Structural basis for power stroke vs. Brownian ratchet mechanisms of motor proteins

Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F1-Fo coupling

(2019) Bonnie J. Murphy et al.   SCIENCE

Molecular rotary motors: Unidirectional motion around double bonds

(2018) Diederik Roke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution cryo-EM structures of actin-bound myosin states reveal the mechanism of myosin force sensing

(2018) Ahmet Mentes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An intermediate along the recovery stroke of myosin VI revealed by X-ray crystallography and molecular dynamics

(2018) Florian Blanc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elastic coupling power stroke mechanism of the F1-ATPase molecular motor

(2018) James L. Martin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane

(2018) Anurag P. Srivastava et al.   SCIENCE

Cryo-EM reveals the structural basis of microtubule depolymerization by kinesin-13s

(2018) Matthieu P.M.H. Benoit et al.   Nature Communications

Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters

(2018) Stephen R. Norris et al.   Nature Communications

Experimental realization of Feynman’s ratchet

(2018) Jaehoon Bang et al.   NEW JOURNAL OF PHYSICS

Nonequilibrium Energetics of Molecular Motor Kinesin

(2018) Takayuki Ariga et al.   PHYSICAL REVIEW LETTERS

Parsing the roles of neck-linker docking and tethered head diffusion in the stepping dynamics of kinesin

(2017) Zhechun Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinematics of the lever arm swing in myosin VI

(2017) Mauro L. Mugnai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinesin rotates unidirectionally and generates torque while walking on microtubules

(2017) Avin Ramaiya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinesin motility driven by subdomain dynamics

(2017) Wonmuk Hwang et al.   eLife

The Kinesin-1 Chemomechanical Cycle: Stepping Toward a Consensus

(2016) William O. Hancock   BIOPHYSICAL JOURNAL

The Physics and Physical Chemistry of Molecular Machines

(2016) R. Dean Astumian et al.   CHEMPHYSCHEM

Molecular Motors: Power Strokes Outperform Brownian Ratchets

(2016) Jason A. Wagoner et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Direct observation of intermediate states during the stepping motion of kinesin-1

(2016) Hiroshi Isojima et al.   Nature Chemical Biology

Theory of single-molecule controlled rotation experiments, predictions, tests, and comparison with stalling experiments in F1-ATPase

(2016) Sándor Volkán-Kacsó et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force-producing ADP state of myosin bound to actin

(2016) Sarah F. Wulf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Backwards Motion in Kinesin-1-Kinesin-14 Chimera: Implication for Kinesin-14 Motility

(2016) Masahiko Yamagishi et al.   STRUCTURE

Kinetic Adaptations of Myosins for Their Diverse Cellular Functions

(2016) Sarah M. Heissler et al.   TRAFFIC

How Myosin Generates Force on Actin Filaments

(2016) Anne Houdusse et al.   TRENDS IN BIOCHEMICAL SCIENCES

Engineered kinesin motor proteins amenable to small-molecule inhibition

(2016) Martin F. Engelke et al.   Nature Communications

Torque Transmission Mechanism via DELSEED Loop of F1-ATPase

(2015) Rikiya Watanabe et al.   BIOPHYSICAL JOURNAL

Mitosis, microtubule dynamics and the evolution of kinesins

(2015) Juan Jesus Vicente et al.   EXPERIMENTAL CELL RESEARCH

Single molecule thermodynamics of ATP synthesis by F1-ATPase

(2015) Shoichi Toyabe et al.   NEW JOURNAL OF PHYSICS

How release of phosphate from mammalian F1-ATPase generates a rotary substep

(2015) John V. Bason et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elasticity, friction, and pathway of γ-subunit rotation in FoF1-ATP synthase

(2015) Kei-ichi Okazaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct measurements of the coordination of lever arm swing and the catalytic cycle in myosin V

(2015) Darshan V. Trivedi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetics of nucleotide-dependent structural transitions in the kinesin-1 hydrolysis cycle

(2015) Keith J. Mickolajczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinesin, 30 years later: Recent insights from structural studies

(2015) Weiyi Wang et al.   PROTEIN SCIENCE

Structural dynamics of myosin 5 during processive motion revealed by interferometric scattering microscopy

(2015) Joanna Andrecka et al.   eLife

None of the Rotor Residues of F1-ATPase Are Essential for Torque Generation

(2014) Ryohei Chiwata et al.   BIOPHYSICAL JOURNAL

Anatomy of F1-ATPase powered rotation

(2014) J. L. Martin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family

(2014) Adeline Goulet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trapping the ATP binding state leads to a detailed understanding of the F1-ATPase mechanism

(2014) Kwangho Nam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of apo-kinesin bound to tubulin links the nucleotide cycle to movement

(2014) Luyan Cao et al.   Nature Communications

Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

(2014) Joseph Atherton et al.   eLife

The ATP synthase: the understood, the uncertain and the unknown

(2013) John E. Walker   BIOCHEMICAL SOCIETY TRANSACTIONS

Tilting and Wobble of Myosin V by High-Speed Single-Molecule Polarized Fluorescence Microscopy

(2013) John F. Beausang et al.   BIOPHYSICAL JOURNAL

Modular Aspects of Kinesin Force Generation Machinery

(2013) William R. Hesse et al.   BIOPHYSICAL JOURNAL

Force generation by kinesin and myosin cytoskeletal motor proteins

(2013) F. Jon Kull et al.   JOURNAL OF CELL SCIENCE

Structure of a kinesin–tubulin complex and implications for kinesin motility

(2013) Benoît Gigant et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Elastic and Conformational Softness of a Globular Protein

(2013) Liang Hong et al.   PHYSICAL REVIEW LETTERS

Nucleotide-Dependent Control of Internal Strains in Ring-Shaped AAA+ Motors

(2012) Wonmuk Hwang et al.   Cellular and Molecular Bioengineering

Microscopic reversibility as the organizing principle of molecular machines

(2012) R. Dean Astumian   Nature Nanotechnology

Measuring collective transport by defined numbers of processive and nonprocessive kinesin motors

(2012) K. Furuta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Switching of myosin-V motion between the lever-arm swing and Brownian search-and-catch

(2012) Keisuke Fujita et al.   Nature Communications

Hysteresis-Based Mechanism for the Directed Motility of the Ncd Motor

(2011) Sirish Kaushik Lakkaraju et al.   BIOPHYSICAL JOURNAL

A universal pathway for kinesin stepping

(2011) Bason E Clancy et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

High-Speed Atomic Force Microscopy Reveals Rotary Catalysis of Rotorless F1-ATPase

(2011) T. Uchihashi et al.   SCIENCE

Electrostatically Biased Binding of Kinesin to Microtubules

(2011) Barry J. Grant et al.   PLOS BIOLOGY

Structural and Functional Insights into the Myosin Motor Mechanism

(2010) H. Lee Sweeney et al.   Annual Review of Biophysics

Structural Basis for Mechanical Force Regulation of the Adhesin FimH via Finger Trap-like β Sheet Twisting

(2010) Isolde Le Trong et al.   CELL

Video imaging of walking myosin V by high-speed atomic force microscopy

(2010) Noriyuki Kodera et al.   NATURE

Myosin VI: an innovative motor that challenged the swinging lever arm hypothesis

(2010) James A. Spudich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nonequilibrium Energetics of a SingleF1-ATPase Molecule

(2010) Shoichi Toyabe et al.   PHYSICAL REVIEW LETTERS

An atomic-level mechanism for activation of the kinesin molecular motors

(2010) C. V. Sindelar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinesin's light chains inhibit the head- and microtubule-binding activity of its tail

(2010) Y. L. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pi Release from Myosin: A Simulation Analysis of Possible Pathways

(2010) Marco Cecchini et al.   STRUCTURE

Mechanical Design of Translocating Motor Proteins

(2009) Wonmuk Hwang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Mechanical Coupling in Myosin V: A Simulation Study

(2009) Victor Ovchinnikov et al.   JOURNAL OF MOLECULAR BIOLOGY

Direct observation of the binding state of the kinesin head to the microtubule

(2009) Nicholas R. Guydosh et al.   NATURE

Mechanochemical model for myosin V

(2009) E. M. Craig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct measurements of kinesin torsional properties reveal flexible domains and occasional stalk reversals during stepping

(2009) B. Gutierrez-Medina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin V from head to tail

(2008) K. M. Trybus   CELLULAR AND MOLECULAR LIFE SCIENCES

How subunit coupling produces the  -subunit rotary motion in F1-ATPase

(2008) J. Pu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinesin's cover-neck bundle folds forward to generate force

(2008) A. S. Khalil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Domain compliance and elastic power transmission in rotary FOF1-ATPase

(2008) H. Sielaff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axle-Less F1-ATPase Rotates in the Correct Direction

(2008) Shou Furuike et al.   SCIENCE

Force Generation in Kinesin Hinges on Cover-Neck Bundle Formation

(2008) Wonmuk Hwang et al.   STRUCTURE

Allosteric Communication in Myosin V: From Small Conformational Changes to Large Directed Movements

(2008) M. Cecchini et al.   PLoS Computational Biology