitochondrial proteases and protein quality control in ageing and longevity

(2015) Marie-Paule Hamon et al.   AGEING RESEARCH REVIEWS

CLPB Mutations Cause 3-Methylglutaconic Aciduria, Progressive Brain Atrophy, Intellectual Disability, Congenital Neutropenia, Cataracts, Movement Disorder

(2015) Saskia B. Wortmann et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ClpL is a chaperone without auxiliary factors

(2015) Sang-Sang Park et al.   FEBS Journal

The Pex1/Pex6 Complex Is a Heterohexameric AAA + Motor with Alternating and Highly Coordinated Subunits

(2015) Brooke M. Gardner et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanistic insights into the recycling machine of the SNARE complex

(2015) Minglei Zhao et al.   NATURE

Structure of the eukaryotic MCM complex at 3.8 Å

(2015) Ningning Li et al.   NATURE

Augmented genetic decoding: global, local and temporal alterations of decoding processes and codon meaning

(2015) Pavel V. Baranov et al.   NATURE REVIEWS GENETICS

DNA replication origin activation in space and time

(2015) Michalis Fragkos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DnaC traps DnaB as an open ring and remodels the domain that binds primase

(2015) Sundari Chodavarapu et al.   NUCLEIC ACIDS RESEARCH

Structure and mechanism of the ATPase that powers viral genome packaging

(2015) Brendan J. Hilbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy

(2015) Neil B. Blok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spring-loaded unraveling of a single SNARE complex by NSF in one round of ATP turnover

(2015) J.-K. Ryu et al.   SCIENCE

Structures of the RNA polymerase- 54 reveal new and conserved regulatory strategies

(2015) Y. Yang et al.   SCIENCE

Asymmetric ring structure of Vps4 required for ESCRT-III disassembly

(2015) Christophe Caillat et al.   Nature Communications

ATP binding to neighbouring subunits and intersubunit allosteric coupling underlie proteasomal ATPase function

(2015) Young-Chan Kim et al.   Nature Communications

Molecular snapshots of the Pex1/6 AAA+ complex in action

(2015) Susanne Ciniawsky et al.   Nature Communications

cryo-EM structures of the E. coli replicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease and τ

(2015) Rafael Fernandez-Leiro et al.   eLife

The Principle of Membrane Fusion in the Cell (Nobel Lecture)

(2014) James Edward Rothman   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy

(2014) Raymond J Deshaies   BMC BIOLOGY

Stochastic but Highly Coordinated Protein Unfolding and Translocation by the ClpXP Proteolytic Machine

(2014) Juan Carlos Cordova et al.   CELL

Three αSNAP and 10 ATP Molecules Are Used in SNARE Complex Disassembly byN-ethylmaleimide-sensitive Factor (NSF)

(2014) Niket Shah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lessons from Yeast on Emerging Roles of the ATAD2 Protein Family in Gene Regulation and Genome Organization

(2014) Matteo Cattaneo et al.   MOLECULES AND CELLS

Structure of human cytoplasmic dynein-2 primed for its power stroke

(2014) Helgo Schmidt et al.   NATURE

Mechanochemical basis of protein degradation by a double-ring AAA+ machine

(2014) Adrian O Olivares et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins

(2014) V. Okreglak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mechanism of Torsin ATPase activation

(2014) Rebecca S. H. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Moyamoya disease-associated protein mysterin/RNF213 is a novel AAA+ ATPase, which dynamically changes its oligomeric state

(2014) Daisuke Morito et al.   Scientific Reports

How lamina-associated polypeptide 1 (LAP1) activates Torsin

(2014) Brian A Sosa et al.   eLife

Analysis of the crystal structure of an active MCM hexamer

(2014) Justin M Miller et al.   eLife

Mechanisms for Initiating Cellular DNA Replication

(2013) Alessandro Costa et al.   Annual Review of Biochemistry

The ClpXP Protease Unfolds Substrates Using a Constant Rate of Pulling but Different Gears

(2013) Maya Sen et al.   CELL

Characterization of the Replication Initiator Orc1/Cdc6 from the Archaeon Picrophilus torridus

(2013) J. Arora et al.   JOURNAL OF BACTERIOLOGY

The Allosteric Role of the AAA+Domain of ChlD Protein from the Magnesium Chelatase ofSynechocystisSpecies PCC 6803

(2013) Nathan B. P. Adams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disassembly of All SNARE Complexes byN-Ethylmaleimide-sensitive Factor (NSF) Is Initiated by a Conserved 1:1 Interaction between α-Soluble NSF Attachment Protein (SNAP) and SNARE Complex

(2013) Sandro Vivona et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Processive ATP-driven Substrate Disassembly by theN-Ethylmaleimide-sensitive Factor (NSF) Molecular Machine

(2013) Daniel J. Cipriano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of the N domain of the AAA+ Lon protease in substrate recognition, allosteric regulation and chaperone activity

(2013) Matthew L. Wohlever et al.   MOLECULAR MICROBIOLOGY

Reconstitution of the 26S proteasome reveals functional asymmetries in its AAA+ unfoldase

(2013) Robyn Beckwith et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle

(2013) Thomas C. Südhof   NEURON

Distinct quaternary structures of the AAA+ Lon protease control substrate degradation

(2013) E. F. Vieux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mechanism for Reorientation of Cortical Microtubule Arrays Driven by Microtubule Severing

(2013) J. J. Lindeboom et al.   SCIENCE

Replication Clamps and Clamp Loaders

(2013) M. Hedglin et al.   Cold Spring Harbor Perspectives in Biology

Replication Proteins and Human Disease

(2013) A. P. Jackson et al.   Cold Spring Harbor Perspectives in Biology

DNA Replication Origins

(2013) A. C. Leonard et al.   Cold Spring Harbor Perspectives in Biology

Clamp loader ATPases and the evolution of DNA replication machinery

(2012) Brian A Kelch et al.   BMC BIOLOGY

Direct electron detection yields cryo-EM reconstructions at resolutions beyond 3/4 Nyquist frequency

(2012) Benjamin E. Bammes et al.   JOURNAL OF STRUCTURAL BIOLOGY

The Role of Bacterial Enhancer Binding Proteins as Specialized Activators of  54-Dependent Transcription

(2012) M. Bush et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Structural characterization of full-length NSF and 20S particles

(2012) Lei-Fu Chang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reconstitution of the Vital Functions of Munc18 and Munc13 in Neurotransmitter Release

(2012) C. Ma et al.   SCIENCE

Large-Scale Conformational Flexibility Determines the Properties of AAA+ TIP49 ATPases

(2012) Michael Petukhov et al.   STRUCTURE

AAA+ Proteases: ATP-Fueled Machines of Protein Destruction

(2011) Robert T. Sauer et al.   Annual Review of Biochemistry

Coupling AAA protein function to regulated gene expression

(2011) Nicolas Joly et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structure and function of the AAA+ nucleotide binding pocket

(2011) Petra Wendler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ClpX(P) Generates Mechanical Force to Unfold and Translocate Its Protein Substrates

(2011) Rodrigo A. Maillard et al.   CELL

A Pathway of Protein Translocation in Mitochondria Mediated by the AAA-ATPase Bcs1

(2011) Nikola Wagener et al.   MOLECULAR CELL

Structure and mechanism of the hexameric MecA–ClpC molecular machine

(2011) Feng Wang et al.   NATURE

DNA stretching by bacterial initiators promotes replication origin opening

(2011) Karl E. Duderstadt et al.   NATURE

The ribosome uses two active mechanisms to unwind messenger RNA during translation

(2011) Xiaohui Qu et al.   NATURE

How a DNA Polymerase Clamp Loader Opens a Sliding Clamp

(2011) B. A. Kelch et al.   SCIENCE

Organization of SNAREs within the Golgi Stack

(2011) J. Malsam et al.   Cold Spring Harbor Perspectives in Biology

Activation of Human VPS4A by ESCRT-III Proteins Reveals Ability of Substrates to Relieve Enzyme Autoinhibition

(2010) Samuel A. Merrill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28

(2010) Daniela Di Bella et al.   NATURE GENETICS

Plant Hsp100/ClpB-like proteins: poorly-analyzed cousins of yeast ClpB machine

(2010) Amanjot Singh et al.   PLANT MOLECULAR BIOLOGY

Structure of RavA MoxR AAA+ protein reveals the design principles of a molecular cage modulating the inducible lysine decarboxylase activity

(2010) M. El Bakkouri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engagement of Arginine Finger to ATP Triggers Large Conformational Changes in NtrC1 AAA+ ATPase for Remodeling Bacterial RNA Polymerase

(2010) Baoyu Chen et al.   STRUCTURE

ATP-Induced Conformational Dynamics in the AAA+ Motor Unit of Magnesium Chelatase

(2010) Joakim Lundqvist et al.   STRUCTURE

AAA+ Ring and Linker Swing Mechanism in the Dynein Motor

(2009) Anthony J. Roberts et al.   CELL

Structures of Asymmetric ClpX Hexamers Reveal Nucleotide-Dependent Motions in a AAA+ Protein-Unfolding Machine

(2009) Steven E. Glynn et al.   CELL

A Conserved Membrane Attachment Site in α-SNAP FacilitatesN-Ethylmaleimide-sensitive Factor (NSF)-driven SNARE Complex Disassembly

(2009) Ulrike Winter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequence analysis of the AAA protein family

(2009) Andreas Beyer   PROTEIN SCIENCE

Clp chaperone–proteases: structure and function

(2009) Wolfgang Kress et al.   RESEARCH IN MICROBIOLOGY

AAA+ ATPases in the Initiation of DNA Replication

(2008) Karl E. Duderstadt et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The atRA-responsive gene neuron navigator 2 functions in neurite outgrowth and axonal elongation

(2008) P.D. Muley et al.   Developmental Neurobiology

Regulatory ATPase Sites of Cytoplasmic Dynein Affect Processivity and Force Generation

(2008) Carol Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improved Structures of Full-Length p97, an AAA ATPase: Implications for Mechanisms of Nucleotide-Dependent Conformational Change

(2008) Jason M. Davies et al.   STRUCTURE